diff --git a/pathways/WP1533/WP1533.gpml b/pathways/WP1533/WP1533.gpml index 43da1010d..77d0cf6fb 100644 --- a/pathways/WP1533/WP1533.gpml +++ b/pathways/WP1533/WP1533.gpml @@ -1,5 +1,5 @@ - + Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain. Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons. @@ -98,7 +98,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. b53 - + @@ -143,7 +143,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. d63 a40 - + @@ -3690,152 +3690,67 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - 4386961 - PubMed - Biosynthesis of dihydrosphingosine in vitro. - Hoppe Seylers Z Physiol Chem - 1968 - Stoffel W - LeKim D - Sticht G - - - 10880336 - PubMed - Sphingosine 1-phosphate signalling in mammalian cells. - Biochem J - 2000 - Pyne S - Pyne NJ - - - 8413223 - PubMed - Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. - Mol Cell Biol - 1993 - Hiscott J - Marois J - Garoufalis J - D'Addario M - Roulston A - Kwan I - Pepin N - Lacoste J - Nguyen H - Bensi G - - - 12815058 + + 12062442 PubMed - Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. - J Biol Chem - 2003 - Johnson KR - Johnson KY - Becker KP - Bielawski J - Mao C - Obeid LM + Selenoprotein W is a glutathione-dependent antioxidant in vivo. + FEBS Lett + 2002 + Jeong D + Kim TS + Chung YW + Lee BJ + Kim IY - - 2175712 + + 2602371 PubMed - Purification, cDNA-cloning and expression of human diacylglycerol kinase. - FEBS Lett - 1990 - Schaap D - de Widt J - van der Wal J - Vandekerckhove J - van Damme J - Gussow D - Ploegh HL - van Blitterswijk WJ - van der Bend RL + Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. + Proc Natl Acad Sci U S A + 1989 + Shigenaga MK + Gimeno CJ + Ames BN - - 14726604 + + 17389926 PubMed - Nitric oxide and superoxide in inflammation and immune regulation. - J Physiol Pharmacol. - 2003 - Guzik TJ - Korbut R - Adamek-Guzik T. + Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. + Int J Biol Sci + 2007 + Ben Jilani KE + Panee J + He Q + Berry MJ + Li PA - - 8656081 + + 18198219 PubMed - Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. - J Lipid Res - 1995 - Moore SA - Hurt E - Yoder E - Sprecher H - Spector AA + Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion. + FASEB J + 2008 + Grumolato L + Ghzili H + Montero-Hadjadje M + Gasman S + Lesage J + Tanguy Y + Galas L + Ait-Ali D + Leprince J + Guérineau NC + Elkahloun AG + Fournier A + Vieau D + Vaudry H + Anouar Y Vitamin B12 (cobalamin) metabolic pathway PW:0000397 Pathway Ontology - - 17276401 - PubMed - The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4. - Biochem Biophys Res Commun - 2007 - Neumann D - Kollewe C - Resch K - Martin MU. - - - 228272 - PubMed - Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. - Proc Natl Acad Sci U S A - 1979 - Faust JR - Goldstein JL - Brown MS - - - 17927969 - PubMed - Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses. - Cell Immunol - 2007 - Bohnenkamp HR - Papazisis KT - Burchell JM - Taylor-Papadimitriou J - - - 9278416 - PubMed - Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. - J Biol Chem - 1997 - May JM - Mendiratta S - Hill KE - Burk RF - - - 12431977 - PubMed - Membrane topography of human phosphatidylethanolamine N-methyltransferase. - J Biol Chem - 2003 - Shields DJ - Lehner R - Agellon LB - Vance DE - 17713401 PubMed @@ -3851,82 +3766,244 @@ Proteins on this pathway have targeted assays available via the [https://assays. 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A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.", - "textContent": "54", + "textContent": "51", "type": [ "PublicationXref", "PubMed:1708392" @@ -29275,7 +29279,7 @@ "id": "publicationXrefa3e", "source": "Biochim Biophys Acta", "standardName": "Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.", - "textContent": "221", + "textContent": "208", "type": [ "PublicationXref", "PubMed:16698314" @@ -29293,7 +29297,7 @@ "id": "publicationXrefa3f", "source": "J Biol Chem", "standardName": "Selenoproteins.", - "textContent": "276", + "textContent": "271", "type": [ "PublicationXref", "PubMed:18757362" @@ -29315,7 +29319,7 @@ "id": "publicationXrefa40", "source": "Biol Trace Elem Res", "standardName": "Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.", - "textContent": "267", + "textContent": "248", "type": [ "PublicationXref", "PubMed:17960332" @@ -29336,7 +29340,7 @@ "id": "publicationXrefa41", "source": "Biochim Biophys Acta", "standardName": "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.", - "textContent": "103", + "textContent": "99", "type": [ "PublicationXref", "PubMed:10101267" @@ -29372,7 +29376,7 @@ "id": "publicationXrefa46", "source": "J Physiol Pharmacol", "standardName": "Nitric oxide and superoxide in inflammation and immune regulation.", - "textContent": "165", + "textContent": "150", "type": [ "PublicationXref", "PubMed:14726604" @@ -29393,7 +29397,7 @@ "id": "publicationXrefa4a", "source": "Antioxid Redox Signal", "standardName": "Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.", - "textContent": "270", + "textContent": "277", "type": [ "PublicationXref", "PubMed:19747065" @@ -29413,7 +29417,7 @@ "id": "publicationXrefa53", "source": "Antioxid Redox Signal", "standardName": "From selenium to selenoproteins: synthesis, identity, and their role in human health.", - "textContent": "235", + "textContent": "229", "type": [ "PublicationXref", "PubMed:17508906" @@ -29452,7 +29456,7 @@ "id": "publicationXrefa62", "source": "Biochem Pharmacol.", "standardName": "The isoprostanes. 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"textContent": "145", + "textContent": "143", "type": [ "PublicationXref", "PubMed:12432932" @@ -29843,7 +29847,7 @@ "id": "publicationXrefade", "source": "Free Radic Biol Med", "standardName": "Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.", - "textContent": "204", + "textContent": "201", "type": [ "PublicationXref", "PubMed:16413410" @@ -29861,7 +29865,7 @@ "id": "publicationXrefae2", "source": "Pharmacol Res", "standardName": "Oxidative stress in normal and impaired wound repair.", - "textContent": "259", + "textContent": "246", "type": [ "PublicationXref", "PubMed:18617006" @@ -29881,7 +29885,7 @@ "id": "publicationXrefae3", "source": "J Biol Chem", "standardName": "Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.", - "textContent": "228", + "textContent": "238", "type": [ "PublicationXref", "PubMed:17526492" @@ -29901,7 +29905,7 @@ "id": "publicationXrefae5", "source": "J Lipid Res", "standardName": "Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.", - "textContent": "97", + "textContent": "98", "type": [ "PublicationXref", "PubMed:10191291" @@ -29939,7 +29943,7 @@ "id": "publicationXrefaeb", "source": "J Biol Chem", "standardName": "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.", - "textContent": "85", + "textContent": "84", "type": [ "PublicationXref", "PubMed:9407135" @@ -29966,7 +29970,7 @@ "id": "publicationXrefaf0", "source": "FEBS Lett", "standardName": "Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.", - "textContent": "200", + "textContent": "214", "type": [ "PublicationXref", "PubMed:16962588" @@ -29984,7 +29988,7 @@ "id": "publicationXrefaf3", "source": "Antioxid Redox Signal", "standardName": "The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.", - "textContent": "131", + "textContent": "125", "type": [ "PublicationXref", "PubMed:11761328" @@ -30001,7 +30005,7 @@ "id": "publicationXrefaf4", "source": "Haemostasis", "standardName": "Does inflammation contribute to thrombotic events?", - "textContent": "119", + "textContent": "111", "type": [ "PublicationXref", "PubMed:11251339" @@ -30018,7 +30022,7 @@ "id": "publicationXrefaf8", "source": "Mol Genet Metab", "standardName": "Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.", - "textContent": "116", + "textContent": "121", "type": [ "PublicationXref", "PubMed:11001804" @@ -30037,7 +30041,7 @@ "id": "publicationXrefaf9", "source": "Biochim Biophys Acta", "standardName": "Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.", - "textContent": "184", + "textContent": "189", "type": [ "PublicationXref", "PubMed:15680232" @@ -30077,7 +30081,7 @@ "id": "publicationXrefafd", "source": "Nutrition", "standardName": "Folic acid says NO to vascular diseases.", - "textContent": "155", + "textContent": "158", "type": [ "PublicationXref", "PubMed:12831960" @@ -30094,7 +30098,7 @@ "id": "publicationXrefaff", "source": "Biochim Biophys Acta", "standardName": "Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.", - "textContent": "193", + "textContent": "198", "type": [ "PublicationXref", "PubMed:15680219" @@ -30131,7 +30135,7 @@ "id": "publicationXrefb13", "source": "J Biol Chem", "standardName": "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase.", - "textContent": "29", + "textContent": "32", "type": [ "PublicationXref", "PubMed:6885824" @@ -30148,7 +30152,7 @@ "id": "publicationXrefb1c", "source": "Clin Rev Allergy Immunol", "standardName": "Oxidative modification of LDL: its pathological role in atherosclerosis.", - "textContent": "289", + "textContent": "273", "type": [ "PublicationXref", "PubMed:18987785" @@ -30171,7 +30175,7 @@ "id": "publicationXrefb1f", "source": "Biochem J", "standardName": "Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.", - "textContent": "137", + "textContent": "138", "type": [ "PublicationXref", "PubMed:11939906" @@ -30192,7 +30196,7 @@ "id": "publicationXrefb21", "source": "J Mol Biol", "standardName": "Structure and mechanism of a eukaryotic FMN adenylyltransferase.", - "textContent": "299", + "textContent": "275", "type": [ "PublicationXref", "PubMed:19375431" @@ -30213,7 +30217,7 @@ "id": "publicationXrefb2a", "source": "Mol Genet Metab", "standardName": "Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c -->t methylenetetrahydrofolate reductase and 2756a -->g methionine synthase genotypes.", - "textContent": "121", + "textContent": "122", "type": [ "PublicationXref", "PubMed:10833329" @@ -30230,7 +30234,7 @@ "id": "publicationXrefb30", "source": "Biochem Pharmacol", "standardName": "New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.", - "textContent": "288", + "textContent": "276", "type": [ "PublicationXref", "PubMed:18761324" @@ -30248,7 +30252,7 @@ "id": "publicationXrefb35", "source": "Biochem J", "standardName": "Sphingosine 1-phosphate signalling in mammalian cells.", - "textContent": "109", + "textContent": "112", "type": [ "PublicationXref", "PubMed:10880336" @@ -30269,7 +30273,7 @@ "id": "publicationXrefb39", "source": "Free Radic Biol Med", "standardName": "Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.", - "textContent": "122", + "textContent": "109", "type": [ "PublicationXref", "PubMed:11121721" @@ -30314,7 +30318,7 @@ "id": "publicationXrefb4a", "source": "J Biol Chem", "standardName": "A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.", - "textContent": "84", + "textContent": "83", "type": [ "PublicationXref", "PubMed:9368067" @@ -30334,7 +30338,7 @@ "id": "publicationXrefb54", "source": "Clin Chem", "standardName": "Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.", - "textContent": "114", + "textContent": "115", "type": [ "PublicationXref", "PubMed:11017945" @@ -30358,7 +30362,7 @@ "id": "publicationXrefb59", "source": "Crit Care Med", "standardName": "Glucose metabolism and catecholamines.", - "textContent": "226", + "textContent": "225", "type": [ "PublicationXref", "PubMed:17713401" @@ -30402,7 +30406,7 @@ "id": "publicationXrefb60", "source": "J Lipid Res", "standardName": "Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).", - "textContent": "219", + "textContent": "220", "type": [ "PublicationXref", "PubMed:16547353" @@ -30419,7 +30423,7 @@ "id": "publicationXrefb63", "source": "Clin Rev Allergy Immunol", "standardName": "Oxidative modification of LDL: its pathological role in atherosclerosis.", - "textContent": "272", + "textContent": "295", "type": [ "PublicationXref", "PubMed:18987785" @@ -30446,7 +30450,7 @@ "id": "publicationXrefb77", "source": "J Immunol", "standardName": "Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.", - "textContent": "245", + "textContent": "247", "type": [ "PublicationXref", "PubMed:18424738" @@ -30472,7 +30476,7 @@ "id": "publicationXrefb78", "source": "Mol Cell Biol", "standardName": "Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.", - "textContent": "61", + "textContent": "62", "type": [ "PublicationXref", "PubMed:8413223" @@ -30491,7 +30495,7 @@ "id": "publicationXrefb91", "source": "Biochim Biophys Acta", "standardName": "Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.", - "textContent": "36", + "textContent": "33", "type": [ "PublicationXref", "PubMed:3918580" @@ -30529,7 +30533,7 @@ "id": "publicationXrefb9d", "source": "Br J Haematol", "standardName": "Acquired and inherited disorders of cobalamin and folate in children.", - "textContent": "218", + "textContent": "211", "type": [ "PublicationXref", "PubMed:16846473" @@ -30549,7 +30553,7 @@ "id": "publicationXrefb9f", "source": "J Trace Elem Med Biol", "standardName": "Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.", - "textContent": "148", + "textContent": "141", "type": [ "PublicationXref", "PubMed:11878747" @@ -30572,7 +30576,7 @@ "id": "publicationXrefba1", "source": "J Biol Chem", "standardName": "Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.", - "textContent": "128", + "textContent": "134", "type": [ "PublicationXref", "PubMed:11447214" @@ -30589,7 +30593,7 @@ "id": "publicationXrefba2", "source": "J Clin Pathol", "standardName": "Cobalamins and nitrous oxide: a review.", - "textContent": "16", + "textContent": "17", "type": [ "PublicationXref", "PubMed:6107306" @@ -30607,7 +30611,7 @@ "id": "publicationXrefba4", "source": "Cell Cycle", "standardName": "FoxO1 integrates insulin signaling to VLDL production.", - "textContent": "256", + "textContent": "258", "type": [ "PublicationXref", "PubMed:18927507" @@ -30647,7 +30651,7 @@ "id": "publicationXrefbac", "source": "Hoppe Seylers Z Physiol Chem", "standardName": "Purification and characterization of amino-acid N-choloyltransferase from human liver.", - "textContent": "30", + "textContent": "28", "type": [ "PublicationXref", "PubMed:6884990" @@ -30672,7 +30676,7 @@ "id": "publicationXrefbbd", "source": "Prostaglandins.", "standardName": "Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone", - "textContent": "27", + "textContent": "25", "type": [ "PublicationXref", "PubMed:6300970" @@ -30689,7 +30693,7 @@ "id": "publicationXrefbc0", "source": "Biochim Biophys Acta", "standardName": "Selenoprotein expression and function-Selenoprotein W.", - "textContent": "269", + "textContent": "274", "type": [ "PublicationXref", "PubMed:19464347" @@ -30713,7 +30717,7 @@ "id": "publicationXrefbc1", "source": "Clin Immunol", "standardName": "Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.", - "textContent": "285", + "textContent": "270", "type": [ "PublicationXref", "PubMed:19740703" @@ -30730,7 +30734,7 @@ "id": "publicationXrefbc2", "source": "Antioxid Redox Signal", "standardName": "F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.", - "textContent": "262", + "textContent": "254", "type": [ "PublicationXref", "PubMed:18522490" @@ -30750,7 +30754,7 @@ "id": "publicationXrefbc6", "source": "J Biol Chem", "standardName": "Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.", - "textContent": "105", + "textContent": "106", "type": [ "PublicationXref", "PubMed:9873062" @@ -30770,7 +30774,7 @@ "id": "publicationXrefbd7", "source": "J Biol Chem", "standardName": "NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.", - "textContent": "212", + "textContent": "222", "type": [ "PublicationXref", "PubMed:16835236" @@ -30789,7 +30793,7 @@ "id": "publicationXrefbdc", "source": "Biochem J", "standardName": "Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.", - "textContent": "22", + "textContent": "27", "type": [ "PublicationXref", "PubMed:6814427" @@ -30808,7 +30812,7 @@ "id": "publicationXrefbe4", "source": "Proc Natl Acad Sci U S A", "standardName": "Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.", - "textContent": "47", + "textContent": "45", "type": [ "PublicationXref", "PubMed:2602371" @@ -30834,7 +30838,7 @@ "id": "publicationXrefbe5", "source": "J Lab Clin Med", "standardName": "Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study.", - "textContent": "188", + "textContent": "197", "type": [ "PublicationXref", "PubMed:15668660" @@ -30852,7 +30856,7 @@ "id": "publicationXrefbe9", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells.", - "textContent": "56", + "textContent": "58", "type": [ "PublicationXref", "PubMed:1492101" @@ -30875,7 +30879,7 @@ "id": "publicationXrefc06", "source": "Science", "standardName": "Characterization of mammalian selenoproteomes.", - "textContent": "163", + "textContent": "161", "type": [ "PublicationXref", "PubMed:12775843" @@ -30898,7 +30902,7 @@ "id": "publicationXrefc0b", "source": "Circulation", "standardName": "Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.", - "textContent": "117", + "textContent": "110", "type": [ "PublicationXref", "PubMed:10653827" @@ -30917,7 +30921,7 @@ "id": "publicationXrefc0f", "source": "Biochem J", "standardName": "Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.", - "textContent": "203", + "textContent": "217", "type": [ "PublicationXref", "PubMed:16716149" @@ -30935,7 +30939,7 @@ "id": "publicationXrefc15", "source": "Front Biosci", "standardName": "Cytokines in acute and chronic inflammation.", - "textContent": "83", + "textContent": "79", "type": [ "PublicationXref", "PubMed:9159205" @@ -30956,7 +30960,7 @@ "id": "publicationXrefc24", "source": "Mol Cell Endocrinol", "standardName": "Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.", - "textContent": "175", + "textContent": "181", "type": [ "PublicationXref", "PubMed:15026176" @@ -30974,7 +30978,7 @@ "id": "publicationXrefc25", "source": "J Steroid Biochem Mol Biol", "standardName": "Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.", - "textContent": "68", + "textContent": "65", "type": [ "PublicationXref", "PubMed:7577714" @@ -30993,7 +30997,7 @@ "id": "publicationXrefc29", "source": "Int J Biochem Cell Biol", "standardName": "Serine hydroxymethyltransferase and threonine aldolase: are they identical?", - "textContent": "110", + "textContent": "114", "type": [ "PublicationXref", "PubMed:10716626" @@ -31010,7 +31014,7 @@ "id": "publicationXrefc2b", "source": "J Leukoc Biol", "standardName": "Myeloperoxidase: friend and foe.", - "textContent": "185", + "textContent": "199", "type": [ "PublicationXref", "PubMed:15689384" @@ -31027,7 +31031,7 @@ "id": "publicationXrefc2d", "source": "Future Oncol", "standardName": "Role of the MTHFR polymorphisms in cancer risk modification and treatment.", - "textContent": "283", + "textContent": "269", "type": [ "PublicationXref", "PubMed:19450180" @@ -31047,7 +31051,7 @@ "id": "publicationXrefc31", "source": "Tenn Med", "standardName": "Fructosamine--an underutilized tool in diabetes management: case report and literature review.", - "textContent": "264", + "textContent": "256", "type": [ "PublicationXref", "PubMed:19024248" @@ -31068,7 +31072,7 @@ "id": "publicationXrefc37", "source": "J Pharm Biomed Anal", "standardName": "Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection.", - "textContent": "186", + "textContent": "184", "type": [ "PublicationXref", "PubMed:15925209" @@ -31089,7 +31093,7 @@ "id": "publicationXrefc47", "source": "Biochem J", "standardName": "Purification and characterization of human phosphatidylserine synthase 1 and 2.", - "textContent": "257", + "textContent": "253", "type": [ "PublicationXref", "PubMed:19014349" @@ -31109,7 +31113,7 @@ "id": "publicationXrefc51", "source": "Biochemistry", "standardName": "Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.", - "textContent": "211", + "textContent": "213", "type": [ "PublicationXref", "PubMed:16430221" @@ -31128,7 +31132,7 @@ "id": "publicationXrefc53", "source": "Diabetes Care", "standardName": "Serum selenium and diabetes in U.S. adults.", - "textContent": "233", + "textContent": "230", "type": [ "PublicationXref", "PubMed:17392543" @@ -31145,7 +31149,7 @@ "id": "publicationXrefc56", "source": "J Clin Invest", "standardName": "Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver.", - "textContent": "35", + "textContent": "34", "type": [ "PublicationXref", "PubMed:3919061" @@ -31163,7 +31167,7 @@ "id": "publicationXrefc58", "source": "Trends Mol Med", "standardName": "New insights into the pathophysiology of cobalamin deficiency.", - "textContent": "201", + "textContent": "209", "type": [ "PublicationXref", "PubMed:16690356" @@ -31184,7 +31188,7 @@ "id": "publicationXrefc59", "source": "Diabetes", "standardName": "HDL as a biomarker, potential therapeutic target, and therapy.", - "textContent": "297", + "textContent": "299", "type": [ "PublicationXref", "PubMed:19940234" @@ -31210,7 +31214,7 @@ "id": "publicationXrefc5d", "source": "Hum Mutat", "standardName": "A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.", - "textContent": "181", + "textContent": "169", "type": [ "PublicationXref", "PubMed:14695536" @@ -31240,7 +31244,7 @@ "id": "publicationXrefc65", "source": "J Clin Invest", "standardName": "Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.", - "textContent": "173", + "textContent": "174", "type": [ "PublicationXref", "PubMed:15314690" @@ -31258,7 +31262,7 @@ "id": "publicationXrefc68", "source": "Biochim Biophys Acta", "standardName": "Protection against reactive oxygen species by selenoproteins.", - "textContent": "278", + "textContent": "272", "type": [ "PublicationXref", "PubMed:19268692" @@ -31278,7 +31282,7 @@ "id": "publicationXrefc69", "source": "Biochem Biophys Res Commun", "standardName": "The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.", - "textContent": "224", + "textContent": "233", "type": [ "PublicationXref", "PubMed:17276401" @@ -31298,7 +31302,7 @@ "id": "publicationXrefc6a", "source": "Appl Environ Microbiol", "standardName": "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.", - "textContent": "23", + "textContent": "22", "type": [ "PublicationXref", "PubMed:6758698" @@ -31316,7 +31320,7 @@ "id": "publicationXrefc6d", "source": "Methods Enzymol", "standardName": "Phospholipase D from rat brain.", - "textContent": "19", + "textContent": "21", "type": [ "PublicationXref", "PubMed:7278682" @@ -31338,7 +31342,7 @@ "id": "publicationXrefc76", "source": "Hum Reprod", "standardName": "Endothelial function in post-menopausal women: effect of folic acid supplementation.", - "textContent": "174", + "textContent": "175", "type": [ "PublicationXref", "PubMed:15016776" @@ -31357,7 +31361,7 @@ "id": "publicationXrefc7a", "source": "Am J Clin Nutr", "standardName": "Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.", - "textContent": "273", + "textContent": "291", "type": [ "PublicationXref", "PubMed:19403638" @@ -31377,7 +31381,7 @@ "id": "publicationXrefc7d", "source": "J Biol Chem", "standardName": "Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.", - "textContent": "187", + "textContent": "188", "type": [ "PublicationXref", "PubMed:16120612" @@ -31398,7 +31402,7 @@ "id": "publicationXrefc82", "source": "J Biol Chem", "standardName": "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.", - "textContent": "72", + "textContent": "75", "type": [ "PublicationXref", "PubMed:8617728" @@ -31429,7 +31433,7 @@ "id": "publicationXrefc83", "source": "FASEB J", "standardName": "Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.", - "textContent": "254", + "textContent": "243", "type": [ "PublicationXref", "PubMed:18198219" @@ -31453,7 +31457,7 @@ "id": "publicationXrefc84", "source": "Atherosclerosis", "standardName": "The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations.", - "textContent": "127", + "textContent": "131", "type": [ "PublicationXref", "PubMed:11472746" @@ -31489,7 +31493,7 @@ "id": "publicationXrefc8e", "source": "Curr Opin Cell Biol", "standardName": "Cyclooxygenases, peroxide tone and the allure of fish oil.", - "textContent": "192", + "textContent": "185", "type": [ "PublicationXref", "PubMed:15780594" @@ -31509,7 +31513,7 @@ "id": "publicationXrefc99", "source": "Biochim Biophys Acta", "standardName": "Phospholipase A(2) activity in non-glycated and glycated low density lipoproteins.", - "textContent": "73", + "textContent": "72", "type": [ "PublicationXref", "PubMed:8652655" @@ -31555,7 +31559,7 @@ "id": "publicationXrefc9c", "source": "Nat Struct Biol", "standardName": "Mechanism of metal activation of human hematopoietic prostaglandin D synthase.", - "textContent": "153", + "textContent": "156", "type": [ "PublicationXref", "PubMed:12627223" @@ -31578,7 +31582,7 @@ "id": "publicationXrefc9e", "source": "Obesity (Silver Spring)", "standardName": "Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-alpha Ligands in Zucker Rats.", - "textContent": "281", + "textContent": "284", "type": [ "PublicationXref", "PubMed:19521349" @@ -31600,7 +31604,7 @@ "id": "publicationXrefca8", "source": "Atherosclerosis", "standardName": "B vitamin status and inflammatory markers.", - "textContent": "157", + "textContent": "153", "type": [ "PublicationXref", "PubMed:12860264" @@ -31619,7 +31623,7 @@ "id": "publicationXrefca9", "source": "Am J Clin Nutr", "standardName": "Studies of biomarker responses to intervention with riboflavin: a systematic review.", - "textContent": "291", + "textContent": "293", "type": [ "PublicationXref", "PubMed:19403631" @@ -31640,7 +31644,7 @@ "id": "publicationXrefcaf", "source": "Eur J Clin Nutr", "standardName": "Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.", - "textContent": "248", + "textContent": "262", "type": [ "PublicationXref", "PubMed:17311055" @@ -31664,7 +31668,7 @@ "id": "publicationXrefcb5", "source": "Diabetologia", "standardName": "Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.", - "textContent": "280", + "textContent": "298", "type": [ "PublicationXref", "PubMed:19707742" @@ -31683,7 +31687,7 @@ "id": "publicationXrefcb6", "source": "Nat Prod Rep", "standardName": "Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.", - "textContent": "231", + "textContent": "235", "type": [ "PublicationXref", "PubMed:17534535" @@ -31708,7 +31712,7 @@ "id": "publicationXrefcb9", "source": "J Immunol", "standardName": "Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.", - "textContent": "51", + "textContent": "53", "type": [ "PublicationXref", "PubMed:1848582" @@ -31781,7 +31785,7 @@ "id": "publicationXrefcbd", "source": "Nat Struct Biol.", "standardName": "Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.", - "textContent": "142", + "textContent": "144", "type": [ "PublicationXref", "PubMed:11731805" @@ -31799,7 +31803,7 @@ "id": "publicationXrefcc7", "source": "Nephrology (Carlton)", "standardName": "Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.", - "textContent": "290", + "textContent": "279", "type": [ "PublicationXref", "PubMed:19674315" @@ -31817,7 +31821,7 @@ "id": "publicationXrefcd5", "source": "Mol Genet Metab", "standardName": "3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.", - "textContent": "190", + "textContent": "193", "type": [ "PublicationXref", "PubMed:15670717" @@ -31857,7 +31861,7 @@ "id": "publicationXrefce5", "source": "Eur J Biochem", "standardName": "Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.", - "textContent": "58", + "textContent": "56", "type": [ "PublicationXref", "PubMed:1730245" @@ -31900,7 +31904,7 @@ "id": "publicationXrefceb", "source": "J Biol Chem", "standardName": "Nitric oxide is a physiological substrate for mammalian peroxidases.", - "textContent": "112", + "textContent": "117", "type": [ "PublicationXref", "PubMed:11090610" @@ -31921,7 +31925,7 @@ "id": "publicationXrefcef", "source": "Diabetes Metab Res Rev", "standardName": "Hemoglobin variants and determination of glycated hemoglobin (HbA1c).", - "textContent": "124", + "textContent": "128", "type": [ "PublicationXref", "PubMed:11307174" @@ -31938,7 +31942,7 @@ "id": "publicationXrefcf3", "source": "Annu Rev Nutr", "standardName": "Homocysteine metabolism.", - "textContent": "99", + "textContent": "101", "type": [ "PublicationXref", "PubMed:10448523" @@ -31956,7 +31960,7 @@ "id": "publicationXrefcf5", "source": "Biochim Biophys Acta", "standardName": "6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.", - "textContent": "102", + "textContent": "100", "type": [ "PublicationXref", "PubMed:10216279" @@ -31975,7 +31979,7 @@ "id": "publicationXrefcf6", "source": "Proc Natl Acad Sci U S A", "standardName": "Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.", - "textContent": "26", + "textContent": "23", "type": [ "PublicationXref", "PubMed:6122208" @@ -32017,7 +32021,7 @@ "id": "publicationXrefcfc", "source": "Blood", "standardName": "Enzymic studies on phosphatidic acid synthesis in human platelets.", - "textContent": "4", + "textContent": "5", "type": [ "PublicationXref", "PubMed:4690137" @@ -32040,7 +32044,7 @@ "id": "publicationXrefd00", "source": "FASEB J", "standardName": "Cyclooxygenase in biology and disease.", - "textContent": "89", + "textContent": "87", "type": [ "PublicationXref", "PubMed:9737710" @@ -32062,7 +32066,7 @@ "id": "publicationXrefd08", "source": "Eur J Clin Pharmacol", "standardName": "The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.", - "textContent": "143", + "textContent": "137", "type": [ "PublicationXref", "PubMed:11956665" @@ -32083,7 +32087,7 @@ "id": "publicationXrefd09", "source": "Nature", "standardName": "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.", - "textContent": "169", + "textContent": "167", "type": [ "PublicationXref", "PubMed:15215856" @@ -32105,7 +32109,7 @@ "id": "publicationXrefd0b", "source": "Cell Mol Life Sci", "standardName": "Enzymology of NAD+ homeostasis in man.", - "textContent": "171", + "textContent": "176", "type": [ "PublicationXref", "PubMed:14704851" @@ -32123,7 +32127,7 @@ "id": "publicationXrefd18", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Thromboxane synthase: structure and function of protein and gene.", - "textContent": "144", + "textContent": "146", "type": [ "PublicationXref", "PubMed:12432933" @@ -32146,7 +32150,7 @@ "id": "publicationXrefd29", "source": "Circulation", "standardName": "Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.", - "textContent": "113", + "textContent": "123", "type": [ "PublicationXref", "PubMed:10653827" @@ -32166,7 +32170,7 @@ "id": "publicationXrefd30", "source": "J Nutr Sci Vitaminol (Tokyo)", "standardName": "Occurrence and characterization of cyanocobalamin reductase (NADPH; CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis.", - "textContent": "43", + "textContent": "44", "type": [ "PublicationXref", "PubMed:3134526" @@ -32189,7 +32193,7 @@ "id": "publicationXrefd34", "source": "J Clin Invest", "standardName": "Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.", - "textContent": "8", + "textContent": "7", "type": [ "PublicationXref", "PubMed:190267" @@ -32234,7 +32238,7 @@ "id": "publicationXrefd42", "source": "Cytokine", "standardName": "Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.", - "textContent": "206", + "textContent": "207", "type": [ "PublicationXref", "PubMed:16574427" @@ -32251,7 +32255,7 @@ "id": "publicationXrefd4f", "source": "Am J Clin Nutr", "standardName": "Fatty acid metabolism in health and disease: the role of delta-6-desaturase.", - "textContent": "62", + "textContent": "61", "type": [ "PublicationXref", "PubMed:8386433" @@ -32274,7 +32278,7 @@ "id": "publicationXrefd53", "source": "J Cardiovasc Pharmacol", "standardName": "Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.", - "textContent": "246", + "textContent": "268", "type": [ "PublicationXref", "PubMed:18209571" @@ -32305,7 +32309,7 @@ "id": "publicationXrefd55", "source": "Birth Defects Res A Clin Mol Teratol", "standardName": "Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.", - "textContent": "198", + "textContent": "195", "type": [ "PublicationXref", "PubMed:15782407" @@ -32322,7 +32326,7 @@ "id": "publicationXrefd63", "source": "Mutat Res", "standardName": "Lipid peroxidation-DNA damage by malondialdehyde.", - "textContent": "101", + "textContent": "97", "type": [ "PublicationXref", "PubMed:10064852" @@ -32344,7 +32348,7 @@ "id": "publicationXrefd6f", "source": "Ann Neurol", "standardName": "Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.", - "textContent": "282", + "textContent": "289", "type": [ "PublicationXref", "PubMed:19557870" @@ -32367,7 +32371,7 @@ "id": "publicationXrefd72", "source": "J Am Coll Cardiol", "standardName": "Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease.", - "textContent": "239", + "textContent": "234", "type": [ "PublicationXref", "PubMed:17964036" @@ -32385,7 +32389,7 @@ "id": "publicationXrefd74", "source": "J Biol Chem", "standardName": "CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.", - "textContent": "182", + "textContent": "192", "type": [ "PublicationXref", "PubMed:15536089" @@ -32411,7 +32415,7 @@ "id": "publicationXrefd77", "source": "Nutr Metab Cardiovasc Dis", "standardName": "Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.", - "textContent": "279", + "textContent": "282", "type": [ "PublicationXref", "PubMed:19854035" @@ -32430,7 +32434,7 @@ "id": "publicationXrefd7f", "source": "Am J Clin Nutr", "standardName": "Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.", - "textContent": "284", + "textContent": "287", "type": [ "PublicationXref", "PubMed:19403638" @@ -32457,7 +32461,7 @@ "id": "publicationXrefd82", "source": "J Nutr", "standardName": "Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.", - "textContent": "247", + "textContent": "244", "type": [ "PublicationXref", "PubMed:18203897" @@ -32474,7 +32478,7 @@ "id": "publicationXrefd95", "source": "Prostaglandins", "standardName": "Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?", - "textContent": "79", + "textContent": "78", "type": [ "PublicationXref", "PubMed:9112289" @@ -32495,7 +32499,7 @@ "id": "publicationXrefd97", "source": "Neurochem Int", "standardName": "Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.", - "textContent": "106", + "textContent": "107", "type": [ "PublicationXref", "PubMed:10100195" @@ -32512,7 +32516,7 @@ "id": "publicationXrefd98", "source": "Gut", "standardName": "Studies on long chain fatty acid:CoA ligase from human small intestine.", - "textContent": "17", + "textContent": "16", "type": [ "PublicationXref", "PubMed:7429333" @@ -32537,7 +32541,7 @@ "id": "publicationXrefd99", "source": "J Biol Chem", "standardName": "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.", - "textContent": "77", + "textContent": "81", "type": [ "PublicationXref", "PubMed:9099683" @@ -32581,7 +32585,7 @@ "id": "publicationXrefda1", "source": "J Biol Chem", "standardName": "Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.", - "textContent": "234", + "textContent": "236", "type": [ "PublicationXref", "PubMed:17916561" @@ -32605,7 +32609,7 @@ "id": "publicationXrefda2", "source": "Atherosclerosis", "standardName": "Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.", - "textContent": "162", + "textContent": "163", "type": [ "PublicationXref", "PubMed:14642406" @@ -32630,7 +32634,7 @@ "id": "publicationXrefda3", "source": "J Exp Med", "standardName": "A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.", - "textContent": "194", + "textContent": "183", "type": [ "PublicationXref", "PubMed:15851485" @@ -32648,7 +32652,7 @@ "id": "publicationXrefdab", "source": "Crit Rev Clin Lab Sci.", "standardName": "Vitamin B12 binders (transcobalamins) in serum.", - "textContent": "25", + "textContent": "26", "type": [ "PublicationXref", "PubMed:6295699" @@ -32721,7 +32725,7 @@ "id": "publicationXrefdb6", "source": "Clin Exp Allergy", "standardName": "Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.", - "textContent": "208", + "textContent": "203", "type": [ "PublicationXref", "PubMed:16911361" @@ -32741,7 +32745,7 @@ "id": "publicationXrefdb9", "source": "J Biol Chem", "standardName": "A new human selenium-containing protein. Purification, characterization, and cDNA sequence.", - "textContent": "87", + "textContent": "93", "type": [ "PublicationXref", "PubMed:9535873" @@ -32813,7 +32817,7 @@ "id": "publicationXrefdd8", "source": "Steroids", "standardName": "Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.", - "textContent": "250", + "textContent": "255", "type": [ "PublicationXref", "PubMed:18394665" @@ -32835,7 +32839,7 @@ "id": "publicationXrefddc", "source": "Hippocampus", "standardName": "Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.", - "textContent": "296", + "textContent": "292", "type": [ "PublicationXref", "PubMed:18680158" @@ -32854,7 +32858,7 @@ "id": "publicationXrefde0", "source": "Antioxid Redox Signal", "standardName": "Evolution of catalases from bacteria to humans.", - "textContent": "261", + "textContent": "259", "type": [ "PublicationXref", "PubMed:18498226" @@ -32878,7 +32882,7 @@ "id": "publicationXrefde1", "source": "Proc Natl Acad Sci U S A", "standardName": "Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis.", - "textContent": "108", + "textContent": "104", "type": [ "PublicationXref", "PubMed:10468579" @@ -32897,7 +32901,7 @@ "id": "publicationXrefde2", "source": "J Inherit Metab Dis", "standardName": "Causes of and diagnostic approach to methylmalonic acidurias.", - "textContent": "255", + "textContent": "251", "type": [ "PublicationXref", "PubMed:18563633" @@ -32959,7 +32963,7 @@ "id": "publicationXrefde8", "source": "Biochem Soc Trans", "standardName": "Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.", - "textContent": "232", + "textContent": "240", "type": [ "PublicationXref", "PubMed:17511631" @@ -32978,7 +32982,7 @@ "id": "publicationXrefdf7", "source": "Anal Biochem", "standardName": "Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.", - "textContent": "45", + "textContent": "47", "type": [ "PublicationXref", "PubMed:2610352" @@ -33002,7 +33006,7 @@ "id": "publicationXrefdfc", "source": "Mol Genet Metab", "standardName": "Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study.", - "textContent": "251", + "textContent": "264", "type": [ "PublicationXref", "PubMed:18226574" @@ -33022,7 +33026,7 @@ "id": "publicationXrefe06", "source": "J Am Coll Nutr", "standardName": "Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.", - "textContent": "96", + "textContent": "89", "type": [ "PublicationXref", "PubMed:9627909" @@ -33040,7 +33044,7 @@ "id": "publicationXrefe0b", "source": "J Clin Invest", "standardName": "Deiodinases: implications of the local control of thyroid hormone action.", - "textContent": "207", + "textContent": "219", "type": [ "PublicationXref", "PubMed:17016550" @@ -33060,7 +33064,7 @@ "id": "publicationXrefe11", "source": "J Trace Elem Med Biol", "standardName": "Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.", - "textContent": "146", + "textContent": "148", "type": [ "PublicationXref", "PubMed:11878747" @@ -33080,7 +33084,7 @@ "id": "publicationXrefe14", "source": "J Biol Chem", "standardName": "Membrane topography of human phosphatidylethanolamine N-methyltransferase.", - "textContent": "152", + "textContent": "166", "type": [ "PublicationXref", "PubMed:12431977" @@ -33100,7 +33104,7 @@ "id": "publicationXrefe15", "source": "Arch Biochem Biophys", "standardName": "Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.", - "textContent": "71", + "textContent": "74", "type": [ "PublicationXref", "PubMed:8806705" @@ -33118,7 +33122,7 @@ "id": "publicationXrefe1b", "source": "J Invest Dermatol", "standardName": "Sphingomyelinase in pig and human epidermis.", - "textContent": "9", + "textContent": "10", "type": [ "PublicationXref", "PubMed:25935" @@ -33181,7 +33185,7 @@ "id": "publicationXrefe2b", "source": "Cell Immunol", "standardName": "Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.", - "textContent": "225", + "textContent": "241", "type": [ "PublicationXref", "PubMed:17927969" @@ -33199,7 +33203,7 @@ "id": "publicationXrefe2c", "source": "Biochim Biophys Acta", "standardName": "Expression and characterization of human group V phospholipase A2.", - "textContent": "86", + "textContent": "88", "type": [ "PublicationXref", "PubMed:9767110" @@ -33218,7 +33222,7 @@ "id": "publicationXrefe2d", "source": "Biofactors", "standardName": "The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.", - "textContent": "123", + "textContent": "116", "type": [ "PublicationXref", "PubMed:10705969" @@ -33243,7 +33247,7 @@ "id": "publicationXrefe2f", "source": "Cancer Res", "standardName": "Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.", - "textContent": "274", + "textContent": "297", "type": [ "PublicationXref", "PubMed:19951991" @@ -33260,7 +33264,7 @@ "id": "publicationXrefe34", "source": "Biomed Pharmacother", "standardName": "The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy.", - "textContent": "197", + "textContent": "191", "type": [ "PublicationXref", "PubMed:16202558" @@ -33281,7 +33285,7 @@ "id": "publicationXrefe35", "source": "J Hum Genet", "standardName": "TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations.", - "textContent": "275", + "textContent": "290", "type": [ "PublicationXref", "PubMed:19373259" @@ -33307,7 +33311,7 @@ "id": "publicationXrefe37", "source": "Blood", "standardName": "Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.", - "textContent": "215", + "textContent": "216", "type": [ "PublicationXref", "PubMed:16219795" @@ -33328,7 +33332,7 @@ "id": "publicationXrefe38", "source": "Int J Vitam Nutr Res", "standardName": "Vitamins, lipids and lipoproteins in a healthy elderly population.", - "textContent": "28", + "textContent": "30", "type": [ "PublicationXref", "PubMed:6668142" @@ -33347,7 +33351,7 @@ "id": "publicationXrefe3f", "source": "Immunobiology", "standardName": "Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.", - "textContent": "252", + "textContent": "265", "type": [ "PublicationXref", "PubMed:18656701" @@ -33387,7 +33391,7 @@ "id": "publicationXrefe4c", "source": "J Biol Chem", "standardName": "Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.", - "textContent": "126", + "textContent": "132", "type": [ "PublicationXref", "PubMed:11044454" @@ -33405,7 +33409,7 @@ "id": "publicationXrefe4d", "source": "J Nutr", "standardName": "Folate and carcinogenesis: an integrated scheme.", - "textContent": "115", + "textContent": "113", "type": [ "PublicationXref", "PubMed:10720158" @@ -33429,7 +33433,7 @@ "id": "publicationXrefe51", "source": "J Clin Endocrinol Metab", "standardName": "Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.", - "textContent": "166", + "textContent": "152", "type": [ "PublicationXref", "PubMed:12679481" @@ -33448,7 +33452,7 @@ "id": "publicationXrefe64", "source": "Eur J Biochem", "standardName": "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.", - "textContent": "5", + "textContent": "4", "type": [ "PublicationXref", "PubMed:4774123" @@ -33468,7 +33472,7 @@ "id": "publicationXrefe66", "source": "Trends Mol Med", "standardName": "Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.", - "textContent": "222", + "textContent": "215", "type": [ "PublicationXref", "PubMed:17049925" @@ -33509,7 +33513,7 @@ "id": "publicationXrefe70", "source": "Biochemistry", "standardName": "Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.", - "textContent": "229", + "textContent": "232", "type": [ "PublicationXref", "PubMed:17198385" @@ -33547,7 +33551,7 @@ "id": "publicationXrefe72", "source": "J Immunol", "standardName": "1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.", - "textContent": "209", + "textContent": "218", "type": [ "PublicationXref", "PubMed:16887964" @@ -33575,7 +33579,7 @@ "id": "publicationXrefe73", "source": "J Med Virol", "standardName": "Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.", - "textContent": "265", + "textContent": "245", "type": [ "PublicationXref", "PubMed:18428149" @@ -33597,7 +33601,7 @@ "id": "publicationXrefe74", "source": "J Biol Chem", "standardName": "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.", - "textContent": "150", + "textContent": "151", "type": [ "PublicationXref", "PubMed:12815058" @@ -33615,7 +33619,7 @@ "id": "publicationXrefe7f", "source": "Pharm World Sci", "standardName": "Pharmacological inhibition of leukotriene actions.", - "textContent": "90", + "textContent": "92", "type": [ "PublicationXref", "PubMed:9584338" @@ -33634,7 +33638,7 @@ "id": "publicationXrefe85", "source": "Prog Lipid Res", "standardName": "Fatty acid elongases in mammals: their regulation and roles in metabolism.", - "textContent": "205", + "textContent": "221", "type": [ "PublicationXref", "PubMed:16564093" @@ -33652,7 +33656,7 @@ "id": "publicationXrefe87", "source": "Am J Clin Nutr", "standardName": "Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994.", - "textContent": "156", + "textContent": "162", "type": [ "PublicationXref", "PubMed:12663279" @@ -33677,7 +33681,7 @@ "id": "publicationXrefe88", "source": "J Lipid Res", "standardName": "Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.", - "textContent": "172", + "textContent": "170", "type": [ "PublicationXref", "PubMed:14993240" @@ -33695,7 +33699,7 @@ "id": "publicationXrefe99", "source": "Circ Res", "standardName": "New insights into the regulation of HDL metabolism and reverse cholesterol transport.", - "textContent": "195", + "textContent": "187", "type": [ "PublicationXref", "PubMed:15976321" @@ -33713,7 +33717,7 @@ "id": "publicationXrefe9b", "source": "Bioessays", "standardName": "Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.", - "textContent": "88", + "textContent": "91", "type": [ "PublicationXref", "PubMed:10048303" @@ -33732,7 +33736,7 @@ "id": "publicationXrefea2", "source": "J Lipid Res", "standardName": "Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.", - "textContent": "34", + "textContent": "35", "type": [ "PublicationXref", "PubMed:4086942" @@ -33752,7 +33756,7 @@ "id": "publicationXrefeac", "source": "Steroids", "standardName": "Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.", - "textContent": "253", + "textContent": "252", "type": [ "PublicationXref", "PubMed:18164739" @@ -33773,7 +33777,7 @@ "id": "publicationXrefeae", "source": "J Biol Chem", "standardName": "Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.", - "textContent": "125", + "textContent": "135", "type": [ "PublicationXref", "PubMed:11279066" @@ -33792,7 +33796,7 @@ "id": "publicationXrefeb5", "source": "Pharmacol Rev", "standardName": "Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.", - "textContent": "167", + "textContent": "177", "type": [ "PublicationXref", "PubMed:15317910" @@ -33812,7 +33816,7 @@ "id": "publicationXrefeb6", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Prostaglandin E synthase.", - "textContent": "147", + "textContent": "145", "type": [ "PublicationXref", "PubMed:12432931" @@ -33831,7 +33835,7 @@ "id": "publicationXrefebb", "source": "J Physiol Pharmacol.", "standardName": "Nitric oxide and superoxide in inflammation and immune regulation.", - "textContent": "151", + "textContent": "154", "type": [ "PublicationXref", "PubMed:14726604" @@ -33855,7 +33859,7 @@ "id": "publicationXrefebc", "source": "J Biol Chem", "standardName": "Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.", - "textContent": "240", + "textContent": "228", "type": [ "PublicationXref", "PubMed:17283068" @@ -33879,7 +33883,7 @@ "id": "publicationXrefebf", "source": "J Leukoc Biol", "standardName": "NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.", - "textContent": "238", + "textContent": "239", "type": [ "PublicationXref", "PubMed:17046972" @@ -33897,7 +33901,7 @@ "id": "publicationXrefec4", "source": "Biochem Pharmacol", "standardName": "The controversial place of vitamin C in cancer treatment.", - "textContent": "249", + "textContent": "260", "type": [ "PublicationXref", "PubMed:18938145" @@ -33947,7 +33951,7 @@ "id": "publicationXrefed1", "source": "Adv Clin Chem", "standardName": "Proinflammatory cytokines in CRP baseline regulation.", - "textContent": "292", + "textContent": "296", "type": [ "PublicationXref", "PubMed:19803417" @@ -33971,7 +33975,7 @@ "id": "publicationXrefed4", "source": "J Biol Chem", "standardName": "Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.", - "textContent": "210", + "textContent": "205", "type": [ "PublicationXref", "PubMed:16951403" @@ -33990,7 +33994,7 @@ "id": "publicationXrefed6", "source": "J Clin Invest", "standardName": "Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.", - "textContent": "7", + "textContent": "8", "type": [ "PublicationXref", "PubMed:874074" @@ -34007,7 +34011,7 @@ "id": "publicationXrefed9", "source": "Annu Rev Nutr", "standardName": "Vitamin E: interactions with free radicals and ascorbate.", - "textContent": "33", + "textContent": "36", "type": [ "PublicationXref", "PubMed:2992548" @@ -34025,7 +34029,7 @@ "id": "publicationXrefedb", "source": "Methods Enzymol", "standardName": "Measurement of ceramide synthase activity.", - "textContent": "111", + "textContent": "120", "type": [ "PublicationXref", "PubMed:10914032" @@ -34049,7 +34053,7 @@ "id": "publicationXrefedd", "source": "BMC Public Health", "standardName": "Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study.", - "textContent": "217", + "textContent": "202", "type": [ "PublicationXref", "PubMed:16472406" @@ -34087,7 +34091,7 @@ "id": "publicationXrefee5", "source": "Biochim Biophys Acta", "standardName": "UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.", - "textContent": "41", + "textContent": "42", "type": [ "PublicationXref", "PubMed:3099851" @@ -34110,7 +34114,7 @@ "id": "publicationXrefeec", "source": "Antioxid Redox Signal", "standardName": "GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.", - "textContent": "260", + "textContent": "267", "type": [ "PublicationXref", "PubMed:18479189" @@ -34130,7 +34134,7 @@ "id": "publicationXrefeed", "source": "J Lipid Res", "standardName": "Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.", - "textContent": "32", + "textContent": "29", "type": [ "PublicationXref", "PubMed:6418841" @@ -34153,7 +34157,7 @@ "id": "publicationXrefef2", "source": "J Biol Chem", "standardName": "Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.", - "textContent": "199", + "textContent": "194", "type": [ "PublicationXref", "PubMed:15817466" @@ -34175,7 +34179,7 @@ "id": "publicationXrefef8", "source": "Mol Pharmacol", "standardName": "The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.", - "textContent": "266", + "textContent": "249", "type": [ "PublicationXref", "PubMed:18524888" @@ -34197,7 +34201,7 @@ "id": "publicationXrefefa", "source": "J Lipid Res", "standardName": "Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.", - "textContent": "21", + "textContent": "19", "type": [ "PublicationXref", "PubMed:7276750" @@ -34224,7 +34228,7 @@ "id": "publicationXrefefb", "source": "Clin Immunol", "standardName": "Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.", - "textContent": "271", + "textContent": "281", "type": [ "PublicationXref", "PubMed:19625220" @@ -34241,7 +34245,7 @@ "id": "publicationXrefefe", "source": "ACS Chem Biol", "standardName": "B12 trafficking in mammals: A for coenzyme escort service.", - "textContent": "223", + "textContent": "210", "type": [ "PublicationXref", "PubMed:17163662" @@ -34260,7 +34264,7 @@ "id": "publicationXreff03", "source": "Pharmacol Ther", "standardName": "Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.", - "textContent": "243", + "textContent": "261", "type": [ "PublicationXref", "PubMed:18420277" @@ -34296,7 +34300,7 @@ "id": "publicationXreff05", "source": "Clin Chim Acta", "standardName": "Monitoring micronutrients in cigarette smokers.", - "textContent": "237", + "textContent": "242", "type": [ "PublicationXref", "PubMed:17045981" @@ -34316,7 +34320,7 @@ "id": "publicationXreff11", "source": "J Proteome Res", "standardName": "Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.", - "textContent": "287", + "textContent": "285", "type": [ "PublicationXref", "PubMed:19415921" @@ -34333,7 +34337,7 @@ "id": "publicationXreff15", "source": "Free Radic Biol Med.", "standardName": "Free radicals, uric acid, and human disease.", - "textContent": "74", + "textContent": "70", "type": [ "PublicationXref", "PubMed:8846925" @@ -34350,7 +34354,7 @@ "id": "publicationXreff17", "source": "Adv Protein Chem", "standardName": "Fibrinogen and fibrin.", - "textContent": "189", + "textContent": "182", "type": [ "PublicationXref", "PubMed:15837518" @@ -34374,7 +34378,7 @@ "id": "publicationXreff18", "source": "J Biol Chem", "standardName": "15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.", - "textContent": "268", + "textContent": "250", "type": [ "PublicationXref", "PubMed:18718914" @@ -34394,7 +34398,7 @@ "id": "publicationXreff1c", "source": "Trends Mol Med", "standardName": "p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.", - "textContent": "295", + "textContent": "286", "type": [ "PublicationXref", "PubMed:19822456" @@ -34413,7 +34417,7 @@ "id": "publicationXreff1e", "source": "J Nutr", "standardName": "Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.", - "textContent": "159", + "textContent": "157", "type": [ "PublicationXref", "PubMed:12730456" @@ -34431,7 +34435,7 @@ "id": "publicationXreff1f", "source": "Annu Rev Pharmacol Toxicol", "standardName": "Properties and biological activities of thioredoxins.", - "textContent": "132", + "textContent": "126", "type": [ "PublicationXref", "PubMed:11264458" @@ -34449,7 +34453,7 @@ "id": "publicationXreff21", "source": "Blood", "standardName": "Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.", - "textContent": "42", + "textContent": "41", "type": [ "PublicationXref", "PubMed:3790723" @@ -34470,7 +34474,7 @@ "id": "publicationXreff2b", "source": "J Lipid Res", "standardName": "Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.", - "textContent": "12", + "textContent": "14", "type": [ "PublicationXref", "PubMed:374662" @@ -34494,7 +34498,7 @@ "id": "publicationXreff3f", "source": "Proc Natl Acad Sci U S A", "standardName": "Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.", - "textContent": "230", + "textContent": "237", "type": [ "PublicationXref", "PubMed:17463087" @@ -34511,7 +34515,7 @@ "id": "publicationXreff4a", "source": "Free Radic Biol Med", "standardName": "Tissue-specific functions of individual glutathione peroxidases.", - "textContent": "104", + "textContent": "108", "type": [ "PublicationXref", "PubMed:10569628" @@ -34530,7 +34534,7 @@ "id": "publicationXreff4c", "source": "IUBMB Life", "standardName": "The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.", - "textContent": "241", + "textContent": "226", "type": [ "PublicationXref", "PubMed:17365173" @@ -34564,7 +34568,7 @@ "id": "publicationXreff4f", "source": "Biochim Biophys Acta", "standardName": "Phosphatidylserine decarboxylase.", - "textContent": "81", + "textContent": "82", "type": [ "PublicationXref", "PubMed:9370338" @@ -34585,7 +34589,7 @@ "id": "publicationXreff54", "source": "J Biol Chem", "standardName": "cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.", - "textContent": "91", + "textContent": "95", "type": [ "PublicationXref", "PubMed:9852097" @@ -34607,7 +34611,7 @@ "id": "publicationXreff5b", "source": "J Gastroenterol", "standardName": "Relationship of plasma folic acid and status of DNA methylation in human gastric cancer.", - "textContent": "82", + "textContent": "76", "type": [ "PublicationXref", "PubMed:9085163" @@ -34627,7 +34631,7 @@ "id": "publicationXreff5c", "source": "Immunol Lett", "standardName": "Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue.", - "textContent": "139", + "textContent": "149", "type": [ "PublicationXref", "PubMed:11716958" @@ -34645,7 +34649,7 @@ "id": "publicationXreff5d", "source": "Annu Rev Nutr", "standardName": "Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.", - "textContent": "180", + "textContent": "179", "type": [ "PublicationXref", "PubMed:15189125" @@ -34663,7 +34667,7 @@ "id": "publicationXreff5f", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "5-lipoxygenase and FLAP.", - "textContent": "160", + "textContent": "159", "type": [ "PublicationXref", "PubMed:12895592" @@ -34680,7 +34684,7 @@ "id": "publicationXreff61", "source": "Am J Cardiol", "standardName": "How, when, and why to use apolipoprotein B in clinical practice.", - "textContent": "136", + "textContent": "142", "type": [ "PublicationXref", "PubMed:12419480" @@ -34700,7 +34704,7 @@ "id": "publicationXreff6b", "source": "Clin Chem", "standardName": "Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults.", - "textContent": "214", + "textContent": "206", "type": [ "PublicationXref", "PubMed:16239338" @@ -34721,7 +34725,7 @@ "id": "publicationXreff6c", "source": "Biochem J", "standardName": "The role of alpha-methylacyl-CoA racemase in bile acid synthesis.", - "textContent": "141", + "textContent": "147", "type": [ "PublicationXref", "PubMed:11964182" @@ -34742,7 +34746,7 @@ "id": "publicationXreff70", "source": "J Lipid Res", "standardName": "Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.", - "textContent": "65", + "textContent": "68", "type": [ "PublicationXref", "PubMed:8656081" @@ -34759,7 +34763,7 @@ "id": "publicationXreff7a", "source": "Ann N Y Acad Sci", "standardName": "Elements of the fibrinolytic system.", - "textContent": "134", + "textContent": "127", "type": [ "PublicationXref", "PubMed:11460480" @@ -34800,7 +34804,7 @@ "id": "publicationXreff7c", "source": "J Interferon Cytokine Res", "standardName": "Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.", - "textContent": "70", + "textContent": "71", "type": [ "PublicationXref", "PubMed:8877730" @@ -34824,7 +34828,7 @@ "id": "publicationXreff7d", "source": "Eur J Immunol", "standardName": "Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.", - "textContent": "183", + "textContent": "186", "type": [ "PublicationXref", "PubMed:15940673" @@ -34848,7 +34852,7 @@ "id": "publicationXreff82", "source": "EMBO J", "standardName": "Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.", - "textContent": "220", + "textContent": "223", "type": [ "PublicationXref", "PubMed:16858407" @@ -34872,7 +34876,7 @@ "id": "publicationXreff84", "source": "Arterioscler Thromb Vasc Biol", "standardName": "Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.", - "textContent": "149", + "textContent": "139", "type": [ "PublicationXref", "PubMed:12231557" @@ -34892,7 +34896,7 @@ "id": "publicationXreff8d", "source": "J Am Coll Cardiol", "standardName": "Omega-3 polyunsaturated fatty acids and cardiovascular diseases.", - "textContent": "277", + "textContent": "280", "type": [ "PublicationXref", "PubMed:19660687" @@ -34910,7 +34914,7 @@ "id": "publicationXreff92", "source": "Drug Metab Dispos", "standardName": "Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.", - "textContent": "263", + "textContent": "266", "type": [ "PublicationXref", "PubMed:18583509" @@ -34930,7 +34934,7 @@ "id": "publicationXreff97", "source": "J Biol Chem", "standardName": "Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase.", - "textContent": "76", + "textContent": "77", "type": [ "PublicationXref", "PubMed:9278416" @@ -34951,7 +34955,7 @@ "id": "publicationXreff9c", "source": "J Biochem", "standardName": "Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.", - "textContent": "107", + "textContent": "103", "type": [ "PublicationXref", "PubMed:10544287" @@ -34971,7 +34975,7 @@ "id": "publicationXreffa0", "source": "EMBO J", "standardName": "Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.", - "textContent": "213", + "textContent": "200", "type": [ "PublicationXref", "PubMed:16990795" @@ -34994,7 +34998,7 @@ "id": "publicationXreffa8", "source": "Zhonghua Yi Xue Za Zhi", "standardName": "[The role of Cubilin in albumin-induced MCP-1, RANTES expression by renal tubular epithelial cells]", - "textContent": "179", + "textContent": "178", "type": [ "PublicationXref", "PubMed:15631778" @@ -35014,7 +35018,7 @@ "id": "publicationXreffad", "source": "Mol Pharmacol", "standardName": "Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.", - "textContent": "53", + "textContent": "55", "type": [ "PublicationXref", "PubMed:1848655" @@ -35039,7 +35043,7 @@ "id": "publicationXreffb2", "source": "J Biol Chem", "standardName": "NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.", - "textContent": "216", + "textContent": "212", "type": [ "PublicationXref", "PubMed:16319061" @@ -35062,7 +35066,7 @@ "id": "publicationXreffb3", "source": "Am J Physiol", "standardName": "Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.", - "textContent": "92", + "textContent": "96", "type": [ "PublicationXref", "PubMed:9730949" @@ -35085,7 +35089,7 @@ "id": "publicationXreffb5", "source": "Am J Kidney Dis", "standardName": "Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route.", - "textContent": "135", + "textContent": "124", "type": [ "PublicationXref", "PubMed:11325678" @@ -35106,7 +35110,7 @@ "id": "publicationXreffb6", "source": "FEBS Lett", "standardName": "Selenoprotein W is a glutathione-dependent antioxidant in vivo.", - "textContent": "138", + "textContent": "136", "type": [ "PublicationXref", "PubMed:12062442" @@ -35123,7 +35127,7 @@ "id": "publicationXreffc0", "source": "Science", "standardName": "Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.", - "textContent": "44", + "textContent": "43", "type": [ "PublicationXref", "PubMed:3283935" @@ -35140,7 +35144,7 @@ "id": "publicationXreffc5", "source": "Cell Mol Life Sci", "standardName": "Molecular basis of homocysteine toxicity in humans.", - "textContent": "170", + "textContent": "173", "type": [ "PublicationXref", "PubMed:14999406" @@ -35159,7 +35163,7 @@ "id": "publicationXreffc9", "source": "Proc Natl Acad Sci U S A", "standardName": "Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.", - "textContent": "55", + "textContent": "54", "type": [ "PublicationXref", "PubMed:1652755" @@ -35179,7 +35183,7 @@ "id": "publicationXreffcb", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "In vivo conversion of linoleic acid to arachidonic acid in human adults.", - "textContent": "100", + "textContent": "102", "type": [ "PublicationXref", "PubMed:10471130" @@ -35197,7 +35201,7 @@ "id": "publicationXreffd5", "source": "Biochim Biophys Acta", "standardName": "Enzymatic sulphation of bile salts in human liver.", - "textContent": "10", + "textContent": "9", "type": [ "PublicationXref", "PubMed:698243" @@ -35215,7 +35219,7 @@ "id": "publicationXreffd7", "source": "Assay Drug Dev Technol", "standardName": "Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.", - "textContent": "242", + "textContent": "227", "type": [ "PublicationXref", "PubMed:17477829" @@ -35238,7 +35242,7 @@ "id": "publicationXreffe6", "source": "Br J Nutr", "standardName": "Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.", - "textContent": "293", + "textContent": "288", "type": [ "PublicationXref", "PubMed:19825219" @@ -35259,7 +35263,7 @@ "id": "publicationXrefffd", "source": "Int J Biol Sci", "standardName": "Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.", - "textContent": "227", + "textContent": "224", "type": [ "PublicationXref", "PubMed:17389926" @@ -35805,7 +35809,7 @@ "a2514", "f8623" ], - "dataSourceVersion": "WP1533_r129508", + "dataSourceVersion": "WP1533_r130784", "displayName": "Vitamin B12 metabolism", "drawAs": "rect", "fill": "white", @@ -35815,7 +35819,7 @@ "height": 2530.999666667, "id": "WP1533", "kaavioType": "Group", - "lastModified": "20240503114150", + "lastModified": "20240530073543", "name": "Vitamin B12 metabolism", "organism": "Homo sapiens", "padding": 5, @@ -35824,7 +35828,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Vitamin B12 metabolism\nLast Modified: 20240503114150\nOrganism: Homo sapiens", + "textContent": "Name: Vitamin B12 metabolism\nLast Modified: 20240530073543\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000397" diff --git a/pathways/WP1533/WP1533.png b/pathways/WP1533/WP1533.png index 9254b3b0f..e6ee75944 100644 Binary files a/pathways/WP1533/WP1533.png and b/pathways/WP1533/WP1533.png differ diff --git a/pathways/WP1533/WP1533.svg b/pathways/WP1533/WP1533.svg index 5c193131b..a1f86d138 100644 --- a/pathways/WP1533/WP1533.svg +++ b/pathways/WP1533/WP1533.svg @@ -544,7 +544,7 @@ - + @@ -2204,7 +2204,7 @@ - + Prostaglandin metabolism @@ -2240,7 +2240,7 @@ - + Lipid peroxidation @@ -3420,7 +3420,7 @@ Name: Vitamin B12 metabolism - Last Modified: 20240503114150 + Last Modified: 20240530073543 Organism: Homo sapiens diff --git a/pathways/WP2431/WP2431-bibliography.tsv b/pathways/WP2431/WP2431-bibliography.tsv index a26f63379..0119afce4 100644 --- a/pathways/WP2431/WP2431-bibliography.tsv +++ b/pathways/WP2431/WP2431-bibliography.tsv @@ -1,43 +1,43 @@ ID Database Citation -9872457 Pubmed "Resnick DK, Graham SH, Dixon CE, Marion DW. Role of cyclooxygenase 2 in acute spinal cord injury. J Neurotrauma. 1998 Dec;15(12):1005–13. PubMed Europe PMC Scholia" -10094148 Pubmed "Farooque M, Isaksson J, Olsson Y. Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. Neuroreport. 1999 Jan 18;10(1):131–4. PubMed Europe PMC Scholia" -11059815 Pubmed "Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res. 2000 Oct;25(9–10):1439–51. PubMed Europe PMC Scholia" -11553680 Pubmed "Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, et al. A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. J Neurochem. 2001 Sep;78(5):1064–72. PubMed Europe PMC Scholia" -11585624 Pubmed "Schwab JM, Frei E, Klusman I, Schnell L, Schwab ME, Schluesener HJ. AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats. J Neuroimmunol. 2001 Oct 1;119(2):214–22. PubMed Europe PMC Scholia" -12666113 Pubmed "Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol. 2003 Apr;53(4):454–68. PubMed Europe PMC Scholia" -12861073 Pubmed "Menet V, Prieto M, Privat A, Giménez y Ribotta M. Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8999–9004. PubMed Europe PMC Scholia" -16295699 Pubmed "Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S. Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages. Biomed Res. 2005 Oct;26(5):223–9. PubMed Europe PMC Scholia" -16504406 Pubmed "Chalimoniuk M, King-Pospisil K, Metz CN, Toborek M. Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons. Neuroscience. 2006;139(3):1117–28. PubMed Europe PMC Scholia" -16602711 Pubmed "Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, et al. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. J Proteome Res. 2006 Apr;5(4):1017–23. PubMed Europe PMC Scholia" -16623828 Pubmed "Fabes J, Anderson P, Yáñez-Muñoz RJ, Thrasher A, Brennan C, Bolsover S. Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Eur J Neurosci. 2006 Apr;23(7):1721–30. PubMed Europe PMC Scholia" -17482149 Pubmed "Tian D, Dong Q, Pan D, He Y, Yu Z, Xie M, et al. Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Brain Res. 2007 Jun 18;1154:206–14. PubMed Europe PMC Scholia" -17567803 Pubmed "Erschbamer M, Pernold K, Olson L. Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury. J Neurosci. 2007 Jun 13;27(24):6428–35. PubMed Europe PMC Scholia" -17621255 Pubmed "Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muià C, Esposito E, et al. TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome. Shock. 2008 Jan;29(1):32–41. PubMed Europe PMC Scholia" -17629414 Pubmed "Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S. Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience. 2007 Aug 10;148(1):175–87. PubMed Europe PMC Scholia" -17698296 Pubmed "Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, et al. Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons. Neuroscience. 2007 Sep 7;148(3):724–36. PubMed Europe PMC Scholia" -17706365 Pubmed "Chu GKT, Yu W, Fehlings MG. The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury. Neuroscience. 2007 Sep 7;148(3):668–82. PubMed Europe PMC Scholia" -17917587 Pubmed "Liu N-K, Zhang YP, Han S, Pei J, Xu LY, Lu P-H, et al. Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. J Neuropathol Exp Neurol. 2007 Oct;66(10):932–43. PubMed Europe PMC Scholia" -18267965 Pubmed "Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008 Apr;131(Pt 4):1087–98. PubMed Europe PMC Scholia" -18637713 Pubmed "Dagci T, Armagan G, Konyalioglu S, Yalcin A. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells. Physiol Res. 2009;58(3):427–34. PubMed Europe PMC Scholia" -19350383 Pubmed "Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I. Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat. Cell Mol Neurobiol. 2009 Sep;29(6–7):1045–51. PubMed Europe PMC Scholia" -19770517 Pubmed "Dekaban GA, Thawer S. Pathogenic antibodies are active participants in spinal cord injury. J Clin Invest. 2009 Oct;119(10):2881–4. PubMed Europe PMC Scholia" -19932745 Pubmed "Pineau I, Sun L, Bastien D, Lacroix S. Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion. Brain Behav Immun. 2010 May;24(4):540–53. PubMed Europe PMC Scholia" -20202079 Pubmed "Puschmann TB, Turnley AM. Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. J Neurochem. 2010 May;113(4):881–94. PubMed Europe PMC Scholia" -20304963 Pubmed "Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, et al. The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Am J Pathol. 2010 May;176(5):2352–66. PubMed Europe PMC Scholia" -21092735 Pubmed "Wang Y, Fan Z, Cao Y, Yu D, Zhang Y, Wang Y. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Brain Res. 2011 Jan 25;1370:220–6. PubMed Europe PMC Scholia" -21168495 Pubmed "Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, et al. CD47 knockout mice exhibit improved recovery from spinal cord injury. Neurobiol Dis. 2011 Apr;42(1):21–34. PubMed Europe PMC Scholia" -21283639 Pubmed "Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV. Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. PLoS One. 2011 Jan 24;6(1):e16135. PubMed Europe PMC Scholia" -21640756 Pubmed "Tohda C, Kuboyama T. Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacol Ther. 2011 Oct;132(1):57–71. PubMed Europe PMC Scholia" -21657851 Pubmed "Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep;28(9):1893–907. PubMed Europe PMC Scholia" -21673720 Pubmed "David S, Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia" -21868473 Pubmed "López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, et al. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec;25(12):4240–52. PubMed Europe PMC Scholia" -21957482 Pubmed "Kitayama M, Ueno M, Itakura T, Yamashita T. Activated microglia inhibit axonal growth through RGMa. PLoS One. 2011;6(9):e25234. PubMed Europe PMC Scholia" -22399755 Pubmed "Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012 Mar 7;32(10):3333–8. PubMed Europe PMC Scholia" -22536415 Pubmed "Fernández-Martos CM, González P, Rodriguez FJ. Acute leptin treatment enhances functional recovery after spinal cord injury. PLoS One. 2012;7(4):e35594. PubMed Europe PMC Scholia" -22564823 Pubmed "Shim S-O, Cafferty WBJ, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Mol Cell Neurosci. 2012 Jun;50(2):193–200. PubMed Europe PMC Scholia" -22771695 Pubmed "Saganová K, Gálik J, Blaško J, Korimová A, Račeková E, Vanický I. Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury. Life Sci. 2012 Aug 21;91(3–4):77–82. PubMed Europe PMC Scholia" -22865681 Pubmed "Ju P, Zhang S, Yeap Y, Feng Z. Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury. Glia. 2012 Nov;60(11):1801–14. PubMed Europe PMC Scholia" -22884909 Pubmed "Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR. Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res. 2012 Sep 26;1475:96–105. PubMed Europe PMC Scholia" -22930444 Pubmed "Zhang S, Huan W, Wei H, Shi J, Fan J, Zhao J, et al. FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. J Cell Biochem. 2013 Feb;114(2):354–65. PubMed Europe PMC Scholia" -23035104 Pubmed "Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann J-M, et al. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J Neurosci. 2012 Oct 3;32(40):13956–70. PubMed Europe PMC Scholia" -23152062 Pubmed "Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK. Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. Cell Death Dis. 2012 Nov 15;3(11):e426. PubMed Europe PMC Scholia" +9872457 Pubmed "Role of cyclooxygenase 2 in acute spinal cord injury. Resnick DK, Graham SH, Dixon CE, Marion DW. J Neurotrauma. 1998 Dec;15(12):1005–13. PubMed Europe PMC Scholia" +10094148 Pubmed "Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. Farooque M, Isaksson J, Olsson Y. Neuroreport. 1999 Jan 18;10(1):131–4. PubMed Europe PMC Scholia" +11059815 Pubmed "Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Eng LF, Ghirnikar RS, Lee YL. Neurochem Res. 2000 Oct;25(9–10):1439–51. PubMed Europe PMC Scholia" +11553680 Pubmed "A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, et al. J Neurochem. 2001 Sep;78(5):1064–72. PubMed Europe PMC Scholia" +11585624 Pubmed "AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats. Schwab JM, Frei E, Klusman I, Schnell L, Schwab ME, Schluesener HJ. J Neuroimmunol. 2001 Oct 1;119(2):214–22. PubMed Europe PMC Scholia" +12666113 Pubmed "Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI. Ann Neurol. 2003 Apr;53(4):454–68. PubMed Europe PMC Scholia" +12861073 Pubmed "Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Menet V, Prieto M, Privat A, Giménez y Ribotta M. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8999–9004. PubMed Europe PMC Scholia" +16295699 Pubmed "Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages. Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S. Biomed Res. 2005 Oct;26(5):223–9. PubMed Europe PMC Scholia" +16504406 Pubmed "Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons. Chalimoniuk M, King-Pospisil K, Metz CN, Toborek M. Neuroscience. 2006;139(3):1117–28. PubMed Europe PMC Scholia" +16602711 Pubmed "Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, et al. J Proteome Res. 2006 Apr;5(4):1017–23. PubMed Europe PMC Scholia" +16623828 Pubmed "Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Fabes J, Anderson P, Yáñez-Muñoz RJ, Thrasher A, Brennan C, Bolsover S. Eur J Neurosci. 2006 Apr;23(7):1721–30. PubMed Europe PMC Scholia" +17482149 Pubmed "Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Tian D shi, Dong Q, Pan D ji, He Y, Yu Z yuan, Xie M jie, et al. Brain Res. 2007 Jun 18;1154:206–14. PubMed Europe PMC Scholia" +17567803 Pubmed "Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury. Erschbamer M, Pernold K, Olson L. J Neurosci. 2007 Jun 13;27(24):6428–35. PubMed Europe PMC Scholia" +17621255 Pubmed "TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome. Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muià C, Esposito E, et al. Shock. 2008 Jan;29(1):32–41. PubMed Europe PMC Scholia" +17629414 Pubmed "Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S. Neuroscience. 2007 Aug 10;148(1):175–87. PubMed Europe PMC Scholia" +17698296 Pubmed "Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons. Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, et al. Neuroscience. 2007 Sep 7;148(3):724–36. PubMed Europe PMC Scholia" +17706365 Pubmed "The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury. Chu GKT, Yu W, Fehlings MG. Neuroscience. 2007 Sep 7;148(3):668–82. PubMed Europe PMC Scholia" +17917587 Pubmed "Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, et al. J Neuropathol Exp Neurol. 2007 Oct;66(10):932–43. PubMed Europe PMC Scholia" +18267965 Pubmed "Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Brain. 2008 Apr;131(Pt 4):1087–98. PubMed Europe PMC Scholia" +18637713 Pubmed "Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells. Dagci T, Armagan G, Konyalioglu S, Yalcin A. Physiol Res. 2009;58(3):427–34. PubMed Europe PMC Scholia" +19350383 Pubmed "Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat. Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I. Cell Mol Neurobiol. 2009 Sep;29(6–7):1045–51. PubMed Europe PMC Scholia" +19770517 Pubmed "Pathogenic antibodies are active participants in spinal cord injury. Dekaban GA, Thawer S. J Clin Invest. 2009 Oct;119(10):2881–4. PubMed Europe PMC Scholia" +19932745 Pubmed "Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion. Pineau I, Sun L, Bastien D, Lacroix S. Brain Behav Immun. 2010 May;24(4):540–53. PubMed Europe PMC Scholia" +20202079 Pubmed "Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. Puschmann TB, Turnley AM. J Neurochem. 2010 May;113(4):881–94. PubMed Europe PMC Scholia" +20304963 Pubmed "The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, et al. Am J Pathol. 2010 May;176(5):2352–66. PubMed Europe PMC Scholia" +21092735 Pubmed "2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang Y feng, Fan Z kai, Cao Y, Yu D shui, Zhang Y qiang, Wang Y song. Brain Res. 2011 Jan 25;1370:220–6. PubMed Europe PMC Scholia" +21168495 Pubmed "CD47 knockout mice exhibit improved recovery from spinal cord injury. Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, et al. Neurobiol Dis. 2011 Apr;42(1):21–34. PubMed Europe PMC Scholia" +21283639 Pubmed "Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV. PLoS One. 2011 Jan 24;6(1):e16135. PubMed Europe PMC Scholia" +21640756 Pubmed "Current and future therapeutic strategies for functional repair of spinal cord injury. Tohda C, Kuboyama T. Pharmacol Ther. 2011 Oct;132(1):57–71. PubMed Europe PMC Scholia" +21657851 Pubmed "Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. J Neurotrauma. 2011 Sep;28(9):1893–907. PubMed Europe PMC Scholia" +21673720 Pubmed "Repertoire of microglial and macrophage responses after spinal cord injury. David S, Kroner A. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia" +21868473 Pubmed "Phospholipase A2 superfamily members play divergent roles after spinal cord injury. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, et al. FASEB J. 2011 Dec;25(12):4240–52. PubMed Europe PMC Scholia" +21957482 Pubmed "Activated microglia inhibit axonal growth through RGMa. Kitayama M, Ueno M, Itakura T, Yamashita T. PLoS One. 2011;6(9):e25234. PubMed Europe PMC Scholia" +22399755 Pubmed "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. J Neurosci. 2012 Mar 7;32(10):3333–8. PubMed Europe PMC Scholia" +22536415 Pubmed "Acute leptin treatment enhances functional recovery after spinal cord injury. Fernández-Martos CM, González P, Rodriguez FJ. PLoS One. 2012;7(4):e35594. PubMed Europe PMC Scholia" +22564823 Pubmed "PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Shim SO, Cafferty WBJ, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. Mol Cell Neurosci. 2012 Jun;50(2):193–200. PubMed Europe PMC Scholia" +22771695 Pubmed "Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury. Saganová K, Gálik J, Blaško J, Korimová A, Račeková E, Vanický I. Life Sci. 2012 Aug 21;91(3–4):77–82. PubMed Europe PMC Scholia" +22865681 Pubmed "Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury. Ju P, Zhang S, Yeap Y, Feng Z. Glia. 2012 Nov;60(11):1801–14. PubMed Europe PMC Scholia" +22884909 Pubmed "Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR. Brain Res. 2012 Sep 26;1475:96–105. PubMed Europe PMC Scholia" +22930444 Pubmed "FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. Zhang S, Huan W, Wei H, Shi J, Fan J, Zhao J, et al. J Cell Biochem. 2013 Feb;114(2):354–65. PubMed Europe PMC Scholia" +23035104 Pubmed "p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, et al. J Neurosci. 2012 Oct 3;32(40):13956–70. PubMed Europe PMC Scholia" +23152062 Pubmed "Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK. Cell Death Dis. 2012 Nov 15;3(11):e426. PubMed Europe PMC Scholia" diff --git a/pathways/WP2431/WP2431-datanodes.tsv b/pathways/WP2431/WP2431-datanodes.tsv index 4d32830d6..af30b9661 100644 --- a/pathways/WP2431/WP2431-datanodes.tsv +++ b/pathways/WP2431/WP2431-datanodes.tsv @@ -1,146 +1,146 @@ Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -LTB4 Metabolite pubchem.compound:169 wikidata:Q41596312 inchikey:VNYSSYRCGWBHLG-UHFFFAOYSA-N -NO Metabolite pubchem.compound:145068 wikidata:Q207843 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N -melittin Metabolite pubchem.compound:16133648 wikidata:Q424512 chebi:6736;chebi:6736 inchikey:VDXZNPDIRNWWCW-JFTDCZMZSA-N -FK506 Metabolite cas:104987-11-3 wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N -FK506 Metabolite cas:104987-11-3 wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N -FK506 Metabolite cas:104987-11-3 wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N -FK506 Metabolite cas:104987-11-3 wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N -Arachidonic acid Metabolite hmdb:HMDB0001043 chebi:15843;chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N -PGH2 Metabolite hmdb:HMDB0001381 chebi:15554;chebi:15554 inchikey:YIBNHAJFJUQSRA-YNNPMVKQSA-N -Olomoucine Metabolite hmdb:HMDB0035233 chebi:44661;chebi:44661 inchikey:GTVPOLSIJWJJNY-UHFFFAOYSA-N -2-Methoxyestradiol Metabolite pubchem.compound:66414 wikidata:Q4596897 chebi:28955;chebi:28955 inchikey:CQOQDQWUFQDJMK-SSTWWWIQSA-N -PD 168393 Metabolite pubchem.compound:4708 wikidata:Q26998221 chebi:131504;chebi:131504 inchikey:HTUBKQUPEREOGA-UHFFFAOYSA-N -NGFR GeneProduct ensembl:ENSG00000064300 ensembl:ENSG00000064300 ncbigene:4804 hgnc.symbol:NGFR uniprot:P08138 -APEX1 GeneProduct ensembl:ENSG00000100823 ensembl:ENSG00000100823 ncbigene:328 hgnc.symbol:APEX1 uniprot:G3V3Y6;uniprot:G3V574;uniprot:A0A0C4DGK8;uniprot:G3V2D9;uniprot:G3V3C7;uniprot:P27695;uniprot:Q5TZP7;uniprot:G3V5D9;uniprot:G3V3M6;uniprot:H7C4A8;uniprot:G3V5Q1;uniprot:G3V5M0;uniprot:G3V359 -MIF GeneProduct ensembl:ENSG00000240972 ensembl:ENSG00000240972 ncbigene:4282 hgnc.symbol:MIF uniprot:I4AY87;uniprot:P14174 -LEP GeneProduct ensembl:ENSG00000174697 ensembl:ENSG00000174697 ncbigene:3952 hgnc.symbol:LEP uniprot:A4D0Y8;uniprot:P41159 -LGALS3 GeneProduct ensembl:ENSG00000131981 ensembl:ENSG00000131981 ncbigene:3958 hgnc.symbol:LGALS3 uniprot:G3V407;uniprot:P17931;uniprot:A0A024R693;uniprot:G3V3R6 -TNFSF13 GeneProduct ensembl:ENSG00000161955 ensembl:ENSG00000161955 ncbigene:8741 hgnc.symbol:TNFSF13 uniprot:K7EJ28;uniprot:Q2QBA2;uniprot:C9JFN2;uniprot:O75888;uniprot:C9JF68 -LTB4R GeneProduct ensembl:ENSG00000213903 ensembl:ENSG00000213903 ncbigene:1241 hgnc.symbol:LTB4R uniprot:G3V244;uniprot:Q15722;uniprot:G3V4Q5 -AQP1 GeneProduct ensembl:ENSG00000240583 ensembl:ENSG00000240583 ncbigene:358 hgnc.symbol:AQP1 uniprot:A0A494C115;uniprot:A0A024RA31;uniprot:A0A494C1U4;uniprot:P29972 -TNFSF13B GeneProduct ensembl:ENSG00000102524 ensembl:ENSG00000102524 ncbigene:10673 hgnc.symbol:TNFSF13B uniprot:A0A0U5J7Q1;uniprot:Q9Y275 -AIF1 GeneProduct ncbigene:199 ensembl:ENSG00000204472 ncbigene:199 hgnc.symbol:AIF1 uniprot:Q4V347;uniprot:I3WTX1;uniprot:Q5STX8;uniprot:P55008 -PTPRZ1 GeneProduct ensembl:ENSG00000106278 ensembl:ENSG00000106278 ncbigene:5803 hgnc.symbol:PTPRZ1 uniprot:A0A494C036;uniprot:A0A494C1B4;uniprot:A0A494C1R4;uniprot:P23471;uniprot:A0A494C087;uniprot:A0A494C0U4;uniprot:A0A494C055;uniprot:A0A494C1H9;uniprot:A0A494C1F0;uniprot:A0A494C0V2;uniprot:A0A494C1J5 -PDYN GeneProduct ensembl:ENSG00000101327 ensembl:ENSG00000101327 ncbigene:5173 hgnc.symbol:PDYN uniprot:P01213;uniprot:A0A494C0B1;uniprot:A0A494C0Y8;uniprot:A0A494C197;uniprot:A0A494C1E3;uniprot:A0A494C0B3;uniprot:A0A494C0X3;uniprot:A0A494C1J4;uniprot:A0A494C1U2 -LTB GeneProduct ensembl:ENSG00000227507 ensembl:ENSG00000227507 ncbigene:4050 hgnc.symbol:LTB uniprot:Q06643;uniprot:Q5STB2 -PLXNA2 GeneProduct ensembl:ENSG00000076356 ensembl:ENSG00000076356 ncbigene:5362 hgnc.symbol:PLXNA2 uniprot:O75051 -FECHP1 GeneProduct ensembl:ENSG00000235534 ensembl:ENSG00000235534 hgnc.symbol:FECHP1 -CSPG4 GeneProduct ensembl:ENSG00000173546 ensembl:ENSG00000173546 ncbigene:1464 hgnc.symbol:CSPG4 uniprot:Q6UVK1 -CD47 GeneProduct ensembl:ENSG00000196776 ensembl:ENSG00000196776 ncbigene:961 hgnc.symbol:CD47 uniprot:H0YC40;uniprot:A0A2R8Y484;uniprot:Q08722;uniprot:H7BYS8 -C1QB GeneProduct ensembl:ENSG00000173369 ensembl:ENSG00000173369 ncbigene:713 hgnc.symbol:C1QB uniprot:D6R934;uniprot:A0A0A0MSV6;uniprot:D6RGJ1 -CDC42 GeneProduct ensembl:ENSG00000070831 ensembl:ENSG00000070831 ncbigene:998 hgnc.symbol:CDC42 uniprot:A0A3B3IRV0;uniprot:A0A494C1M1;uniprot:Q5JYX0;uniprot:A0A024RAE6;uniprot:A0A590UJK8;uniprot:A0A024RAA5;uniprot:P60953;uniprot:A0A494BZX6 -ZFP36 GeneProduct ensembl:ENSG00000128016 ensembl:ENSG00000128016 ncbigene:7538 hgnc.symbol:ZFP36 uniprot:M0QY76;uniprot:M0R252;uniprot:P26651 -FCGR2A GeneProduct ensembl:ENSG00000143226 ensembl:ENSG00000143226 ncbigene:2212 hgnc.symbol:FCGR2A uniprot:V9GY83;uniprot:P12318;uniprot:V9GY55;uniprot:F5GXY9;uniprot:F5GX41 -PRB1 GeneProduct ensembl:ENSG00000251655 ensembl:ENSG00000251655 ncbigene:653247;ncbigene:5542 hgnc.symbol:PRB1 uniprot:G3V1R1;uniprot:A0A0D9SET1;uniprot:A0A4W8X8U3 -PTPRA GeneProduct ensembl:ENSG00000132670 ensembl:ENSG00000132670 ncbigene:5786 hgnc.symbol:PTPRA uniprot:Q5JWG0;uniprot:Q5JWG2;uniprot:Q5JWG3;uniprot:P18433 -IL1B GeneProduct ensembl:ENSG00000125538 ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 -ZFP36 GeneProduct ensembl:ENSG00000128016 ensembl:ENSG00000128016 ncbigene:7538 hgnc.symbol:ZFP36 uniprot:M0QY76;uniprot:M0R252;uniprot:P26651 -NOS2 GeneProduct ensembl:ENSG00000007171 ensembl:ENSG00000007171 ncbigene:4843 hgnc.symbol:NOS2 uniprot:A0A2R8YDS4;uniprot:P35228 -TNF GeneProduct ensembl:ENSG00000232810 ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 -NR4A1 GeneProduct ensembl:ENSG00000123358 ensembl:ENSG00000123358 ncbigene:3164 hgnc.symbol:NR4A1 uniprot:F8VVX9;uniprot:H3BT85;uniprot:P22736;uniprot:A0A024R126;uniprot:H3BQG5;uniprot:F5GXF0;uniprot:H3BSM8;uniprot:H3BPN8;uniprot:H3BSB9 -IL4 GeneProduct ensembl:ENSG00000113520 ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 -BTG2 GeneProduct ensembl:ENSG00000159388 ensembl:ENSG00000159388 ncbigene:7832 hgnc.symbol:BTG2 uniprot:P78543 -BTG2 GeneProduct ensembl:ENSG00000159388 ensembl:ENSG00000159388 ncbigene:7832 hgnc.symbol:BTG2 uniprot:P78543 -CDK2 GeneProduct ensembl:ENSG00000123374 ensembl:ENSG00000123374 ncbigene:1017 hgnc.symbol:CDK2 uniprot:E7ESI2;uniprot:A0A024RB10;uniprot:A0A024RB77;uniprot:P24941;uniprot:G3V5T9;uniprot:G3V317 -NOS1 GeneProduct ensembl:ENSG00000089250 ensembl:ENSG00000089250 ncbigene:4842 hgnc.symbol:NOS1 uniprot:P29475;uniprot:B3VK56 -IL2 GeneProduct ensembl:ENSG00000109471 ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 -TNF GeneProduct ensembl:ENSG00000232810 ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 -IL6 GeneProduct ensembl:ENSG00000136244 ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 -TLR4 GeneProduct ensembl:ENSG00000136869 ensembl:ENSG00000136869 ncbigene:7099 hgnc.symbol:TLR4 uniprot:O00206;uniprot:A0A2R8Y7P4 -FOS GeneProduct ensembl:ENSG00000170345 ensembl:ENSG00000170345 ncbigene:2353 hgnc.symbol:FOS uniprot:G3V5N7;uniprot:H0YJM3;uniprot:G3V5N9;uniprot:Q6FG41;uniprot:G3V5J9;uniprot:G3V289;uniprot:G3V2V7;uniprot:P01100 -IL1B GeneProduct ensembl:ENSG00000125538 ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 -TGFB1 GeneProduct ensembl:ENSG00000105329 ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 -TLR4 GeneProduct ensembl:ENSG00000136869 ensembl:ENSG00000136869 ncbigene:7099 hgnc.symbol:TLR4 uniprot:O00206;uniprot:A0A2R8Y7P4 -TNF GeneProduct ensembl:ENSG00000232810 ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 -EGR1 GeneProduct ensembl:ENSG00000120738 ensembl:ENSG00000120738 ncbigene:1958 hgnc.symbol:EGR1 uniprot:P18146;uniprot:Q546S1 -FOS GeneProduct ensembl:ENSG00000170345 ensembl:ENSG00000170345 ncbigene:2353 hgnc.symbol:FOS uniprot:G3V5N7;uniprot:H0YJM3;uniprot:G3V5N9;uniprot:Q6FG41;uniprot:G3V5J9;uniprot:G3V289;uniprot:G3V2V7;uniprot:P01100 -MMP12 GeneProduct ensembl:ENSG00000262406 ensembl:ENSG00000262406 ncbigene:4321 hgnc.symbol:MMP12 uniprot:P39900 -IFNG GeneProduct ensembl:ENSG00000111537 ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:P01579 -MBP GeneProduct ensembl:ENSG00000197971 ensembl:ENSG00000197971 ncbigene:4155 hgnc.symbol:MBP uniprot:F5H7N4;uniprot:E9PJ72;uniprot:E9PNZ1;uniprot:P02686;uniprot:E9PKX9;uniprot:E9PLU9;uniprot:E9PMR5;uniprot:H0YF02;uniprot:E9PLQ9;uniprot:J3QL64;uniprot:J3KS94;uniprot:F8WEU6;uniprot:A0A024R384;uniprot:J3QKL5;uniprot:C9J6H1;uniprot:J3QKN5;uniprot:A8MZH3;uniprot:E9PSE2;uniprot:H0YEA2;uniprot:J3KT01;uniprot:J3KT34;uniprot:E9PQE7;uniprot:H7BYR8;uniprot:J3QQK6 -RTN4 GeneProduct ensembl:ENSG00000115310 ensembl:ENSG00000115310 ncbigene:57142 hgnc.symbol:RTN4 uniprot:C9J685;uniprot:A0A0U1RQR6;uniprot:H7C106;uniprot:Q9NQC3 -C5 GeneProduct ensembl:ENSG00000106804 ensembl:ENSG00000106804 ncbigene:727 hgnc.symbol:C5 uniprot:P01031 -CXCL1 GeneProduct ensembl:ENSG00000163739 ensembl:ENSG00000163739 ncbigene:2919 hgnc.symbol:CXCL1 uniprot:P09341 -CXCL8 GeneProduct ensembl:ENSG00000169429 ensembl:ENSG00000169429 ncbigene:3576 hgnc.symbol:CXCL8 uniprot:C9J4T6;uniprot:A0A024RDA5;uniprot:P10145 -AQP4 GeneProduct ensembl:ENSG00000171885 ensembl:ENSG00000171885 ncbigene:361 hgnc.symbol:AQP4 uniprot:V9PBN7;uniprot:H0Y3H5;uniprot:P55087;uniprot:A0A5F9ZHR4;uniprot:J3KRM4;uniprot:F1DSG4 -IL1B GeneProduct ensembl:ENSG00000125538 ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 -NOS2 GeneProduct ensembl:ENSG00000007171 ensembl:ENSG00000007171 ncbigene:4843 hgnc.symbol:NOS2 uniprot:A0A2R8YDS4;uniprot:P35228 -TNF GeneProduct ensembl:ENSG00000232810 ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 -ARG1 GeneProduct ensembl:ENSG00000118520 ensembl:ENSG00000118520 ncbigene:383 hgnc.symbol:ARG1 uniprot:A0A5F9ZH78;uniprot:A0A5F9ZGN6;uniprot:P05089;uniprot:A0A5F9ZGY6 -EPHA4 GeneProduct ensembl:ENSG00000116106 ensembl:ENSG00000116106 ncbigene:2043 hgnc.symbol:EPHA4 uniprot:H7C1N8;uniprot:C9JFX5;uniprot:C9JEM6;uniprot:F8WBU0;uniprot:C9JIX8;uniprot:A1MA61;uniprot:H7C2W7;uniprot:E9PG71;uniprot:F5GZZ5;uniprot:P54764 -EPHNB2 GeneProduct ensembl:ENSG00000125266 ensembl:ENSG00000125266 ncbigene:1948 hgnc.symbol:EFNB2 uniprot:P52799 -CXCL10 GeneProduct ensembl:ENSG00000169245 ensembl:ENSG00000169245 ncbigene:3627 hgnc.symbol:CXCL10 uniprot:P02778 -CCNG1 GeneProduct ensembl:ENSG00000113328 ensembl:ENSG00000113328 ncbigene:900 hgnc.symbol:CCNG1 uniprot:P51959;uniprot:D6RGX3;uniprot:D6RD30;uniprot:E7ERZ1;uniprot:D6RCC5 -MMP9 GeneProduct ensembl:ENSG00000100985 ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 -NCAN GeneProduct ensembl:ENSG00000130287 ensembl:ENSG00000130287 ncbigene:1463 hgnc.symbol:NCAN uniprot:O14594;uniprot:A0A024R7M3;uniprot:K7EKF8 -SLIT1 GeneProduct ensembl:ENSG00000187122 ensembl:ENSG00000187122 ncbigene:6585 hgnc.symbol:SLIT1 uniprot:Q5T0V4;uniprot:Q5T0V0;uniprot:Q5T0V2;uniprot:O75093 -SLIT2 GeneProduct ensembl:ENSG00000145147 ensembl:ENSG00000145147 ncbigene:9353 hgnc.symbol:SLIT2 uniprot:O94813;uniprot:X6R3P0;uniprot:H0Y968;uniprot:F5H0U4;uniprot:E9PCX4;uniprot:H0Y9Z6;uniprot:A0A087WYV5 -SLIT3 GeneProduct ensembl:ENSG00000184347 ensembl:ENSG00000184347 ncbigene:6586 hgnc.symbol:SLIT3 uniprot:A0A0A0MSC8;uniprot:O75094 -NTN1 GeneProduct ensembl:ENSG00000065320 ensembl:ENSG00000065320 ncbigene:9423 hgnc.symbol:NTN1 uniprot:H7BZF4;uniprot:O95631 -RGMA GeneProduct ensembl:ENSG00000182175 ensembl:ENSG00000182175 ncbigene:56963 hgnc.symbol:RGMA uniprot:A0A0A0MTQ4;uniprot:G3V3Z3;uniprot:G3V4C2;uniprot:Q96B86;uniprot:F5H7G2;uniprot:G3V545;uniprot:A0A0G2JL92 -MMP9 GeneProduct ensembl:ENSG00000100985 ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 -MMP9 GeneProduct ensembl:ENSG00000100985 ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 -MMP9 GeneProduct ensembl:ENSG00000100985 ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 -CCR2 GeneProduct ensembl:ENSG00000121807 ensembl:ENSG00000121807 ncbigene:729230 hgnc.symbol:CCR2 uniprot:E9PH76;uniprot:A0A024R2Q0;uniprot:P41597 -IL1R1 GeneProduct ensembl:ENSG00000115594 ensembl:ENSG00000115594 ncbigene:3554 hgnc.symbol:IL1R1 uniprot:B8ZZW4;uniprot:C9J3W8;uniprot:C9J686;uniprot:C9JQ36;uniprot:B8ZZ73;uniprot:C9JW84;uniprot:B9A040;uniprot:P14778;uniprot:H7BZM5;uniprot:F8WF92;uniprot:C9JWB2 -IL1A GeneProduct ncbigene:3552 ensembl:ENSG00000115008 ncbigene:3552 hgnc.symbol:IL1A uniprot:P01583 -CXCL1 GeneProduct ensembl:ENSG00000163739 ensembl:ENSG00000163739 ncbigene:2919 hgnc.symbol:CXCL1 uniprot:P09341 -CXCL2 GeneProduct ensembl:ENSG00000081041 ensembl:ENSG00000081041 ncbigene:2920 hgnc.symbol:CXCL2 uniprot:A0A024RDD9;uniprot:P19875 -CCL2 GeneProduct ensembl:ENSG00000108691 ensembl:ENSG00000108691 ncbigene:6347 hgnc.symbol:CCL2 uniprot:P13500;uniprot:J3KRT7 -PLA2G6 GeneProduct ensembl:ENSG00000184381 ensembl:ENSG00000184381 ncbigene:8398 hgnc.symbol:PLA2G6 uniprot:A0A590UJC7;uniprot:A0A590UJZ2;uniprot:B0QYE9;uniprot:H7C3P5;uniprot:A0A590UJH4;uniprot:M0R1Q9;uniprot:H0Y7G5;uniprot:A0A590UK67;uniprot:F8WEQ9;uniprot:F8WEN3;uniprot:A0A590UK51;uniprot:M0R3D9;uniprot:E7EX67;uniprot:O60733;uniprot:H0Y6T3 -PLA2G5 GeneProduct ensembl:ENSG00000127472 ensembl:ENSG00000127472 ncbigene:5322 hgnc.symbol:PLA2G5 uniprot:P39877 -PLA2G2A GeneProduct ensembl:ENSG00000188257 ensembl:ENSG00000188257 ncbigene:5320 hgnc.symbol:PLA2G2A uniprot:P14555;uniprot:A0A3B3IRX2;uniprot:A0A024RA96 -ANXA1 GeneProduct ensembl:ENSG00000135046 ensembl:ENSG00000135046 ncbigene:301 hgnc.symbol:ANXA1 uniprot:P04083;uniprot:Q5TZZ9;uniprot:Q5T3N1;uniprot:Q5T3N0 -ICAM1 GeneProduct ensembl:ENSG00000090339 ensembl:ENSG00000090339 ncbigene:3383 hgnc.symbol:ICAM1 uniprot:A0A384MEK5;uniprot:K7EKL8;uniprot:E7ESS4;uniprot:P05362 -SELP GeneProduct ensembl:ENSG00000174175 ensembl:ENSG00000174175 ncbigene:6403 hgnc.symbol:SELP uniprot:Q5R349;uniprot:F6VVT6;uniprot:P16109;uniprot:Q5R345;uniprot:A0A024R8Y9;uniprot:Q5R341;uniprot:Q5R342 -KLK8 GeneProduct ensembl:ENSG00000129455 ensembl:ENSG00000129455 ncbigene:11202 hgnc.symbol:KLK8 uniprot:M0R231;uniprot:A0A0A0MQY9;uniprot:M0R390;uniprot:O60259 -GFAP GeneProduct ensembl:ENSG00000131095 ensembl:ENSG00000131095 ncbigene:2670 hgnc.symbol:GFAP uniprot:A0A0G2JLI8;uniprot:K7EKH9;uniprot:K7EPI4;uniprot:K7EKD1;uniprot:A0A1X7SBR3;uniprot:K7EPT8;uniprot:A0A1W2PPA3;uniprot:K7ELP4;uniprot:P14136;uniprot:K7EJK1;uniprot:A0A1W2PPF0;uniprot:A0A1W2PQ25;uniprot:A0A1W2PR46;uniprot:A0A1X7SCE1;uniprot:A0A1W2PQU7;uniprot:K7EJU1;uniprot:A0A1W2PPL2;uniprot:A0A1W2PS58;uniprot:B4DIR1;uniprot:A0A1W2PP21;uniprot:A0A1W2PQS4;uniprot:A0A1W2PRT3 -CDK4 GeneProduct ensembl:ENSG00000135446 ensembl:ENSG00000135446 ncbigene:1019 hgnc.symbol:CDK4 uniprot:F8VTV8;uniprot:F8VWX7;uniprot:F8VXD2;uniprot:F8VZ51;uniprot:F8VZ13;uniprot:F8W1L8;uniprot:F8VYH9;uniprot:F8VZZ0;uniprot:P11802;uniprot:A0A024RBB6;uniprot:F8VYY1;uniprot:Q96BE9 -TACR1 GeneProduct ensembl:ENSG00000115353 ensembl:ENSG00000115353 ncbigene:6869 hgnc.symbol:TACR1 uniprot:P25103 -E2F5 GeneProduct ensembl:ENSG00000133740 ensembl:ENSG00000133740 ncbigene:1875 hgnc.symbol:E2F5 uniprot:Q15329;uniprot:C9JYE9;uniprot:E5RHD4;uniprot:H0YBK0;uniprot:H0YBW8 -RB1 GeneProduct ensembl:ENSG00000139687 ensembl:ENSG00000139687 ncbigene:5925 hgnc.symbol:RB1 uniprot:A0A3B3IS71;uniprot:Q92728;uniprot:A0A024RDV3;uniprot:A0A2R8YFL6;uniprot:A0A2R8Y743;uniprot:P06400 -PRKCA GeneProduct ensembl:ENSG00000154229 ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 -E2F1 GeneProduct ensembl:ENSG00000101412 ensembl:ENSG00000101412 ncbigene:1869 hgnc.symbol:E2F1 uniprot:Q01094 -MAPK1 GeneProduct ensembl:ENSG00000100030 ensembl:ENSG00000100030 ncbigene:5594 hgnc.symbol:MAPK1 uniprot:P28482;uniprot:Q1HBJ4 -CCND1 GeneProduct ensembl:ENSG00000110092 ensembl:ENSG00000110092 ncbigene:595 hgnc.symbol:CCND1 uniprot:P24385;uniprot:Q6FI00;uniprot:F5H437 -MYC GeneProduct ensembl:ENSG00000136997 ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 -GADD45A GeneProduct ensembl:ENSG00000116717 ensembl:ENSG00000116717 ncbigene:1647 hgnc.symbol:GADD45A uniprot:A0A3B3ITF9;uniprot:A0A087WZQ0;uniprot:A5JUZ3;uniprot:P24522 -MAPK3 GeneProduct ensembl:ENSG00000102882 ensembl:ENSG00000102882 ncbigene:5595 hgnc.symbol:MAPK3 uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9 -TP53 GeneProduct ensembl:ENSG00000141510 ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -CHST11 GeneProduct ensembl:ENSG00000171310 ensembl:ENSG00000171310 ncbigene:50515 hgnc.symbol:CHST11 uniprot:Q9NPF2;uniprot:F8VXK3;uniprot:A0A024RBL0;uniprot:F8VXK7;uniprot:F8VRG6 -VCAN GeneProduct ensembl:ENSG00000038427 ensembl:ENSG00000038427 ncbigene:1462 hgnc.symbol:VCAN uniprot:P13611;uniprot:E9PF17;uniprot:Q86W61;uniprot:A0A024RAP3;uniprot:D6RGZ6;uniprot:A0A024RAL1;uniprot:A0A024RAQ9 -COL4A1 GeneProduct ensembl:ENSG00000187498 ensembl:ENSG00000187498 ncbigene:1282 hgnc.symbol:COL4A1 uniprot:A0A3B3ITS9;uniprot:A0A087WTY5;uniprot:A0A3B3ITC8;uniprot:A0A3B3IU02;uniprot:A0A3B3ITG7;uniprot:A0A3B3ISH5;uniprot:A0A3B3ISV3;uniprot:A0A3B3ISZ8;uniprot:A0A3B3IUD0;uniprot:P02462 -XYLT1 GeneProduct ensembl:ENSG00000103489 ensembl:ENSG00000103489 ncbigene:64131 hgnc.symbol:XYLT1 uniprot:Q86Y38 -COL2A1 GeneProduct ensembl:ENSG00000139219 ensembl:ENSG00000139219 ncbigene:1280 hgnc.symbol:COL2A1 uniprot:P02458 -ACAN GeneProduct ensembl:ENSG00000157766 ensembl:ENSG00000157766 ncbigene:176 hgnc.symbol:ACAN uniprot:H0YMF1;uniprot:Q6PID9;uniprot:P16112;uniprot:A0A5K1VW97;uniprot:H0YK70 -BCAN GeneProduct ensembl:ENSG00000132692 ensembl:ENSG00000132692 ncbigene:63827 hgnc.symbol:BCAN uniprot:Q96GW7;uniprot:Q5T3I6;uniprot:V9GXZ8;uniprot:Q5T3I8;uniprot:V9GY88;uniprot:Q5T3I7 -SOX9 GeneProduct ensembl:ENSG00000125398 ensembl:ENSG00000125398 ncbigene:6662 hgnc.symbol:SOX9 uniprot:P48436 -TP53 GeneProduct ensembl:ENSG00000141510 ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -GRIN1 GeneProduct ensembl:ENSG00000176884 ensembl:ENSG00000176884 ncbigene:2902 hgnc.symbol:GRIN1 uniprot:A2AVK2;uniprot:Q05586;uniprot:Q5VSF9 -VIM GeneProduct ensembl:ENSG00000026025 ensembl:ENSG00000026025 ncbigene:7431 hgnc.symbol:VIM uniprot:B0YJC5;uniprot:A0A1B0GVG8;uniprot:P08670;uniprot:V9HWE1;uniprot:A0A1B0GTT5;uniprot:B0YJC4 -PPP3CA GeneProduct ensembl:ENSG00000138814 ensembl:ENSG00000138814 ncbigene:5530 hgnc.symbol:PPP3CA uniprot:E9PPC8;uniprot:A0A0S2Z4B5;uniprot:A0A0S2Z4C6;uniprot:E7ETC2;uniprot:E9PK68;uniprot:Q08209;uniprot:H0YAB4 -GAP43 GeneProduct ensembl:ENSG00000172020 ensembl:ENSG00000172020 ncbigene:2596 hgnc.symbol:GAP43 uniprot:Q5U058;uniprot:P17677 -FKBP1A GeneProduct ensembl:ENSG00000088832 ensembl:ENSG00000088832 ncbigene:2280 hgnc.symbol:FKBP1A uniprot:F6T7Q3;uniprot:A0A7I2V3S6;uniprot:A0A087WZM5;uniprot:A0A087WTS4;uniprot:Q5W0X3;uniprot:Q1JUQ3;uniprot:P62942;uniprot:Q1JUQ5 -IL2 GeneProduct ensembl:ENSG00000109471 ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 -MAG GeneProduct ensembl:ENSG00000105695 ensembl:ENSG00000105695 ncbigene:4099 hgnc.symbol:MAG uniprot:P20916;uniprot:M0QZU4;uniprot:M0R3B9;uniprot:M0R3I4 -RTN4 GeneProduct ensembl:ENSG00000115310 ensembl:ENSG00000115310 ncbigene:57142 hgnc.symbol:RTN4 uniprot:C9J685;uniprot:A0A0U1RQR6;uniprot:H7C106;uniprot:Q9NQC3 -RHOA GeneProduct ensembl:ENSG00000067560 ensembl:ENSG00000067560 ncbigene:387 hgnc.symbol:RHOA uniprot:P61586;uniprot:A0A7I2V5E6;uniprot:C9JNR4;uniprot:A0A024R324;uniprot:A0A7I2YQV1;uniprot:C9JRM1;uniprot:A0A7I2V3G1;uniprot:C9JX21 -RHOC GeneProduct ensembl:ENSG00000155366 ensembl:ENSG00000155366 ncbigene:389 hgnc.symbol:RHOC