Project Ribeye Protein Family Analysis

Project Ribeye protein Family Analysis (Thomas).

Project Ribeye protein Family Analysis (Thomas)

Project Name: Ribeye protein Family Analysis

Project Start Date: 2009/06/01

Collaborators: Hernan Lopez ([email protected]), Cedric

Description:

Ribeye proteins are essential for forming packing structures of synapses in vertebrate eyes and ears. They are built from a so-called "a domain" and a CTBP2 domain, which are located on different exons.

However, it's unclear how the Ribeye protein evolved, since in invertebrates no homologous protein to the a domain is known.

In this project we try to find out how the protein could have evolved.

This includes standard homology analysis like PSI-BLAST, but also more sophisticated approaches including novel machine learning-based methods.

Lab-Book:

Links:

Bibliography:

• RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.