diff --git a/pathways/WP2038/WP2038-datanodes.tsv b/pathways/WP2038/WP2038-datanodes.tsv index 7fc32278..d76bfe8a 100644 --- a/pathways/WP2038/WP2038-datanodes.tsv +++ b/pathways/WP2038/WP2038-datanodes.tsv @@ -1,13 +1,15 @@ Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI +PIP3 Metabolite chebi:16618 "" wikidata:Q28797898 chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N +PIP3 Metabolite chebi:16618 "" wikidata:Q28797898 chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N RTK GeneProduct wikipathways:WP5471 "" RHO GeneProduct ensembl:ENSG00000163914 "" ensembl:ENSG00000163914 ncbigene:6010 hgnc.symbol:RHO uniprot:P08100 -TAU GeneProduct ensembl:ENSG00000186868 "" ensembl:ENSG00000186868 ncbigene:4137 hgnc.symbol:MAPT uniprot:A0A7I2PLE3;uniprot:A0A7P0T936;uniprot:I3L2Z2;uniprot:A0A024R9Y0;uniprot:A0A024R9Y1;uniprot:P10636;uniprot:A0A7I2PJZ2;uniprot:A0A024RA17;uniprot:A0A024RA19 +MAPT GeneProduct ensembl:ENSG00000186868 "" ensembl:ENSG00000186868 ncbigene:4137 hgnc.symbol:MAPT uniprot:A0A7I2PLE3;uniprot:A0A7P0T936;uniprot:I3L2Z2;uniprot:A0A024R9Y0;uniprot:A0A024R9Y1;uniprot:P10636;uniprot:A0A7I2PJZ2;uniprot:A0A024RA17;uniprot:A0A024RA19 LL5b GeneProduct ensembl:ENSG00000144824 "" ensembl:ENSG00000144824 ncbigene:90102 hgnc.symbol:PHLDB2 uniprot:E9PGF6;uniprot:A0A1W2PQ63;uniprot:A0A1W2PRJ2;uniprot:E9PFQ4;uniprot:G5E9V3;uniprot:Q86SQ0;uniprot:E9PDY7;uniprot:A0A1W2PRT1 TPPP GeneProduct ensembl:ENSG00000171368 "" ensembl:ENSG00000171368 ncbigene:11076 hgnc.symbol:TPPP uniprot:O94811;uniprot:Q4L233 LIMK GeneProduct ensembl:ENSG00000106683 "" ensembl:ENSG00000106683 ncbigene:3984 hgnc.symbol:LIMK1 uniprot:E9PC47;uniprot:P53667 TESK GeneProduct ensembl:ENSG00000070759 "" ensembl:ENSG00000070759 ncbigene:10420 hgnc.symbol:TESK2 uniprot:Q96S53 -MAPKAPK GeneProduct ensembl:ENSG00000162889 "" ensembl:ENSG00000162889 ncbigene:9261 hgnc.symbol:MAPKAPK2 uniprot:P49137 -DVL GeneProduct ensembl:ENSG00000107404 "" ensembl:ENSG00000107404 ncbigene:1855 hgnc.symbol:DVL1 uniprot:A0A0J9YWZ5;uniprot:O14640;uniprot:A0A0J9YYK1 +MAPKAPK2 GeneProduct ensembl:ENSG00000162889 "" ensembl:ENSG00000162889 ncbigene:9261 hgnc.symbol:MAPKAPK2 uniprot:P49137 +DVL1 GeneProduct ensembl:ENSG00000107404 "" ensembl:ENSG00000107404 ncbigene:1855 hgnc.symbol:DVL1 uniprot:A0A0J9YWZ5;uniprot:O14640;uniprot:A0A0J9YYK1 PKC GeneProduct ensembl:ENSG00000154229 "" ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 PAR6 GeneProduct ensembl:ENSG00000102981 "" ensembl:ENSG00000102981 ncbigene:50855 hgnc.symbol:PARD6A uniprot:R4GMM2;uniprot:Q9NPB6 TAOK GeneProduct ensembl:ENSG00000160551 "" ensembl:ENSG00000160551 ncbigene:57551 hgnc.symbol:TAOK1 uniprot:J3QS76;uniprot:A0A024QZ70;uniprot:Q7L7X3 @@ -28,14 +30,14 @@ GNAQ GeneProduct ensembl:ENSG00000156052 "" ensembl:ENSG00000156052 ncbigene:27 WNT GeneProduct ensembl:ENSG00000154342 "" ensembl:ENSG00000154342 ncbigene:89780 hgnc.symbol:WNT3A uniprot:P56704 LPR GeneProduct ensembl:ENSG00000132670 "" ensembl:ENSG00000132670 ncbigene:5786 hgnc.symbol:PTPRA uniprot:Q5JWG0;uniprot:Q5JWG2;uniprot:Q5JWG3;uniprot:P18433 STAT3 GeneProduct ensembl:ENSG00000168610 "" ensembl:ENSG00000168610 ncbigene:6774 hgnc.symbol:STAT3 uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9 -STMN GeneProduct ensembl:ENSG00000117632 "" ensembl:ENSG00000117632 ncbigene:3925 hgnc.symbol:STMN1 uniprot:A2A2D0;uniprot:P16949;uniprot:A0A140VJW2 +STMN1 GeneProduct ensembl:ENSG00000117632 "" ensembl:ENSG00000117632 ncbigene:3925 hgnc.symbol:STMN1 uniprot:A2A2D0;uniprot:P16949;uniprot:A0A140VJW2 PAK GeneProduct ensembl:ENSG00000149269 "" ensembl:ENSG00000149269 ncbigene:5058 hgnc.symbol:PAK1 uniprot:E9PRP6;uniprot:H0YCG5;uniprot:E9PJF8;uniprot:E9PKH9;uniprot:B3KNX7;uniprot:E9PMP2;uniprot:E9PQW5;uniprot:H0YCM0;uniprot:H0YF55;uniprot:A0A024R5P0;uniprot:E9PM17;uniprot:Q13153 PRKACA GeneProduct ensembl:ENSG00000072062 "" ensembl:ENSG00000072062 ncbigene:5566 hgnc.symbol:PRKACA uniprot:A0A024R7J0;uniprot:P17612;uniprot:A0A7I2YQ82;uniprot:K7EMV1;uniprot:K7ERP6;uniprot:Q15136;uniprot:K7ENJ5;uniprot:B7Z708;uniprot:A0A7I2V5J4 AURKB GeneProduct ensembl:ENSG00000178999 "" ensembl:ENSG00000178999 ncbigene:9212 hgnc.symbol:AURKB uniprot:Q96GD4;uniprot:J3QLN8;uniprot:J3KT86;uniprot:J3KTD6;uniprot:J3QR41;uniprot:J3KRF8;uniprot:J3KRJ2 CAMK GeneProduct ensembl:ENSG00000152495 "" ensembl:ENSG00000152495 ncbigene:814 hgnc.symbol:CAMK4 uniprot:D6RE65;uniprot:D6REY7;uniprot:Q16566;uniprot:D6RCD6 CDK1 GeneProduct ensembl:ENSG00000170312 "" ensembl:ENSG00000170312 ncbigene:983 hgnc.symbol:CDK1 uniprot:P06493;uniprot:E5RIU6;uniprot:A0A024QZP7;uniprot:A0A024QZJ8 MCAK GeneProduct ensembl:ENSG00000142945 "" ensembl:ENSG00000142945 ncbigene:11004 hgnc.symbol:KIF2C uniprot:Q5JR89;uniprot:Q99661;uniprot:A0A140VKF1;uniprot:Q5JR91;uniprot:H0Y5Z9 -c-ABL GeneProduct ensembl:ENSG00000097007 "" ensembl:ENSG00000097007 ncbigene:25 hgnc.symbol:ABL1 uniprot:A0A024R8E2;uniprot:R4GRW0;uniprot:P00519 +ABL1 GeneProduct ensembl:ENSG00000097007 "" ensembl:ENSG00000097007 ncbigene:25 hgnc.symbol:ABL1 uniprot:A0A024R8E2;uniprot:R4GRW0;uniprot:P00519 TRIO GeneProduct ensembl:ENSG00000038382 "" ensembl:ENSG00000038382 ncbigene:7204 hgnc.symbol:TRIO uniprot:E7EPJ7;uniprot:O75962;uniprot:A0A1W2PRD7;uniprot:E7EWP2;uniprot:F5H228 TIAM1 GeneProduct ensembl:ENSG00000156299 "" ensembl:ENSG00000156299 ncbigene:7074 hgnc.symbol:TIAM1 uniprot:Q13009;uniprot:A0A1B0GW57;uniprot:C9JMB5;uniprot:A0A2X0TW27;uniprot:H7C079 SRC GeneProduct ensembl:ENSG00000197122 "" ensembl:ENSG00000197122 ncbigene:6714 hgnc.symbol:SRC uniprot:P12931 @@ -43,20 +45,20 @@ CLASP GeneProduct ensembl:ENSG00000074054 "" ensembl:ENSG00000074054 ncbigene:23 CLIP GeneProduct ensembl:ENSG00000130779 "" ensembl:ENSG00000130779 ncbigene:6249 hgnc.symbol:CLIP1 uniprot:F5H270;uniprot:P30622;uniprot:A0A024RBR1;uniprot:A0A3B3IS27;uniprot:F5H367;uniprot:F5H6A0;uniprot:F5H1T5;uniprot:A0A3B3ITA2;uniprot:J3KP58;uniprot:F5H0N7;uniprot:A0A3B3ISJ8 MAP1B GeneProduct ensembl:ENSG00000131711 "" ensembl:ENSG00000131711 ncbigene:4131 hgnc.symbol:MAP1B uniprot:D6RCL2;uniprot:D6RA32;uniprot:D6RGJ3;uniprot:D6RA40;uniprot:P46821 CRMP2 GeneProduct ensembl:ENSG00000092964 "" ensembl:ENSG00000092964 ncbigene:1808 hgnc.symbol:DPYSL2 uniprot:E5RFU4;uniprot:Q16555;uniprot:A0A1C7CYX9 -EB1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 +MAPRE1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 APC GeneProduct ensembl:ENSG00000134982 "" ensembl:ENSG00000134982 ncbigene:324 hgnc.symbol:APC uniprot:A0A087X2F3;uniprot:E7EMH9;uniprot:D6RFL6;uniprot:E9PFT7;uniprot:R4GMU6;uniprot:A0A087WYF3;uniprot:A0A2Q2SV78;uniprot:P25054 -mDIA GeneProduct ncbigene:1729 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 -mDIA GeneProduct ncbigene:1729 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 -EB1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 +DIAPH1 GeneProduct ensembl:ENSG00000131504 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 +DIAPH1 GeneProduct ensembl:ENSG00000131504 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 +MAPRE1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 CLIP GeneProduct ensembl:ENSG00000130779 "" ensembl:ENSG00000130779 ncbigene:6249 hgnc.symbol:CLIP1 uniprot:F5H270;uniprot:P30622;uniprot:A0A024RBR1;uniprot:A0A3B3IS27;uniprot:F5H367;uniprot:F5H6A0;uniprot:F5H1T5;uniprot:A0A3B3ITA2;uniprot:J3KP58;uniprot:F5H0N7;uniprot:A0A3B3ISJ8 CLIP GeneProduct ensembl:ENSG00000130779 "" ensembl:ENSG00000130779 ncbigene:6249 hgnc.symbol:CLIP1 uniprot:F5H270;uniprot:P30622;uniprot:A0A024RBR1;uniprot:A0A3B3IS27;uniprot:F5H367;uniprot:F5H6A0;uniprot:F5H1T5;uniprot:A0A3B3ITA2;uniprot:J3KP58;uniprot:F5H0N7;uniprot:A0A3B3ISJ8 CLIP GeneProduct ensembl:ENSG00000130779 "" ensembl:ENSG00000130779 ncbigene:6249 hgnc.symbol:CLIP1 uniprot:F5H270;uniprot:P30622;uniprot:A0A024RBR1;uniprot:A0A3B3IS27;uniprot:F5H367;uniprot:F5H6A0;uniprot:F5H1T5;uniprot:A0A3B3ITA2;uniprot:J3KP58;uniprot:F5H0N7;uniprot:A0A3B3ISJ8 CLASP GeneProduct ensembl:ENSG00000074054 "" ensembl:ENSG00000074054 ncbigene:23332 hgnc.symbol:CLASP1 uniprot:C9J151;uniprot:Q7Z460;uniprot:C9JP76;uniprot:F8WA11;uniprot:H0Y5T1 -EB1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 +MAPRE1 GeneProduct ensembl:ENSG00000101367 "" ensembl:ENSG00000101367 ncbigene:22919 hgnc.symbol:MAPRE1 uniprot:Q15691 APC GeneProduct ensembl:ENSG00000134982 "" ensembl:ENSG00000134982 ncbigene:324 hgnc.symbol:APC uniprot:A0A087X2F3;uniprot:E7EMH9;uniprot:D6RFL6;uniprot:E9PFT7;uniprot:R4GMU6;uniprot:A0A087WYF3;uniprot:A0A2Q2SV78;uniprot:P25054 RAC1 GeneProduct ensembl:ENSG00000136238 "" ensembl:ENSG00000136238 ncbigene:5879 hgnc.symbol:RAC1 uniprot:P63000;uniprot:A4D2P0;uniprot:A4D2P1 RHO GeneProduct ensembl:ENSG00000163914 "" ensembl:ENSG00000163914 ncbigene:6010 hgnc.symbol:RHO uniprot:P08100 -mDIA1 GeneProduct ncbigene:1729 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 +DIAPH1 GeneProduct ensembl:ENSG00000131504 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 GNAQ GeneProduct ensembl:ENSG00000156052 "" ensembl:ENSG00000156052 ncbigene:2776 hgnc.symbol:GNAQ uniprot:P50148;uniprot:A0A024R240;uniprot:B1AM21 RHO GeneProduct ensembl:ENSG00000163914 "" ensembl:ENSG00000163914 ncbigene:6010 hgnc.symbol:RHO uniprot:P08100 RHO GeneProduct ensembl:ENSG00000163914 "" ensembl:ENSG00000163914 ncbigene:6010 hgnc.symbol:RHO uniprot:P08100 diff --git a/pathways/WP2038/WP2038.gpml b/pathways/WP2038/WP2038.gpml index d7d8b961..1f2740c3 100644 --- a/pathways/WP2038/WP2038.gpml +++ b/pathways/WP2038/WP2038.gpml @@ -1,882 +1,888 @@ - - Microtubules (MTs) are essential for vesicle transport, cellular polarity and the segregation of chromosomes