uniprot:E9PQH6;uniprot:Q5JR06;uniprot:Q5JR05;uniprot:A0A024R0C8;uniprot:E9PLA2;uniprot:Q5JR08;uniprot:E9PN11;uniprot:Q5JR07;uniprot:P08134 -RHOB GeneProduct ensembl:ENSG00000143878 ensembl:ENSG00000143878 ncbigene:388 hgnc.symbol:RHOB uniprot:P62745 -ROCK2 GeneProduct ensembl:ENSG00000134318 ensembl:ENSG00000134318 ncbigene:9475 hgnc.symbol:ROCK2 uniprot:A0A2P9DU05;uniprot:O75116;uniprot:C9JFJ0;uniprot:E9PF63;uniprot:D6REE7 -OMG GeneProduct ensembl:ENSG00000126861 ensembl:ENSG00000126861 ncbigene:101927057;ncbigene:4974 hgnc.symbol:OMG uniprot:P23515 -RTN4R GeneProduct ensembl:ENSG00000040608 ensembl:ENSG00000040608 ncbigene:65078 hgnc.symbol:RTN4R uniprot:H7C215;uniprot:Q9BZR6;uniprot:H7C0V4 -LILRB3 GeneProduct ensembl:ENSG00000204577 ensembl:ENSG00000204577 ncbigene:107987462;ncbigene:102725035;ncbigene:11025;ncbigene:107987425 hgnc.symbol:LILRB3 uniprot:C9JWL8;uniprot:O75022;uniprot:F8W6G6;uniprot:F8WD89 -PTGS2 GeneProduct ncbigene:5743 ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7 -ROS GeneProduct ncbigene:6098 ensembl:ENSG00000047936 ncbigene:6098 hgnc.symbol:ROS1 uniprot:P08922;uniprot:H0Y3T9;uniprot:Q5H8Y1 -NOX4 GeneProduct ensembl:ENSG00000086991 ensembl:ENSG00000086991 ncbigene:50507 hgnc.symbol:NOX4 uniprot:E9PI95;uniprot:Q9NPH5;uniprot:E9PR43;uniprot:E9PPP2 -CDK1 GeneProduct ensembl:ENSG00000170312 ensembl:ENSG00000170312 ncbigene:983 hgnc.symbol:CDK1 uniprot:P06493;uniprot:E5RIU6;uniprot:A0A024QZP7;uniprot:A0A024QZJ8 -GDNF GeneProduct ensembl:ENSG00000168621 ensembl:ENSG00000168621 ncbigene:2668 hgnc.symbol:GDNF uniprot:A0A0C4DGC2;uniprot:P39905;uniprot:A0A0S2Z3T2;uniprot:A0A0S2Z3V2 -SEMA6A GeneProduct ensembl:ENSG00000092421 ensembl:ENSG00000092421 ncbigene:57556 hgnc.symbol:SEMA6A uniprot:Q9H2E6;uniprot:E9PDV9;uniprot:H0Y8V9;uniprot:A0A0A0MQU6;uniprot:D6RAG9;uniprot:D6RCR0;uniprot:B3KU01 -GJA1 GeneProduct ensembl:ENSG00000152661 ensembl:ENSG00000152661 ncbigene:2697 hgnc.symbol:GJA1 uniprot:A0A654IBU3;uniprot:P17302 -BDNF GeneProduct ensembl:ENSG00000176697 ensembl:ENSG00000176697 ncbigene:627 hgnc.symbol:BDNF uniprot:P23560;uniprot:A0A0E3SU01;uniprot:E9PMP3 -RAC1 GeneProduct ensembl:ENSG00000136238 ensembl:ENSG00000136238 ncbigene:5879 hgnc.symbol:RAC1 uniprot:P63000;uniprot:A4D2P0;uniprot:A4D2P1 -FOXO3 GeneProduct ensembl:ENSG00000118689 ensembl:ENSG00000118689 ncbigene:2309 hgnc.symbol:FOXO3 uniprot:O43524 -CDKN1B GeneProduct ensembl:ENSG00000111276 ensembl:ENSG00000111276 ncbigene:1027 hgnc.symbol:CDKN1B uniprot:Q6I9V6;uniprot:E7ES52;uniprot:P46527;uniprot:H7C2T1 -EGFR GeneProduct ensembl:ENSG00000146648 ensembl:ENSG00000146648 ncbigene:1956 hgnc.symbol:EGFR uniprot:P00533;uniprot:E9PFD7;uniprot:Q504U8;uniprot:C9JYS6 -CASP3 GeneProduct ensembl:ENSG00000164305 ensembl:ENSG00000164305 ncbigene:836 hgnc.symbol:CASP3 uniprot:A8MVM1;uniprot:C9JXR7;uniprot:P42574 +LTB4 Metabolite pubchem.compound:169 "" wikidata:Q41596312 inchikey:VNYSSYRCGWBHLG-UHFFFAOYSA-N +NO Metabolite pubchem.compound:145068 "" wikidata:Q207843 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N +melittin Metabolite pubchem.compound:16133648 "" wikidata:Q424512 chebi:6736;chebi:6736 inchikey:VDXZNPDIRNWWCW-JFTDCZMZSA-N +FK506 Metabolite cas:104987-11-3 "" wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N +FK506 Metabolite cas:104987-11-3 "" wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N +FK506 Metabolite cas:104987-11-3 "" wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N +FK506 Metabolite cas:104987-11-3 "" wikidata:Q411648 chebi:61049;chebi:61049 inchikey:QJJXYPPXXYFBGM-LFZNUXCKSA-N;inchikey:QJJXYPPXXYFBGM-LJIGMGMYSA-N +Arachidonic acid Metabolite hmdb:HMDB0001043 "" chebi:15843;chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N +PGH2 Metabolite hmdb:HMDB0001381 "" chebi:15554;chebi:15554 inchikey:YIBNHAJFJUQSRA-YNNPMVKQSA-N +Olomoucine Metabolite hmdb:HMDB0035233 "" chebi:44661;chebi:44661 inchikey:GTVPOLSIJWJJNY-UHFFFAOYSA-N +2-Methoxyestradiol Metabolite pubchem.compound:66414 "" wikidata:Q4596897 chebi:28955;chebi:28955 inchikey:CQOQDQWUFQDJMK-SSTWWWIQSA-N +PD 168393 Metabolite pubchem.compound:4708 "" wikidata:Q26998221 chebi:131504;chebi:131504 inchikey:HTUBKQUPEREOGA-UHFFFAOYSA-N +NGFR GeneProduct ensembl:ENSG00000064300 "" ensembl:ENSG00000064300 ncbigene:4804 hgnc.symbol:NGFR uniprot:P08138 +APEX1 GeneProduct ensembl:ENSG00000100823 "" ensembl:ENSG00000100823 ncbigene:328 hgnc.symbol:APEX1 uniprot:G3V3Y6;uniprot:G3V574;uniprot:A0A0C4DGK8;uniprot:G3V2D9;uniprot:G3V3C7;uniprot:P27695;uniprot:Q5TZP7;uniprot:G3V5D9;uniprot:G3V3M6;uniprot:H7C4A8;uniprot:G3V5Q1;uniprot:G3V5M0;uniprot:G3V359 +MIF GeneProduct ensembl:ENSG00000240972 "" ensembl:ENSG00000240972 ncbigene:4282 hgnc.symbol:MIF uniprot:I4AY87;uniprot:P14174 +LEP GeneProduct ensembl:ENSG00000174697 "" ensembl:ENSG00000174697 ncbigene:3952 hgnc.symbol:LEP uniprot:A4D0Y8;uniprot:P41159 +LGALS3 GeneProduct ensembl:ENSG00000131981 "" ensembl:ENSG00000131981 ncbigene:3958 hgnc.symbol:LGALS3 uniprot:G3V407;uniprot:P17931;uniprot:A0A024R693;uniprot:G3V3R6 +TNFSF13 GeneProduct ensembl:ENSG00000161955 "" ensembl:ENSG00000161955 ncbigene:8741 hgnc.symbol:TNFSF13 uniprot:K7EJ28;uniprot:Q2QBA2;uniprot:C9JFN2;uniprot:O75888;uniprot:C9JF68 +LTB4R GeneProduct ensembl:ENSG00000213903 "" ensembl:ENSG00000213903 ncbigene:1241 hgnc.symbol:LTB4R uniprot:G3V244;uniprot:Q15722;uniprot:G3V4Q5 +AQP1 GeneProduct ensembl:ENSG00000240583 "" ensembl:ENSG00000240583 ncbigene:358 hgnc.symbol:AQP1 uniprot:A0A494C115;uniprot:A0A024RA31;uniprot:A0A494C1U4;uniprot:P29972 +TNFSF13B GeneProduct ensembl:ENSG00000102524 "" ensembl:ENSG00000102524 ncbigene:10673 hgnc.symbol:TNFSF13B uniprot:A0A0U5J7Q1;uniprot:Q9Y275 +AIF1 GeneProduct ncbigene:199 "" ensembl:ENSG00000204472 ncbigene:199 hgnc.symbol:AIF1 uniprot:Q4V347;uniprot:I3WTX1;uniprot:Q5STX8;uniprot:P55008 +PTPRZ1 GeneProduct ensembl:ENSG00000106278 "" ensembl:ENSG00000106278 ncbigene:5803 hgnc.symbol:PTPRZ1 uniprot:A0A494C036;uniprot:A0A494C1B4;uniprot:A0A494C1R4;uniprot:P23471;uniprot:A0A494C087;uniprot:A0A494C0U4;uniprot:A0A494C055;uniprot:A0A494C1H9;uniprot:A0A494C1F0;uniprot:A0A494C0V2;uniprot:A0A494C1J5 +PDYN GeneProduct ensembl:ENSG00000101327 "" ensembl:ENSG00000101327 ncbigene:5173 hgnc.symbol:PDYN uniprot:P01213;uniprot:A0A494C0B1;uniprot:A0A494C0Y8;uniprot:A0A494C197;uniprot:A0A494C1E3;uniprot:A0A494C0B3;uniprot:A0A494C0X3;uniprot:A0A494C1J4;uniprot:A0A494C1U2 +LTB GeneProduct ensembl:ENSG00000227507 "" ensembl:ENSG00000227507 ncbigene:4050 hgnc.symbol:LTB uniprot:Q06643;uniprot:Q5STB2 +PLXNA2 GeneProduct ensembl:ENSG00000076356 "" ensembl:ENSG00000076356 ncbigene:5362 hgnc.symbol:PLXNA2 uniprot:O75051 +FECHP1 GeneProduct ensembl:ENSG00000235534 "" ensembl:ENSG00000235534 hgnc.symbol:FECHP1 +CSPG4 GeneProduct ensembl:ENSG00000173546 "" ensembl:ENSG00000173546 ncbigene:1464 hgnc.symbol:CSPG4 uniprot:Q6UVK1 +CD47 GeneProduct ensembl:ENSG00000196776 "" ensembl:ENSG00000196776 ncbigene:961 hgnc.symbol:CD47 uniprot:H0YC40;uniprot:A0A2R8Y484;uniprot:Q08722;uniprot:H7BYS8 +C1QB GeneProduct ensembl:ENSG00000173369 "" ensembl:ENSG00000173369 ncbigene:713 hgnc.symbol:C1QB uniprot:D6R934;uniprot:A0A0A0MSV6;uniprot:D6RGJ1 +CDC42 GeneProduct ensembl:ENSG00000070831 "" ensembl:ENSG00000070831 ncbigene:998 hgnc.symbol:CDC42 uniprot:A0A3B3IRV0;uniprot:A0A494C1M1;uniprot:Q5JYX0;uniprot:A0A024RAE6;uniprot:A0A590UJK8;uniprot:A0A024RAA5;uniprot:P60953;uniprot:A0A494BZX6 +ZFP36 GeneProduct ensembl:ENSG00000128016 "" ensembl:ENSG00000128016 ncbigene:7538 hgnc.symbol:ZFP36 uniprot:M0QY76;uniprot:M0R252;uniprot:P26651 +FCGR2A GeneProduct ensembl:ENSG00000143226 "" ensembl:ENSG00000143226 ncbigene:2212 hgnc.symbol:FCGR2A uniprot:V9GY83;uniprot:P12318;uniprot:V9GY55;uniprot:F5GXY9;uniprot:F5GX41 +PRB1 GeneProduct ensembl:ENSG00000251655 "" ensembl:ENSG00000251655 ncbigene:653247;ncbigene:5542 hgnc.symbol:PRB1 uniprot:G3V1R1;uniprot:A0A0D9SET1;uniprot:A0A4W8X8U3 +PTPRA GeneProduct ensembl:ENSG00000132670 "" ensembl:ENSG00000132670 ncbigene:5786 hgnc.symbol:PTPRA uniprot:Q5JWG0;uniprot:Q5JWG2;uniprot:Q5JWG3;uniprot:P18433 +IL1B GeneProduct ensembl:ENSG00000125538 "" ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 +ZFP36 GeneProduct ensembl:ENSG00000128016 "" ensembl:ENSG00000128016 ncbigene:7538 hgnc.symbol:ZFP36 uniprot:M0QY76;uniprot:M0R252;uniprot:P26651 +NOS2 GeneProduct ensembl:ENSG00000007171 "" ensembl:ENSG00000007171 ncbigene:4843 hgnc.symbol:NOS2 uniprot:A0A2R8YDS4;uniprot:P35228 +TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 +NR4A1 GeneProduct ensembl:ENSG00000123358 "" ensembl:ENSG00000123358 ncbigene:3164 hgnc.symbol:NR4A1 uniprot:F8VVX9;uniprot:H3BT85;uniprot:P22736;uniprot:A0A024R126;uniprot:H3BQG5;uniprot:F5GXF0;uniprot:H3BSM8;uniprot:H3BPN8;uniprot:H3BSB9 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +BTG2 GeneProduct ensembl:ENSG00000159388 "" ensembl:ENSG00000159388 ncbigene:7832 hgnc.symbol:BTG2 uniprot:P78543 +BTG2 GeneProduct ensembl:ENSG00000159388 "" ensembl:ENSG00000159388 ncbigene:7832 hgnc.symbol:BTG2 uniprot:P78543 +CDK2 GeneProduct ensembl:ENSG00000123374 "" ensembl:ENSG00000123374 ncbigene:1017 hgnc.symbol:CDK2 uniprot:E7ESI2;uniprot:A0A024RB10;uniprot:A0A024RB77;uniprot:P24941;uniprot:G3V5T9;uniprot:G3V317 +NOS1 GeneProduct ensembl:ENSG00000089250 "" ensembl:ENSG00000089250 ncbigene:4842 hgnc.symbol:NOS1 uniprot:P29475;uniprot:B3VK56 +IL2 GeneProduct ensembl:ENSG00000109471 "" ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 +TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 +IL6 GeneProduct ensembl:ENSG00000136244 "" ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 +TLR4 GeneProduct ensembl:ENSG00000136869 "" ensembl:ENSG00000136869 ncbigene:7099 hgnc.symbol:TLR4 uniprot:O00206;uniprot:A0A2R8Y7P4 +FOS GeneProduct ensembl:ENSG00000170345 "" ensembl:ENSG00000170345 ncbigene:2353 hgnc.symbol:FOS uniprot:G3V5N7;uniprot:H0YJM3;uniprot:G3V5N9;uniprot:Q6FG41;uniprot:G3V5J9;uniprot:G3V289;uniprot:G3V2V7;uniprot:P01100 +IL1B GeneProduct ensembl:ENSG00000125538 "" ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 +TGFB1 GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 +TLR4 GeneProduct ensembl:ENSG00000136869 "" ensembl:ENSG00000136869 ncbigene:7099 hgnc.symbol:TLR4 uniprot:O00206;uniprot:A0A2R8Y7P4 +TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 +EGR1 GeneProduct ensembl:ENSG00000120738 "" ensembl:ENSG00000120738 ncbigene:1958 hgnc.symbol:EGR1 uniprot:P18146;uniprot:Q546S1 +FOS GeneProduct ensembl:ENSG00000170345 "" ensembl:ENSG00000170345 ncbigene:2353 hgnc.symbol:FOS uniprot:G3V5N7;uniprot:H0YJM3;uniprot:G3V5N9;uniprot:Q6FG41;uniprot:G3V5J9;uniprot:G3V289;uniprot:G3V2V7;uniprot:P01100 +MMP12 GeneProduct ensembl:ENSG00000262406 "" ensembl:ENSG00000262406 ncbigene:4321 hgnc.symbol:MMP12 uniprot:P39900 +IFNG GeneProduct ensembl:ENSG00000111537 "" ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:A0A7R8GUN6;uniprot:P01579 +MBP GeneProduct ensembl:ENSG00000197971 "" ensembl:ENSG00000197971 ncbigene:4155 hgnc.symbol:MBP uniprot:F5H7N4;uniprot:E9PJ72;uniprot:E9PNZ1;uniprot:P02686;uniprot:E9PKX9;uniprot:E9PLU9;uniprot:E9PMR5;uniprot:H0YF02;uniprot:E9PLQ9;uniprot:J3QL64;uniprot:J3KS94;uniprot:F8WEU6;uniprot:A0A024R384;uniprot:J3QKL5;uniprot:C9J6H1;uniprot:J3QKN5;uniprot:A8MZH3;uniprot:E9PSE2;uniprot:H0YEA2;uniprot:J3KT01;uniprot:J3KT34;uniprot:E9PQE7;uniprot:H7BYR8;uniprot:J3QQK6 +RTN4 GeneProduct ensembl:ENSG00000115310 "" ensembl:ENSG00000115310 ncbigene:57142 hgnc.symbol:RTN4 uniprot:C9J685;uniprot:A0A0U1RQR6;uniprot:H7C106;uniprot:Q9NQC3 +C5 GeneProduct ensembl:ENSG00000106804 "" ensembl:ENSG00000106804 ncbigene:727 hgnc.symbol:C5 uniprot:P01031 +CXCL1 GeneProduct ensembl:ENSG00000163739 "" ensembl:ENSG00000163739 ncbigene:2919 hgnc.symbol:CXCL1 uniprot:P09341 +CXCL8 GeneProduct ensembl:ENSG00000169429 "" ensembl:ENSG00000169429 ncbigene:3576 hgnc.symbol:CXCL8 uniprot:C9J4T6;uniprot:A0A024RDA5;uniprot:P10145 +AQP4 GeneProduct ensembl:ENSG00000171885 "" ensembl:ENSG00000171885 ncbigene:361 hgnc.symbol:AQP4 uniprot:V9PBN7;uniprot:H0Y3H5;uniprot:P55087;uniprot:A0A5F9ZHR4;uniprot:J3KRM4;uniprot:F1DSG4 +IL1B GeneProduct ensembl:ENSG00000125538 "" ensembl:ENSG00000125538 ncbigene:3553 hgnc.symbol:IL1B uniprot:C9JSC2;uniprot:C9JWV2;uniprot:C9JVK0;uniprot:P01584 +NOS2 GeneProduct ensembl:ENSG00000007171 "" ensembl:ENSG00000007171 ncbigene:4843 hgnc.symbol:NOS2 uniprot:A0A2R8YDS4;uniprot:P35228 +TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 +ARG1 GeneProduct ensembl:ENSG00000118520 "" ensembl:ENSG00000118520 ncbigene:383 hgnc.symbol:ARG1 uniprot:A0A5F9ZH78;uniprot:A0A5F9ZGN6;uniprot:P05089;uniprot:A0A5F9ZGY6 +EPHA4 GeneProduct ensembl:ENSG00000116106 "" ensembl:ENSG00000116106 ncbigene:2043 hgnc.symbol:EPHA4 uniprot:H7C1N8;uniprot:C9JFX5;uniprot:C9JEM6;uniprot:C9JIX8;uniprot:A1MA61;uniprot:H7C2W7;uniprot:E9PG71;uniprot:F5GZZ5;uniprot:P54764 +EPHNB2 GeneProduct ensembl:ENSG00000125266 "" ensembl:ENSG00000125266 ncbigene:1948 hgnc.symbol:EFNB2 uniprot:P52799 +CXCL10 GeneProduct ensembl:ENSG00000169245 "" ensembl:ENSG00000169245 ncbigene:3627 hgnc.symbol:CXCL10 uniprot:P02778 +CCNG1 GeneProduct ensembl:ENSG00000113328 "" ensembl:ENSG00000113328 ncbigene:900 hgnc.symbol:CCNG1 uniprot:P51959;uniprot:D6RGX3;uniprot:D6RD30;uniprot:E7ERZ1;uniprot:D6RCC5 +MMP9 GeneProduct ensembl:ENSG00000100985 "" ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 +NCAN GeneProduct ensembl:ENSG00000130287 "" ensembl:ENSG00000130287 ncbigene:1463 hgnc.symbol:NCAN uniprot:O14594;uniprot:A0A024R7M3;uniprot:K7EKF8 +SLIT1 GeneProduct ensembl:ENSG00000187122 "" ensembl:ENSG00000187122 ncbigene:6585 hgnc.symbol:SLIT1 uniprot:Q5T0V4;uniprot:Q5T0V0;uniprot:Q5T0V2;uniprot:O75093 +SLIT2 GeneProduct ensembl:ENSG00000145147 "" ensembl:ENSG00000145147 ncbigene:9353 hgnc.symbol:SLIT2 uniprot:O94813;uniprot:X6R3P0;uniprot:H0Y968;uniprot:F5H0U4;uniprot:E9PCX4;uniprot:H0Y9Z6;uniprot:A0A087WYV5 +SLIT3 GeneProduct ensembl:ENSG00000184347 "" ensembl:ENSG00000184347 ncbigene:6586 hgnc.symbol:SLIT3 uniprot:A0A0A0MSC8;uniprot:O75094 +NTN1 GeneProduct ensembl:ENSG00000065320 "" ensembl:ENSG00000065320 ncbigene:9423 hgnc.symbol:NTN1 uniprot:H7BZF4;uniprot:O95631 +RGMA GeneProduct ensembl:ENSG00000182175 "" ensembl:ENSG00000182175 ncbigene:56963 hgnc.symbol:RGMA uniprot:A0A0A0MTQ4;uniprot:G3V3Z3;uniprot:G3V4C2;uniprot:Q96B86;uniprot:F5H7G2;uniprot:G3V545;uniprot:A0A0G2JL92 +MMP9 GeneProduct ensembl:ENSG00000100985 "" ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 +MMP9 GeneProduct ensembl:ENSG00000100985 "" ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 +MMP9 GeneProduct ensembl:ENSG00000100985 "" ensembl:ENSG00000100985 ncbigene:4318 hgnc.symbol:MMP9 uniprot:P14780 +CCR2 GeneProduct ensembl:ENSG00000121807 "" ensembl:ENSG00000121807 ncbigene:729230 hgnc.symbol:CCR2 uniprot:E9PH76;uniprot:A0A024R2Q0;uniprot:P41597 +IL1R1 GeneProduct ensembl:ENSG00000115594 "" ensembl:ENSG00000115594 ncbigene:3554 hgnc.symbol:IL1R1 uniprot:B8ZZW4;uniprot:C9J3W8;uniprot:C9J686;uniprot:C9JQ36;uniprot:B8ZZ73;uniprot:C9JW84;uniprot:B9A040;uniprot:P14778;uniprot:H7BZM5;uniprot:F8WF92;uniprot:C9JWB2 +IL1A GeneProduct ncbigene:3552 "" ensembl:ENSG00000115008 ncbigene:3552 hgnc.symbol:IL1A uniprot:P01583 +CXCL1 GeneProduct ensembl:ENSG00000163739 "" ensembl:ENSG00000163739 ncbigene:2919 hgnc.symbol:CXCL1 uniprot:P09341 +CXCL2 GeneProduct ensembl:ENSG00000081041 "" ensembl:ENSG00000081041 ncbigene:2920 hgnc.symbol:CXCL2 uniprot:A0A024RDD9;uniprot:P19875 +CCL2 GeneProduct ensembl:ENSG00000108691 "" ensembl:ENSG00000108691 ncbigene:6347 hgnc.symbol:CCL2 uniprot:P13500;uniprot:J3KRT7 +PLA2G6 GeneProduct ensembl:ENSG00000184381 "" ensembl:ENSG00000184381 ncbigene:8398 hgnc.symbol:PLA2G6 uniprot:A0A590UJC7;uniprot:A0A590UJZ2;uniprot:B0QYE9;uniprot:H7C3P5;uniprot:A0A590UJH4;uniprot:M0R1Q9;uniprot:H0Y7G5;uniprot:A0A590UK67;uniprot:F8WEQ9;uniprot:F8WEN3;uniprot:A0A590UK51;uniprot:M0R3D9;uniprot:E7EX67;uniprot:O60733;uniprot:H0Y6T3 +PLA2G5 GeneProduct ensembl:ENSG00000127472 "" ensembl:ENSG00000127472 ncbigene:5322 hgnc.symbol:PLA2G5 uniprot:P39877 +PLA2G2A GeneProduct ensembl:ENSG00000188257 "" ensembl:ENSG00000188257 ncbigene:5320 hgnc.symbol:PLA2G2A uniprot:P14555;uniprot:A0A3B3IRX2;uniprot:A0A024RA96 +ANXA1 GeneProduct ensembl:ENSG00000135046 "" ensembl:ENSG00000135046 ncbigene:301 hgnc.symbol:ANXA1 uniprot:P04083;uniprot:Q5TZZ9;uniprot:Q5T3N1;uniprot:Q5T3N0 +ICAM1 GeneProduct ensembl:ENSG00000090339 "" ensembl:ENSG00000090339 ncbigene:3383 hgnc.symbol:ICAM1 uniprot:A0A384MEK5;uniprot:K7EKL8;uniprot:E7ESS4;uniprot:P05362 +SELP GeneProduct ensembl:ENSG00000174175 "" ensembl:ENSG00000174175 ncbigene:6403 hgnc.symbol:SELP uniprot:Q5R349;uniprot:F6VVT6;uniprot:P16109;uniprot:Q5R345;uniprot:A0A024R8Y9;uniprot:Q5R341;uniprot:Q5R342 +KLK8 GeneProduct ensembl:ENSG00000129455 "" ensembl:ENSG00000129455 ncbigene:11202 hgnc.symbol:KLK8 uniprot:M0R231;uniprot:A0A0A0MQY9;uniprot:M0R390;uniprot:O60259 +GFAP GeneProduct ensembl:ENSG00000131095 "" ensembl:ENSG00000131095 ncbigene:2670 hgnc.symbol:GFAP uniprot:A0A0G2JLI8;uniprot:K7EKH9;uniprot:K7EPI4;uniprot:K7EKD1;uniprot:A0A1X7SBR3;uniprot:K7EPT8;uniprot:A0A1W2PPA3;uniprot:K7ELP4;uniprot:P14136;uniprot:K7EJK1;uniprot:A0A1W2PPF0;uniprot:A0A1W2PQ25;uniprot:A0A1W2PR46;uniprot:A0A1X7SCE1;uniprot:A0A1W2PQU7;uniprot:K7EJU1;uniprot:A0A1W2PPL2;uniprot:A0A1W2PS58;uniprot:B4DIR1;uniprot:A0A1W2PP21;uniprot:A0A1W2PQS4;uniprot:A0A1W2PRT3 +CDK4 GeneProduct ensembl:ENSG00000135446 "" ensembl:ENSG00000135446 ncbigene:1019 hgnc.symbol:CDK4 uniprot:F8VTV8;uniprot:F8VWX7;uniprot:F8VXD2;uniprot:F8VZ51;uniprot:F8VZ13;uniprot:F8W1L8;uniprot:F8VYH9;uniprot:F8VZZ0;uniprot:P11802;uniprot:A0A024RBB6;uniprot:F8VYY1;uniprot:Q96BE9 +TACR1 GeneProduct ensembl:ENSG00000115353 "" ensembl:ENSG00000115353 ncbigene:6869 hgnc.symbol:TACR1 uniprot:P25103 +E2F5 GeneProduct ensembl:ENSG00000133740 "" ensembl:ENSG00000133740 ncbigene:1875 hgnc.symbol:E2F5 uniprot:Q15329;uniprot:C9JYE9;uniprot:E5RHD4;uniprot:H0YBK0;uniprot:H0YBW8 +RB1 GeneProduct ensembl:ENSG00000139687 "" ensembl:ENSG00000139687 ncbigene:5925 hgnc.symbol:RB1 uniprot:A0A3B3IS71;uniprot:Q92728;uniprot:A0A024RDV3;uniprot:A0A2R8YFL6;uniprot:A0A2R8Y743;uniprot:P06400 +PRKCA GeneProduct ensembl:ENSG00000154229 "" ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 +E2F1 GeneProduct ensembl:ENSG00000101412 "" ensembl:ENSG00000101412 ncbigene:1869 hgnc.symbol:E2F1 uniprot:Q01094 +MAPK1 GeneProduct ensembl:ENSG00000100030 "" ensembl:ENSG00000100030 ncbigene:5594 hgnc.symbol:MAPK1 uniprot:P28482;uniprot:Q1HBJ4 +CCND1 GeneProduct ensembl:ENSG00000110092 "" ensembl:ENSG00000110092 ncbigene:595 hgnc.symbol:CCND1 uniprot:P24385;uniprot:Q6FI00;uniprot:F5H437 +MYC GeneProduct ensembl:ENSG00000136997 "" ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 +GADD45A GeneProduct ensembl:ENSG00000116717 "" ensembl:ENSG00000116717 ncbigene:1647 hgnc.symbol:GADD45A uniprot:A0A3B3ITF9;uniprot:A0A087WZQ0;uniprot:A5JUZ3;uniprot:P24522 +MAPK3 GeneProduct ensembl:ENSG00000102882 "" ensembl:ENSG00000102882 ncbigene:5595 hgnc.symbol:MAPK3 uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9 +TP53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 +CHST11 GeneProduct ensembl:ENSG00000171310 "" ensembl:ENSG00000171310 ncbigene:50515 hgnc.symbol:CHST11 uniprot:Q9NPF2;uniprot:F8VXK3;uniprot:A0A024RBL0;uniprot:F8VXK7;uniprot:F8VRG6 +VCAN GeneProduct ensembl:ENSG00000038427 "" ensembl:ENSG00000038427 ncbigene:1462 hgnc.symbol:VCAN uniprot:P13611;uniprot:E9PF17;uniprot:Q86W61;uniprot:A0A024RAP3;uniprot:D6RGZ6;uniprot:A0A024RAL1;uniprot:A0A024RAQ9 +COL4A1 GeneProduct ensembl:ENSG00000187498 "" ensembl:ENSG00000187498 ncbigene:1282 hgnc.symbol:COL4A1 uniprot:A0A3B3ITS9;uniprot:A0A087WTY5;uniprot:A0A3B3ITC8;uniprot:A0A3B3IU02;uniprot:A0A3B3ITG7;uniprot:A0A3B3ISH5;uniprot:A0A3B3ISV3;uniprot:A0A3B3ISZ8;uniprot:A0A3B3IUD0;uniprot:P02462 +XYLT1 GeneProduct ensembl:ENSG00000103489 "" ensembl:ENSG00000103489 ncbigene:64131 hgnc.symbol:XYLT1 uniprot:Q86Y38 +COL2A1 GeneProduct ensembl:ENSG00000139219 "" ensembl:ENSG00000139219 ncbigene:1280 hgnc.symbol:COL2A1 uniprot:P02458 +ACAN GeneProduct ensembl:ENSG00000157766 "" ensembl:ENSG00000157766 ncbigene:176 hgnc.symbol:ACAN uniprot:H0YMF1;uniprot:Q6PID9;uniprot:P16112;uniprot:A0A5K1VW97;uniprot:H0YK70 +BCAN GeneProduct ensembl:ENSG00000132692 "" ensembl:ENSG00000132692 ncbigene:63827 hgnc.symbol:BCAN uniprot:Q96GW7;uniprot:Q5T3I6;uniprot:V9GXZ8;uniprot:Q5T3I8;uniprot:V9GY88;uniprot:Q5T3I7 +SOX9 GeneProduct ensembl:ENSG00000125398 "" ensembl:ENSG00000125398 ncbigene:6662 hgnc.symbol:SOX9 uniprot:P48436 +TP53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 +GRIN1 GeneProduct ensembl:ENSG00000176884 "" ensembl:ENSG00000176884 ncbigene:2902 hgnc.symbol:GRIN1 uniprot:A2AVK2;uniprot:Q05586;uniprot:Q5VSF9 +VIM GeneProduct ensembl:ENSG00000026025 "" ensembl:ENSG00000026025 ncbigene:7431 hgnc.symbol:VIM uniprot:B0YJC5;uniprot:A0A1B0GVG8;uniprot:P08670;uniprot:V9HWE1;uniprot:A0A1B0GTT5;uniprot:B0YJC4 +PPP3CA GeneProduct ensembl:ENSG00000138814 "" ensembl:ENSG00000138814 ncbigene:5530 hgnc.symbol:PPP3CA uniprot:E9PPC8;uniprot:A0A0S2Z4B5;uniprot:A0A0S2Z4C6;uniprot:E7ETC2;uniprot:E9PK68;uniprot:Q08209;uniprot:H0YAB4 +GAP43 GeneProduct ensembl:ENSG00000172020 "" ensembl:ENSG00000172020 ncbigene:2596 hgnc.symbol:GAP43 uniprot:Q5U058;uniprot:P17677 +FKBP1A GeneProduct ensembl:ENSG00000088832 "" ensembl:ENSG00000088832 ncbigene:2280 hgnc.symbol:FKBP1A uniprot:F6T7Q3;uniprot:A0A7I2V3S6;uniprot:A0A087WZM5;uniprot:A0A087WTS4;uniprot:Q5W0X3;uniprot:Q1JUQ3;uniprot:P62942;uniprot:Q1JUQ5 +IL2 GeneProduct ensembl:ENSG00000109471 "" ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 +MAG GeneProduct ensembl:ENSG00000105695 "" ensembl:ENSG00000105695 ncbigene:4099 hgnc.symbol:MAG uniprot:P20916;uniprot:M0QZU4;uniprot:M0R3B9;uniprot:M0R3I4 +RTN4 GeneProduct ensembl:ENSG00000115310 "" ensembl:ENSG00000115310 ncbigene:57142 hgnc.symbol:RTN4 uniprot:C9J685;uniprot:A0A0U1RQR6;uniprot:H7C106;uniprot:Q9NQC3 +RHOA GeneProduct ensembl:ENSG00000067560 "" ensembl:ENSG00000067560 ncbigene:387 hgnc.symbol:RHOA uniprot:P61586;uniprot:A0A7I2V5E6;uniprot:C9JNR4;uniprot:A0A024R324;uniprot:A0A7I2YQV1;uniprot:C9JRM1;uniprot:A0A7I2V3G1;uniprot:C9JX21 +RHOC GeneProduct ensembl:ENSG00000155366 "" ensembl:ENSG00000155366 ncbigene:389 hgnc.symbol:RHOC uniprot:E9PQH6;uniprot:Q5JR06;uniprot:Q5JR05;uniprot:A0A024R0C8;uniprot:E9PLA2;uniprot:Q5JR08;uniprot:E9PN11;uniprot:Q5JR07;uniprot:P08134 +RHOB GeneProduct ensembl:ENSG00000143878 "" ensembl:ENSG00000143878 ncbigene:388 hgnc.symbol:RHOB uniprot:P62745 +ROCK2 GeneProduct ensembl:ENSG00000134318 "" ensembl:ENSG00000134318 ncbigene:9475 hgnc.symbol:ROCK2 uniprot:A0A2P9DU05;uniprot:O75116;uniprot:C9JFJ0;uniprot:E9PF63;uniprot:D6REE7 +OMG GeneProduct ensembl:ENSG00000126861 "" ensembl:ENSG00000126861 ncbigene:101927057;ncbigene:4974 hgnc.symbol:OMG uniprot:P23515 +RTN4R GeneProduct ensembl:ENSG00000040608 "" ensembl:ENSG00000040608 ncbigene:65078 hgnc.symbol:RTN4R uniprot:H7C215;uniprot:Q9BZR6;uniprot:H7C0V4 +LILRB3 GeneProduct ensembl:ENSG00000204577 "" ensembl:ENSG00000204577 ncbigene:107987462;ncbigene:102725035;ncbigene:11025;ncbigene:107987425 hgnc.symbol:LILRB3 uniprot:C9JWL8;uniprot:O75022;uniprot:F8W6G6;uniprot:F8WD89 +PTGS2 GeneProduct ncbigene:5743 "" ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7;uniprot:A0A7P0T828 +ROS GeneProduct ncbigene:6098 "" ensembl:ENSG00000047936 ncbigene:6098 hgnc.symbol:ROS1 uniprot:P08922;uniprot:H0Y3T9;uniprot:Q5H8Y1 +NOX4 GeneProduct ensembl:ENSG00000086991 "" ensembl:ENSG00000086991 ncbigene:50507 hgnc.symbol:NOX4 uniprot:E9PI95;uniprot:Q9NPH5;uniprot:E9PR43;uniprot:E9PPP2 +CDK1 GeneProduct ensembl:ENSG00000170312 "" ensembl:ENSG00000170312 ncbigene:983 hgnc.symbol:CDK1 uniprot:P06493;uniprot:E5RIU6;uniprot:A0A024QZP7;uniprot:A0A024QZJ8 +GDNF GeneProduct ensembl:ENSG00000168621 "" ensembl:ENSG00000168621 ncbigene:2668 hgnc.symbol:GDNF uniprot:A0A0C4DGC2;uniprot:P39905;uniprot:A0A0S2Z3T2;uniprot:A0A0S2Z3V2 +SEMA6A GeneProduct ensembl:ENSG00000092421 "" ensembl:ENSG00000092421 ncbigene:57556 hgnc.symbol:SEMA6A uniprot:Q9H2E6;uniprot:E9PDV9;uniprot:H0Y8V9;uniprot:A0A0A0MQU6;uniprot:D6RAG9;uniprot:D6RCR0;uniprot:B3KU01 +GJA1 GeneProduct ensembl:ENSG00000152661 "" ensembl:ENSG00000152661 ncbigene:2697 hgnc.symbol:GJA1 uniprot:A0A654IBU3;uniprot:P17302 +BDNF GeneProduct ensembl:ENSG00000176697 "" ensembl:ENSG00000176697 ncbigene:627 hgnc.symbol:BDNF uniprot:P23560;uniprot:A0A0E3SU01;uniprot:E9PMP3 +RAC1 GeneProduct ensembl:ENSG00000136238 "" ensembl:ENSG00000136238 ncbigene:5879 hgnc.symbol:RAC1 uniprot:P63000;uniprot:A4D2P0;uniprot:A4D2P1 +FOXO3 GeneProduct ensembl:ENSG00000118689 "" ensembl:ENSG00000118689 ncbigene:2309 hgnc.symbol:FOXO3 uniprot:O43524;uniprot:A0A856PRE8 +CDKN1B GeneProduct ensembl:ENSG00000111276 "" ensembl:ENSG00000111276 ncbigene:1027 hgnc.symbol:CDKN1B uniprot:Q6I9V6;uniprot:E7ES52;uniprot:P46527;uniprot:H7C2T1 +EGFR GeneProduct ensembl:ENSG00000146648 "" ensembl:ENSG00000146648 ncbigene:1956 hgnc.symbol:EGFR uniprot:P00533;uniprot:Q504U8;uniprot:C9JYS6 +CASP3 GeneProduct ensembl:ENSG00000164305 "" ensembl:ENSG00000164305 ncbigene:836 hgnc.symbol:CASP3 uniprot:A8MVM1;uniprot:C9JXR7;uniprot:P42574 diff --git a/pathways/WP2431/WP2431.gpml b/pathways/WP2431/WP2431.gpml index 2f9b31b9d..167cb8daf 100644 --- a/pathways/WP2431/WP2431.gpml +++ b/pathways/WP2431/WP2431.gpml @@ -1,5 +1,5 @@ - + This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2431 CPTAC Assay Portal]. @@ -94,7 +94,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - e7b + f7f @@ -570,7 +570,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -636,326 +636,326 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - - + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + @@ -963,2245 +963,2245 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + - - + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + ef0 - - + + - - + + - - + + - - + + eac - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + 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34c3b51f2..137884da2 100644 --- a/pathways/WP2431/WP2431.json +++ b/pathways/WP2431/WP2431.json @@ -1,71 +1,5 @@ { "entitiesById": { - "190432": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "190432", - "paused": true, - "source": null, - "writable": true - }, - "314263": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "314263", - "paused": true, - "source": null, - "writable": true - }, - "875006": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "875006", - "paused": true, - "source": null, - "writable": true - }, "a05ee": { "drawAs": "TrianglePathVisio", "fill": "#00cccc", @@ -108,7 +42,7 @@ "gpmlElementName": "Shape", "height": 3.8925754771341943, "id": "a0940", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -170,16 +104,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a0b8f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c276e", "x": 261.5, "y": 175.94747899159682 }, { - "id": "e9c3a", "x": 258, "y": 173.69747899159682 } @@ -197,16 +129,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a0d4a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e3e4c", "x": 56.25, "y": 151.00000000000006 }, { - "id": "fb4f6", "x": 55, "y": 155.00000000000006 } @@ -229,7 +159,7 @@ "gpmlElementName": "Shape", "height": 13.274494583436024, "id": "a0d82", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -262,7 +192,7 @@ "gpmlElementName": "Shape", "height": 2.9289501148499575, "id": "a0dea", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -311,7 +241,6 @@ 0.5 ] }, - "id": "c986d", "isAttachedTo": "d3b7f", "orientation": [ 1, @@ -331,7 +260,6 @@ 1 ] }, - "id": "c00e5", "isAttachedTo": "ece06", "orientation": [ 0, @@ -363,7 +291,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "a11b7", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -396,7 +324,7 @@ "gpmlElementName": "Shape", "height": 6.161912671938866, "id": "a123b", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -429,7 +357,7 @@ "gpmlElementName": "Shape", "height": 2.9289501148499575, "id": "a13cc", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -462,7 +390,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a1473", - "isPartOf": "f7f65", + "isPartOf": "a6f39", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -503,7 +431,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "a15f4", - "isPartOf": "a6aaf", + "isPartOf": "a8190", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -535,7 +463,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a174c", - "isPartOf": "f1db9", + "isPartOf": "a3b9a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -574,16 +502,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a17bf", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d4b14", "x": 51, "y": 181.25000000000006 }, { - "id": "caebb", "x": 58.25, "y": 175.00000000000006 } @@ -606,7 +532,7 @@ "e9b3b" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -619,7 +545,6 @@ 1 ] }, - "id": "e6d68", "isAttachedTo": "eb26d", "orientation": [ 0, @@ -639,7 +564,6 @@ 0 ] }, - "id": "f596f", "isAttachedTo": "e9b3b", "orientation": [ 0, @@ -653,7 +577,9 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 35288 }, @@ -662,16 +588,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a1bc6", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e96c1", "x": 156.75, "y": 31.000000000000057 }, { - "id": "b3a86", "x": 147.75, "y": 36.00000000000006 } @@ -689,16 +613,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a1d43", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cdab0", "x": 276.25, "y": 255.4474789915967 }, { - "id": "a40b7", "x": 281.25, "y": 246.1974789915967 } @@ -741,16 +663,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a206f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f7c90", "x": 250.75, "y": 201.94747899159682 }, { - "id": "cdea7", "x": 258.5, "y": 194.69747899159682 } @@ -768,16 +688,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a2082", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", 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"isPartOf": "f1db9", + "isPartOf": "a3b9a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3277,16 +3205,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a985d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d6b07", "x": 266, "y": 228.1974789915967 }, { - "id": "b6d11", "x": 271.75, "y": 225.4474789915967 } @@ -3309,7 +3235,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "a9b67", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3336,16 +3262,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a9c5b", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e4c45", "x": 178.5, "y": 138.50000000000006 }, { - "id": "cb805", "x": 184.5, "y": 144.00000000000006 } @@ -3363,16 +3287,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a9de9", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fe254", "x": 143.25, "y": 24 }, { - "id": "ea0f4", "x": 147.77941176470586, "y": 36.41386554621846 } @@ -3390,16 +3312,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "a9e56", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "aa96c", "x": 22.75, "y": 127.00000000000006 }, { - "id": "d7b4f", "x": 18.5, "y": 129.00000000000006 } @@ -3417,16 +3337,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "aa151", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "dce03", "x": 35.5, "y": 65.50000000000006 }, { - "id": "efe72", "x": 47, "y": 61.50000000000006 } @@ -3475,16 +3393,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "aa206", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f8642", "x": 107.5, "y": 22.250000000000057 }, { - "id": 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{ - "id": "a1b43", "x": 113.25, "y": 17.250000000000057 } @@ -3910,7 +3814,7 @@ "gpmlElementName": "Shape", "height": 52.73768021460501, "id": "abdf2", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3938,16 +3842,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ac0da", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "af287", "x": 15.75, "y": 138.75000000000006 }, { - "id": "bda1a", "x": 18.25, "y": 143.75000000000006 } @@ -3965,16 +3867,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ac1cb", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ee4c1", "x": 145.5, "y": 53.00000000000006 }, { - "id": "a380e", "x": 167.5, "y": 43.00000000000006 } @@ -4055,7 +3955,6 @@ 0.25 ] }, - "id": "ee576", "isAttachedTo": "e8936", "orientation": [ 1, @@ -4075,7 +3974,6 @@ 0.75 ] }, - "id": "c5781", "isAttachedTo": 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"kaavioType": "Edge", "points": [ { - "id": "f11a1", "x": 139.75, "y": 40.00000000000006 }, { - "id": "a3808", "x": 142.75, "y": 35.00000000000006 } @@ -4616,16 +4476,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ae319", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d525c", "x": 208.02941176470586, "y": 184.16386554621846 }, { - "id": "dc0dc", "x": 213.52941176470586, "y": 205.16386554621846 } @@ -4648,7 +4506,7 @@ "gpmlElementName": "Label", "height": 30.647058823529278, "id": "ae572", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4675,16 +4533,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ae643", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b43f0", "x": 115, "y": 31.250000000000057 }, { - "id": "de110", "x": 113.25, "y": 27.250000000000057 } @@ -4707,7 +4563,7 @@ "gpmlElementName": "Shape", "height": 8.033333333333333, "id": "ae85b", - "isPartOf": "a7827", + "isPartOf": "fce76", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4734,16 +4590,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "aea8a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e5546", "x": 121, "y": 41.00000000000006 }, { - "id": "ff073", "x": 123.75, "y": 40.00000000000006 } @@ -4761,16 +4615,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "aeabb", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c9369", "x": 132.25, "y": 97.00000000000006 }, { - "id": "b0b08", "x": 145.02941176470586, "y": 118.66386554621846 } @@ -4793,7 +4645,7 @@ "gpmlElementName": "Shape", "height": 12.518708043277465, "id": "aeb26", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4826,7 +4678,7 @@ "gpmlElementName": "Shape", "height": 3.336377435939356, "id": "aed09", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4859,7 +4711,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "aed72", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4918,16 +4770,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "aee5b", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d44a6", "x": 211, "y": 258.1974789915967 }, { - "id": "b6e52", "x": 207.25, "y": 265.6974789915968 } @@ -4945,16 +4795,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "af16d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a147c", "x": 216.75, "y": 250.4474789915967 }, { - "id": "ad6db", "x": 223, "y": 261.6974789915967 } @@ -4972,16 +4820,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "af296", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ba424", "x": 263, "y": 182.19747899159682 }, { - "id": "d8b76", "x": 261.75, "y": 175.94747899159682 } @@ -5049,16 +4895,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "af653", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ed776", "x": 37.5, "y": 48.25000000000006 }, { - "id": "bbd3e", "x": 41, "y": 54.25000000000006 } @@ -5076,16 +4920,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "af66f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c5cf7", "x": 221.5, "y": 273.1974789915968 }, { - "id": "b748d", "x": 217.75, "y": 276.9474789915968 } @@ -5134,16 +4976,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "afd78", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b1553", "x": 242, "y": 210.1974789915967 }, { - "id": "ee976", "x": 244.25, "y": 213.4474789915967 } @@ -5192,16 +5032,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b023d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a092d", "x": 80.83333333333303, "y": 12.333333333333258 }, { - "id": "f6a2d", "x": 75.02941176470586, "y": 24.91386554621846 } @@ -5255,7 +5093,7 @@ "gpmlElementName": "Shape", "height": 11.975296236419826, "id": "b06dc", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5283,16 +5121,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b0a5f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fde68", "x": 64.75, "y": 188.25000000000006 }, { - "id": "a0718", "x": 62.25, "y": 168.75000000000006 } @@ -5315,7 +5151,7 @@ "gpmlElementName": "Shape", "height": 54.11439370653575, "id": "b0b8a", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5343,16 +5179,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b10be", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e7123", "x": 114.25, "y": 59.75000000000006 }, { - "id": "d8fe5", "x": 116.25, "y": 52.25000000000006 } @@ -5370,16 +5204,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b12be", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f5a53", "x": 151, "y": 38.75000000000006 }, { - "id": "c00ac", "x": 157.5, "y": 38.00000000000006 } @@ -5397,16 +5229,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b1602", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f96a5", "x": 222.25, "y": 226.6974789915967 }, { - "id": "f1e7a", "x": 228, "y": 228.4474789915967 } @@ -5481,16 +5311,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b192e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d7fb3", "x": 244.25, "y": 213.6974789915967 }, { - "id": "b3f95", "x": 246, "y": 221.6974789915967 } @@ -5508,16 +5336,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b1acf", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "bcd38", "x": 226.75, "y": 265.4474789915968 }, { - "id": "a4ffd", "x": 235.25, "y": 268.9474789915968 } @@ -5629,16 +5455,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b23dc", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ad584", "x": 113.25, "y": 40.75000000000006 }, { - "id": "f5f2d", "x": 115, "y": 31.500000000000057 } @@ -5661,7 +5485,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "b2528", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5728,7 +5552,7 @@ "ea176" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -5741,7 +5565,6 @@ 0.5 ] }, - "id": "d5c0c", "isAttachedTo": "bfa85", "orientation": [ -1, @@ -5761,7 +5584,6 @@ 0.5 ] }, - "id": "c91f0", "isAttachedTo": "ea176", "orientation": [ -1, @@ -5775,7 +5597,9 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 36216 }, @@ -5802,7 +5626,6 @@ 0.5 ] }, - "id": "c5a54", "isAttachedTo": "a7275", "orientation": [ 1, @@ -5812,7 +5635,6 @@ "y": 497.09243697478996 }, { - "id": "bdff7", "x": 567, "y": 568.546218487395 }, @@ -5827,7 +5649,6 @@ 0.5 ] }, - "id": "af1d3", "isAttachedTo": "ead30", "orientation": [ 1, @@ -5854,16 +5675,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b2c80", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c7e7a", "x": 220.25, "y": 214.4474789915967 }, { - "id": "e0646", "x": 221, "y": 220.4474789915967 } @@ -5881,16 +5700,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b30ff", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ec5cd", "x": 99.5, "y": 9.5 }, { - "id": "f6d92", "x": 101.25, "y": 8 } @@ -5903,6 +5720,36 @@ ], "zIndex": 36351 }, + "b312b": { + "contains": [ + "bd92b", + "e97db", + "d9517" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 52, + "id": "b312b", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 193.5826590923707, + "x": 562.4173409076293, + "y": 377, + "zIndex": 35224 + }, "b376d": { "drawAs": "rect", "fill": "#ffffff", @@ -5913,7 +5760,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b376d", - "isPartOf": "ec3f2", + "isPartOf": "dd5ca", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5952,16 +5799,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b3770", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f098f", "x": 10.25, "y": 128.75000000000006 }, { - "id": "d764a", "x": 17.75, "y": 134.25000000000006 } @@ -5987,7 +5832,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b37b1", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6033,7 +5878,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "b398c", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6065,7 +5910,7 @@ "e353e" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -6078,7 +5923,6 @@ 1 ] }, - "id": "b9955", "isAttachedTo": "eb26d", "orientation": [ 0, @@ -6098,7 +5942,6 @@ 0 ] }, - "id": "d96a6", "isAttachedTo": "e353e", "orientation": [ 0, @@ -6112,7 +5955,9 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 35286 }, @@ -6167,16 +6012,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b3e3f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b27f5", "x": 141.52941176470586, "y": 117.66386554621846 }, { - "id": "d42a2", "x": 115.5, "y": 118.50000000000006 } @@ -6194,16 +6037,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b3f10", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f88d3", "x": 78.25, "y": 45.00000000000006 }, { - "id": "e1b4c", "x": 87, "y": 34.00000000000006 } @@ -6229,7 +6070,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b3f36", - "isPartOf": "ad851", + "isPartOf": "a63d1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6267,16 +6108,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b42ea", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e844d", "x": 21.25, "y": 119.25000000000006 }, { - "id": "de2c3", "x": 32.25, "y": 123.00000000000006 } @@ -6299,7 +6138,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b49f2", - "isPartOf": "a2f0a", + "isPartOf": "eeea2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6337,16 +6176,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b4cec", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d57f5", "x": 66, "y": 31.1666666666668 }, { - "id": "c52c0", "x": 64, "y": 34.6666666666668 } @@ -6427,16 +6264,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b5a10", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "da2e0", "x": 266.5, "y": 247.4474789915967 }, { - "id": "d4598", "x": 275, "y": 250.9474789915967 } @@ -6454,16 +6289,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b5f12", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d3c01", "x": 237.25, "y": 241.6974789915967 }, { - "id": "bc777", "x": 233, "y": 234.6974789915967 } @@ -6481,16 +6314,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b60be", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a0fdd", "x": 78.25, "y": 44.50000000000006 }, { - "id": "f1b28", "x": 77.25, "y": 28.250000000000057 } @@ -6513,7 +6344,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b62d8", - "isPartOf": "f0d8c", + "isPartOf": "d7ee9", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6560,16 +6391,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b6380", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cbcd6", "x": 211.25, "y": 252.9474789915967 }, { - "id": "e9cfb", "x": 214.5, "y": 247.4474789915967 } @@ -6619,16 +6448,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b6d43", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ce24e", "x": 287.25, "y": 179.44747899159682 }, { - "id": "e88ef", "x": 292.5, "y": 181.69747899159682 } @@ -6646,16 +6473,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b6d49", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b6277", "x": 125.75, "y": 23.750000000000057 }, { - "id": "cf624", "x": 131.75, "y": 23.250000000000057 } @@ -6681,7 +6506,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b7275", - "isPartOf": "f1db9", + "isPartOf": "a3b9a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6770,7 +6595,7 @@ "gpmlElementName": "Shape", "height": 23.692167460869154, "id": "b75ad", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6798,16 +6623,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b767c", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a565e", "x": 80, "y": 145.75000000000006 }, { - "id": "d3155", "x": 87.25, "y": 149.50000000000006 } @@ -6859,16 +6682,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b7873", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a5730", "x": 280.5, "y": 186.44747899159682 }, { - "id": "d324c", "x": 274.75, "y": 183.44747899159682 } @@ -6886,16 +6707,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b7882", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ba336", "x": 42, "y": 98.50000000000006 }, { - "id": "ed361", "x": 32.25, "y": 102.50000000000006 } @@ -6949,7 +6768,7 @@ "gpmlElementName": "Shape", "height": 2.9289501148499575, "id": "b7a98", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6972,21 +6791,79 @@ "y": 27.126238555457235, "zIndex": 35347 }, + "b7af4": { + "contains": [ + "ae572", + "bfbb9", + "e843c", + "b0b8a", + "e075c", + "d68ba", + "d2291", + "e3323", + "fb426", + "be744", + "e5f8e", + "a0940", + "aeb26", + "b06dc", + "f14a2", + "e6af2", + "b2528", + "b8524", + "bb35a", + "a53f3", + "fa1c1", + "ad40f", + "d6e33", + "ff580", + "d869c", + "a0dea", + "a13cc", + "a0d82", + "e2031", + "b98e3", + "ccb9a", + "a444c", + "b7a98" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 111.74027418594596, + "id": "b7af4", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 108.68530658225654, + "x": 1182.4491471992528, + "y": 686.259725814054, + "zIndex": 35315 + }, "b7c10": { "drawAs": "StraightLine", "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b7c10", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e049b", "x": 257.75, "y": 173.44747899159682 }, { - "id": "c872c", "x": 267.5, "y": 170.44747899159682 } @@ -7004,16 +6881,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b7d93", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cf0c5", "x": 232.75, "y": 234.1974789915967 }, { - "id": "cafda", "x": 236.5, "y": 234.9474789915967 } @@ -7031,16 +6906,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b7fa9", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d46e9", "x": 279.5, "y": 189.69747899159682 }, { - "id": "e49e4", "x": 280.75, "y": 194.94747899159682 } @@ -7058,16 +6931,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b8218", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ab6a1", "x": 247.5, "y": 230.1974789915967 }, { - "id": "cb556", "x": 248.75, "y": 240.6974789915967 } @@ -7085,16 +6956,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b823e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d51c0", "x": 228.25, "y": 228.4474789915967 }, { - "id": "b0289", "x": 229.5, "y": 232.9474789915967 } @@ -7117,7 +6986,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "b8524", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7145,16 +7014,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b860f", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b63c1", "x": 116, "y": 47.75000000000006 }, { - "id": "c3f39", "x": 121.25, "y": 41.00000000000006 } @@ -7177,7 +7044,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "b8c34", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7204,16 +7071,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b8c59", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c3e6c", "x": 32, "y": 123.25000000000006 }, { - "id": "b8762", "x": 22.5, "y": 127.00000000000006 } @@ -7231,16 +7096,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b8e45", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f90ce", "x": 209, "y": 228.9474789915967 }, { - "id": "c0d5e", "x": 204.75, "y": 232.4474789915967 } @@ -7309,7 +7172,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b914f", - "isPartOf": "e262b", + "isPartOf": "cf7a1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7355,7 +7218,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "b98e3", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7383,16 +7246,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b99ba", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b4e92", "x": 98.5, "y": 149.25000000000006 }, { - "id": "cc9e0", "x": 91.75, "y": 148.75000000000006 } @@ -7410,16 +7271,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b9b41", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "edfa7", "x": 115.75, "y": 118.50000000000006 }, { - "id": "b47ba", "x": 104.25, "y": 119.25000000000006 } @@ -7437,16 +7296,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b9b48", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "feab4", "x": 243.75, "y": 230.1974789915967 }, { - "id": "fcc29", "x": 239.5, "y": 233.6974789915967 } @@ -7464,16 +7321,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "b9bba", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c7c61", "x": 279, "y": 168.44747899159682 }, { - "id": "f8478", "x": 278.75, "y": 162.44747899159682 } @@ -7496,7 +7351,7 @@ "gpmlElementName": "Shape", "height": 22.923137643507594, "id": "b9c17", - "isPartOf": "c6d7f", + "isPartOf": "d9720", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7604,16 +7459,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bad89", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c7ab2", "x": 247.25, "y": 243.4474789915967 }, { - "id": "b873c", "x": 243, "y": 246.4474789915967 } @@ -7636,7 +7489,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bae98", - "isPartOf": "ec3f2", + "isPartOf": "dd5ca", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7808,7 +7661,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bb225", - "isPartOf": "a2f0a", + "isPartOf": "eeea2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7897,7 +7750,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "bb35a", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7925,16 +7778,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bb82a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d04e7", "x": 88.75, "y": 37.00000000000006 }, { - "id": "ee375", "x": 84.5, "y": 44.25000000000006 } @@ -8015,16 +7866,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bbcba", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "dd719", "x": 80.77941176470586, "y": 12.41386554621846 }, { - "id": "bea9c", "x": 81.75, "y": 17.6666666666668 } @@ -8047,7 +7896,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bbcd6", - "isPartOf": "e66bb", + "isPartOf": "e357d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8086,16 +7935,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bc0c0", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b3cbe", "x": 219.75, "y": 224.6974789915967 }, { - "id": "e388f", "x": 218.75, "y": 235.6974789915967 } @@ -8113,16 +7960,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bc22b", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "df3bb", "x": 77.5, "y": 170.25000000000006 }, { - "id": "f32bb", "x": 77.75, "y": 149.75000000000006 } @@ -8140,16 +7985,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bc327", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d1ef9", "x": 94.75, "y": 163.00000000000006 }, { - "id": "c1c6e", "x": 91, "y": 154.25000000000006 } @@ -8167,16 +8010,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bc351", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e559c", "x": 34.5, "y": 88.75000000000006 }, { - "id": "fef4f", "x": 20.279411764705856, "y": 87.91386554621846 } @@ -8194,16 +8035,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bc65b", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cf528", "x": 121.75, "y": 63.25000000000006 }, { - "id": "a5ddf", "x": 133.25, "y": 48.75000000000006 } @@ -8216,6 +8055,35 @@ ], "zIndex": 36381 }, + "bc6bc": { + "contains": [ + "ee4af", + "d2149" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 54.084033613445854, + "id": "bc6bc", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 130, + "x": 428, + "y": 381, + "zIndex": 35111 + }, "bc910": { "drawAs": "rect", "fill": "#ffffff", @@ -8226,7 +8094,7 @@ "gpmlElementName": "DataNode", "height": 19.444444444444457, "id": "bc910", - "isPartOf": "c7855", + "isPartOf": "ec232", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8432,7 +8300,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "bce93", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8492,8 +8360,8 @@ "gpmlElementName": "Interaction", "id": "bd355", "isAttachedTo": [ - "c7f7e", - "dffba" + "e3619", + "e3ed4" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -8509,8 +8377,7 @@ 0.25 ] }, - "id": "d209c", - "isAttachedTo": "c7f7e", + "isAttachedTo": "e3619", "orientation": [ 1, 0 @@ -8529,8 +8396,7 @@ 0.5 ] }, - "id": "d9a49", - "isAttachedTo": "dffba", + "isAttachedTo": "e3ed4", "orientation": [ 1, 0 @@ -8587,16 +8453,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bd718", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cc754", "x": 108.5, "y": 19.000000000000057 }, { - "id": "ee66f", "x": 99.5, "y": 9.5 } @@ -8657,7 +8521,7 @@ "gpmlElementName": "Label", "height": 19, "id": "bd92b", - "isPartOf": "ee321", + "isPartOf": "b312b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8741,16 +8605,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bdbe0", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d3388", "x": 69.27941176470586, "y": 16.66386554621846 }, { - "id": "c55c7", "x": 75.27941176470586, "y": 24.91386554621846 } @@ -8793,16 +8655,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bdf08", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fb191", "x": 198, "y": 232.9474789915967 }, { - "id": "f4fe7", "x": 201.75, "y": 233.6974789915967 } @@ -8871,7 +8731,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "be219", - "isPartOf": "daa13", + "isPartOf": "a6348", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8955,16 +8815,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "be619", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ddffe", "x": 165.25, "y": 32.75000000000006 }, { - "id": "a815e", "x": 166, "y": 29.500000000000057 } @@ -9034,7 +8892,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "be714", - "isPartOf": "c7f7e", + "isPartOf": "e3619", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9080,7 +8938,7 @@ "gpmlElementName": "Shape", "height": 3.6631602259175993, "id": "be744", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9108,16 +8966,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "be960", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fea47", "x": 90.5, "y": 59.50000000000006 }, { - "id": "e1ab4", "x": 81.25, "y": 59.75000000000006 } @@ -9135,16 +8991,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "beb3e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a68dc", "x": 244.75, "y": 233.4474789915967 }, { - "id": "a9c6d", "x": 247.5, "y": 230.1974789915967 } @@ -9193,16 +9047,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bedf5", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c5e54", "x": 74.66666666666697, "y": 52.00000000000006 }, { - "id": "a1e6d", "x": 72.66666666666697, "y": 32.50000000000006 } @@ -9225,7 +9077,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bf0d4", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9263,16 +9115,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bf258", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e7bd3", "x": 89.5, "y": 162.00000000000006 }, { - "id": "ae675", "x": 94.75, "y": 162.75000000000006 } @@ -9295,7 +9145,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "bf332", - "isPartOf": "ad851", + "isPartOf": "a63d1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9322,16 +9172,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bf384", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cbc68", "x": 157.5, "y": 70.25000000000006 }, { - "id": "a7eec", "x": 154.5, "y": 64.00000000000006 } @@ -9349,16 +9197,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bf5d4", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f8411", "x": 22.779411764705856, "y": 91.66386554621846 }, { - "id": "a7f2b", "x": 38.5, "y": 93.00000000000006 } @@ -9492,16 +9338,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bfb5e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cee29", "x": 31.25, "y": 135.50000000000006 }, { - "id": "bfcd2", "x": 29, "y": 140.50000000000006 } @@ -9524,7 +9368,7 @@ "gpmlElementName": "Shape", "height": 52.73768021460501, "id": "bfbb9", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9577,16 +9421,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bfdce", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ea687", "x": 60.75, "y": 160.75000000000006 }, { - "id": "ea158", "x": 54.75, "y": 166.50000000000006 } @@ -9604,16 +9446,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bfe94", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ca5ff", "x": 195.5, "y": 255.9474789915967 }, { - "id": "d46ff", "x": 198.25, "y": 245.6974789915967 } @@ -9662,16 +9502,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "bff6a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d5f70", "x": 29.75, "y": 100.50000000000006 }, { - "id": "e6fa5", "x": 38.75, "y": 93.00000000000006 } @@ -9734,16 +9572,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c026a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d69fb", "x": 276.75, "y": 200.69747899159682 }, { - "id": "caa88", "x": 272.25, "y": 203.9474789915967 } @@ -9761,16 +9597,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c0292", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e7764", "x": 271.5, "y": 208.9474789915967 }, { - "id": "a1e22", "x": 268.25, "y": 206.1974789915967 } @@ -9783,35 +9617,6 @@ ], "zIndex": 36369 }, - "c038c": { - "contains": [ - "ee4af", - "d2149" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 54.084033613445854, - "id": "c038c", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 130, - "x": 428, - "y": 381, - "zIndex": 35111 - }, "c0432": { "drawAs": "StraightLine", "fill": "none", @@ -9819,7 +9624,7 @@ "id": "c0432", "isAttachedTo": [ "e77ac", - "c7f7e" + "e3619" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -9835,7 +9640,6 @@ 0.5 ] }, - "id": "eb38b", "isAttachedTo": "e77ac", "orientation": [ 1, @@ -9855,8 +9659,7 @@ 0.5 ] }, - "id": "c0fde", - "isAttachedTo": "c7f7e", + "isAttachedTo": "e3619", "orientation": [ 1, 0 @@ -9883,8 +9686,8 @@ "gpmlElementName": "Interaction", "id": "c0441", "isAttachedTo": [ - "dffba", - "c7855" + "e3ed4", + "ec232" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -9900,8 +9703,7 @@ 0.75 ] }, - "id": "d9e42", - "isAttachedTo": "dffba", + "isAttachedTo": "e3ed4", "orientation": [ 1, 0 @@ -9920,8 +9722,7 @@ 0 ] }, - "id": "c3061", - "isAttachedTo": "c7855", + "isAttachedTo": "ec232", "orientation": [ 0, 1 @@ -9947,16 +9748,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c089c", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ce82e", "x": 239.5, "y": 233.6974789915967 }, { - "id": "f9f23", "x": 236.5, "y": 234.6974789915967 } @@ -9992,7 +9791,6 @@ 0.5 ] }, - "id": "e3de9", "isAttachedTo": "dd2f3", "orientation": [ 1, @@ -10012,7 +9810,6 @@ 0.5 ] }, - "id": "aa574", "isAttachedTo": "a2fe7", "orientation": [ 1, @@ -10040,16 +9837,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c0963", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f0e08", "x": 217.75, "y": 276.9474789915968 }, { - "id": "f7307", "x": 228.5, "y": 277.6974789915968 } @@ -10062,46 +9857,19 @@ ], "zIndex": 36332 }, - "c0a28": { - "attachmentDisplay": { - "offset": [ - 0, - 0 - ], - "position": [ - 0, - 0 - ] - }, - "drawAs": "none", - "gpmlElementName": "Anchor", - "height": 0, - "id": "c0a28", - "isAttachedTo": "c700d", - "kaavioType": "Burr", - "strokeWidth": 0, - "type": [ - "Anchor", - "Burr" - ], - "width": 0, - "zIndex": 12288 - }, "c1393": { "drawAs": "StraightLine", "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1393", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d5198", "x": 69.27941176470586, "y": 16.66386554621846 }, { - "id": "e2edc", "x": 64.52941176470586, "y": 16.16386554621846 } @@ -10119,16 +9887,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1421", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e33be", "x": 47.25, "y": 94.00000000000006 }, { - "id": "e3f32", "x": 41.5, "y": 99.00000000000006 } @@ -10147,7 +9913,7 @@ "gpmlElementName": "Interaction", "id": "c145f", "isAttachedTo": [ - "f1db9", + "a3b9a", "a910b" ], "kaavioType": "Edge", @@ -10164,8 +9930,7 @@ 0.75 ] }, - "id": "f5dd1", - "isAttachedTo": "f1db9", + "isAttachedTo": "a3b9a", "orientation": [ 1, 0 @@ -10184,7 +9949,6 @@ 0.5 ] }, - "id": "f3f05", "isAttachedTo": "a910b", "orientation": [ 1, @@ -10261,7 +10025,7 @@ "gpmlElementName": "Label", "height": 26.73120138288641, "id": "c1745", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10288,16 +10052,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1aba", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e4bbf", "x": 49.25, "y": 37.25000000000006 }, { - "id": "d74b2", "x": 43.91666666666697, "y": 29.6666666666668 } @@ -10315,16 +10077,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1af0", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a4c51", "x": 104.25, "y": 119.25000000000006 }, { - "id": "be666", "x": 98, "y": 121.50000000000006 } @@ -10342,16 +10102,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1b73", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e1ff3", "x": 62, "y": 168.50000000000006 }, { - "id": "c4d86", "x": 66.5, "y": 161.75000000000006 } @@ -10369,16 +10127,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c1e9a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e3f04", "x": 167.75, "y": 43.00000000000006 }, { - "id": "d1452", "x": 171, "y": 43.75000000000006 } @@ -10477,7 +10233,7 @@ "gpmlElementName": "Shape", "height": 57.151391509535486, "id": "c22ca", - "isPartOf": "a7827", + "isPartOf": "fce76", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10505,16 +10261,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c22cd", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "aacde", "x": 263.75, "y": 201.94747899159682 }, { - "id": "c0944", "x": 270.25, "y": 202.69747899159682 } @@ -10532,16 +10286,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c24b4", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "bfd9f", "x": 108.75, "y": 38.75000000000006 }, { - "id": "ce3d0", "x": 113, "y": 41.25000000000006 } @@ -10564,7 +10316,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c25f8", - "isPartOf": "c90b4", + "isPartOf": "ed63c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10610,7 +10362,7 @@ "gpmlElementName": "Label", "height": 30.647058823529278, "id": "c267c", - "isPartOf": "a7827", + "isPartOf": "fce76", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10667,7 +10419,8 @@ "Entrez Gene:5743", "HGNC:PTGS2", "UniProt:P35354", - "UniProt:Q6ZYK7" + "UniProt:Q6ZYK7", + "UniProt:A0A7P0T828" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10737,7 +10490,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c2ea9", - "isPartOf": "c7855", + "isPartOf": "ec232", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10811,7 +10564,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c2fa1", - "isPartOf": "f0d8c", + "isPartOf": "d7ee9", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10849,16 +10602,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c3001", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "febef", "x": 274.25, "y": 234.6974789915967 }, { - "id": "ee5b7", "x": 279.25, "y": 232.6974789915967 } @@ -10881,7 +10632,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c302a", - "isPartOf": "f1db9", + "isPartOf": "a3b9a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10919,16 +10670,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "c3293", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ad3eb", "x": 227.75, "y": 225.1974789915967 }, { - "id": "a1fd7", "x": 232.75, "y": 223.1974789915967 } @@ -10951,7 +10700,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c38fe", - "isPartOf": 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+ "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "edc7e", "x": 140.75, "y": 27.5 }, { - "id": "e5c5e", "x": 143, "y": 23.75 } @@ -20655,7 +20142,6 @@ 0.5 ] }, - "id": "d603d", "isAttachedTo": "a910b", "orientation": [ 1, @@ -20675,7 +20161,6 @@ 0.5 ] }, - "id": "d5c17", "isAttachedTo": "bf631", "orientation": [ 1, @@ -20707,7 +20192,7 @@ "gpmlElementName": "Label", "height": 17.73120138288664, "id": "e453f", - "isPartOf": "d1e71", + "isPartOf": "f63fd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -20769,56 +20254,25 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e4a9d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ffa21", "x": 214, "y": 203.6974789915967 }, { - "id": "fc936", "x": 215.25, "y": 213.9474789915967 - } - ], - "stroke": "#000000", - "strokeWidth": 1, - "type": [ - "GraphicalLine", - "Edge" - ], - "zIndex": 36514 - }, - "e4f21": { - "contains": [ - "fb248", - 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"y": 220.6974789915967 }, { - "id": "dc59c", "x": 277.5, "y": 228.6974789915967 } @@ -20919,16 +20371,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e56e4", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b87e0", "x": 18.25, "y": 128.75000000000006 }, { - "id": "d0354", "x": 12.75, "y": 127.00000000000006 } @@ -20951,7 +20401,7 @@ "gpmlElementName": "Label", "height": 22, "id": "e5869", - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -20978,16 +20428,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e5a96", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e5c6c", "x": 39, "y": 67.25000000000006 }, { - "id": "baf75", "x": 35.75, "y": 65.75000000000006 } @@ -21039,16 +20487,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e5b66", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e89c4", "x": 251.5, "y": 232.4474789915967 }, { - "id": "bcc1e", "x": 252.5, "y": 228.6974789915967 } @@ -21173,7 +20619,7 @@ "gpmlElementName": "Shape", "height": 3.8925754771341943, "id": "e5f8e", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -21201,16 +20647,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e5feb", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e9ef1", "x": 87, "y": 130.50000000000006 }, { - "id": "eb194", "x": 78.75, "y": 141.75000000000006 } @@ -21228,16 +20672,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e6230", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b2ad9", "x": 47.75, "y": 180.75000000000006 }, { - "id": "bd6cb", "x": 50.5, "y": 181.00000000000006 } @@ -21255,16 +20697,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e6319", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c55e6", "x": 151.5, "y": 61.00000000000006 }, { - "id": "ff3ee", "x": 158, "y": 55.50000000000006 } @@ -21282,16 +20722,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e6321", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c0b86", "x": 66.5, "y": 162.00000000000006 }, { - "id": "d60e1", "x": 70.5, "y": 152.75000000000006 } @@ -21304,38 +20742,6 @@ ], "zIndex": 36317 }, - "e66bb": { - "contains": [ - "c4fed", - "ad964", - "ccd99", - "f6d0e", - "bbcd6" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76, - "id": "e66bb", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - 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+ "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "deef2", "x": 56.25, "y": 171.25000000000006 }, { - "id": "e43e5", "x": 48.25, "y": 178.25000000000006 } @@ -21462,16 +20864,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e6e49", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fd801", "x": 213.75, "y": 222.1974789915967 }, { - "id": "cdaa6", "x": 208.75, "y": 229.1974789915967 } @@ -21494,7 +20894,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e6e72", - "isPartOf": "a6aaf", + "isPartOf": "a8190", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -21538,16 +20938,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e7094", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ed54d", "x": 120, "y": 49.00000000000006 }, { - "id": "ad1e7", "x": 116, "y": 53.00000000000006 } @@ -21570,7 +20968,7 @@ "gpmlElementName": "Shape", 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"isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a57ca", "x": 286.25, "y": 186.19747899159682 }, { - "id": "fc281", "x": 280.5, "y": 186.44747899159682 } @@ -21903,16 +21296,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e85fd", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ab7ac", "x": 202.5, "y": 240.4474789915967 }, { - "id": "e390f", "x": 198.25, "y": 233.4474789915967 } @@ -21935,7 +21326,7 @@ "gpmlElementName": "Label", "height": 26.64705882352939, "id": "e8936", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -21962,16 +21353,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e8b16", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "def97", "x": 91, "y": 154.25000000000006 }, { - "id": "e6000", "x": 98.5, "y": 149.00000000000006 } @@ -22033,16 +21422,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e8f6e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f106e", "x": 98.25, "y": 121.50000000000006 }, { - "id": "c8190", "x": 92.25, "y": 125.50000000000006 } @@ -22060,16 +21447,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e8fd3", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a999e", "x": 49, "y": 120.00000000000006 }, { - "id": "b7c6d", "x": 46, "y": 129.00000000000006 } @@ -22092,7 +21477,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e901e", - "isPartOf": "a6aaf", + "isPartOf": "a8190", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -22135,7 +21520,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e9044", - "isPartOf": "e262b", + "isPartOf": "cf7a1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -22196,16 +21581,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e936c", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ce3e6", "x": 42.75, "y": 143.50000000000006 }, { - "id": "dd057", "x": 41, "y": 140.50000000000006 } @@ -22223,16 +21606,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e937a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d63ea", "x": 281.75, "y": 170.94747899159682 }, { - "id": "e3a01", "x": 286.25, "y": 169.94747899159682 } @@ -22250,16 +21631,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e9756", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f4e80", "x": 275.5, "y": 247.9474789915967 }, { - "id": "d08c1", "x": 281.25, "y": 245.9474789915967 } @@ -22282,7 +21661,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e97db", - "isPartOf": "ee321", + "isPartOf": "b312b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -22329,7 +21708,7 @@ "gpmlElementName": "DataNode", "height": 19, "id": "e98a0", - "isPartOf": "eeba9", + "isPartOf": "d497e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -22488,16 +21867,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "e9ce6", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "abe12", "x": 35.75, "y": 86.75000000000006 }, { - "id": "df242", "x": 34.25, "y": 89.00000000000006 } @@ -22555,21 +21932,83 @@ "y": 839.9081440700741, "zIndex": 36217 }, + "ea41a": { + "contains": [ + "fbf41", + "abdf2", + "e3507", + "edfed", + "a123b", + "facae", + "e7a5f", + "f3ece", + "a5864", + "ef2c8", + "e14fb", + "a8d5c", + "dde39", + "e417d", + "fb398", + "d354a", + "a11b7", + "bce93", + "db279", + "d64a4", + "edca8", + "d7d0e", + "aed72", + "f84b4", + "ded82", + "d06e4", + "ffa14", + "ee2f6", + "f9544", + "dc1f4", + "ffad6", + "d92a3", + "f0aa7", + "f000c", + "f4676", + "fefd5", + "db159" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 113.74027418594596, + "id": "ea41a", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 150.9781562689841, + "x": 111, + "y": 373.25972581405404, + "zIndex": 34166 + }, "ea5a8": { "drawAs": "StraightLine", "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ea5a8", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a4552", "x": 55.5, "y": 60.50000000000006 }, { - "id": "d37f5", "x": 48, "y": 56.50000000000006 } @@ -22587,16 +22026,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ea8a1", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d45fd", "x": 251, "y": 243.9474789915967 }, { - "id": "dfadf", "x": 252.5, "y": 240.1974789915967 } @@ -22614,16 +22051,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "ea94d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ef27f", "x": 154.75, "y": 64.00000000000006 }, { - "id": "e929d", "x": 151.5, "y": 61.00000000000006 } @@ -22731,16 +22166,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "eb083", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a6ddb", "x": 233.5, "y": 201.19747899159682 }, { - "id": "d75a0", "x": 237.25, "y": 201.69747899159682 } @@ -22804,16 +22237,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "eb183", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d2c78", "x": 90.5, "y": 59.50000000000006 }, { - "id": "b6605", "x": 95.5, "y": 61.25000000000006 } @@ -22831,16 +22262,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "eb1ae", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e770f", "x": 41.5, "y": 48.25000000000006 }, { - "id": "b17d5", "x": 37.25, "y": 47.75000000000006 } @@ -22910,7 +22339,7 @@ "gpmlElementName": "Label", "height": 22, "id": "eb2dc", - "isPartOf": "f7f65", + "isPartOf": "a6f39", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -22937,16 +22366,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "eb8a4", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f0d40", "x": 157, "y": 33.75000000000006 }, { - "id": "d77da", "x": 165.5, "y": 33.00000000000006 } @@ -22959,21 +22386,50 @@ ], "zIndex": 36414 }, + "ec232": { + "contains": [ + "f300a", + "cddf4", + "c2ea9", + "bc910" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 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"points": [ { - "id": "b501d", "x": 63.08333333333303, "y": 29.333333333333314 }, { - "id": "c9a68", "x": 55.75, "y": 36.25000000000006 } @@ -26913,16 +26131,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f89eb", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b386d", "x": 101.25, "y": 18.000000000000057 }, { - "id": "cc33a", "x": 108.5, "y": 18.500000000000057 } @@ -26940,16 +26156,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f8b30", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f85aa", "x": 57, "y": 59.25000000000006 }, { - "id": "b13bc", "x": 55.75, "y": 60.50000000000006 } @@ -26967,16 +26181,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f8c49", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e0d63", "x": 113.5, "y": 27.750000000000057 }, { - "id": "d16fc", "x": 107.25, "y": 21.750000000000057 } @@ -27025,16 +26237,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f9140", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "ae001", "x": 250.25, "y": 218.4474789915967 }, { - "id": "a717d", "x": 253, "y": 223.9474789915967 } @@ -27057,7 +26267,7 @@ "gpmlElementName": "Shape", "height": 2.9289501148499575, "id": "f9544", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -27103,7 +26313,6 @@ 0.5 ] }, - "id": "bb0e1", "isAttachedTo": "ead0d", "orientation": [ -1, @@ -27131,7 +26340,6 @@ 0 ] }, - "id": "fddb4", "isAttachedTo": "ece06", "orientation": [ 0, @@ -27158,16 +26366,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f9a47", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "cd647", "x": 162.5, "y": 40.50000000000006 }, { - "id": "d84a7", "x": 166.75, "y": 39.25000000000006 } @@ -27216,16 +26422,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f9c85", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a19f6", "x": 204.75, "y": 232.4474789915967 }, { - "id": "a9093", "x": 201.75, "y": 233.4474789915967 } @@ -27243,16 +26447,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f9de8", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "a08d8", "x": 266.25, "y": 181.69747899159682 }, { - "id": "ce439", "x": 278.75, "y": 168.19747899159682 } @@ -27270,16 +26472,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "f9f31", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "d1d7a", "x": 207.5, "y": 265.6974789915968 }, { - "id": "f21b7", "x": 208.25, "y": 269.9474789915968 } @@ -27365,7 +26565,7 @@ "gpmlElementName": "Shape", "height": 4.171793454461175, "id": "fa1c1", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -27393,16 +26593,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fa25e", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "b3673", "x": 50.75, "y": 173.25000000000006 }, { - "id": "b8987", "x": 56.5, "y": 170.75000000000006 } @@ -27447,66 +26645,6 @@ "y": 528.4340436546358, "zIndex": 36276 }, - "fa603": { - "contains": [ - "ae572", - "bfbb9", - "e843c", - "b0b8a", - "e075c", - "d68ba", - "d2291", - "e3323", - "fb426", - "be744", - "e5f8e", - "a0940", - "aeb26", - "b06dc", - "f14a2", - "e6af2", - "b2528", - "b8524", - "bb35a", - "a53f3", - "fa1c1", - "ad40f", - "d6e33", - "ff580", - "d869c", - "a0dea", - "a13cc", - "a0d82", - "e2031", - "b98e3", - "ccb9a", - "a444c", - "b7a98" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 111.74027418594596, - "id": "fa603", - 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"kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -27658,7 +26794,7 @@ "gpmlElementName": "Shape", "height": 11.975296236419826, "id": "fb398", - "isPartOf": "f6f12", + "isPartOf": "ea41a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -27691,7 +26827,7 @@ "gpmlElementName": "Shape", "height": 3.8925754771341943, "id": "fb426", - "isPartOf": "fa603", + "isPartOf": "b7af4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -27719,16 +26855,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fb862", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c2a05", "x": 257.75, "y": 227.6974789915967 }, { - "id": "a6a6d", "x": 265.75, "y": 228.1974789915967 } @@ -27746,16 +26880,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fb906", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "fc466", "x": 221.25, 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"gpmlElementName": "GraphicalLine", "id": "fd067", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c1ddf", "x": 79, "y": 141.75000000000006 }, { - "id": "ee963", "x": 80, "y": 145.50000000000006 } @@ -28113,7 +27270,7 @@ "gpmlElementName": "Shape", "height": 24.86443629579588, "id": "fd289", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -28141,16 +27298,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fd31d", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "e1472", "x": 210.75, "y": 258.4474789915967 }, { - "id": "f725a", "x": 216.75, "y": 250.4474789915967 } @@ -28168,16 +27323,14 @@ "fill": "none", "gpmlElementName": "Interaction", "id": "fd32c", - "isPartOf": "a47d8", + "isPartOf": "a8a79", "kaavioType": "Edge", "points": [ { - "id": "d1282", "x": 54.18841704339491, "y": 27.085974079948755 }, { - "id": 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"fe1b4", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "c6aa7", "x": 128.5, "y": 87.00000000000006 }, { - "id": "b0422", "x": 132.5, "y": 97.50000000000006 } @@ -28480,7 +27625,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fe3e0", - "isPartOf": "daa13", + "isPartOf": "a6348", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -28581,16 +27726,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fe86a", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "f28ec", "x": 259, "y": 231.1974789915967 }, { - "id": "aba1a", "x": 274.5, "y": 237.9474789915967 } @@ -28608,16 +27751,14 @@ "fill": "none", "gpmlElementName": "GraphicalLine", "id": "fe9b1", - "isPartOf": "df465", + "isPartOf": "d1361", "kaavioType": "Edge", "points": [ { - "id": "df313", "x": 236.5, "y": 273.4474789915968 }, { - "id": "eacc5", "x": 241.5, "y": 264.1974789915967 } @@ -28635,16 +27776,14 @@ 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"type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "CL:0000100" + }, + "http://identifiers.org/cl/CL:0000129": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/cl/CL:0000129", + "ontology": "Cell Type", + "term": "microglial cell", + "type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "CL:0000129" + }, + "http://identifiers.org/cl/CL:0000236": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/cl/CL:0000236", + "ontology": "Cell Type", + "term": "B cell", + "type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "CL:0000236" + }, + "http://identifiers.org/cl/CL:0000576": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/cl/CL:0000576", + "ontology": "Cell Type", + "term": "monocyte", + "type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "CL:0000576" + }, + "http://identifiers.org/cl/CL:0002606": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/cl/CL:0002606", + "ontology": "Cell Type", + "term": "astrocyte of the spinal cord", + "type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "CL:0002606" + }, + "http://identifiers.org/cl/CL:0011001": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/cl/CL:0011001", + "ontology": "Cell Type", + "term": "spinal cord motor neuron", "type": [ - "GraphicalLine", - "Edge" + "openControlledVocabulary" ], - "zIndex": 36407 + "xrefIdentifier": "CL:0011001" }, - "ffffe": { - "drawAs": "StraightLine", - "fill": "none", - "gpmlElementName": "GraphicalLine", - "id": "ffffe", - "isPartOf": "df465", - "kaavioType": "Edge", - "points": [ - { - "id": "e379a", - "x": 264.75, - "y": 230.4474789915967 - }, - { - "id": "dc62a", - "x": 274, - "y": 234.6974789915967 - } + "http://identifiers.org/doid/DOID:2055": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/doid/DOID:2055", + "ontology": "Disease", + "term": "traumatic neurosis", + "type": [ + "openControlledVocabulary" ], - "stroke": "#000000", - "strokeWidth": 1, + "xrefIdentifier": "DOID:2055" + }, + "http://identifiers.org/doid/DOID:319": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/doid/DOID:319", + "ontology": "Disease", + "term": "spinal cord disease", "type": [ - "GraphicalLine", - "Edge" + "openControlledVocabulary" ], - "zIndex": 36433 + "xrefIdentifier": "DOID:319" }, "http://identifiers.org/pw/PW:0000013": { "gpmlElementName": "openControlledVocabulary", @@ -28985,7 +28235,6 @@ 0.5 ] }, - "id": "d2b40", "isAttachedTo": "a7275", "orientation": [ 1, @@ -28995,7 +28244,6 @@ "y": 497.09243697478996 }, { - "id": "dc13d", "x": 567, "y": 523.546218487395 }, @@ -29010,7 +28258,6 @@ 0.5 ] }, - "id": "f2217", "isAttachedTo": "e218a", "orientation": [ -1, @@ -29055,7 +28302,6 @@ 0 ] }, - "id": "e72a0", "isAttachedTo": "a72ae", "orientation": [ 0, @@ -29075,7 +28321,6 @@ 1 ] }, - "id": "dbda1", "isAttachedTo": "d1b24", "orientation": [ 0, @@ -29121,7 +28366,6 @@ 0.5 ] }, - "id": "b4340", "isAttachedTo": "eb0e0", "orientation": [ 1, @@ -29141,7 +28385,6 @@ 0.5 ] }, - "id": "ae031", "isAttachedTo": "db2a2", "orientation": [ 1, @@ -29169,7 +28412,7 @@ "gpmlElementName": "Interaction", "id": "id1d0d65d8", "isAttachedTo": [ - "c7855", + "ec232", "d1b24" ], "kaavioType": "Edge", @@ -29186,8 +28429,7 @@ 1 ] }, - "id": "a942c", - "isAttachedTo": "c7855", + "isAttachedTo": "ec232", "orientation": [ 0, 1 @@ -29206,7 +28448,6 @@ 0 ] }, - "id": "dcf52", "isAttachedTo": "d1b24", "orientation": [ 0, @@ -29237,12 +28478,10 @@ "kaavioType": "Edge", "points": [ { - "id": "dea5f", "x": 155, "y": 638 }, { - "id": "f8fab", "x": 347, "y": 638 } @@ -29278,7 +28517,6 @@ 0 ] }, - "id": "de668", "isAttachedTo": "dc6f8", "orientation": [ 0, @@ -29298,7 +28536,6 @@ 1 ] }, - "id": "f4339", "isAttachedTo": "a833f", "orientation": [ 0, @@ -29343,7 +28580,6 @@ 0 ] }, - "id": "c7aa7", "isAttachedTo": "a833f", "orientation": [ 0, @@ -29363,7 +28599,6 @@ 1 ] }, - "id": "fdae3", "isAttachedTo": "bb029", "orientation": [ 0, @@ -29395,7 +28630,7 @@ "cbf29" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -29408,7 +28643,6 @@ 0 ] }, - "id": "edcfa", "isAttachedTo": "f7ce0", "orientation": [ 0, @@ -29432,7 +28666,6 @@ 1 ] }, - "id": "c9828", "isAttachedTo": "cbf29", "orientation": [ 0, @@ -29446,7 +28679,9 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 12288 }, @@ -29457,7 +28692,7 @@ "id": "id3791afda", "isAttachedTo": [ "e7eae", - "df465" + "d1361" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -29473,7 +28708,6 @@ 1 ] }, - "id": "c044b", "isAttachedTo": "e7eae", "orientation": [ 0, @@ -29493,14 +28727,13 @@ 0 ] }, - "id": "aaef9", - "isAttachedTo": "df465", + "isAttachedTo": "d1361", "orientation": [ 0, 1 ], "x": 255.34558823529414, - "y": 143.08613445378148 + "y": 143.0861344537815 } ], "stroke": "#000000", @@ -29524,9 +28757,9 @@ "b37b1", "b49f2" ], - "isPartOf": "c3fc0", + "isPartOf": "c6d8c", "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -29539,7 +28772,6 @@ 1 ] }, - "id": "c6174", "isAttachedTo": "b37b1", "orientation": [ 0, @@ -29559,7 +28791,6 @@ 0 ] }, - "id": "e6f32", "isAttachedTo": "b49f2", "orientation": [ 0, @@ -29573,7 +28804,9 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 35242 }, @@ -29600,7 +28833,6 @@ 0.5 ] }, - "id": "d3e20", "isAttachedTo": "db650", "orientation": [ 1, @@ -29610,7 +28842,6 @@ "y": 568.5 }, { - "id": "fdcbf", "x": 987, "y": 555.84375 }, @@ -29625,7 +28856,6 @@ 0.75 ] }, - "id": "f6c1c", "isAttachedTo": "dd2f3", "orientation": [ 1, @@ -29657,7 +28887,7 @@ "ide7f10f6f" ], "kaavioType": "Edge", - 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"publicationXrefa26": { + "authors": [ + "Cafferty WB", + "Duffy P", + "Huebner E", + "Strittmatter SM" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefa26", + "source": "J Neurosci", + "standardName": "MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.", + "textContent": "28", + "type": [ + "PublicationXref", + "PubMed:20484625" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "20484625", + "year": 2010 + }, + "publicationXrefaa6": { + "authors": [ + "Sharma HS" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefaa6", + "source": "J Neural Transm (Vienna)", + "standardName": "Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection.", + "textContent": "30", + "type": [ + "PublicationXref", + "PubMed:21161717" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "21161717", + "year": 2011 + }, "publicationXrefab0": { "authors": [ "Myers SA", @@ -31242,7 +30470,7 @@ "id": "publicationXrefab0", "source": "Neurobiol Dis", "standardName": "CD47 knockout mice exhibit improved recovery from spinal cord injury.", - "textContent": "30", + "textContent": "32", "type": [ "PublicationXref", "PubMed:21168495" @@ -31281,7 +30509,7 @@ "id": "publicationXrefabe", "source": "J Neurosci", "standardName": "Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.", - "textContent": "17", + "textContent": "15", "type": [ "PublicationXref", "PubMed:17567803" @@ -31301,7 +30529,7 @@ "id": "publicationXrefad1", "source": "PLoS One", "standardName": "Activated microglia inhibit axonal growth through RGMa.", - "textContent": "28", + "textContent": "39", "type": [ "PublicationXref", "PubMed:21957482" @@ -31401,7 +30629,7 @@ "id": "publicationXrefb6f", "source": "Cell Mol Neurobiol", "standardName": "Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat.", - "textContent": "22", + "textContent": "23", "type": [ "PublicationXref", "PubMed:19350383" @@ -31423,7 +30651,7 @@ "id": "publicationXrefb75", "source": "Ann Neurol", "standardName": "Gene profiling in spinal cord injury shows role of cell cycle in neuronal death.", - "textContent": "6", + "textContent": "7", "type": [ "PublicationXref", "PubMed:12666113" @@ -31432,6 +30660,30 @@ "xrefIdentifier": "12666113", "year": 2003 }, + "publicationXrefb9b": { + "authors": [ + "Lee JK", + "Geoffroy CG", + "Chan AF", + "Tolentino KE", + "Crawford MJ", + "Leal MA", + "Kang B", + "Zheng B" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefb9b", + "source": "Neuron", + "standardName": "Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice.", + "textContent": "26", + "type": [ + "PublicationXref", + "PubMed:20547125" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "20547125", + "year": 2010 + }, "publicationXrefbc0": { "authors": [ "Saganovأ، K", @@ -31445,7 +30697,7 @@ "id": "publicationXrefbc0", "source": "Life Sci", "standardName": "Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury.", - "textContent": "39", + "textContent": "48", "type": [ "PublicationXref", "PubMed:22771695" @@ -31464,7 +30716,7 @@ "id": "publicationXrefbc2", "source": "Neuroscience", "standardName": "The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury.", - "textContent": "12", + "textContent": "14", "type": [ "PublicationXref", "PubMed:17706365" @@ -31512,7 +30764,7 @@ "id": "publicationXrefbd9", "source": "J Neurochem", "standardName": "A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.", - "textContent": "4", + "textContent": "5", "type": [ "PublicationXref", "PubMed:11553680" @@ -31541,7 +30793,7 @@ "id": "publicationXrefc0d", "source": "J Neurosci", "standardName": "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.", - "textContent": "40", + "textContent": "50", "type": [ "PublicationXref", "PubMed:22399755" @@ -31560,7 +30812,7 @@ "id": "publicationXrefc5f", "source": "PLoS One", "standardName": "Acute leptin treatment enhances functional recovery after spinal cord injury.", - "textContent": "35", + "textContent": "49", "type": [ "PublicationXref", "PubMed:22536415" @@ -31582,7 +30834,7 @@ "id": "publicationXrefc8a", "source": "Neuroscience", "standardName": "Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.", - "textContent": "15", + "textContent": "13", "type": [ "PublicationXref", "PubMed:17629414" @@ -31591,6 +30843,58 @@ "xrefIdentifier": "17629414", "year": 2007 }, + "publicationXrefcae": { + "gpmlElementName": "PublicationXref", + "id": "publicationXrefcae", + "textContent": "52", + "type": [ + "PublicationXref", + "PubMed:16498630" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "16498630" + }, + "publicationXrefcd2": { + "authors": [ + "Lavezzi AM", + "Casale V", + "Oneda R", + "Weese-Mayer DE", + "Matturri L" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefcd2", + "source": "Pediatr Res", + "standardName": "Sudden Infant Death Syndrome and Sudden Intrauterine Unexplained Death: Correlation Between Hypoplasia of Reaphé Nuclei and Serotonin Transporter Gene Promoter Polymorphism.", + "textContent": "22", + "type": [ + "PublicationXref", + "PubMed:19342987" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "19342987", + "year": 2009 + }, + "publicationXrefd28": { + "authors": [ + "McKillop WM", + "Dragan M", + "Schedl A", + "Brown A" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefd28", + "source": "Glia", + "standardName": "Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury.", + "textContent": "53", + "type": [ + "PublicationXref", + "PubMed:23027386" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "23027386", + "year": 2013 + }, "publicationXrefd33": { "authors": [ "Chalimoniuk M", @@ -31602,7 +30906,7 @@ "id": "publicationXrefd33", "source": "Neuroscience", "standardName": "Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons.", - "textContent": "10", + "textContent": "9", "type": [ "PublicationXref", "PubMed:16504406" @@ -31622,7 +30926,7 @@ "id": "publicationXrefd54", "source": "Physiol Res", "standardName": "Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells.", - "textContent": "21", + "textContent": "20", "type": [ "PublicationXref", "PubMed:18637713" @@ -31631,6 +30935,17 @@ "xrefIdentifier": "18637713", "year": 2009 }, + "publicationXrefd57": { + "gpmlElementName": "PublicationXref", + "id": "publicationXrefd57", + "textContent": "37", + "type": [ + "PublicationXref", + "PubMed:19061375" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "19061375" + }, "publicationXrefd81": { "authors": [ "Lأ³pez-Vales R", @@ -31652,7 +30967,7 @@ "id": "publicationXrefd81", "source": "FASEB J", "standardName": "Phospholipase A2 superfamily members play divergent roles after spinal cord injury.", - "textContent": "27", + "textContent": "41", "type": [ "PublicationXref", "PubMed:21868473" @@ -31695,7 +31010,7 @@ "id": "publicationXrefda7", "source": "Mol Cell Neurosci", "standardName": "PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition.", - "textContent": "37", + "textContent": "47", "type": [ "PublicationXref", "PubMed:22564823" @@ -31737,7 +31052,7 @@ "id": "publicationXrefdb9", "source": "Brain Res", "standardName": "2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury.", - "textContent": "29", + "textContent": "40", "type": [ "PublicationXref", "PubMed:21092735" @@ -31757,7 +31072,7 @@ "id": "publicationXrefdc5", "source": "Glia", "standardName": "Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury.", - "textContent": "34", + "textContent": "36", "type": [ "PublicationXref", "PubMed:22865681" @@ -31775,7 +31090,7 @@ "id": "publicationXrefdce", "source": "Nat Rev Neurosci", "standardName": "Repertoire of microglial and macrophage responses after spinal cord injury.", - "textContent": "26", + "textContent": "34", "type": [ "PublicationXref", "PubMed:21673720" @@ -31795,7 +31110,7 @@ "id": "publicationXrefe0c", "source": "Brain Behav Immun", "standardName": "Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion.", - "textContent": "23", + "textContent": "25", "type": [ "PublicationXref", "PubMed:19932745" @@ -31815,7 +31130,7 @@ "id": "publicationXrefe7b", "source": "Brain Res", "standardName": "Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice.", - "textContent": "36", + "textContent": "46", "type": [ "PublicationXref", "PubMed:22884909" @@ -31824,6 +31139,28 @@ "xrefIdentifier": "22884909", "year": 2012 }, + "publicationXrefe83": { + "authors": [ + "Yu CG", + "Yezierski RP", + "Joshi A", + "Raza K", + "Li Y", + "Geddes JW" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefe83", + "source": "J Neurochem", + "standardName": "Involvement of ERK2 in traumatic spinal cord injury.", + "textContent": "29", + "type": [ + "PublicationXref", + "PubMed:20067580" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "20067580", + "year": 2010 + }, "publicationXrefe9c": { "authors": [ "Schwab JM", @@ -31837,7 +31174,7 @@ "id": "publicationXrefe9c", "source": "J Neuroimmunol", "standardName": "AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats.", - "textContent": "5", + "textContent": "4", "type": [ "PublicationXref", "PubMed:11585624" @@ -31861,7 +31198,7 @@ "id": "publicationXrefea4", "source": "J Neuropathol Exp Neurol", "standardName": "Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury.", - "textContent": "14", + "textContent": "12", "type": [ "PublicationXref", "PubMed:17917587" @@ -31881,7 +31218,7 @@ "id": "publicationXrefeac", "source": "PLoS One", "standardName": "Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury.", - "textContent": "33", + "textContent": "38", "type": [ "PublicationXref", "PubMed:21283639" @@ -31890,6 +31227,42 @@ "xrefIdentifier": "21283639", "year": 2011 }, + "publicationXrefeb2": { + "authors": [ + "Sharma HS" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefeb2", + "source": "J Neural Transm", + "standardName": "Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection.", + "textContent": "42", + "type": [ + "PublicationXref", + "PubMed:21161717" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "21161717", + "year": 2011 + }, + "publicationXrefebb": { + "authors": [ + "Wu J", + "Stoica BA", + "Faden AI" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefebb", + "source": "Neurotherapeutics", + "standardName": "Cell cycle activation and spinal cord injury.", + "textContent": "43", + "type": [ + "PublicationXref", + "PubMed:21373950" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "21373950", + "year": 2011 + }, "publicationXrefec6": { "authors": [ "Fabes J", @@ -31903,7 +31276,7 @@ "id": "publicationXrefec6", "source": "Eur J Neurosci", "standardName": "Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion.", - "textContent": "9", + "textContent": "10", "type": [ "PublicationXref", "PubMed:16623828" @@ -31925,7 +31298,7 @@ "id": "publicationXrefef0", "source": "Cell Death Dis", "standardName": "Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord.", - "textContent": "41", + "textContent": "35", "type": [ "PublicationXref", "PubMed:23152062" @@ -31962,7 +31335,7 @@ "id": "publicationXreff35", "source": "Pharmacol Ther", "standardName": "Current and future therapeutic strategies for functional repair of spinal cord injury.", - "textContent": "32", + "textContent": "33", "type": [ "PublicationXref", "PubMed:21640756" @@ -31987,7 +31360,7 @@ "id": "publicationXreff41", "source": "Am J Pathol", "standardName": "The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.", - "textContent": "25", + "textContent": "27", "type": [ "PublicationXref", "PubMed:20304963" @@ -32005,7 +31378,7 @@ "id": "publicationXreff5c", "source": "J Clin Invest", "standardName": "Pathogenic antibodies are active participants in spinal cord injury.", - "textContent": "20", + "textContent": "21", "type": [ "PublicationXref", "PubMed:19770517" @@ -32025,7 +31398,7 @@ "id": "publicationXreff6b", "source": "Proc Natl Acad Sci U S A", "standardName": "Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes.", - "textContent": "7", + "textContent": "6", "type": [ "PublicationXref", "PubMed:12861073" @@ -32052,6 +31425,26 @@ "xrefIdentifier": "20202079", "year": 2010 }, + "publicationXreff7f": { + "authors": [ + "Pajoohesh-Ganji A", + "Knoblach SM", + "Faden AI", + "Byrnes KR" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXreff7f", + "source": "Brain Res", + "standardName": "Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice.", + "textContent": "44", + "type": [ + "PublicationXref", + "PubMed:22884909" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "22884909", + "year": 2012 + }, "publicationXreff8f": { "authors": [ "Floriddia EM", @@ -32068,7 +31461,7 @@ "id": "publicationXreff8f", "source": "J Neurosci", "standardName": "p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury.", - "textContent": "38", + "textContent": "45", "type": [ "PublicationXref", "PubMed:23035104" @@ -32077,6 +31470,17 @@ "xrefIdentifier": "23035104", "year": 2012 }, + "publicationXreff97": { + "gpmlElementName": "PublicationXref", + "id": "publicationXreff97", + "textContent": "54", + "type": [ + "PublicationXref", + "PubMed:19770513" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "19770513" + }, "publicationXreffce": { "authors": [ "Hashimoto M", @@ -32113,7 +31517,7 @@ "id": "publicationXreffed", "source": "Neuroscience", "standardName": "Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons.", - "textContent": "13", + "textContent": "17", "type": [ "PublicationXref", "PubMed:17698296" @@ -32121,13 +31525,38 @@ "xrefDataSource": "PubMed", "xrefIdentifier": "17698296", "year": 2007 + }, + "pvjsgeneratedidffad7": { + "attachmentDisplay": { + "offset": [ + 0, + 0 + ], + "position": [ + 0, + 0 + ] + }, + "drawAs": "rect", + "gpmlElementName": "Anchor", + "height": 4, + "id": "pvjsgeneratedidffad7", + "isAttachedTo": "c700d", + "kaavioType": "Burr", + "strokeWidth": 0, + "type": [ + "Anchor", + "Burr" + ], + "width": 4, + "zIndex": 12288 } }, "pathway": { "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP2431/" + "@base": "WP2431/" } ], "author": "[DMicael, MaintBot, Nsalomonis, Egonw, Ariutta, Mkutmon, Evelo, Zari, Khanspers, Lindarieswijk, DeSl, Eweitz, Susan]", @@ -32186,17 +31615,17 @@ "e5f54", "f543f", "f80b6", - "f1db9", - "daa13", - "f7f65", - "a6aaf", - "eeba9", - "e4f21", - "f6f12", + "a3b9a", + "a6348", + "a6f39", + "a8190", + "d497e", + "ecb59", + "ea41a", "e7eae", "bd4ba", - "ec3f2", - "e66bb", + "dd5ca", + "e357d", "b7444", "c5fa4", "ef575", @@ -32208,7 +31637,7 @@ "ece06", "d3b7f", "aabe3", - "e262b", + "cf7a1", "b5794", "acb58", "f0d38", @@ -32232,7 +31661,7 @@ "f2b3d", "cf66b", "f1e9f", - "c90b4", + "ed63c", "cd722", "e427f", "bf631", @@ -32249,7 +31678,7 @@ "ad026", "fc918", "d1583", - "c038c", + "bc6bc", "cce5a", "f1a3a", "b01b2", @@ -32263,7 +31692,7 @@ "db45c", "a0a29", "b3b8f", - "c6d7f", + "d9720", "f06e8", "acc87", "f3bde", @@ -32271,7 +31700,7 @@ "fa027", "d82e7", "ed64e", - "d1e71", + "f63fd", "ead30", "c15c5", "e5b24", @@ -32281,19 +31710,19 @@ "dbc1c", "d6f0e", "c3d33", - "ad851", + "a63d1", "f0358", "bff03", "d6f90", "d4a70", - "ee321", + "b312b", "ac9de", "d8a90", "c700d", "fc10b", "c4394", - "c3fc0", - "a2f0a", + "c6d8c", + "eeea2", "a7f68", "e9c52", "c5d82", @@ -32306,7 +31735,7 @@ "ba026", "fdbbc", "f0fda", - "a7827", + "fce76", "f6d4b", "ec911", "e218a", @@ -32328,10 +31757,10 @@ "f340a", "bcab9", "cde0e", - "fa603", + "b7af4", "c4d48", "bb029", - "cfe67", + "ff12f", "e84a4", "f5108", "fe741", @@ -32341,7 +31770,7 @@ "c08f9", "ead0d", "c145f", - "f0d8c", + "d7ee9", "ad80a", "a7275", "b2595", @@ -32375,14 +31804,14 @@ "cc9d4", "d58e5", "e85e7", - "c7f7e", - "c7855", + "e3619", + "ec232", "bd355", "c0441", "f18e5", - "dffba", + "e3ed4", "d56ea", - "a47d8", + "a8a79", "id1d0d65d8", "cdcfd", "a10e6", @@ -32467,9 +31896,9 @@ "a25ae", "efe34", "ec451", - "df465" + "d1361" ], - "dataSourceVersion": "WP2431_r120812", + "dataSourceVersion": "WP2431_r130893", "displayName": "Spinal cord injury", "drawAs": "rect", "fill": "white", @@ -32477,9 +31906,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 1014.219600725953, - "id": "http://identifiers.org/wikipathways/WP2431", + "id": "WP2431", "kaavioType": "Group", - "lastModified": "20220111150358", + "lastModified": "20240531002824", "name": "Spinal cord injury", "organism": "Homo sapiens", "padding": 5, @@ -32488,11 +31917,11 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Spinal cord injury\nLast Modified: 20220111150358\nOrganism: Homo sapiens", + "textContent": "Name: Spinal cord injury\nLast Modified: 20240531002824\nOrganism: Homo sapiens", "type": [ "Pathway", - "http://identifiers.org/pw/PW:0000013", - "http://identifiers.org/pw/PW:0000178" + "http://identifiers.org/pw/PW:0000178", + "http://identifiers.org/pw/PW:0000013" ], "verticalAlign": "top", "width": 1791, diff --git a/pathways/WP2431/WP2431.png b/pathways/WP2431/WP2431.png index 582701ecc..62e769c3e 100644 Binary files a/pathways/WP2431/WP2431.png and b/pathways/WP2431/WP2431.png differ diff --git a/pathways/WP2431/WP2431.svg b/pathways/WP2431/WP2431.svg index 304b87a3f..87bc8439b 100644 --- a/pathways/WP2431/WP2431.svg +++ b/pathways/WP2431/WP2431.svg @@ -1,5 +1,5 @@ - + @@ -765,8 +765,8 @@ - - + + @@ -802,9 +802,9 @@ - + - + @@ -832,9 +832,9 @@ - + - + @@ -865,14 +865,14 @@ - + - + - + - + @@ -880,14 +880,14 @@ - + - + - - + + @@ -910,9 +910,9 @@ - + - + @@ -1022,8 +1022,8 @@ C1QB - - + + @@ -1080,8 +1080,8 @@ - - + + @@ -1119,8 +1119,8 @@ - - + + @@ -1164,8 +1164,8 @@ - - + + @@ -1221,8 +1221,8 @@ - - + + @@ -1236,8 +1236,8 @@ - - + + @@ -1251,8 +1251,8 @@ - - + + @@ -1381,8 +1381,8 @@ Time - - + + @@ -1444,8 +1444,8 @@ - - + + @@ -1519,7 +1519,7 @@ MMP12 - + IFNG @@ -1543,8 +1543,8 @@ Swelling/Edema - - + + @@ -1650,7 +1650,7 @@ - + @@ -1691,8 +1691,8 @@ Repair - - + + @@ -1776,15 +1776,15 @@ - - + + Focal Adensions - + EPHA4 @@ -1872,8 +1872,8 @@ CCNG1 - - + + @@ -1928,8 +1928,8 @@ Recruitment - - + + @@ -1995,8 +1995,8 @@ - - + + @@ -2040,8 +2040,8 @@ ECM Breakdown - - + + @@ -2077,8 +2077,8 @@ - - + + @@ -2090,11 +2090,11 @@ - - - + + + - + @@ -2151,8 +2151,8 @@ - - + + @@ -2247,8 +2247,8 @@ - - + + @@ -2298,14 +2298,14 @@ Fillament - + - + - + - + @@ -2392,8 +2392,8 @@ TT - - + + @@ -2513,8 +2513,8 @@ Apoptosis/Necrosis - - + + @@ -2576,8 +2576,8 @@ - - + + @@ -2777,9 +2777,9 @@ - + - + @@ -2794,8 +2794,8 @@ C1Q and Fc receptive cells - - + + @@ -2815,8 +2815,8 @@ - - + + @@ -2857,8 +2857,8 @@ - - + + @@ -2877,8 +2877,8 @@ - - + + @@ -2946,7 +2946,7 @@ - + PTGS2 @@ -2963,9 +2963,9 @@ TT - + - + @@ -2985,7 +2985,7 @@ NOX4 - + MIR23B @@ -2997,9 +2997,9 @@ Olomoucine - + - + @@ -3107,7 +3107,7 @@ Astroctye - + FOXO3 @@ -3244,7 +3244,7 @@ - + EGFR @@ -3262,9 +3262,9 @@ TT - + - + @@ -3290,8 +3290,8 @@ TT - - + + @@ -5031,9 +5031,9 @@ - + Name: Spinal cord injury - Last Modified: 20220111150358 + Last Modified: 20240531002824 Organism: Homo sapiens diff --git a/pathways/WP306/WP306-datanodes.tsv b/pathways/WP306/WP306-datanodes.tsv index fe0048e72..9db68dbf9 100644 --- a/pathways/WP306/WP306-datanodes.tsv +++ b/pathways/WP306/WP306-datanodes.tsv @@ -1,203 +1,203 @@ Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -PIP3 Metabolite hmdb:HMDB0004249 chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N -PIP2 Metabolite chebi:18348 wikidata:Q28797894 chebi:18348;chebi:18348 -PDGFRA GeneProduct ncbigene:5156 ensembl:ENSG00000134853 ncbigene:5156 hgnc.symbol:PDGFRA uniprot:D6RDX0;uniprot:D6RJH0;uniprot:D6RG11;uniprot:D6RIG5;uniprot:P16234 -CAPN2 GeneProduct ensembl:ENSG00000162909 ensembl:ENSG00000162909 ncbigene:824 hgnc.symbol:CAPN2 uniprot:C9JWY7;uniprot:P17655 -RAC1 GeneProduct ncbigene:5879 ensembl:ENSG00000136238 ncbigene:5879 hgnc.symbol:RAC1 uniprot:P63000;uniprot:A4D2P0;uniprot:A4D2P1 -LAMA1 GeneProduct ncbigene:284217 ensembl:ENSG00000101680 ncbigene:284217 hgnc.symbol:LAMA1 uniprot:P25391 -COL1A1 GeneProduct ncbigene:1277 ensembl:ENSG00000108821 ncbigene:1277 hgnc.symbol:COL1A1 uniprot:I3L3H7;uniprot:P02452 -MAPK3 GeneProduct ensembl:ENSG00000102882 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-] ensembl:ENSG00000102882 ncbigene:5595 hgnc.symbol:MAPK3 uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9 -VTN GeneProduct ncbigene:7448 ensembl:ENSG00000109072 ncbigene:7448 hgnc.symbol:VTN uniprot:D9ZGG2;uniprot:P04004;uniprot:F5GX75 -HGF GeneProduct ncbigene:3082 ensembl:ENSG00000019991 ncbigene:3082 hgnc.symbol:HGF uniprot:A0A2R8YEI1;uniprot:C9WSJ4;uniprot:C9WSJ3;uniprot:C9JS80;uniprot:P14210;uniprot:C9JDP4 -SHC3 GeneProduct ncbigene:53358 SHC3; neuronal Sh ensembl:ENSG00000148082 ncbigene:53358 hgnc.symbol:SHC3 uniprot:Q92529;uniprot:Q5T7I8 -THBS3 GeneProduct ncbigene:7059 ensembl:ENSG00000169231 ncbigene:7059 hgnc.symbol:THBS3 uniprot:B4DQH6;uniprot:Q2HIZ1;uniprot:F5H4Z8;uniprot:P49746 -PIK3R1 GeneProduct ncbigene:5295 ensembl:ENSG00000145675 ncbigene:5295 hgnc.symbol:PIK3R1 uniprot:P27986;uniprot:A0A2X0SFG1;uniprot:E5RGI8;uniprot:H0YBC2;uniprot:H0YB27;uniprot:E5RK66;uniprot:E5RJY0;uniprot:B3KWZ7;uniprot:E5RHI0 -FGR GeneProduct ncbigene:2268 ensembl:ENSG00000000938 ncbigene:2268 hgnc.symbol:FGR uniprot:P09769;uniprot:Q5TGY6 -BRAF GeneProduct ncbigene:673 ensembl:ENSG00000157764 ncbigene:673 hgnc.symbol:BRAF uniprot:A0A2R8Y492;uniprot:A0A2R8Y8E0;uniprot:H7C4S5;uniprot:A0A2R8Y467;uniprot:A0A2R8YES9;uniprot:H7C560;uniprot:A0A2U3TZI2;uniprot:P15056;uniprot:A0A2R8YDP5;uniprot:H7C5K3;uniprot:A0A2R8Y679 -ITGB6 GeneProduct ncbigene:3694 ensembl:ENSG00000115221 ncbigene:3694 hgnc.symbol:ITGB6 uniprot:E9PEE8;uniprot:A0A087WXP3;uniprot:P18564;uniprot:F8WBJ8 -ITGA10 GeneProduct ncbigene:8515 ensembl:ENSG00000143127 ncbigene:8515 hgnc.symbol:ITGA10 uniprot:O75578 -COL4A4 GeneProduct ncbigene:1286 ensembl:ENSG00000081052 ncbigene:1286 hgnc.symbol:COL4A4 uniprot:A0A804HLF6;uniprot:A0A804HI86;uniprot:A0A804HI71;uniprot:P53420;uniprot:A0A2R8Y548 -THBS1 GeneProduct ncbigene:7057 ensembl:ENSG00000137801 ncbigene:7057 hgnc.symbol:THBS1 uniprot:A8MZG1;uniprot:P07996 -ILK GeneProduct ncbigene:3611 ILK; integrin-linked kinase [EC:2.7.1.-] ensembl:ENSG00000166333 ncbigene:3611 hgnc.symbol:ILK uniprot:Q13418;uniprot:V9HWF0;uniprot:A0A0A0MTH3;uniprot:A0A087WWY6;uniprot:E9PQ52;uniprot:A0A087WW45 -CCND2 GeneProduct ncbigene:894 ensembl:ENSG00000118971 ncbigene:894 hgnc.symbol:CCND2 uniprot:A0A6Q8PGZ3;uniprot:P30279 -THBS4 GeneProduct ncbigene:7060 ensembl:ENSG00000113296 ncbigene:7060 hgnc.symbol:THBS4 uniprot:E7ES19;uniprot:P35443 -LAMA2 GeneProduct ncbigene:3908 ensembl:ENSG00000196569 ncbigene:3908 hgnc.symbol:LAMA2 uniprot:P24043;uniprot:A0A087WX80;uniprot:A0A087WYF1 -TNR GeneProduct ncbigene:7143 ensembl:ENSG00000116147 ncbigene:7143 hgnc.symbol:TNR uniprot:H0Y668;uniprot:Q92752 -ITGB8 GeneProduct ncbigene:3696 ensembl:ENSG00000105855 ncbigene:3696 hgnc.symbol:ITGB8 uniprot:P26012 -ROCK1 GeneProduct ncbigene:6093 ensembl:ENSG00000067900 ncbigene:6093 hgnc.symbol:ROCK1 uniprot:J3KRH6;uniprot:Q13464;uniprot:A0A0U1RQV4 -ITGA6 GeneProduct ncbigene:3655 ensembl:ENSG00000091409 ncbigene:3655 hgnc.symbol:ITGA6 uniprot:H7BZ97;uniprot:P23229;uniprot:A0A8C8KBL6;uniprot:C9JXX7 -FYN GeneProduct ncbigene:2534 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112] ensembl:ENSG00000010810 ncbigene:2534 hgnc.symbol:FYN uniprot:E5RHF7;uniprot:E5RFM4;uniprot:E5RI25;uniprot:E5RK23;uniprot:P06241;uniprot:E5RFM6;uniprot:E5RGM6;uniprot:E5RIX5;uniprot:E5RGT0;uniprot:E5RFM0;uniprot:E5RJX7;uniprot:E5RHX7;uniprot:E5RFS5;uniprot:E5RH71 -PPP1R12A GeneProduct ncbigene:4659 ensembl:ENSG00000058272 ncbigene:4659 hgnc.symbol:PPP1R12A uniprot:A0A3B3ISH4;uniprot:H0YIM2;uniprot:H0YIS4;uniprot:A0A0U1RQZ1;uniprot:H0YHI8;uniprot:H0YIS3;uniprot:F8VW28;uniprot:F8VZN8;uniprot:H0YHL8;uniprot:H0YIL7;uniprot:O14974 -TNK2 GeneProduct ncbigene:10188 ensembl:ENSG00000061938 ncbigene:10188 hgnc.symbol:TNK2 uniprot:A0A5F9ZHK8;uniprot:A0A5F9ZHB0;uniprot:A0A5F9ZHI7;uniprot:A0A5F9ZHC7;uniprot:Q07912;uniprot:A0A5F9ZHJ2;uniprot:A0A5F9ZHL4;uniprot:A0A5F9ZI29;uniprot:A0A5F9ZHD0;uniprot:A0A499FJ16;uniprot:A0A5F9ZHP9;uniprot:A0A5F9ZH66;uniprot:A0A5F9ZHQ1;uniprot:A0A5F9ZHX6;uniprot:A0A5F9ZHP4;uniprot:A0A5F9ZH01;uniprot:A0A5F9ZI44;uniprot:C9J1X3;uniprot:A0A5F9ZGY5;uniprot:A0A5F9ZGX5 -VAV1 GeneProduct ncbigene:7409 ensembl:ENSG00000141968 ncbigene:7409 hgnc.symbol:VAV1 uniprot:Q96D37;uniprot:P15498;uniprot:F5H5P4;uniprot:A0A0A0MR07 -ELK1 GeneProduct ncbigene:2002 ensembl:ENSG00000126767 ncbigene:2002 hgnc.symbol:ELK1 uniprot:P19419;uniprot:A0A024R1A7 -PDGFD GeneProduct ncbigene:80310 ensembl:ENSG00000170962 ncbigene:80310 hgnc.symbol:PDGFD uniprot:Q9GZP0;uniprot:H0YD37 -VEGF GeneProduct ncbigene:7422 ensembl:ENSG00000112715 ncbigene:7422 hgnc.symbol:VEGFA uniprot:A0A0A0MTB2;uniprot:A0A0A0MSI7;uniprot:A0A0Y0IMM4;uniprot:A0A0A0MSH7;uniprot:H3BLW8;uniprot:A0A024RD33;uniprot:A0A0A0MSH5;uniprot:J3KPA4;uniprot:A0A024RD37;uniprot:A0A0A0MRQ4;uniprot:A0A5F9ZH41;uniprot:H0YBI8;uniprot:A2A2V4;uniprot:A0A0A0MR43;uniprot:P15692;uniprot:H0YBZ0 -MET GeneProduct ncbigene:4233 ensembl:ENSG00000105976 ncbigene:4233 hgnc.symbol:MET uniprot:A0A024R759;uniprot:P08581;uniprot:A0A024R728;uniprot:C9JKM5;uniprot:H7C130;uniprot:H7C174 -KDR GeneProduct ncbigene:3791 ensembl:ENSG00000128052 ncbigene:3791 hgnc.symbol:KDR uniprot:P35968 -CRK GeneProduct ncbigene:1398 ensembl:ENSG00000167193 ncbigene:1398 hgnc.symbol:CRK uniprot:L7RT18;uniprot:A0A0S2Z3Q4;uniprot:P46108;uniprot:I3L297;uniprot:A0A0S2Z3K9 -CTNNB1 GeneProduct ncbigene:1499 ensembl:ENSG00000168036 ncbigene:1499 hgnc.symbol:CTNNB1 uniprot:A0A2R8Y6G0;uniprot:A0A2R8Y804;uniprot:A0A2R8Y815;uniprot:A0A2R8Y5A3;uniprot:C9IZ65;uniprot:A0A2R8Y5C3;uniprot:P35222;uniprot:A0A2R8Y7Z0;uniprot:A0A2R8YG06;uniprot:A0A2R8Y5Z1;uniprot:A0A2R8Y750;uniprot:A0A2R8YCH5;uniprot:A0A024R2Q3;uniprot:A0A2R8Y543;uniprot:B4DGU4 -ITGA2 GeneProduct ncbigene:3673 ensembl:ENSG00000164171 ncbigene:3673 hgnc.symbol:ITGA2 uniprot:D6RG08;uniprot:D6R9H3;uniprot:E7ESP4;uniprot:E7EMF1;uniprot:E9PB77;uniprot:P17301 -RELN GeneProduct ncbigene:5649 ensembl:ENSG00000189056 ncbigene:5649 hgnc.symbol:RELN uniprot:A0A7P0TA83;uniprot:J3KQ66;uniprot:P78509;uniprot:H7C2B0 -ITGA5 GeneProduct ncbigene:3678 ensembl:ENSG00000161638 ncbigene:3678 hgnc.symbol:ITGA5 uniprot:B4E3F4;uniprot:P08648;uniprot:H0YIV7;uniprot:H0YHL9 -MAPK8 GeneProduct ncbigene:5599 ensembl:ENSG00000107643 ncbigene:5599 hgnc.symbol:MAPK8 uniprot:C9J762;uniprot:C9JWQ4;uniprot:A0A3B3IRW7;uniprot:A1L4K2;uniprot:P45983 -PAK3 GeneProduct ncbigene:5063 ensembl:ENSG00000077264 ncbigene:5063 hgnc.symbol:PAK3 uniprot:B1AKS5;uniprot:O75914 -PARVB GeneProduct ncbigene:29780 ensembl:ENSG00000188677 ncbigene:29780 hgnc.symbol:PARVB uniprot:A0A087WZB5;uniprot:B0QYP8;uniprot:Q9HBI1 -ZYX GeneProduct ncbigene:7791 ZYX; zyxin ensembl:ENSG00000159840 ncbigene:7791 hgnc.symbol:ZYX uniprot:C9JJK5;uniprot:H0Y2Y8;uniprot:Q15942;uniprot:H7C3R3;uniprot:H7C3D3;uniprot:C9IZ41 -IBSP GeneProduct ncbigene:3381 ensembl:ENSG00000029559 ncbigene:3381 hgnc.symbol:IBSP uniprot:P21815 -SPP1 GeneProduct ncbigene:6696 ensembl:ENSG00000118785 ncbigene:6696 hgnc.symbol:SPP1 uniprot:A0A804HLB3;uniprot:A0A024RDE2;uniprot:Q3LGB0;uniprot:A0A024RDE6;uniprot:A0A024RDJ0;uniprot:P10451 -COL6A2 GeneProduct ncbigene:1292 ensembl:ENSG00000142173 ncbigene:1292 hgnc.symbol:COL6A2 uniprot:A0A384MDP3;uniprot:H7C0M5;uniprot:C9JH44;uniprot:P12110 -PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 ensembl:ENSG00000169398 ncbigene:5747 hgnc.symbol:PTK2 uniprot:E5RJN1;uniprot:H0YB16;uniprot:E5RIR5;uniprot:H0YBP1;uniprot:E7ESA6;uniprot:H0YB33;uniprot:H0YB99;uniprot:E5RG54;uniprot:A0A1D5RMT1;uniprot:E5RI72;uniprot:E5RJP0;uniprot:E5RGP1;uniprot:H0YBZ1;uniprot:E5RGA6;uniprot:E5RJI4;uniprot:H0YAS0;uniprot:Q05397;uniprot:E5RHK7;uniprot:E5RII9;uniprot:E9PEI4;uniprot:E5RJQ2;uniprot:E5RH48;uniprot:E5RI03;uniprot:E5RIK4;uniprot:E5RH08;uniprot:E5RI29;uniprot:E5RG86;uniprot:B4DWJ1;uniprot:E5RH01;uniprot:E5RG66;uniprot:E5RFW9;uniprot:E5RHD8;uniprot:E5RG80 -JUN GeneProduct ncbigene:3725 ensembl:ENSG00000177606 ncbigene:3725 hgnc.symbol:JUN uniprot:P05412 -PAK6 GeneProduct ncbigene:56924 ensembl:ENSG00000137843 ncbigene:106821730;ncbigene:56924 hgnc.symbol:PAK6 uniprot:H0YKB6;uniprot:H0YL47;uniprot:A0A024R9Q4;uniprot:H0YL02;uniprot:H0YMS4;uniprot:H0YL16;uniprot:H0YK38;uniprot:H0YLZ9;uniprot:H0YM99;uniprot:Q9NQU5;uniprot:H0YK74;uniprot:H0YK91 -ITGAV GeneProduct ncbigene:3685 ensembl:ENSG00000138448 ncbigene:3685 hgnc.symbol:ITGAV uniprot:P06756;uniprot:H7BZG1;uniprot:L7RXH0 -ITGB1 GeneProduct ncbigene:3688 ensembl:ENSG00000150093 ncbigene:3688 hgnc.symbol:ITGB1 uniprot:H7C4K3;uniprot:P05556;uniprot:A0A7I2V2F9;uniprot:E7EUI6;uniprot:C9JPK5;uniprot:C9JNE0;uniprot:E9PLR6;uniprot:Q5T3E4;uniprot:Q5T3E6;uniprot:Q5T3E5;uniprot:A0A7I2V2T4;uniprot:A0A7I2V5T3;uniprot:E7EQW5;uniprot:A0A7I2V5Z8;uniprot:E9PQJ2;uniprot:A0A7I2V348;uniprot:H7C4N8 -LAMA5 GeneProduct ncbigene:3911 ensembl:ENSG00000130702 ncbigene:3911 hgnc.symbol:LAMA5 uniprot:O15230;uniprot:H7C5J6;uniprot:A0A087WYH7 -ITGA4 GeneProduct ncbigene:3676 ensembl:ENSG00000115232 ncbigene:3676 hgnc.symbol:ITGA4 uniprot:P13612;uniprot:E7EP60 -RAF1 GeneProduct ncbigene:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-] ensembl:ENSG00000132155 ncbigene:5894 hgnc.symbol:RAF1 uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6 -BUB1B-PAK6 GeneProduct ensembl:ENSG00000259288 ensembl:ENSG00000259288 hgnc.symbol:BUB1B-PAK6 uniprot:H3BTB9 -ITGA2B GeneProduct ncbigene:3674 ensembl:ENSG00000005961 ncbigene:3674 hgnc.symbol:ITGA2B uniprot:K7EP83;uniprot:A0A3B3IU79;uniprot:P08514 -MAP2K1 GeneProduct ncbigene:5604 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-] ensembl:ENSG00000169032 ncbigene:5604 hgnc.symbol:MAP2K1 uniprot:B4DFY5;uniprot:H3BRW9;uniprot:A4QPA9;uniprot:Q02750 -LAMB1 GeneProduct ncbigene:3912 ensembl:ENSG00000091136 ncbigene:3912 hgnc.symbol:LAMB1 uniprot:E9PCS6;uniprot:A0A7I2V4J9;uniprot:C9J296;uniprot:E7EPA6;uniprot:P07942;uniprot:A0A7I2V682;uniprot:G3XAI2;uniprot:A0A7I2V2R2;uniprot:A0A7I2V5X5;uniprot:A0A7I2V378;uniprot:A0A7I2V5R0;uniprot:A0A7I2V2J0;uniprot:A0A7I2V2T9;uniprot:A0A7I2V5T9;uniprot:A0A7I2V407;uniprot:A0A7I2V3J7;uniprot:A0A7I2V3I5 -FIGF GeneProduct ncbigene:2277 ensembl:ENSG00000165197 ncbigene:2277 hgnc.symbol:VEGFD uniprot:O43915 -FLT1 GeneProduct ncbigene:2321 ensembl:ENSG00000102755 ncbigene:2321 hgnc.symbol:FLT1 uniprot:A0A1W2PNW4;uniprot:H9N1E8;uniprot:H9N1E7;uniprot:L7RSL3;uniprot:P17948 -PDPK1 GeneProduct ncbigene:5170 ensembl:ENSG00000140992 ncbigene:5170 hgnc.symbol:PDPK1 uniprot:O15530;uniprot:H3BQ10;uniprot:E9PER6;uniprot:H3BPR5;uniprot:H3BQA3;uniprot:H3BNV5;uniprot:H3BPW1 -ERBB2 GeneProduct ncbigene:2064 ensembl:ENSG00000141736 ncbigene:2064 hgnc.symbol:ERBB2 uniprot:J3QL83;uniprot:J3QLV2;uniprot:J3KRI9;uniprot:F5H1T4;uniprot:J3KTI5;uniprot:P04626;uniprot:X5DNK3;uniprot:J3QRJ7;uniprot:J3QLU9;uniprot:J3QRX1;uniprot:B4DTR1 -EGF GeneProduct ncbigene:1950 ensembl:ENSG00000138798 ncbigene:1950 hgnc.symbol:EGF uniprot:A0A494C018;uniprot:P01133 -CAV1 GeneProduct ncbigene:857 CAV1; caveolin 1 caveolae protein 22kD ensembl:ENSG00000105974 ncbigene:857 hgnc.symbol:CAV1 uniprot:Q2TNI1;uniprot:Q03135;uniprot:F8WDM7;uniprot:C9JKI3;uniprot:A0A024R757;uniprot:A0A7P0YWJ6;uniprot:E9PCT5 -MYLK GeneProduct ncbigene:4638 ensembl:ENSG00000065534 ncbigene:4638 hgnc.symbol:MYLK uniprot:F8WBL7;uniprot:Q15746;uniprot:D6R9C2 -CAV3 GeneProduct ncbigene:859 CAV3; caveolin 3 ensembl:ENSG00000182533 ncbigene:859 hgnc.symbol:CAV3 uniprot:P56539 -MAPK1 GeneProduct ncbigene:5594 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-] ensembl:ENSG00000100030 ncbigene:5594 hgnc.symbol:MAPK1 uniprot:P28482;uniprot:Q1HBJ4 -CHAD GeneProduct ncbigene:1101 ensembl:ENSG00000136457 ncbigene:1101 hgnc.symbol:CHAD uniprot:O15335;uniprot:H0YA03 -BCL2 GeneProduct ncbigene:596 ensembl:ENSG00000171791 ncbigene:596 hgnc.symbol:BCL2 uniprot:A0A7I2V3S7;uniprot:P10415;uniprot:A0A024R2B3;uniprot:A0A024R2C4;uniprot:A0A7I2V5Q7;uniprot:A0A7I2V4W1;uniprot:A0A7I2V5Q9 -COMP GeneProduct ncbigene:1311 ensembl:ENSG00000105664 ncbigene:1311 hgnc.symbol:COMP uniprot:G3XAP6;uniprot:P49747 -EMP2 GeneProduct ncbigene:2013 ensembl:ENSG00000213853 ncbigene:2013 hgnc.symbol:EMP2 uniprot:P54851 -TNC GeneProduct ncbigene:3371 ensembl:ENSG00000041982 ncbigene:3371 hgnc.symbol:TNC uniprot:F5H7V9;uniprot:H0YGZ3;uniprot:J3QSU6;uniprot:A0A0U1RR80;uniprot:E9PC84;uniprot:P24821;uniprot:F5H5D6 -LAMC3 GeneProduct ncbigene:10319 ensembl:ENSG00000050555 ncbigene:10319 hgnc.symbol:LAMC3 uniprot:A0A7I2V3S4;uniprot:A0A7I2YQP4;uniprot:Q9Y6N6;uniprot:H7BY04 -CRKL GeneProduct ensembl:ENSG00000099942 ensembl:ENSG00000099942 ncbigene:1399 hgnc.symbol:CRKL uniprot:P46109 -SHC1 GeneProduct ncbigene:6464 SHC1; SHC (Src homology 2 domain containing) transforming protein 1 ensembl:ENSG00000160691 ncbigene:6464 hgnc.symbol:SHC1 uniprot:X6R6D0;uniprot:Q5T187;uniprot:H0Y539;uniprot:Q5T181;uniprot:Q5T182;uniprot:P29353;uniprot:Q5T188 -LAMB2 GeneProduct ncbigene:3913 ensembl:ENSG00000172037 ncbigene:3913 hgnc.symbol:LAMB2 uniprot:P55268;uniprot:F5H520 -PIK3R3 GeneProduct ensembl:ENSG00000117461 ensembl:ENSG00000117461 ncbigene:8503 hgnc.symbol:PIK3R3 uniprot:Q5T4P3;uniprot:Q92569 -CDC42 GeneProduct ncbigene:998 ensembl:ENSG00000070831 ncbigene:998 hgnc.symbol:CDC42 uniprot:A0A3B3IRV0;uniprot:A0A494C1M1;uniprot:Q5JYX0;uniprot:A0A024RAE6;uniprot:A0A590UJK8;uniprot:A0A024RAA5;uniprot:P60953;uniprot:A0A494BZX6 -RAP1B GeneProduct ncbigene:5908 RAP1B; RAP1B member of RAS oncogene family ensembl:ENSG00000127314 ncbigene:5908 hgnc.symbol:RAP1B uniprot:F5H4H0;uniprot:F5GWU8;uniprot:F5H6R7;uniprot:A0A024RB87;uniprot:F5H004;uniprot:F5H7Y6;uniprot:F5GX62;uniprot:F5H500;uniprot:F8WBC0;uniprot:F5H823;uniprot:P61224;uniprot:F5H491;uniprot:F5GYB5;uniprot:E7ESV4;uniprot:F5H077;uniprot:F5H0S2;uniprot:F5GZG1;uniprot:F5H0B7;uniprot:F5GYH7;uniprot:B7ZB78 -PTEN GeneProduct ncbigene:5728 ensembl:ENSG00000171862 ncbigene:5728 hgnc.symbol:PTEN uniprot:P60484;uniprot:A0A087X033;uniprot:F6KD01 -LAMA3 GeneProduct ncbigene:3909 ensembl:ENSG00000053747 ncbigene:3909 hgnc.symbol:LAMA3 uniprot:A0A3B3ITG1;uniprot:K7EMU9;uniprot:A0A0A0MTS5;uniprot:K7EQ42;uniprot:K7EIP4;uniprot:A0A0A0MSA0;uniprot:Q16787;uniprot:A0A075B783;uniprot:K7ERM0;uniprot:A0A0A6YYF2;uniprot:K7EPP3 -ACTB GeneProduct ncbigene:60 ensembl:ENSG00000075624 ncbigene:60 hgnc.symbol:ACTB uniprot:C9JTX5;uniprot:P60709;uniprot:A0A6Q8PFE4;uniprot:Q1KLZ0;uniprot:C9JUM1;uniprot:A0A6Q8PGD7;uniprot:A0A2R8YFE2;uniprot:A0A2R8Y793;uniprot:C9JZR7;uniprot:G5E9R0;uniprot:A0A2R8YEA7;uniprot:E7EVS6;uniprot:A0A2R8YGF8;uniprot:A0A6Q8PH58 -GRB2 GeneProduct ncbigene:2885 GRB2; growth factor receptor-bound protein 2 ensembl:ENSG00000177885 ncbigene:2885 hgnc.symbol:GRB2 uniprot:P62993;uniprot:B0LPF3;uniprot:J3QRL5;uniprot:J3KT38;uniprot:J3QLF6 -ITGA9 GeneProduct ncbigene:3680 ensembl:ENSG00000144668 ncbigene:3680 hgnc.symbol:ITGA9 uniprot:H7C2L1;uniprot:Q13797;uniprot:E9PDS3 -COL4A2 GeneProduct ncbigene:1284 ensembl:ENSG00000134871 ncbigene:1284 hgnc.symbol:COL4A2 uniprot:A0A3B3IRV2;uniprot:A0A3B3IT80;uniprot:P08572;uniprot:A0A3B3ITN7;uniprot:A2A352;uniprot:A0A3B3ITQ8;uniprot:A0A087WY39;uniprot:A0A3B3IS47;uniprot:A0A3B3IS04;uniprot:A0A024RDW8 -PAK4 GeneProduct ncbigene:10298 ensembl:ENSG00000130669 ncbigene:10298 hgnc.symbol:PAK4 uniprot:M0R3G6;uniprot:A0A024R0L8;uniprot:M0R1R1;uniprot:O96013;uniprot:A0A024R0J1;uniprot:M0R2X4;uniprot:M0R0L9 -CCND1 GeneProduct ncbigene:595 ensembl:ENSG00000110092 ncbigene:595 hgnc.symbol:CCND1 uniprot:P24385;uniprot:Q6FI00;uniprot:F5H437 -TXK GeneProduct ncbigene:7294 ensembl:ENSG00000074966 ncbigene:7294 hgnc.symbol:TXK uniprot:D6RBM7;uniprot:D6RA14;uniprot:P42681;uniprot:D6R9F2;uniprot:E7EQN8 -RAC3 GeneProduct ncbigene:5881 ensembl:ENSG00000169750 ncbigene:5881 hgnc.symbol:RAC3 uniprot:J3QLK0;uniprot:J3KSC4;uniprot:P60763 -TESK2 GeneProduct ncbigene:10420 ensembl:ENSG00000070759 ncbigene:10420 hgnc.symbol:TESK2 uniprot:Q96S53 -SRMS GeneProduct ncbigene:6725 ensembl:ENSG00000125508 ncbigene:6725 hgnc.symbol:SRMS uniprot:Q9H3Y6 -COL1A2 GeneProduct ncbigene:1278 ensembl:ENSG00000164692 ncbigene:1278 hgnc.symbol:COL1A2 uniprot:P08123;uniprot:A0A0S2Z3H5 -MAPK9 GeneProduct ncbigene:5601 ensembl:ENSG00000050748 ncbigene:5601 hgnc.symbol:MAPK9 uniprot:D7R525;uniprot:D7R528;uniprot:J3KNK1;uniprot:E5RJ57;uniprot:P45984 -ITGA8 GeneProduct ncbigene:8516 ensembl:ENSG00000077943 ncbigene:8516 hgnc.symbol:ITGA8 uniprot:P53708 -VEGFB GeneProduct ncbigene:7423 ensembl:ENSG00000173511 ncbigene:7423 hgnc.symbol:VEGFB uniprot:H0YGB6;uniprot:Q7LAP4;uniprot:P49765 -AKT2 GeneProduct ncbigene:208 ensembl:ENSG00000105221 ncbigene:208 hgnc.symbol:AKT2 uniprot:M0QZK3;uniprot:J3QKW1;uniprot:A0A5F9ZHJ8;uniprot:E7EVP8;uniprot:J3KRI8;uniprot:C9JIJ1;uniprot:J3QLS6;uniprot:A8MX96;uniprot:C9JIF6;uniprot:A0A0A0MRF1;uniprot:J3QL45;uniprot:M0R0P9;uniprot:C9J258;uniprot:M0QZW8;uniprot:J3KTC6;uniprot:A0A1B0GXA2;uniprot:M0R275;uniprot:C9JC83;uniprot:J3KSY8;uniprot:J3KT31;uniprot:P31751;uniprot:C9JHS6;uniprot:J3KTP4;uniprot:M0R283 -COL5A3 GeneProduct ncbigene:50509 ensembl:ENSG00000080573 ncbigene:50509 hgnc.symbol:COL5A3 uniprot:P25940 -PDGFRB GeneProduct ncbigene:5159 ensembl:ENSG00000113721 ncbigene:5159 hgnc.symbol:PDGFRB uniprot:P09619;uniprot:E5RH16;uniprot:E5RJ14;uniprot:E5RII0 -VASP GeneProduct ncbigene:7408 VASP; vasodilator-stimulated phosphoprotein ensembl:ENSG00000125753 ncbigene:7408 hgnc.symbol:VASP uniprot:A0A024R0V4;uniprot:K7EIG8;uniprot:K7EQD0;uniprot:K7ENL7;uniprot:K7EM16;uniprot:P50552;uniprot:K7ENR7 -SOS1 GeneProduct ncbigene:6654 SOS1; son of sevenless homolog 1 (Drosophila) ensembl:ENSG00000115904 ncbigene:6654 hgnc.symbol:SOS1 uniprot:G5E9C8;uniprot:Q07889;uniprot:C9K0N6 -LAMA4 GeneProduct ncbigene:3910 ensembl:ENSG00000112769 ncbigene:3910 hgnc.symbol:LAMA4 uniprot:E5RHF3;uniprot:A0A0A0MTC7;uniprot:E5RFD7;uniprot:E5RK79;uniprot:Q6LET9;uniprot:A0A494C1K8;uniprot:A0A494C139;uniprot:H0YAQ5;uniprot:Q16363;uniprot:A0A0A0MQS9;uniprot:H0Y351;uniprot:H0YAP9;uniprot:E5RFQ2 -ARHGAP5 GeneProduct ncbigene:394 ensembl:ENSG00000100852 ncbigene:394 hgnc.symbol:ARHGAP5 uniprot:H0YK04;uniprot:G3V360;uniprot:Q13017;uniprot:G3V444;uniprot:G3V5I7 -COL2A1 GeneProduct ncbigene:1280 ensembl:ENSG00000139219 ncbigene:1280 hgnc.symbol:COL2A1 uniprot:P02458 -LAMB3 GeneProduct ncbigene:3914 ensembl:ENSG00000196878 ncbigene:3914 hgnc.symbol:LAMB3 uniprot:A0A0S2Z3R6;uniprot:Q13751;uniprot:X1WI29;uniprot:Q5THA1 -RAP1A GeneProduct ncbigene:5906 RAP1A; RAP1A member of RAS oncogene family ensembl:ENSG00000116473 ncbigene:5906 hgnc.symbol:RAP1A uniprot:A8KAH9;uniprot:P62834 -TNK1 GeneProduct ncbigene:8711 ensembl:ENSG00000174292 ncbigene:8711 hgnc.symbol:TNK1 uniprot:I3L334;uniprot:U3KPR9;uniprot:Q13470 -COL5A2 GeneProduct ncbigene:1290 ensembl:ENSG00000204262 ncbigene:1290 hgnc.symbol:COL5A2 uniprot:P05997;uniprot:A0A087WYX9;uniprot:A0A3B3IRH9 -DOCK1 GeneProduct ncbigene:1793 DOCK1; dedicator of cyto-kinesis ensembl:ENSG00000150760 ncbigene:1793 hgnc.symbol:DOCK1 uniprot:A0A096LNH6;uniprot:Q14185 -ITGB7 GeneProduct ncbigene:3695 ensembl:ENSG00000139626 ncbigene:3695 hgnc.symbol:ITGB7 uniprot:H3BRM2;uniprot:F8VNX4;uniprot:F8W186;uniprot:P26010;uniprot:H3BRX4;uniprot:F5H6T4 -COL4A6 GeneProduct ncbigene:1288 ensembl:ENSG00000197565 ncbigene:1288 hgnc.symbol:COL4A6 uniprot:A0A087WZY5;uniprot:A8MXH5;uniprot:F5H3Q5;uniprot:Q14031 -XIAP GeneProduct ensembl:ENSG00000101966 ensembl:ENSG00000101966 ncbigene:331 hgnc.symbol:XIAP uniprot:B1AKU2;uniprot:B1AKU3;uniprot:P98170 -PIK3R2 GeneProduct ncbigene:5296 ensembl:ENSG00000105647 ncbigene:5296 hgnc.symbol:PIK3R2 uniprot:E9PFP1;uniprot:O00459;uniprot:A0A7I2U3A3;uniprot:V9GYJ4;uniprot:A0A087X257;uniprot:A0A5F9ZHY3 -THBS2 GeneProduct ncbigene:7058 ensembl:ENSG00000186340 ncbigene:7058 hgnc.symbol:THBS2 uniprot:A0A7I2V585;uniprot:P35442;uniprot:A0A7I2V344;uniprot:Q5RI53;uniprot:A0A3B3ITK0;uniprot:A0A7I2YQ86;uniprot:A0A7I2YQT6 -HCK GeneProduct ncbigene:3055 ensembl:ENSG00000101336 ncbigene:3055 hgnc.symbol:HCK uniprot:J3KPD6;uniprot:H7BXG4;uniprot:H0Y3C5;uniprot:P08631;uniprot:H7C5P9 -IGF1 GeneProduct ncbigene:3479 ensembl:ENSG00000017427 ncbigene:3479 hgnc.symbol:IGF1 uniprot:P05019;uniprot:Q5U743 -FLNA GeneProduct ncbigene:2316 ensembl:ENSG00000196924 ncbigene:2316 hgnc.symbol:FLNA uniprot:Q60FE5;uniprot:A0A7I2V3E6;uniprot:A0A087WWY3;uniprot:A0A669KBC6;uniprot:A0A7P0NMY4;uniprot:H7C2E7;uniprot:H0Y5C6;uniprot:F8WE98;uniprot:H0Y5F3;uniprot:P21333 -GSK3B GeneProduct ncbigene:2932 ensembl:ENSG00000082701 ncbigene:2932 hgnc.symbol:GSK3B uniprot:A0A3B3ITW1;uniprot:A0A7I2V4F3;uniprot:A0A7I2YQ81;uniprot:A0A7I2V5B5;uniprot:A0A7I2V3D8;uniprot:A0A7I2V2Y0;uniprot:A0A7I2YQU1;uniprot:A0A7I2YQK0;uniprot:A0A7I2V2U4;uniprot:A0A7I2V441;uniprot:A0A7I2V4W7;uniprot:A0A7I2V589;uniprot:A0A7I2V3S5;uniprot:A0A7I2YQK2;uniprot:A0A7I2V5M2;uniprot:A0A7I2V626;uniprot:A0A7I2V606;uniprot:A0A7I2V2I5;uniprot:A0A7I2V2K7;uniprot:A0A7I2V3K8;uniprot:A0A7I2YQG6;uniprot:A0A7I2V4G2;uniprot:P49841;uniprot:A0A7I2V5G5;uniprot:A0A7I2V5K9;uniprot:A0A7I2V3A4;uniprot:A0A7I2V3G9;uniprot:Q6FI27;uniprot:A0A7I2V3Z5;uniprot:A0A7I2V4X2;uniprot:A0A7I2V2T2;uniprot:A0A7I2V2V4;uniprot:A0A7I2V4X3;uniprot:A0A7I2V3T3;uniprot:A0A7I2V675;uniprot:A0A7I2V432;uniprot:A0A7I2V2N4;uniprot:A0A7I2V5P4;uniprot:A0A7I2YQB0;uniprot:A0A7I2V3N7;uniprot:A0A7I2V3J4 -BLK GeneProduct ncbigene:640 ensembl:ENSG00000136573 ncbigene:640 hgnc.symbol:BLK uniprot:E9PJX5;uniprot:P51451 -LAMC1 GeneProduct ncbigene:3915 ensembl:ENSG00000135862 ncbigene:3915 hgnc.symbol:LAMC1 uniprot:P11047;uniprot:R4GNC7 -FN1 GeneProduct ncbigene:2335 ensembl:ENSG00000115414 ncbigene:2335 hgnc.symbol:FN1 uniprot:H0Y7Z1;uniprot:H0Y4K8;uniprot:P02751 -LAMC2 GeneProduct ncbigene:3918 ensembl:ENSG00000058085 ncbigene:3918 hgnc.symbol:LAMC2 uniprot:Q13753 -PGF GeneProduct ncbigene:5228 ensembl:ENSG00000119630 ncbigene:5228 hgnc.symbol:PGF uniprot:P49763;uniprot:G3XA84;uniprot:Q53XY6 -ITGA3 GeneProduct ncbigene:3675 ensembl:ENSG00000005884 ncbigene:3675 hgnc.symbol:ITGA3 uniprot:P26006;uniprot:A0A140VJM0;uniprot:D6R9X8;uniprot:H0YA32;uniprot:K7EMU3;uniprot:H0YA49;uniprot:K7EQJ2 -PIK3CA GeneProduct ncbigene:5290 ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336 -TNN GeneProduct ncbigene:63923 ensembl:ENSG00000120332 ncbigene:63923 hgnc.symbol:TNN uniprot:Q9UQP3;uniprot:A0A087WXC4 -BIRC3 GeneProduct ncbigene:330 ensembl:ENSG00000023445 ncbigene:330 hgnc.symbol:BIRC3 uniprot:H0YCJ5;uniprot:Q13489;uniprot:A0A669KBC7 -CCND3 GeneProduct ncbigene:896 ensembl:ENSG00000112576 ncbigene:896 hgnc.symbol:CCND3 uniprot:H0Y8M4;uniprot:D6RDL3;uniprot:A0A1D5RMS0;uniprot:D6RI00;uniprot:Q5T8J1;uniprot:P30281;uniprot:D6RIX2;uniprot:D6RDF8 -BIRC2 GeneProduct ncbigene:329 ensembl:ENSG00000110330 ncbigene:329 hgnc.symbol:BIRC2 uniprot:E9PNM6;uniprot:H0YDY3;uniprot:Q13490;uniprot:E9PI77;uniprot:E9PMH5;uniprot:E9PQZ9;uniprot:E9PIW1 -AKT1 GeneProduct ncbigene:207 ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56 -TNXB GeneProduct ncbigene:7148 ensembl:ENSG00000168477 ncbigene:7148 hgnc.symbol:TNXB uniprot:A0A087WWA5;uniprot:A0A1B0GX77;uniprot:C9J7W4;uniprot:A0A087X0I0;uniprot:A0A3B3ISX9;uniprot:P22105 -PAK1 GeneProduct ncbigene:5058 ensembl:ENSG00000149269 ncbigene:5058 hgnc.symbol:PAK1 uniprot:E9PRP6;uniprot:H0YCG5;uniprot:E9PJF8;uniprot:E9PKH9;uniprot:B3KNX7;uniprot:E9PMP2;uniprot:E9PQW5;uniprot:H0YCM0;uniprot:H0YF55;uniprot:A0A024R5P0;uniprot:E9PM17;uniprot:Q13153 -PXN GeneProduct ncbigene:5829 ensembl:ENSG00000089159 ncbigene:5829 hgnc.symbol:PXN uniprot:F5GZ78;uniprot:F8W0G0;uniprot:A0A1B0GWE7;uniprot:F5H836;uniprot:F8W0K8;uniprot:F8W1E0;uniprot:P49023;uniprot:A0A140VJQ8;uniprot:A0A1B0GTU4;uniprot:A0A1B0GV30;uniprot:F8VZ39;uniprot:A0A1B0GU60 -PIP5K1C GeneProduct ncbigene:23396 ensembl:ENSG00000186111 ncbigene:23396 hgnc.symbol:PIP5K1C uniprot:O60331;uniprot:A0A7P0T808;uniprot:A0A7P0TAE7 -BAD GeneProduct ncbigene:572 ensembl:ENSG00000002330 ncbigene:572 hgnc.symbol:BAD uniprot:F5GYS3;uniprot:A8MXU7;uniprot:A0A024R562;uniprot:F5H1R6;uniprot:Q92934;uniprot:F5H3B1 -ITGA1 GeneProduct ensembl:ENSG00000213949 ensembl:ENSG00000213949 ncbigene:3672 hgnc.symbol:ITGA1 uniprot:P56199;uniprot:A0A494C0F7 -IGF1R GeneProduct ncbigene:3480 ensembl:ENSG00000140443 ncbigene:3480 hgnc.symbol:IGF1R uniprot:C9J5X1;uniprot:H3BSZ8;uniprot:H0YNR0;uniprot:H0YMJ5;uniprot:P08069 -ACTN4 GeneProduct ensembl:ENSG00000130402 ensembl:ENSG00000130402 ncbigene:81 hgnc.symbol:ACTN4 uniprot:A0A0S2Z3G9;uniprot:K7EP19;uniprot:O43707;uniprot:H7C144;uniprot:F5GXS2 -SRC GeneProduct ncbigene:6714 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] ensembl:ENSG00000197122 ncbigene:6714 hgnc.symbol:SRC uniprot:P12931 -ACTG1 GeneProduct ncbigene:71 ensembl:ENSG00000184009 ncbigene:71 hgnc.symbol:ACTG1 uniprot:I3L3I0;uniprot:I3L1U9;uniprot:I3L3R2;uniprot:A0A804GS07;uniprot:P63261;uniprot:A0A7P0TBL1;uniprot:J3KT65;uniprot:I3L4N8;uniprot:K7EM38 -HRAS GeneProduct ncbigene:3265 ensembl:ENSG00000174775 ncbigene:3265 hgnc.symbol:HRAS uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2 -ITGA7 GeneProduct ncbigene:3679 ensembl:ENSG00000135424 ncbigene:3679 hgnc.symbol:ITGA7 uniprot:H0YJ26;uniprot:J3KNV4;uniprot:G3V2I4;uniprot:G3V3L8;uniprot:H0YJS5;uniprot:H0YJ98;uniprot:G3V2C6;uniprot:Q13683;uniprot:G3V2Q6 -PDGFA GeneProduct ncbigene:5154 ensembl:ENSG00000197461 ncbigene:5154 hgnc.symbol:PDGFA uniprot:H7BYW6;uniprot:A0A0A0MSC4;uniprot:P04085 -BCAR1 GeneProduct ncbigene:9564 ensembl:ENSG00000050820 ncbigene:9564 hgnc.symbol:BCAR1 uniprot:P56945;uniprot:H3BVF0;uniprot:H3BSB2;uniprot:H3BU42;uniprot:H3BTB0;uniprot:H3BTL5;uniprot:H3BQJ7;uniprot:H3BSY4;uniprot:F5H855;uniprot:H3BN62 -VCL GeneProduct ncbigene:7414 VCL; vinculin ensembl:ENSG00000035403 ncbigene:7414 hgnc.symbol:VCL uniprot:V9HWK2;uniprot:P18206;uniprot:A0A024QZN4;uniprot:A0A096LPE1 -CAV2 GeneProduct ncbigene:858 CAV2; caveolin 2 ensembl:ENSG00000105971 ncbigene:858 hgnc.symbol:CAV2 uniprot:P51636;uniprot:Q53X57;uniprot:E9PCT3 -PIK3CB GeneProduct ncbigene:5291 ensembl:ENSG00000051382 ncbigene:5291 hgnc.symbol:PIK3CB uniprot:C9JYX0;uniprot:C9J345;uniprot:H7C527;uniprot:P42338;uniprot:H7C5C3;uniprot:H7C565;uniprot:Q68DL0;uniprot:H0Y871;uniprot:F8WDJ8 -ITGB5 GeneProduct ncbigene:3693 ensembl:ENSG00000082781 ncbigene:3693 hgnc.symbol:ITGB5 uniprot:V9GYD8;uniprot:V9GYZ1;uniprot:F8WBG2;uniprot:P18084;uniprot:H7C5U2;uniprot:L7RT22;uniprot:H7C580;uniprot:H7C4W1;uniprot:V9GZ57 -AKT3 GeneProduct ncbigene:10000 ensembl:ENSG00000117020 ncbigene:10000 hgnc.symbol:AKT3 uniprot:A0A7P0T8T9;uniprot:A0A7P0TBJ6;uniprot:A0A5F9ZHU3;uniprot:A0A7P0TB29;uniprot:Q9Y243;uniprot:A0A5F9ZHA9;uniprot:A0A5F9ZGY0;uniprot:A0A5F9ZGZ4;uniprot:A0A5K1VW74;uniprot:A0A7P0T872;uniprot:A0A7P0TB32 -STYK1 GeneProduct ncbigene:55359 ensembl:ENSG00000060140 ncbigene:55359 hgnc.symbol:STYK1 uniprot:F5GZF6;uniprot:H0YGL5;uniprot:F5H4G3;uniprot:F5H2I9;uniprot:Q6J9G0;uniprot:F5H366 -TLN1 GeneProduct ncbigene:7094 ensembl:ENSG00000137076 ncbigene:7094 hgnc.symbol:TLN1 uniprot:Q9Y490 -ROCK2 GeneProduct ncbigene:9475 ensembl:ENSG00000134318 ncbigene:9475 hgnc.symbol:ROCK2 uniprot:A0A2P9DU05;uniprot:O75116;uniprot:C9JFJ0;uniprot:E9PF63;uniprot:D6REE7 -RAC2 GeneProduct ncbigene:5880 ensembl:ENSG00000128340 ncbigene:5880 hgnc.symbol:RAC2 uniprot:B1AH79;uniprot:B1AH78;uniprot:B1AH77;uniprot:A0A024R1P2;uniprot:P15153;uniprot:B1AH80 -PIK3CD GeneProduct ncbigene:5293 ensembl:ENSG00000171608 ncbigene:5293 hgnc.symbol:PIK3CD uniprot:B7ZM44;uniprot:F8W9P4;uniprot:O00329;uniprot:A0A2K8FKV1 -PDGFC GeneProduct ncbigene:56034 ensembl:ENSG00000145431 ncbigene:56034 hgnc.symbol:PDGFC uniprot:H0Y9N2;uniprot:Q9NRA1;uniprot:J3KN71 -VWF GeneProduct ncbigene:7450 ensembl:ENSG00000110799 ncbigene:7450 hgnc.symbol:VWF uniprot:P04275;uniprot:I3L4K4 -ITGA11 GeneProduct ncbigene:22801 ensembl:ENSG00000137809 ncbigene:22801 hgnc.symbol:ITGA11 uniprot:Q9UKX5 -ITGB4 GeneProduct ncbigene:3691 ensembl:ENSG00000132470 ncbigene:3691 hgnc.symbol:ITGB4 uniprot:J3QQL2;uniprot:J3QRK0;uniprot:A0A024R8K7;uniprot:A0A024R8T0;uniprot:P16144;uniprot:J3KSH9 -RAPGEF1 GeneProduct ncbigene:2889 ensembl:ENSG00000107263 ncbigene:2889 