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wikipathways · Jun 23, 2023 · f23e4b0 · f23e4b0
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diff --git a/pathways/WP1968/WP1968-datanodes.tsv b/pathways/WP1968/WP1968-datanodes.tsv
@@ -1,6 +1,6 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI
 Pik3ca	GeneProduct	ensembl:ENSRNOG00000056371		ensembl:ENSRNOG00000056371	ncbigene:170911		uniprot:A0A0G2K344			
-Erbb2	GeneProduct	ensembl:ENSRNOG00000006450		ensembl:ENSRNOG00000006450	ncbigene:24337		uniprot:Q8K3F9;uniprot:A0A0G2JT61;uniprot:F1LRR9			
+Erbb2	GeneProduct	ensembl:ENSRNOG00000006450		ensembl:ENSRNOG00000006450	ncbigene:24337		uniprot:Q8K3F9			
 Egfr	GeneProduct	ensembl:ENSRNOG00000004332		ensembl:ENSRNOG00000004332	ncbigene:24329		uniprot:G3V6K6			
 ERK	GeneProduct	ensembl:ENSRNOG00000001849		ensembl:ENSRNOG00000001849	ncbigene:116590		uniprot:P63086			
 Map2k1	GeneProduct	ensembl:ENSRNOG00000010176		ensembl:ENSRNOG00000010176	ncbigene:170851		uniprot:A0A0H2UHI2			
@@ -9,20 +9,20 @@ Rasl11b	GeneProduct	ensembl:ENSRNOG00000002097		ensembl:ENSRNOG00000002097	ncbig
 Akt1	GeneProduct	ensembl:ENSRNOG00000028629		ensembl:ENSRNOG00000028629	ncbigene:24185		uniprot:P47196			
 MYC	GeneProduct	ensembl:ENSRNOG00000042556		ensembl:ENSRNOG00000042556	ncbigene:311807		uniprot:P15063			
 Tgfb1	GeneProduct	ensembl:ENSRNOG00000020652		ensembl:ENSRNOG00000020652	ncbigene:59086		uniprot:P17246			
-Smad4	GeneProduct	ensembl:ENSRNOG00000051965		ensembl:ENSRNOG00000051965	ncbigene:50554		uniprot:A0A0G2K970;uniprot:A0A0G2JXW2			
+Smad4	GeneProduct	ensembl:ENSRNOG00000051965		ensembl:ENSRNOG00000051965	ncbigene:50554		uniprot:O70437;uniprot:A0A0G2K970;uniprot:A0A0G2JXW2			
 Smad2	GeneProduct	ensembl:ENSRNOG00000018140		ensembl:ENSRNOG00000018140	ncbigene:29357		uniprot:A0A0G2K0P2;uniprot:O70436			
-TGF-beta R1/2	GeneProduct	ensembl:ENSRNOG00000002418		ensembl:ENSRNOG00000002418	ncbigene:81809		uniprot:Q07257;uniprot:G3V6B1			
+TGF-beta R1/2	GeneProduct	ensembl:ENSRNOG00000002418		ensembl:ENSRNOG00000002418	ncbigene:81809		uniprot:G3V6B1;uniprot:Q496Y8			
 Ccnd1	GeneProduct	ensembl:ENSRNOG00000020918		ensembl:ENSRNOG00000020918	ncbigene:58919		uniprot:P39948;uniprot:Q1JUA4			
-Cdk4	GeneProduct	ensembl:ENSRNOG00000025602		ensembl:ENSRNOG00000025602	ncbigene:94201		uniprot:P35426			
-RB 	GeneProduct	ensembl:ENSRNOG00000016029		ensembl:ENSRNOG00000016029	ncbigene:24708		uniprot:R9PXV5			
+Cdk4	GeneProduct	ensembl:ENSRNOG00000025602		ensembl:ENSRNOG00000025602			uniprot:P35426			
+RB	GeneProduct	ensembl:ENSRNOG00000016029		ensembl:ENSRNOG00000016029	ncbigene:24708		uniprot:R9PXV5;uniprot:P33568			
 E2F	GeneProduct	ensembl:ENSRNOG00000016708		ensembl:ENSRNOG00000016708	ncbigene:399489;ncbigene:311562		uniprot:D3ZKY0;uniprot:O09139;uniprot:A0A0G2JWW3			
 Dmp1	GeneProduct	ensembl:ENSRNOG00000002167		ensembl:ENSRNOG00000002167	ncbigene:25312		uniprot:A2VD06			
 Mdm2	GeneProduct	ensembl:ENSRNOG00000006304		ensembl:ENSRNOG00000006304	ncbigene:314856		uniprot:D3ZVH5;uniprot:A0A0G2JVC1			
 CBP	GeneProduct	ensembl:ENSRNOG00000005330		ensembl:ENSRNOG00000005330	ncbigene:54244		uniprot:F1M9G7			
 Tp53	GeneProduct	ensembl:ENSRNOG00000010756		ensembl:ENSRNOG00000010756	ncbigene:24842		uniprot:A0A0G2KBB2;uniprot:P10361;uniprot:A0A0G2KB75;uniprot:Q9EQL0			
-Atm	GeneProduct	ensembl:ENSRNOG00000029773		ensembl:ENSRNOG00000029773	ncbigene:300711		uniprot:A0A0G2K3I0;uniprot:D4ACL8			
-p300	GeneProduct	ensembl:ENSRNOG00000000190		ensembl:ENSRNOG00000000190			uniprot:A0A0G2QC09			