during mitosis. MTs are dynamic, undergoing assembly and depolymerization (primarily at the "plus end") by processes actively regulated by signaling pathways. The tubulin dimers that constitute MTs (depicted in green) are bound and sequestered by stathmin (STMN), enhancing MT dynamics by increasing rapid depolymerization (a.k.a., "MT catastrophe"). MT dynamics are also enhanced by collapsin response mediator protein (CRMP2), which increases MT growth by promoting the addition of tubulin dimers onto microtubule plus ends. Other proteins that associate with assembled MTs include those that stabilize MTs (e.g. tau or MAPT), those that promote assembly (e.g., XMAP215), and those that maintain MTs in a dynamic state (e.g., MAP1B). Complexes between the adenomateous polyposis coli (APC) protein and plus end binding proteins (e.g., EB1) stabilize MTs by increasing the duration of the MT elongation phase. MT instability is promoted by several nonmotile kinesins from the kinesin-13 family, e.g., the mitotic centromere associated kinesin, MCAK, by accelerating the transition to catastrophe by weakening the lateral interactions between the protofilaments. Upstream from these processes, major signaling pathways act to regulate MT dynamics, e.g., those converging on GSK3B, a kinase which targets tau and CRMP2. + + Microtubules (MTs) are essential for vesicle transport, cellular polarity and the segregation of chromosomes during mitosis. +MTs are dynamic, undergoing assembly and depolymerization (primarily at the "plus end") by processes actively regulated by signaling pathways. The tubulin dimers that constitute MTs (depicted in green) are bound and sequestered by stathmin (STMN1), enhancing MT dynamics by increasing rapid depolymerization (a.k.a., "MT catastrophe"). +MT dynamics are also enhanced by collapsin response mediator protein (CRMP2), which increases MT growth by promoting the addition of tubulin dimers onto microtubule plus ends. Other proteins that associate with assembled MTs include those that stabilize MTs (e.g. tau or MAPT), those that promote assembly (e.g., XMAP215), and those that maintain MTs in a dynamic state (e.g., MAP1B). Complexes between the adenomateous polyposis coli (APC) protein and plus end binding proteins (e.g., EB1) stabilize MTs by increasing the duration of the MT elongation phase. MT instability is promoted by several nonmotile kinesins from the kinesin-13 family, e.g., the mitotic centromere associated kinesin, MCAK, by accelerating the transition to catastrophe by weakening the lateral interactions between the protofilaments. + +Upstream from these processes, major signaling pathways act to regulate MT dynamics, e.g., those converging on GSK3B, a kinase which targets tau and CRMP2. Reference: https://www.cellsignal.com/contents/science-pathway-research-cytoskeletal/regulation-of-microtubule-dynamics-signaling-pathway/pathways-micro Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2038 CPTAC Assay Portal] e01 a28 - + + + + + - + - + - - + + - + - + - + - + - - + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - - - + + + - - - + + + - - + + - + - + - + - + - - + + - + - + - + - - - + + + - + - + - + - + - + - + + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -893,14 +899,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. PW:0000646 Pathway Ontology - - 20031384 - PubMed - From signaling pathways to microtubule dynamics: the key players. - Curr Opin Cell Biol - 2010 - Etienne-Manneville S - 22193159 PubMed @@ -910,6 +908,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. Anitei M Hoflack B + + 20031384 + PubMed + From signaling pathways to microtubule dynamics: the key players. + Curr Opin Cell Biol + 2010 + Etienne-Manneville S + diff --git a/pathways/WP2038/WP2038.json b/pathways/WP2038/WP2038.json index bbbcd9b6..50f2ed4c 100644 --- a/pathways/WP2038/WP2038.json +++ b/pathways/WP2038/WP2038.json @@ -80,10 +80,10 @@ "whiteSpace": "pre", "width": 60, "wpType": "GeneProduct", - "x": 634.768337987067, + "x": 614.768337987067, "xrefDataSource": "Ensembl", "xrefIdentifier": "ENSG00000134982", - "y": 724.4299052814971, + "y": 642.4299052814971, "zIndex": 32834 }, "a1e68": { @@ -98,7 +98,7 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 74.45201238390058, + "height": 76.04274419228307, "id": "a1e68", "kaavioType": "Group", "padding": 8, @@ -112,8 +112,8 @@ ], "verticalAlign": "middle", "width": 76, - "x": 289.82948714685773, - "y": 184.13361331248854, + "x": 288.64691900389374, + "y": 136.13361331248854, "zIndex": 32777 }, "a1ed0": { @@ -191,7 +191,7 @@ "x": 532.0791685791571, "xrefDataSource": "Ensembl", "xrefIdentifier": "ENSG00000133216", - 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"x": 328.3355140161847, - "y": 815.4586610967476 + "x": 340.3355140161847, + "y": 727.4586610967476 } ], "stroke": "#000000", @@ -8707,7 +8725,7 @@ 0, 1 ], - "x": 774.0913035931254, + "x": 746.0913035931254, "y": 38.30527107562352 }, { @@ -8726,8 +8744,8 @@ 0, 1 ], - "x": 774, - "y": 95.85714285714286 + "x": 746, + "y": 63.85714285714286 } ], "stroke": "#000000", @@ -8798,8 +8816,8 @@ ], "verticalAlign": "middle", "width": 94.64917771281557, - "x": 393.2555841919452, - "y": 645.809523809524, + "x": 345.2555841919452, + "y": 583.809523809524, "zIndex": 32831 }, "pvjsgeneratedidffb64": { @@ -8830,8 +8848,8 @@ ], "verticalAlign": "middle", "width": 163.64285714285813, - "x": 755.9761904761912, - "y": 242.40476190476068, + "x": 756.9761904761912, + "y": 207.40476190476068, "zIndex": 16384 }, "pvjsgeneratedidffb65": { @@ -8859,8 +8877,8 @@ ], "verticalAlign": "middle", "width": 76, - "x": 736, - "y": 87.85714285714286, + "x": 708, + "y": 55.85714285714286, "zIndex": 32768 } }, @@ -8874,7 +8892,7 @@ "author": "[CarlosBorroto, Khanspers, MaintBot, Zari, Lindarieswijk, Mkutmon, AlexanderPico, Eweitz]", "comments": [ { - "content": "Microtubules (MTs) are essential for vesicle transport, cellular polarity and the segregation of chromosomes during mitosis. MTs are dynamic, undergoing assembly and depolymerization (primarily at the \"plus end\") by processes actively regulated by signaling pathways. The tubulin dimers that constitute MTs (depicted in green) are bound and sequestered by stathmin (STMN), enhancing MT dynamics by increasing rapid depolymerization (a.k.a., \"MT catastrophe\"). MT dynamics are also enhanced by collapsin response mediator protein (CRMP2), which