+Atm	GeneProduct	ensembl:ENSRNOG00000029773		ensembl:ENSRNOG00000029773			uniprot:D4ACL8			
+p300	GeneProduct	ensembl:ENSRNOG00000000190		ensembl:ENSRNOG00000000190			uniprot:A0A0G2QC09;uniprot:Q91XT0			
 Ccne1	GeneProduct	ensembl:ENSRNOG00000014786		ensembl:ENSRNOG00000014786	ncbigene:25729		uniprot:B1WC54			
-Cdk2	GeneProduct	ensembl:ENSRNOG00000006469		ensembl:ENSRNOG00000006469	ncbigene:362817		uniprot:Q6P751			
+Cdk2	GeneProduct	ensembl:ENSRNOG00000006469		ensembl:ENSRNOG00000006469			uniprot:Q6P751			
 p21	GeneProduct	ensembl:ENSRNOG00000000521		ensembl:ENSRNOG00000000521	ncbigene:114851		uniprot:Q64315			
 Pik3cd	GeneProduct	ensembl:ENSRNOG00000016846		ensembl:ENSRNOG00000016846	ncbigene:366508		uniprot:D4A5Q1			
diff --git a/pathways/WP1968/WP1968.gpml b/pathways/WP1968/WP1968.gpml
diff --git a/pathways/WP1968/WP1968.json b/pathways/WP1968/WP1968.json
@@ -96,7 +96,7 @@
     },
     "a5f59": {
       "drawAs": "rect",
-      "fill": "#0000ff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -108,7 +108,7 @@
       "lineHeight": 1.1,
       "overflow": "hidden",
       "padding": 8,
-      "stroke": "#ffffff",
+      "stroke": "#000000",
       "strokeWidth": 1,
       "textAlign": "center",
       "textContent": "p16INK4A",
@@ -191,7 +191,7 @@
     },
     "a9947": {
       "drawAs": "rect",
-      "fill": "#0000ff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -203,7 +203,7 @@
       "lineHeight": 1.1,
       "overflow": "hidden",
       "padding": 8,
-      "stroke": "#ffffff",
+      "stroke": "#000000",
       "strokeWidth": 1,
       "textAlign": "center",
       "textContent": "TGF-beta R1/2",
@@ -231,7 +231,7 @@
     },
     "a9bd7": {
       "drawAs": "rect",
-      "fill": "#ff0000",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -271,7 +271,7 @@
     },
     "b0768": {
       "drawAs": "rect",
-      "fill": "#ff0000",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -424,7 +424,7 @@
     },
     "b4ad7": {
       "drawAs": "rect",
-      "fill": "#00ccff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -805,7 +805,7 @@
     },
     "c93f9": {
       "drawAs": "rect",
-      "fill": "#ff0000",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -957,7 +957,7 @@
     },
     "ce1a1": {
       "drawAs": "rect",
-      "fill": "#0000ff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -969,7 +969,7 @@
       "lineHeight": 1.1,
       "overflow": "hidden",
       "padding": 8,
-      "stroke": "#ffffff",
+      "stroke": "#000000",
       "strokeWidth": 1,
       "textAlign": "center",
       "textContent": "Tp53",
@@ -1204,7 +1204,7 @@
         "publicationXrefb0f"
       ],
       "drawAs": "rect",
-      "fill": "#0000ff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -1216,7 +1216,7 @@
       "lineHeight": 1.1,
       "overflow": "hidden",
       "padding": 8,
-      "stroke": "#ffffff",
+      "stroke": "#000000",
       "strokeWidth": 1,
       "textAlign": "center",
       "textContent": "p14ARF",
@@ -1342,7 +1342,7 @@
     },
     "e55fb": {
       "drawAs": "rect",
-      "fill": "#0000ff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -1355,7 +1355,7 @@
       "lineHeight": 1.1,
       "overflow": "hidden",
       "padding": 8,
-      "stroke": "#ffffff",
+      "stroke": "#000000",
       "strokeWidth": 1,
       "textAlign": "center",
       "textContent": "RB",
@@ -1580,8 +1580,6 @@
         "Ensembl:ENSRNOG00000006469",
         "GeneProduct",