increases MT growth by promoting the addition of tubulin dimers onto microtubule plus ends. Other proteins that associate with assembled MTs include those that stabilize MTs (e.g. tau or MAPT), those that promote assembly (e.g., XMAP215), and those that maintain MTs in a dynamic state (e.g., MAP1B). Complexes between the adenomateous polyposis coli (APC) protein and plus end binding proteins (e.g., EB1) stabilize MTs by increasing the duration of the MT elongation phase. MT instability is promoted by several nonmotile kinesins from the kinesin-13 family, e.g., the mitotic centromere associated kinesin, MCAK, by accelerating the transition to catastrophe by weakening the lateral interactions between the protofilaments. Upstream from these processes, major signaling pathways act to regulate MT dynamics, e.g., those converging on GSK3B, a kinase which targets tau and CRMP2.\r\n\r\n\r\nReference: https://www.cellsignal.com/contents/science-pathway-research-cytoskeletal/regulation-of-microtubule-dynamics-signaling-pathway/pathways-micro\r\n\r\nProteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2038 CPTAC Assay Portal]", + "content": "Microtubules (MTs) are essential for vesicle transport, cellular polarity and the segregation of chromosomes during mitosis. \r\nMTs are dynamic, undergoing assembly and depolymerization (primarily at the \"plus end\") by processes actively regulated by signaling pathways. The tubulin dimers that constitute MTs (depicted in green) are bound and sequestered by stathmin (STMN1), enhancing MT dynamics by increasing rapid depolymerization (a.k.a., \"MT catastrophe\"). \r\n\r\nMT dynamics are also enhanced by collapsin response mediator protein (CRMP2), which increases MT growth by promoting the addition of tubulin dimers onto microtubule plus ends. Other proteins that associate with assembled MTs include those that stabilize MTs (e.g. tau or MAPT), those that promote assembly (e.g., XMAP215), and those that maintain MTs in a dynamic state (e.g., MAP1B). Complexes between the adenomateous polyposis coli (APC) protein and plus end binding proteins (e.g., EB1) stabilize MTs by increasing the duration of the MT elongation phase. MT instability is promoted by several nonmotile kinesins from the kinesin-13 family, e.g., the mitotic centromere associated kinesin, MCAK, by accelerating the transition to catastrophe by weakening the lateral interactions between the protofilaments.\r\n\r\nUpstream from these processes, major signaling pathways act to regulate MT dynamics, e.g., those converging on GSK3B, a kinase which targets tau and CRMP2.\r\n\r\nReference: https://www.cellsignal.com/contents/science-pathway-research-cytoskeletal/regulation-of-microtubule-dynamics-signaling-pathway/pathways-micro\r\n\r\nProteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2038 CPTAC Assay Portal]", "source": "WikiPathways-description" } ], @@ -8954,7 +8972,6 @@ "eef70", "pvjsgeneratedidffb64", "aabf5", - "b0c80", "c02e7", "ccc0b", "ce1a0", @@ -8967,6 +8984,7 @@ "eb132", "eb7fa", "f8497", + "e3725", "pvjsgeneratedidffb65", "ae50c", "a8c17", @@ -9026,7 +9044,6 @@ "ef9bd", "e58ba", "e7f0a", - "f1ff6", "e6862", "a67b1", "cef97", @@ -9035,19 +9052,20 @@ "e364a", "bedaa", "f1711", - "e5533" + "e5533", + "b671a" ], - "dataSourceVersion": "WP2038_r129843", + "dataSourceVersion": "WP2038_r129877", "displayName": "Microtubule cytoskeleton regulation", "drawAs": "rect", "fill": "white", "fontSize": 12, "fontWeight": "bold", "gpmlElementName": "Pathway", - "height": 885, + "height": 811, "id": "WP2038", "kaavioType": "Group", - "lastModified": "20240523020029", + "lastModified": "20240523115346", "name": "Microtubule cytoskeleton regulation", "organism": "Homo sapiens", "padding": 5, @@ -9056,13 +9074,13 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Microtubule cytoskeleton regulation\nLast Modified: 20240523020029\nOrganism: Homo sapiens", + "textContent": "Name: Microtubule cytoskeleton regulation\nLast Modified: 20240523115346\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000646" ], "verticalAlign": "top", - "width": 1179, + "width": 1159, "x": 0, "y": 0, "zIndex": 0 diff --git a/pathways/WP2038/WP2038.png b/pathways/WP2038/WP2038.png index 8e7d6993..97d4d44b 100644 Binary files a/pathways/WP2038/WP2038.png and b/pathways/WP2038/WP2038.png differ diff --git a/pathways/WP2038/WP2038.svg b/pathways/WP2038/WP2038.svg index 8a5ff343..a5c33e43 100644 --- a/pathways/WP2038/WP2038.svg +++ b/pathways/WP2038/WP2038.svg @@ -1,5 +1,5 @@ - + @@ -10,58 +10,64 @@ - + - + - - + + - - + + - + - + - + - + - + - + - + + + + + + + - + - + - + - + - + - + - + @@ -478,375 +484,375 @@ - - + + - - + + - + - - + + - + - + - + - + - + - + - + - + - - + + - - + + - - + + - - + + - - + + - + - + - + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - - + + - - + + - - + + - + - - + + - - + + - - + + - - + + - - + + - + - - + + - - + + - - + + - - + + - + - + - + - + - - + + - + - - + + - - + + - + - + - - + + - + - + - + - - + + - - + + - - + + - - + + - + Microtubule - + - + - + @@ -864,96 +870,96 @@ - + MT stability - - - - PIP3 - - - + "Dynamic microtubules" - + Plus end - + Focal adhesion - + Plus end proteins - + Actin filaments - + +/- end destabilizing - + + end growth promoting - + Delivery to MT plus ends - + MT catastrophe - + Minus end - + Neurotrophins - + MT polymerization - + + + + PIP3 + + + @@ -968,56 +974,56 @@ - + RHO - + - TAU + MAPT - + LL5b - + TPPP - + LIMK - + TESK - + - MAPKAPK + MAPKAPK2 - + - DVL + DVL1 - - + + @@ -1030,38 +1036,38 @@ PAR6 - + PAR3 - + TAOK - + SPRED1 - + ROCK - + RAC1 - + @@ -1076,50 +1082,50 @@ - + CFL - + GSK3B - + MARK2 - + PTEN - + AKT - + ERK - + CDC42 - - + + @@ -1133,73 +1139,73 @@ - + LPR - + STAT3 - + - STMN + STMN1 - + PAK - + PRKACA - + AURKB - + CAMK - + CDK1 - + MCAK - + XMAP215 - + ICIS - + @@ -1214,60 +1220,60 @@ - + - c-ABL + ABL1 - + TRIO - + TIAM1 - + SRC - + CLASP - + CLIP - + MAP1B - + CRMP2 - + - + - EB1 + MAPRE1 @@ -1276,38 +1282,38 @@ APC - + - mDIA + DIAPH1 - + - mDIA + DIAPH1 - + - EB1 + MAPRE1 - + CLIP - + CLIP - + @@ -1319,104 +1325,104 @@ - + CLASP - + - EB1 + MAPRE1 - + APC - + RAC1 - + RHO - + - mDIA1 + DIAPH1 - + GNAQ - + RHO - + MAP1B - + ERK - - - - PIP3 - - - - + + - + - + - + - + - + - + - + - + + + + + PIP3 + + Name: Microtubule cytoskeleton regulation - Last Modified: 20240523020029 + Last Modified: 20240523115346 Organism: Homo sapiens