         "P594:ENSRNOG00000006469",
-        "Entrez Gene:362817",
-        "P351:362817",
         "Wikidata:Q24397344"
       ],
       "verticalAlign": "middle",
@@ -1689,7 +1687,7 @@
     },
     "f3ca7": {
       "drawAs": "rect",
-      "fill": "#00ccff",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -1824,8 +1822,6 @@
         "Ensembl:ENSRNOG00000025602",
         "GeneProduct",
         "P594:ENSRNOG00000025602",
-        "Entrez Gene:94201",
-        "P351:94201",
         "Wikidata:Q24406279"
       ],
       "verticalAlign": "middle",
@@ -1933,8 +1929,6 @@
         "Ensembl:ENSRNOG00000029773",
         "GeneProduct",
         "P594:ENSRNOG00000029773",
-        "Entrez Gene:300711",
-        "P351:300711",
         "Wikidata:Q24396416"
       ],
       "verticalAlign": "middle",
@@ -1949,7 +1943,7 @@
     },
     "fb943": {
       "drawAs": "rect",
-      "fill": "#ff0000",
+      "fill": "#ffffff",
       "fontFamily": "Arial",
       "fontSize": 10,
       "fontStyle": "normal",
@@ -3978,7 +3972,7 @@
       "id": "publicationXrefb88",
       "source": "Nat Cell Biol",
       "standardName": "Repression of p15INK4b expression by Myc through association with Miz-1.",
-      "textContent": "3",
+      "textContent": "2",
       "type": [
         "PublicationXref",
         "PubMed:11283613"
@@ -4000,7 +3994,7 @@
       "id": "publicationXrefe39",
       "source": "Nat Cell Biol",
       "standardName": "HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.",
-      "textContent": "2",
+      "textContent": "3",
       "type": [
         "PublicationXref",
         "PubMed:11715018",
@@ -4039,7 +4033,7 @@
     "author": "[Gustav, MaintBot, Khanspers, Mkutmon, Christine Chichester, Jmelius, AlexanderPico, Egonw, Fehrhart, L Dupuis, Marvin M2]",
     "comments": [
       {
-        "content": "Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are given in red, those who are inactivated in blue. The dark blue ones are frequent and the light blue infrequent inactivated. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.",
+        "content": "Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are Egfr, Erbb2, Rasl11b, and MYC in the Oncogenic singalling part. Frequent inactivated are TGF-beta R1/2, RB, p16INK4A, Tp53, and p14ARF, whie infrequent inactivated are Smad2 and Sma4. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.",
         "source": "WikiPathways-description"
       }
     ],
@@ -4114,7 +4108,7 @@
       "b5feb",
       "a3284"
     ],
-    "dataSourceVersion": "WP1968_r126413",
+    "dataSourceVersion": "WP1968_r126776",
     "displayName": "Genetic alterations of lung cancer",
     "drawAs": "rect",
     "fill": "white",
@@ -4124,7 +4118,7 @@
     "height": 770,
     "id": "WP1968",
     "kaavioType": "Group",
-    "lastModified": "20230426201431",
+    "lastModified": "20230622054443",
     "name": "Genetic alterations of lung cancer",
     "organism": "Rattus norvegicus",
     "padding": 5,
@@ -4133,7 +4127,7 @@
     "stroke": "black",
     "strokeWidth": 0,
     "textAlign": "left",
-    "textContent": "Name: Genetic alterations of lung cancer\nLast Modified: 20230426201431\nOrganism: Rattus norvegicus",
+    "textContent": "Name: Genetic alterations of lung cancer\nLast Modified: 20230622054443\nOrganism: Rattus norvegicus",
     "type": [
       "Pathway",
       "http://identifiers.org/pw/PW:0000605",

diff --git a/pathways/WP1968/WP1968.png b/pathways/WP1968/WP1968.png