hgnc.symbol:RAPGEF1 uniprot:A0A804HL87;uniprot:H0Y6R4;uniprot:Q5JUE9;uniprot:Q13905 -ITGB3 GeneProduct ncbigene:3690 ensembl:ENSG00000259207 ncbigene:3690 hgnc.symbol:ITGB3 uniprot:P05106;uniprot:I3L4X8;uniprot:Q16157 -EGFR GeneProduct ncbigene:1956 ensembl:ENSG00000146648 ncbigene:1956 hgnc.symbol:EGFR uniprot:P00533;uniprot:Q504U8;uniprot:C9JYS6 -VEGFC GeneProduct ncbigene:7424 ensembl:ENSG00000150630 ncbigene:7424 hgnc.symbol:VEGFC uniprot:P49767 -PAK2 GeneProduct ncbigene:5062 ensembl:ENSG00000180370 ncbigene:5062 hgnc.symbol:PAK2 uniprot:H7C1X3;uniprot:Q13177 -DIAPH1 GeneProduct ensembl:ENSG00000131504 ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 -PTK6 GeneProduct ncbigene:5753 ensembl:ENSG00000101213 ncbigene:5753 hgnc.symbol:PTK6 uniprot:Q13882 -RHOA GeneProduct ncbigene:387 ensembl:ENSG00000067560 ncbigene:387 hgnc.symbol:RHOA uniprot:P61586;uniprot:A0A7I2V5E6;uniprot:C9JNR4;uniprot:A0A024R324;uniprot:A0A7I2YQV1;uniprot:C9JRM1;uniprot:A0A7I2V3G1;uniprot:C9JX21 -RASGRF1 GeneProduct ensembl:ENSG00000058335 ensembl:ENSG00000058335 ncbigene:5923 hgnc.symbol:RASGRF1 uniprot:Q13972 -MYLK2 GeneProduct ncbigene:85366 ensembl:ENSG00000101306 ncbigene:85366 hgnc.symbol:MYLK2 uniprot:Q9H1R3 -PDGFB GeneProduct ncbigene:5155 ensembl:ENSG00000100311 ncbigene:5155 hgnc.symbol:PDGFB uniprot:A9UJP0;uniprot:P01127;uniprot:A0A384NYY3;uniprot:A9UJN9 -MYL5 GeneProduct ensembl:ENSG00000215375 ensembl:ENSG00000215375 ncbigene:4636 hgnc.symbol:MYL5 uniprot:D6RJ91;uniprot:Q02045;uniprot:D6RA88;uniprot:D6RB15 -COL4A1 GeneProduct ncbigene:1282 ensembl:ENSG00000187498 ncbigene:1282 hgnc.symbol:COL4A1 uniprot:A0A3B3ITS9;uniprot:A0A087WTY5;uniprot:A0A3B3ITC8;uniprot:A0A3B3IU02;uniprot:A0A3B3ITG7;uniprot:A0A3B3ISH5;uniprot:A0A3B3ISV3;uniprot:A0A3B3ISZ8;uniprot:A0A3B3IUD0;uniprot:P02462 -SHC2 GeneProduct ensembl:ENSG00000129946 SHC1; SHC (Src homology 2 domain containing) transforming protein 1 ensembl:ENSG00000129946 ncbigene:25759 hgnc.symbol:SHC2 uniprot:K7ENB2;uniprot:K7EKS8;uniprot:P98077 -SHC4 GeneProduct ensembl:ENSG00000185634 SHC1; SHC (Src homology 2 domain containing) transforming protein 1 ensembl:ENSG00000185634 ncbigene:399694 hgnc.symbol:SHC4 uniprot:H0YLU6;uniprot:Q6S5L8;uniprot:F5H5M1;uniprot:H0YLZ2 -PRKCA GeneProduct ensembl:ENSG00000154229 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 -PRKCB GeneProduct ensembl:ENSG00000166501 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] ensembl:ENSG00000166501 ncbigene:5579 hgnc.symbol:PRKCB uniprot:I3L1Z0;uniprot:I3L148;uniprot:H3BV73;uniprot:P05771 -PRKCG GeneProduct ensembl:ENSG00000126583 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] ensembl:ENSG00000126583 ncbigene:5582 hgnc.symbol:PRKCG uniprot:P05129;uniprot:M0R0I9;uniprot:A0A804HIU5;uniprot:H7BZ60;uniprot:M0R0Z4;uniprot:A0A804HHY0 -ARHGAP35 GeneProduct ensembl:ENSG00000160007 ensembl:ENSG00000160007 ncbigene:2909 hgnc.symbol:ARHGAP35 uniprot:Q9NRY4 -PPP1R12B GeneProduct ensembl:ENSG00000077157 ensembl:ENSG00000077157 ncbigene:4660 hgnc.symbol:PPP1R12B uniprot:A0A0U1RQP2;uniprot:E1CKY7;uniprot:H7C4R6;uniprot:Q6GQY8;uniprot:O60237;uniprot:A0A0U1RQI8 -PPP1R12C GeneProduct ensembl:ENSG00000125503 ensembl:ENSG00000125503 ncbigene:54776 hgnc.symbol:PPP1R12C uniprot:K7ER83;uniprot:Q9BZL4;uniprot:K7EL81 -PPP1CA GeneProduct ensembl:ENSG00000172531 ensembl:ENSG00000172531 ncbigene:5499 hgnc.symbol:PPP1CA uniprot:P62136;uniprot:A0A7I2V4F7;uniprot:A0A140VJS9;uniprot:E9PMD7 -PPP1CB GeneProduct ensembl:ENSG00000213639 ensembl:ENSG00000213639 ncbigene:5500 hgnc.symbol:PPP1CB uniprot:C9JP48;uniprot:H0Y3Y6;uniprot:P62140;uniprot:C9J9S3;uniprot:B4DJ75;uniprot:F8WE71;uniprot:V9HW04;uniprot:E7ETD8 -PPP1CC GeneProduct ensembl:ENSG00000186298 ensembl:ENSG00000186298 ncbigene:5501 hgnc.symbol:PPP1CC uniprot:F8VR82;uniprot:F8VYE8;uniprot:A0A087WYY5;uniprot:F8W0W8;uniprot:A0A024RBP2;uniprot:F8W1A0;uniprot:P36873;uniprot:F8W0V8 -PPP1CC GeneProduct ensembl:ENSG00000186298 ensembl:ENSG00000186298 ncbigene:5501 hgnc.symbol:PPP1CC uniprot:F8VR82;uniprot:F8VYE8;uniprot:A0A087WYY5;uniprot:F8W0W8;uniprot:A0A024RBP2;uniprot:F8W1A0;uniprot:P36873;uniprot:F8W0V8 -MYL7 GeneProduct ensembl:ENSG00000106631 ensembl:ENSG00000106631 ncbigene:58498 hgnc.symbol:MYL7 uniprot:C9JEG4;uniprot:Q01449;uniprot:H7BZE4;uniprot:F8WD94;uniprot:H7C243;uniprot:H7C3E3;uniprot:H7C1B1;uniprot:H7C482 -MYL10 GeneProduct ensembl:ENSG00000106436 ensembl:ENSG00000106436 ncbigene:93408 hgnc.symbol:MYL10 uniprot:Q9BUA6;uniprot:A0A2R8YDI2 -MYL12A GeneProduct ensembl:ENSG00000101608 ensembl:ENSG00000101608 ncbigene:10627 hgnc.symbol:MYL12A uniprot:J3KT92;uniprot:J3KTJ1;uniprot:J3QRS3;uniprot:P19105 -MYL12B GeneProduct ensembl:ENSG00000118680 ensembl:ENSG00000118680 ncbigene:103910 hgnc.symbol:MYL12B uniprot:O14950 -MYL2 GeneProduct ensembl:ENSG00000111245 ensembl:ENSG00000111245 ncbigene:4633 hgnc.symbol:MYL2 uniprot:P10916;uniprot:A0A590UJU8;uniprot:A0A590UK07;uniprot:G3V1V8;uniprot:Q6IB42 -MYL9 GeneProduct ensembl:ENSG00000101335 ensembl:ENSG00000101335 ncbigene:10398 hgnc.symbol:MYL9 uniprot:A0A384NY64;uniprot:P24844 -MYLPF GeneProduct ensembl:ENSG00000180209 ensembl:ENSG00000180209 ncbigene:29895 hgnc.symbol:MYL11 uniprot:H3BN54;uniprot:Q96A32;uniprot:H3BPK4;uniprot:A0A024QZG6;uniprot:H3BML9 -MYLK3 GeneProduct ensembl:ENSG00000140795 ensembl:ENSG00000140795 ncbigene:91807 hgnc.symbol:MYLK3 uniprot:Q32MK0 -MYLK4 GeneProduct ensembl:ENSG00000145949 ensembl:ENSG00000145949 ncbigene:340156 hgnc.symbol:MYLK4 uniprot:Q86YV6;uniprot:A0A2R8Y4U5 -ACTN1 GeneProduct ncbigene:87 ensembl:ENSG00000072110 ncbigene:87 hgnc.symbol:ACTN1 uniprot:G3V380;uniprot:A0A804HJU8;uniprot:G3V2W4;uniprot:A0A804HL31;uniprot:H7C5W8;uniprot:A0A804HJN7;uniprot:H0YJW3;uniprot:P12814;uniprot:G3V2E8;uniprot:A0A7I2V4Y4;uniprot:A0A804HIN7;uniprot:A0A804HJQ9;uniprot:H9KV75;uniprot:G3V5M4;uniprot:A0A804HKE2;uniprot:A0A804HLD0;uniprot:H0YJ11;uniprot:A0A024R694;uniprot:A0A804HII9;uniprot:A0A804HLF4;uniprot:G3V2X9;uniprot:A0A804HK61;uniprot:A0A804HIY0;uniprot:G3V2N5 -PARVA GeneProduct ensembl:ENSG00000197702 ensembl:ENSG00000197702 ncbigene:55742 hgnc.symbol:PARVA uniprot:Q9NVD7;uniprot:E9PS97 -PARVG GeneProduct ensembl:ENSG00000138964 ensembl:ENSG00000138964 ncbigene:64098 hgnc.symbol:PARVG uniprot:U3KQ67;uniprot:A0A024R4U4;uniprot:Q9HBI0;uniprot:B0QYN0;uniprot:B0QYM9 -FLNB GeneProduct ensembl:ENSG00000136068 ensembl:ENSG00000136068 ncbigene:2317 hgnc.symbol:FLNB uniprot:A0A804HL72;uniprot:A0A0C4DGA1;uniprot:A0A804HJC2;uniprot:A0A804HK76;uniprot:O75369;uniprot:E7EN95;uniprot:H7C5L4 -FLNC GeneProduct ensembl:ENSG00000128591 ensembl:ENSG00000128591 ncbigene:2318 hgnc.symbol:FLNC uniprot:Q14315 -TLN2 GeneProduct ensembl:ENSG00000171914 ensembl:ENSG00000171914 ncbigene:83660 hgnc.symbol:TLN2 uniprot:H0YN01;uniprot:A0A1B0GVU7;uniprot:H0YMT1;uniprot:Q9Y4G6 -MAPK10 GeneProduct ensembl:ENSG00000109339 ensembl:ENSG00000109339 ncbigene:5602 hgnc.symbol:MAPK10 uniprot:A0A1P0B7D2;uniprot:A0A286YFM6;uniprot:A0A1W2PQX4;uniprot:P53779;uniprot:A0A286YFI3;uniprot:A0A1W2PRZ2;uniprot:A0A286YFE2;uniprot:A0A1W2PPZ3;uniprot:A0A286YF43;uniprot:A0A286YEW9;uniprot:A0A286YF02;uniprot:A0A286YES9;uniprot:A0A286YES8;uniprot:A0A286YF04;uniprot:A0A286YF80;uniprot:A0A286YF83;uniprot:A0A1W2PPM4;uniprot:A0A286YF85;uniprot:A0A286YES0;uniprot:A0A286YEW4;uniprot:D6RFZ7;uniprot:A0A286YFD7;uniprot:A0A286YFD9;uniprot:A0A286YEN5;uniprot:D6RDG1;uniprot:A0A286YFH4;uniprot:A0A286YEV5;uniprot:A0A286YEV8;uniprot:A0A286YF35;uniprot:A0A286YEZ1;uniprot:D6RAU3;uniprot:A0A286YEV3;uniprot:D6RJF9;uniprot:A0A286YFC3;uniprot:D6RBH2;uniprot:A0A286YFK3;uniprot:F8W9R5;uniprot:A0A286YFC0;uniprot:A0A1W2PRG9;uniprot:A0A286YEQ0;uniprot:D6RCB1;uniprot:A0A286YEQ7;uniprot:A0A286YEY0;uniprot:A0A286YEY2;uniprot:A8MPV1;uniprot:A0A286YF62;uniprot:A0A1W2PQ03;uniprot:D6RAJ0;uniprot:A0A286YFB7;uniprot:D6RFX8;uniprot:A0A286YFB6;uniprot:A0A286YFJ0;uniprot:A0A286YF19;uniprot:A0A286YFJ4;uniprot:A0A1W2PPW1;uniprot:A0A286YFJ6;uniprot:A0A286YEX7;uniprot:A0A286YF53;uniprot:A0A286YF97;uniprot:A0A286YFN2;uniprot:A0A286YFA7;uniprot:A0A1W2PRF2;uniprot:A0A1W2PNF5;uniprot:A0A286YF95;uniprot:A0A286YFA3;uniprot:D6R9C1;uniprot:D6RC26;uniprot:A0A286YFA6;uniprot:A0A286YFE9 -VAV2 GeneProduct ensembl:ENSG00000160293 ensembl:ENSG00000160293 ncbigene:7410 hgnc.symbol:VAV2 uniprot:P52735 -VAV3 GeneProduct ensembl:ENSG00000134215 ensembl:ENSG00000134215 ncbigene:10451 hgnc.symbol:VAV3 uniprot:H0YDG2;uniprot:E9PMJ5;uniprot:H0YCG7;uniprot:Q9UKW4 +PIP3 Metabolite hmdb:HMDB0004249 "" chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N +PIP2 Metabolite chebi:18348 "" wikidata:Q28797894 chebi:18348;chebi:18348 +PDGFRA GeneProduct ncbigene:5156 "" ensembl:ENSG00000134853 ncbigene:5156 hgnc.symbol:PDGFRA uniprot:D6RDX0;uniprot:D6RJH0;uniprot:D6RG11;uniprot:D6RIG5;uniprot:P16234 +CAPN2 GeneProduct ensembl:ENSG00000162909 "" ensembl:ENSG00000162909 ncbigene:824 hgnc.symbol:CAPN2 uniprot:C9JWY7;uniprot:P17655 +RAC1 GeneProduct ncbigene:5879 "" ensembl:ENSG00000136238 ncbigene:5879 hgnc.symbol:RAC1 uniprot:P63000;uniprot:A4D2P0;uniprot:A4D2P1 +LAMA1 GeneProduct ncbigene:284217 "" ensembl:ENSG00000101680 ncbigene:284217 hgnc.symbol:LAMA1 uniprot:P25391 +COL1A1 GeneProduct ncbigene:1277 "" ensembl:ENSG00000108821 ncbigene:1277 hgnc.symbol:COL1A1 uniprot:I3L3H7;uniprot:P02452 +MAPK3 GeneProduct ensembl:ENSG00000102882 "MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]" ensembl:ENSG00000102882 ncbigene:5595 hgnc.symbol:MAPK3 uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9 +VTN GeneProduct ncbigene:7448 "" ensembl:ENSG00000109072 ncbigene:7448 hgnc.symbol:VTN uniprot:D9ZGG2;uniprot:P04004;uniprot:F5GX75 +HGF GeneProduct ncbigene:3082 "" ensembl:ENSG00000019991 ncbigene:3082 hgnc.symbol:HGF uniprot:A0A2R8YEI1;uniprot:C9WSJ4;uniprot:C9WSJ3;uniprot:C9JS80;uniprot:P14210;uniprot:C9JDP4 +SHC3 GeneProduct ncbigene:53358 "SHC3; neuronal Sh" ensembl:ENSG00000148082 ncbigene:53358 hgnc.symbol:SHC3 uniprot:Q92529;uniprot:Q5T7I8 +THBS3 GeneProduct ncbigene:7059 "" ensembl:ENSG00000169231 ncbigene:7059 hgnc.symbol:THBS3 uniprot:B4DQH6;uniprot:Q2HIZ1;uniprot:F5H4Z8;uniprot:P49746 +PIK3R1 GeneProduct ncbigene:5295 "" ensembl:ENSG00000145675 ncbigene:5295 hgnc.symbol:PIK3R1 uniprot:P27986;uniprot:A0A2X0SFG1;uniprot:E5RGI8;uniprot:H0YBC2;uniprot:H0YB27;uniprot:E5RK66;uniprot:E5RJY0;uniprot:B3KWZ7;uniprot:E5RHI0 +FGR GeneProduct ncbigene:2268 "" ensembl:ENSG00000000938 ncbigene:2268 hgnc.symbol:FGR uniprot:P09769;uniprot:Q5TGY6 +BRAF GeneProduct ncbigene:673 "" ensembl:ENSG00000157764 ncbigene:673 hgnc.symbol:BRAF uniprot:A0A2R8Y492;uniprot:A0A2R8Y8E0;uniprot:H7C4S5;uniprot:A0A2R8Y467;uniprot:A0A2R8YES9;uniprot:H7C560;uniprot:A0A2U3TZI2;uniprot:P15056;uniprot:A0A2R8YDP5;uniprot:H7C5K3;uniprot:A0A2R8Y679 +ITGB6 GeneProduct ncbigene:3694 "" ensembl:ENSG00000115221 ncbigene:3694 hgnc.symbol:ITGB6 uniprot:E9PEE8;uniprot:A0A087WXP3;uniprot:P18564;uniprot:F8WBJ8 +ITGA10 GeneProduct ncbigene:8515 "" ensembl:ENSG00000143127 ncbigene:8515 hgnc.symbol:ITGA10 uniprot:O75578 +COL4A4 GeneProduct ncbigene:1286 "" ensembl:ENSG00000081052 ncbigene:1286 hgnc.symbol:COL4A4 uniprot:A0A804HLF6;uniprot:A0A804HI86;uniprot:A0A804HI71;uniprot:P53420;uniprot:A0A2R8Y548 +THBS1 GeneProduct ncbigene:7057 "" ensembl:ENSG00000137801 ncbigene:7057 hgnc.symbol:THBS1 uniprot:A8MZG1;uniprot:P07996 +ILK GeneProduct ncbigene:3611 "ILK; integrin-linked kinase [EC:2.7.1.-]" ensembl:ENSG00000166333 ncbigene:3611 hgnc.symbol:ILK uniprot:Q13418;uniprot:V9HWF0;uniprot:A0A0A0MTH3;uniprot:A0A087WWY6;uniprot:E9PQ52;uniprot:A0A087WW45 +CCND2 GeneProduct ncbigene:894 "" ensembl:ENSG00000118971 ncbigene:894 hgnc.symbol:CCND2 uniprot:A0A6Q8PGZ3;uniprot:P30279 +THBS4 GeneProduct ncbigene:7060 "" ensembl:ENSG00000113296 ncbigene:7060 hgnc.symbol:THBS4 uniprot:E7ES19;uniprot:P35443 +LAMA2 GeneProduct ncbigene:3908 "" ensembl:ENSG00000196569 ncbigene:3908 hgnc.symbol:LAMA2 uniprot:P24043;uniprot:A0A087WX80;uniprot:A0A087WYF1 +TNR GeneProduct ncbigene:7143 "" ensembl:ENSG00000116147 ncbigene:7143 hgnc.symbol:TNR uniprot:H0Y668;uniprot:Q92752 +ITGB8 GeneProduct ncbigene:3696 "" ensembl:ENSG00000105855 ncbigene:3696 hgnc.symbol:ITGB8 uniprot:P26012 +ROCK1 GeneProduct ncbigene:6093 "" ensembl:ENSG00000067900 ncbigene:6093 hgnc.symbol:ROCK1 uniprot:J3KRH6;uniprot:Q13464;uniprot:A0A0U1RQV4 +ITGA6 GeneProduct ncbigene:3655 "" ensembl:ENSG00000091409 ncbigene:3655 hgnc.symbol:ITGA6 uniprot:H7BZ97;uniprot:P23229;uniprot:A0A8C8KBL6;uniprot:C9JXX7 +FYN GeneProduct ncbigene:2534 "FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]" ensembl:ENSG00000010810 ncbigene:2534 hgnc.symbol:FYN uniprot:E5RHF7;uniprot:E5RFM4;uniprot:E5RI25;uniprot:E5RK23;uniprot:P06241;uniprot:E5RFM6;uniprot:E5RGM6;uniprot:E5RIX5;uniprot:E5RGT0;uniprot:E5RFM0;uniprot:E5RJX7;uniprot:E5RHX7;uniprot:E5RFS5;uniprot:E5RH71 +PPP1R12A GeneProduct ncbigene:4659 "" ensembl:ENSG00000058272 ncbigene:4659 hgnc.symbol:PPP1R12A uniprot:A0A3B3ISH4;uniprot:H0YIM2;uniprot:H0YIS4;uniprot:A0A0U1RQZ1;uniprot:H0YHI8;uniprot:H0YIS3;uniprot:F8VW28;uniprot:F8VZN8;uniprot:H0YHL8;uniprot:H0YIL7;uniprot:O14974 +TNK2 GeneProduct ncbigene:10188 "" ensembl:ENSG00000061938 ncbigene:10188 hgnc.symbol:TNK2 uniprot:A0A5F9ZHK8;uniprot:A0A5F9ZHB0;uniprot:A0A5F9ZHI7;uniprot:A0A5F9ZHC7;uniprot:Q07912;uniprot:A0A5F9ZHJ2;uniprot:A0A5F9ZHL4;uniprot:A0A5F9ZI29;uniprot:A0A5F9ZHD0;uniprot:A0A499FJ16;uniprot:A0A5F9ZHP9;uniprot:A0A5F9ZH66;uniprot:A0A5F9ZHQ1;uniprot:A0A5F9ZHX6;uniprot:A0A5F9ZHP4;uniprot:A0A5F9ZH01;uniprot:A0A5F9ZI44;uniprot:C9J1X3;uniprot:A0A5F9ZGY5;uniprot:A0A5F9ZGX5 +VAV1 GeneProduct ncbigene:7409 "" ensembl:ENSG00000141968 ncbigene:7409 hgnc.symbol:VAV1 uniprot:Q96D37;uniprot:P15498;uniprot:F5H5P4;uniprot:A0A0A0MR07 +ELK1 GeneProduct ncbigene:2002 "" ensembl:ENSG00000126767 ncbigene:2002 hgnc.symbol:ELK1 uniprot:P19419;uniprot:A0A024R1A7 +PDGFD GeneProduct ncbigene:80310 "" ensembl:ENSG00000170962 ncbigene:80310 hgnc.symbol:PDGFD uniprot:Q9GZP0;uniprot:H0YD37 +VEGF GeneProduct ncbigene:7422 "" ensembl:ENSG00000112715 ncbigene:7422 hgnc.symbol:VEGFA uniprot:A0A0A0MTB2;uniprot:A0A0A0MSI7;uniprot:A0A0Y0IMM4;uniprot:A0A0A0MSH7;uniprot:H3BLW8;uniprot:A0A024RD33;uniprot:A0A0A0MSH5;uniprot:J3KPA4;uniprot:A0A024RD37;uniprot:A0A0A0MRQ4;uniprot:A0A5F9ZH41;uniprot:H0YBI8;uniprot:A2A2V4;uniprot:A0A0A0MR43;uniprot:P15692;uniprot:H0YBZ0 +MET GeneProduct ncbigene:4233 "" ensembl:ENSG00000105976 ncbigene:4233 hgnc.symbol:MET uniprot:A0A024R759;uniprot:P08581;uniprot:A0A024R728;uniprot:C9JKM5;uniprot:H7C130;uniprot:H7C174 +KDR GeneProduct ncbigene:3791 "" ensembl:ENSG00000128052 ncbigene:3791 hgnc.symbol:KDR uniprot:P35968 +CRK GeneProduct ncbigene:1398 "" ensembl:ENSG00000167193 ncbigene:1398 hgnc.symbol:CRK uniprot:L7RT18;uniprot:A0A0S2Z3Q4;uniprot:P46108;uniprot:I3L297;uniprot:A0A0S2Z3K9 +CTNNB1 GeneProduct ncbigene:1499 "" ensembl:ENSG00000168036 ncbigene:1499 hgnc.symbol:CTNNB1 uniprot:A0A2R8Y6G0;uniprot:A0A2R8Y804;uniprot:A0A2R8Y815;uniprot:A0A2R8Y5A3;uniprot:C9IZ65;uniprot:A0A2R8Y5C3;uniprot:P35222;uniprot:A0A2R8Y7Z0;uniprot:A0A2R8YG06;uniprot:A0A2R8Y5Z1;uniprot:A0A2R8Y750;uniprot:A0A2R8YCH5;uniprot:A0A024R2Q3;uniprot:A0A2R8Y543;uniprot:B4DGU4 +ITGA2 GeneProduct ncbigene:3673 "" ensembl:ENSG00000164171 ncbigene:3673 hgnc.symbol:ITGA2 uniprot:D6RG08;uniprot:D6R9H3;uniprot:E7ESP4;uniprot:E7EMF1;uniprot:E9PB77;uniprot:P17301 +RELN GeneProduct ncbigene:5649 "" ensembl:ENSG00000189056 ncbigene:5649 hgnc.symbol:RELN uniprot:A0A7P0TA83;uniprot:J3KQ66;uniprot:P78509;uniprot:H7C2B0 +ITGA5 GeneProduct ncbigene:3678 "" ensembl:ENSG00000161638 ncbigene:3678 hgnc.symbol:ITGA5 uniprot:B4E3F4;uniprot:P08648;uniprot:H0YIV7;uniprot:H0YHL9 +MAPK8 GeneProduct ncbigene:5599 "" ensembl:ENSG00000107643 ncbigene:5599 hgnc.symbol:MAPK8 uniprot:C9J762;uniprot:C9JWQ4;uniprot:A0A3B3IRW7;uniprot:A1L4K2;uniprot:P45983 +PAK3 GeneProduct ncbigene:5063 "" ensembl:ENSG00000077264 ncbigene:5063 hgnc.symbol:PAK3 uniprot:B1AKS5;uniprot:O75914 +PARVB GeneProduct ncbigene:29780 "" ensembl:ENSG00000188677 ncbigene:29780 hgnc.symbol:PARVB uniprot:A0A087WZB5;uniprot:B0QYP8;uniprot:Q9HBI1 +ZYX GeneProduct ncbigene:7791 "ZYX; zyxin" ensembl:ENSG00000159840 ncbigene:7791 hgnc.symbol:ZYX uniprot:C9JJK5;uniprot:H0Y2Y8;uniprot:Q15942;uniprot:H7C3R3;uniprot:H7C3D3;uniprot:C9IZ41 +IBSP GeneProduct ncbigene:3381 "" ensembl:ENSG00000029559 ncbigene:3381 hgnc.symbol:IBSP uniprot:P21815 +SPP1 GeneProduct ncbigene:6696 "" ensembl:ENSG00000118785 ncbigene:6696 hgnc.symbol:SPP1 uniprot:A0A804HLB3;uniprot:A0A024RDE2;uniprot:Q3LGB0;uniprot:A0A024RDE6;uniprot:A0A024RDJ0;uniprot:P10451 +COL6A2 GeneProduct ncbigene:1292 "" ensembl:ENSG00000142173 ncbigene:1292 hgnc.symbol:COL6A2 uniprot:A0A384MDP3;uniprot:H7C0M5;uniprot:C9JH44;uniprot:P12110 +PTK2 GeneProduct ncbigene:5747 "PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112" ensembl:ENSG00000169398 ncbigene:5747 hgnc.symbol:PTK2 uniprot:E5RJN1;uniprot:H0YB16;uniprot:E5RIR5;uniprot:H0YBP1;uniprot:E7ESA6;uniprot:H0YB33;uniprot:H0YB99;uniprot:E5RG54;uniprot:A0A1D5RMT1;uniprot:E5RI72;uniprot:E5RJP0;uniprot:E5RGP1;uniprot:H0YBZ1;uniprot:E5RGA6;uniprot:E5RJI4;uniprot:H0YAS0;uniprot:Q05397;uniprot:E5RHK7;uniprot:E5RII9;uniprot:E9PEI4;uniprot:E5RJQ2;uniprot:E5RH48;uniprot:E5RI03;uniprot:E5RIK4;uniprot:E5RH08;uniprot:E5RI29;uniprot:E5RG86;uniprot:B4DWJ1;uniprot:E5RH01;uniprot:E5RG66;uniprot:E5RFW9;uniprot:E5RHD8;uniprot:E5RG80 +JUN GeneProduct ncbigene:3725 "" ensembl:ENSG00000177606 ncbigene:3725 hgnc.symbol:JUN uniprot:P05412 +PAK6 GeneProduct ncbigene:56924 "" ensembl:ENSG00000137843 ncbigene:106821730;ncbigene:56924 hgnc.symbol:PAK6 uniprot:H0YKB6;uniprot:H0YL47;uniprot:A0A024R9Q4;uniprot:H0YL02;uniprot:H0YMS4;uniprot:H0YL16;uniprot:H0YK38;uniprot:H0YLZ9;uniprot:H0YM99;uniprot:Q9NQU5;uniprot:H0YK74;uniprot:H0YK91 +ITGAV GeneProduct ncbigene:3685 "" ensembl:ENSG00000138448 ncbigene:3685 hgnc.symbol:ITGAV uniprot:P06756;uniprot:H7BZG1;uniprot:L7RXH0 +ITGB1 GeneProduct ncbigene:3688 "" ensembl:ENSG00000150093 ncbigene:3688 hgnc.symbol:ITGB1 uniprot:H7C4K3;uniprot:P05556;uniprot:A0A7I2V2F9;uniprot:E7EUI6;uniprot:C9JPK5;uniprot:C9JNE0;uniprot:E9PLR6;uniprot:Q5T3E4;uniprot:Q5T3E6;uniprot:Q5T3E5;uniprot:A0A7I2V2T4;uniprot:A0A7I2V5T3;uniprot:E7EQW5;uniprot:A0A7I2V5Z8;uniprot:E9PQJ2;uniprot:A0A7I2V348;uniprot:H7C4N8 +LAMA5 GeneProduct ncbigene:3911 "" ensembl:ENSG00000130702 ncbigene:3911 hgnc.symbol:LAMA5 uniprot:O15230;uniprot:H7C5J6;uniprot:A0A087WYH7 +ITGA4 GeneProduct ncbigene:3676 "" ensembl:ENSG00000115232 ncbigene:3676 hgnc.symbol:ITGA4 uniprot:P13612;uniprot:E7EP60 +RAF1 GeneProduct ncbigene:5894 "RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]" ensembl:ENSG00000132155 ncbigene:5894 hgnc.symbol:RAF1 uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6 +BUB1B-PAK6 GeneProduct ensembl:ENSG00000259288 "" ensembl:ENSG00000259288 hgnc.symbol:BUB1B-PAK6 uniprot:H3BTB9 +ITGA2B GeneProduct ncbigene:3674 "" ensembl:ENSG00000005961 ncbigene:3674 hgnc.symbol:ITGA2B uniprot:K7EP83;uniprot:A0A3B3IU79;uniprot:P08514 +MAP2K1 GeneProduct ncbigene:5604 "MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]" ensembl:ENSG00000169032 ncbigene:5604 hgnc.symbol:MAP2K1 uniprot:B4DFY5;uniprot:H3BRW9;uniprot:A4QPA9;uniprot:Q02750 +LAMB1 GeneProduct ncbigene:3912 "" ensembl:ENSG00000091136 ncbigene:3912 hgnc.symbol:LAMB1 uniprot:E9PCS6;uniprot:A0A7I2V4J9;uniprot:C9J296;uniprot:E7EPA6;uniprot:P07942;uniprot:A0A7I2V682;uniprot:G3XAI2;uniprot:A0A7I2V2R2;uniprot:A0A7I2V5X5;uniprot:A0A7I2V378;uniprot:A0A7I2V5R0;uniprot:A0A7I2V2J0;uniprot:A0A7I2V2T9;uniprot:A0A7I2V5T9;uniprot:A0A7I2V407;uniprot:A0A7I2V3J7;uniprot:A0A7I2V3I5 +FIGF GeneProduct ncbigene:2277 "" ensembl:ENSG00000165197 ncbigene:2277 hgnc.symbol:VEGFD uniprot:O43915 +FLT1 GeneProduct ncbigene:2321 "" ensembl:ENSG00000102755 ncbigene:2321 hgnc.symbol:FLT1 uniprot:A0A1W2PNW4;uniprot:H9N1E8;uniprot:H9N1E7;uniprot:L7RSL3;uniprot:P17948 +PDPK1 GeneProduct ncbigene:5170 "" ensembl:ENSG00000140992 ncbigene:5170 hgnc.symbol:PDPK1 uniprot:O15530;uniprot:H3BQ10;uniprot:E9PER6;uniprot:H3BPR5;uniprot:H3BQA3;uniprot:H3BNV5;uniprot:H3BPW1 +ERBB2 GeneProduct ncbigene:2064 "" ensembl:ENSG00000141736 ncbigene:2064 hgnc.symbol:ERBB2 uniprot:J3QL83;uniprot:J3QLV2;uniprot:J3KRI9;uniprot:F5H1T4;uniprot:J3KTI5;uniprot:P04626;uniprot:X5DNK3;uniprot:J3QRJ7;uniprot:J3QLU9;uniprot:J3QRX1;uniprot:B4DTR1 +EGF GeneProduct ncbigene:1950 "" ensembl:ENSG00000138798 ncbigene:1950 hgnc.symbol:EGF uniprot:A0A494C018;uniprot:P01133 +CAV1 GeneProduct ncbigene:857 "CAV1; caveolin 1 caveolae protein 22kD" ensembl:ENSG00000105974 ncbigene:857 hgnc.symbol:CAV1 uniprot:Q2TNI1;uniprot:Q03135;uniprot:F8WDM7;uniprot:C9JKI3;uniprot:A0A024R757;uniprot:A0A7P0YWJ6;uniprot:E9PCT5 +MYLK GeneProduct ncbigene:4638 "" ensembl:ENSG00000065534 ncbigene:4638 hgnc.symbol:MYLK uniprot:F8WBL7;uniprot:Q15746;uniprot:D6R9C2 +CAV3 GeneProduct ncbigene:859 "CAV3; caveolin 3" ensembl:ENSG00000182533 ncbigene:859 hgnc.symbol:CAV3 uniprot:P56539 +MAPK1 GeneProduct ncbigene:5594 "MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]" ensembl:ENSG00000100030 ncbigene:5594 hgnc.symbol:MAPK1 uniprot:P28482;uniprot:Q1HBJ4 +CHAD GeneProduct ncbigene:1101 "" ensembl:ENSG00000136457 ncbigene:1101 hgnc.symbol:CHAD uniprot:O15335;uniprot:H0YA03 +BCL2 GeneProduct ncbigene:596 "" ensembl:ENSG00000171791 ncbigene:596 hgnc.symbol:BCL2 uniprot:A0A7I2V3S7;uniprot:P10415;uniprot:A0A024R2B3;uniprot:A0A024R2C4;uniprot:A0A7I2V5Q7;uniprot:A0A7I2V4W1;uniprot:A0A7I2V5Q9 +COMP GeneProduct ncbigene:1311 "" ensembl:ENSG00000105664 ncbigene:1311 hgnc.symbol:COMP uniprot:G3XAP6;uniprot:P49747 +EMP2 GeneProduct ncbigene:2013 "" ensembl:ENSG00000213853 ncbigene:2013 hgnc.symbol:EMP2 uniprot:P54851 +TNC GeneProduct ncbigene:3371 "" ensembl:ENSG00000041982 ncbigene:3371 hgnc.symbol:TNC uniprot:F5H7V9;uniprot:H0YGZ3;uniprot:J3QSU6;uniprot:A0A0U1RR80;uniprot:E9PC84;uniprot:P24821;uniprot:F5H5D6 +LAMC3 GeneProduct ncbigene:10319 "" ensembl:ENSG00000050555 ncbigene:10319 hgnc.symbol:LAMC3 uniprot:A0A7I2V3S4;uniprot:A0A7I2YQP4;uniprot:Q9Y6N6;uniprot:H7BY04 +CRKL GeneProduct ensembl:ENSG00000099942 "" ensembl:ENSG00000099942 ncbigene:1399 hgnc.symbol:CRKL uniprot:P46109 +SHC1 GeneProduct ncbigene:6464 "SHC1; SHC (Src homology 2 domain containing) transforming protein 1" ensembl:ENSG00000160691 ncbigene:6464 hgnc.symbol:SHC1 uniprot:X6R6D0;uniprot:Q5T187;uniprot:H0Y539;uniprot:Q5T181;uniprot:Q5T182;uniprot:P29353;uniprot:Q5T188 +LAMB2 GeneProduct ncbigene:3913 "" ensembl:ENSG00000172037 ncbigene:3913 hgnc.symbol:LAMB2 uniprot:P55268;uniprot:F5H520 +PIK3R3 GeneProduct ensembl:ENSG00000117461 "" ensembl:ENSG00000117461 ncbigene:8503 hgnc.symbol:PIK3R3 uniprot:Q5T4P3;uniprot:Q92569 +CDC42 GeneProduct ncbigene:998 "" ensembl:ENSG00000070831 ncbigene:998 hgnc.symbol:CDC42 uniprot:A0A3B3IRV0;uniprot:A0A494C1M1;uniprot:Q5JYX0;uniprot:A0A024RAE6;uniprot:A0A590UJK8;uniprot:A0A024RAA5;uniprot:P60953;uniprot:A0A494BZX6 +RAP1B GeneProduct ncbigene:5908 "RAP1B; RAP1B member of RAS oncogene family" ensembl:ENSG00000127314 ncbigene:5908 hgnc.symbol:RAP1B uniprot:F5H4H0;uniprot:F5GWU8;uniprot:F5H6R7;uniprot:A0A024RB87;uniprot:F5H004;uniprot:F5H7Y6;uniprot:F5GX62;uniprot:F5H500;uniprot:F8WBC0;uniprot:F5H823;uniprot:P61224;uniprot:F5H491;uniprot:F5GYB5;uniprot:E7ESV4;uniprot:F5H077;uniprot:F5H0S2;uniprot:F5GZG1;uniprot:F5H0B7;uniprot:F5GYH7;uniprot:B7ZB78 +PTEN GeneProduct ncbigene:5728 "" ensembl:ENSG00000171862 ncbigene:5728 hgnc.symbol:PTEN uniprot:P60484;uniprot:A0A087X033;uniprot:F6KD01 +LAMA3 GeneProduct ncbigene:3909 "" ensembl:ENSG00000053747 ncbigene:3909 hgnc.symbol:LAMA3 uniprot:A0A3B3ITG1;uniprot:K7EMU9;uniprot:A0A0A0MTS5;uniprot:K7EQ42;uniprot:K7EIP4;uniprot:A0A0A0MSA0;uniprot:Q16787;uniprot:A0A075B783;uniprot:K7ERM0;uniprot:A0A0A6YYF2;uniprot:K7EPP3 +ACTB GeneProduct ncbigene:60 "" ensembl:ENSG00000075624 ncbigene:60 hgnc.symbol:ACTB uniprot:C9JTX5;uniprot:P60709;uniprot:A0A6Q8PFE4;uniprot:Q1KLZ0;uniprot:C9JUM1;uniprot:A0A6Q8PGD7;uniprot:A0A2R8YFE2;uniprot:A0A2R8Y793;uniprot:C9JZR7;uniprot:G5E9R0;uniprot:A0A2R8YEA7;uniprot:E7EVS6;uniprot:A0A2R8YGF8;uniprot:A0A6Q8PH58 +GRB2 GeneProduct ncbigene:2885 "GRB2; growth factor receptor-bound protein 2" ensembl:ENSG00000177885 ncbigene:2885 hgnc.symbol:GRB2 uniprot:P62993;uniprot:B0LPF3;uniprot:J3QRL5;uniprot:J3KT38;uniprot:J3QLF6 +ITGA9 GeneProduct ncbigene:3680 "" ensembl:ENSG00000144668 ncbigene:3680 hgnc.symbol:ITGA9 uniprot:H7C2L1;uniprot:Q13797;uniprot:E9PDS3 +COL4A2 GeneProduct ncbigene:1284 "" ensembl:ENSG00000134871 ncbigene:1284 hgnc.symbol:COL4A2 uniprot:A0A3B3IRV2;uniprot:A0A3B3IT80;uniprot:P08572;uniprot:A0A3B3ITN7;uniprot:A2A352;uniprot:A0A3B3ITQ8;uniprot:A0A087WY39;uniprot:A0A3B3IS47;uniprot:A0A3B3IS04;uniprot:A0A024RDW8 +PAK4 GeneProduct ncbigene:10298 "" ensembl:ENSG00000130669 ncbigene:10298 hgnc.symbol:PAK4 uniprot:M0R3G6;uniprot:A0A024R0L8;uniprot:M0R1R1;uniprot:O96013;uniprot:A0A024R0J1;uniprot:M0R2X4;uniprot:M0R0L9 +CCND1 GeneProduct ncbigene:595 "" ensembl:ENSG00000110092 ncbigene:595 hgnc.symbol:CCND1 uniprot:P24385;uniprot:Q6FI00;uniprot:F5H437 +TXK GeneProduct ncbigene:7294 "" ensembl:ENSG00000074966 ncbigene:7294 hgnc.symbol:TXK uniprot:D6RBM7;uniprot:D6RA14;uniprot:P42681;uniprot:D6R9F2;uniprot:E7EQN8 +RAC3 GeneProduct ncbigene:5881 "" ensembl:ENSG00000169750 ncbigene:5881 hgnc.symbol:RAC3 uniprot:J3QLK0;uniprot:J3KSC4;uniprot:P60763 +TESK2 GeneProduct ncbigene:10420 "" ensembl:ENSG00000070759 ncbigene:10420 hgnc.symbol:TESK2 uniprot:Q96S53 +SRMS GeneProduct ncbigene:6725 "" ensembl:ENSG00000125508 ncbigene:6725 hgnc.symbol:SRMS uniprot:Q9H3Y6 +COL1A2 GeneProduct ncbigene:1278 "" ensembl:ENSG00000164692 ncbigene:1278 hgnc.symbol:COL1A2 uniprot:P08123;uniprot:A0A0S2Z3H5 +MAPK9 GeneProduct ncbigene:5601 "" ensembl:ENSG00000050748 ncbigene:5601 hgnc.symbol:MAPK9 uniprot:D7R525;uniprot:D7R528;uniprot:J3KNK1;uniprot:E5RJ57;uniprot:P45984 +ITGA8 GeneProduct ncbigene:8516 "" ensembl:ENSG00000077943 ncbigene:8516 hgnc.symbol:ITGA8 uniprot:P53708 +VEGFB GeneProduct ncbigene:7423 "" ensembl:ENSG00000173511 ncbigene:7423 hgnc.symbol:VEGFB uniprot:H0YGB6;uniprot:Q7LAP4;uniprot:P49765 +AKT2 GeneProduct ncbigene:208 "" ensembl:ENSG00000105221 ncbigene:208 hgnc.symbol:AKT2 uniprot:M0QZK3;uniprot:J3QKW1;uniprot:A0A5F9ZHJ8;uniprot:E7EVP8;uniprot:J3KRI8;uniprot:C9JIJ1;uniprot:J3QLS6;uniprot:A8MX96;uniprot:C9JIF6;uniprot:A0A0A0MRF1;uniprot:J3QL45;uniprot:M0R0P9;uniprot:C9J258;uniprot:M0QZW8;uniprot:J3KTC6;uniprot:A0A1B0GXA2;uniprot:M0R275;uniprot:C9JC83;uniprot:J3KSY8;uniprot:J3KT31;uniprot:P31751;uniprot:C9JHS6;uniprot:J3KTP4;uniprot:M0R283 +COL5A3 GeneProduct ncbigene:50509 "" ensembl:ENSG00000080573 ncbigene:50509 hgnc.symbol:COL5A3 uniprot:P25940 +PDGFRB GeneProduct ncbigene:5159 "" ensembl:ENSG00000113721 ncbigene:5159 hgnc.symbol:PDGFRB uniprot:P09619;uniprot:E5RH16;uniprot:E5RJ14;uniprot:E5RII0 +VASP GeneProduct ncbigene:7408 "VASP; vasodilator-stimulated phosphoprotein" ensembl:ENSG00000125753 ncbigene:7408 hgnc.symbol:VASP uniprot:A0A024R0V4;uniprot:K7EIG8;uniprot:K7EQD0;uniprot:K7ENL7;uniprot:K7EM16;uniprot:P50552;uniprot:K7ENR7 +SOS1 GeneProduct ncbigene:6654 "SOS1; son of sevenless homolog 1 (Drosophila)" ensembl:ENSG00000115904 ncbigene:6654 hgnc.symbol:SOS1 uniprot:G5E9C8;uniprot:Q07889;uniprot:C9K0N6 +LAMA4 GeneProduct ncbigene:3910 "" ensembl:ENSG00000112769 ncbigene:3910 hgnc.symbol:LAMA4 uniprot:E5RHF3;uniprot:A0A0A0MTC7;uniprot:E5RFD7;uniprot:E5RK79;uniprot:Q6LET9;uniprot:A0A494C1K8;uniprot:A0A494C139;uniprot:H0YAQ5;uniprot:Q16363;uniprot:A0A0A0MQS9;uniprot:H0Y351;uniprot:H0YAP9;uniprot:E5RFQ2 +ARHGAP5 GeneProduct ncbigene:394 "" ensembl:ENSG00000100852 ncbigene:394 hgnc.symbol:ARHGAP5 uniprot:H0YK04;uniprot:G3V360;uniprot:Q13017;uniprot:G3V444;uniprot:G3V5I7 +COL2A1 GeneProduct ncbigene:1280 "" ensembl:ENSG00000139219 ncbigene:1280 hgnc.symbol:COL2A1 uniprot:P02458 +LAMB3 GeneProduct ncbigene:3914 "" ensembl:ENSG00000196878 ncbigene:3914 hgnc.symbol:LAMB3 uniprot:A0A0S2Z3R6;uniprot:Q13751;uniprot:X1WI29;uniprot:Q5THA1 +RAP1A GeneProduct ncbigene:5906 "RAP1A; RAP1A member of RAS oncogene family" ensembl:ENSG00000116473 ncbigene:5906 hgnc.symbol:RAP1A uniprot:A8KAH9;uniprot:P62834 +TNK1 GeneProduct ncbigene:8711 "" ensembl:ENSG00000174292 ncbigene:8711 hgnc.symbol:TNK1 uniprot:I3L334;uniprot:U3KPR9;uniprot:Q13470 +COL5A2 GeneProduct ncbigene:1290 "" ensembl:ENSG00000204262 ncbigene:1290 hgnc.symbol:COL5A2 uniprot:P05997;uniprot:A0A087WYX9;uniprot:A0A3B3IRH9 +DOCK1 GeneProduct ncbigene:1793 "DOCK1; dedicator of cyto-kinesis" ensembl:ENSG00000150760 ncbigene:1793 hgnc.symbol:DOCK1 uniprot:A0A096LNH6;uniprot:Q14185 +ITGB7 GeneProduct ncbigene:3695 "" ensembl:ENSG00000139626 ncbigene:3695 hgnc.symbol:ITGB7 uniprot:H3BRM2;uniprot:F8VNX4;uniprot:F8W186;uniprot:P26010;uniprot:H3BRX4;uniprot:F5H6T4 +COL4A6 GeneProduct ncbigene:1288 "" ensembl:ENSG00000197565 ncbigene:1288 hgnc.symbol:COL4A6 uniprot:A0A087WZY5;uniprot:A8MXH5;uniprot:F5H3Q5;uniprot:Q14031 +XIAP GeneProduct ensembl:ENSG00000101966 "" ensembl:ENSG00000101966 ncbigene:331 hgnc.symbol:XIAP uniprot:B1AKU2;uniprot:B1AKU3;uniprot:P98170 +PIK3R2 GeneProduct ncbigene:5296 "" ensembl:ENSG00000105647 ncbigene:5296 hgnc.symbol:PIK3R2 uniprot:E9PFP1;uniprot:O00459;uniprot:A0A7I2U3A3;uniprot:V9GYJ4;uniprot:A0A087X257;uniprot:A0A5F9ZHY3 +THBS2 GeneProduct ncbigene:7058 "" ensembl:ENSG00000186340 ncbigene:7058 hgnc.symbol:THBS2 uniprot:A0A7I2V585;uniprot:P35442;uniprot:A0A7I2V344;uniprot:Q5RI53;uniprot:A0A3B3ITK0;uniprot:A0A7I2YQ86;uniprot:A0A7I2YQT6 +HCK GeneProduct ncbigene:3055 "" ensembl:ENSG00000101336 ncbigene:3055 hgnc.symbol:HCK uniprot:J3KPD6;uniprot:H7BXG4;uniprot:H0Y3C5;uniprot:P08631;uniprot:H7C5P9 +IGF1 GeneProduct ncbigene:3479 "" ensembl:ENSG00000017427 ncbigene:3479 hgnc.symbol:IGF1 uniprot:P05019;uniprot:Q5U743 +FLNA GeneProduct ncbigene:2316 "" ensembl:ENSG00000196924 ncbigene:2316 hgnc.symbol:FLNA uniprot:Q60FE5;uniprot:A0A7I2V3E6;uniprot:A0A087WWY3;uniprot:A0A669KBC6;uniprot:A0A7P0NMY4;uniprot:H7C2E7;uniprot:H0Y5C6;uniprot:F8WE98;uniprot:H0Y5F3;uniprot:P21333 +GSK3B GeneProduct ncbigene:2932 "" ensembl:ENSG00000082701 ncbigene:2932 hgnc.symbol:GSK3B uniprot:A0A3B3ITW1;uniprot:A0A7I2V4F3;uniprot:A0A7I2YQ81;uniprot:A0A7I2V5B5;uniprot:A0A7I2V3D8;uniprot:A0A7I2V2Y0;uniprot:A0A7I2YQU1;uniprot:A0A7I2YQK0;uniprot:A0A7I2V2U4;uniprot:A0A7I2V441;uniprot:A0A7I2V4W7;uniprot:A0A7I2V589;uniprot:A0A7I2V3S5;uniprot:A0A7I2YQK2;uniprot:A0A7I2V5M2;uniprot:A0A7I2V626;uniprot:A0A7I2V606;uniprot:A0A7I2V2I5;uniprot:A0A7I2V2K7;uniprot:A0A7I2V3K8;uniprot:A0A7I2YQG6;uniprot:A0A7I2V4G2;uniprot:P49841;uniprot:A0A7I2V5G5;uniprot:A0A7I2V5K9;uniprot:A0A7I2V3A4;uniprot:A0A7I2V3G9;uniprot:Q6FI27;uniprot:A0A7I2V3Z5;uniprot:A0A7I2V4X2;uniprot:A0A7I2V2T2;uniprot:A0A7I2V2V4;uniprot:A0A7I2V4X3;uniprot:A0A7I2V3T3;uniprot:A0A7I2V675;uniprot:A0A7I2V432;uniprot:A0A7I2V2N4;uniprot:A0A7I2V5P4;uniprot:A0A7I2YQB0;uniprot:A0A7I2V3N7;uniprot:A0A7I2V3J4 +BLK GeneProduct ncbigene:640 "" ensembl:ENSG00000136573 ncbigene:640 hgnc.symbol:BLK uniprot:E9PJX5;uniprot:P51451 +LAMC1 GeneProduct ncbigene:3915 "" ensembl:ENSG00000135862 ncbigene:3915 hgnc.symbol:LAMC1 uniprot:P11047;uniprot:R4GNC7 +FN1 GeneProduct ncbigene:2335 "" ensembl:ENSG00000115414 ncbigene:2335 hgnc.symbol:FN1 uniprot:H0Y7Z1;uniprot:H0Y4K8;uniprot:P02751 +LAMC2 GeneProduct ncbigene:3918 "" ensembl:ENSG00000058085 ncbigene:3918 hgnc.symbol:LAMC2 uniprot:Q13753 +PGF GeneProduct ncbigene:5228 "" ensembl:ENSG00000119630 ncbigene:5228 hgnc.symbol:PGF uniprot:P49763;uniprot:G3XA84;uniprot:Q53XY6 +ITGA3 GeneProduct ncbigene:3675 "" ensembl:ENSG00000005884 ncbigene:3675 hgnc.symbol:ITGA3 uniprot:P26006;uniprot:A0A140VJM0;uniprot:D6R9X8;uniprot:H0YA32;uniprot:K7EMU3;uniprot:H0YA49;uniprot:K7EQJ2 +PIK3CA GeneProduct ncbigene:5290 "" ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336 +TNN GeneProduct ncbigene:63923 "" ensembl:ENSG00000120332 ncbigene:63923 hgnc.symbol:TNN uniprot:Q9UQP3;uniprot:A0A087WXC4 +BIRC3 GeneProduct ncbigene:330 "" ensembl:ENSG00000023445 ncbigene:330 hgnc.symbol:BIRC3 uniprot:H0YCJ5;uniprot:Q13489;uniprot:A0A669KBC7 +CCND3 GeneProduct ncbigene:896 "" ensembl:ENSG00000112576 ncbigene:896 hgnc.symbol:CCND3 uniprot:H0Y8M4;uniprot:D6RDL3;uniprot:A0A1D5RMS0;uniprot:D6RI00;uniprot:Q5T8J1;uniprot:P30281;uniprot:D6RIX2;uniprot:D6RDF8 +BIRC2 GeneProduct ncbigene:329 "" ensembl:ENSG00000110330 ncbigene:329 hgnc.symbol:BIRC2 uniprot:E9PNM6;uniprot:H0YDY3;uniprot:Q13490;uniprot:E9PI77;uniprot:E9PMH5;uniprot:E9PQZ9;uniprot:E9PIW1 +AKT1 GeneProduct ncbigene:207 "" ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56 +TNXB GeneProduct ncbigene:7148 "" ensembl:ENSG00000168477 ncbigene:7148 hgnc.symbol:TNXB uniprot:A0A087WWA5;uniprot:A0A1B0GX77;uniprot:C9J7W4;uniprot:A0A087X0I0;uniprot:A0A3B3ISX9;uniprot:P22105 +PAK1 GeneProduct ncbigene:5058 "" ensembl:ENSG00000149269 ncbigene:5058 hgnc.symbol:PAK1 uniprot:E9PRP6;uniprot:H0YCG5;uniprot:E9PJF8;uniprot:E9PKH9;uniprot:B3KNX7;uniprot:E9PMP2;uniprot:E9PQW5;uniprot:H0YCM0;uniprot:H0YF55;uniprot:A0A024R5P0;uniprot:E9PM17;uniprot:Q13153 +PXN GeneProduct ncbigene:5829 "" ensembl:ENSG00000089159 ncbigene:5829 hgnc.symbol:PXN uniprot:F5GZ78;uniprot:F8W0G0;uniprot:A0A1B0GWE7;uniprot:F5H836;uniprot:F8W0K8;uniprot:F8W1E0;uniprot:P49023;uniprot:A0A140VJQ8;uniprot:A0A1B0GTU4;uniprot:A0A1B0GV30;uniprot:F8VZ39;uniprot:A0A1B0GU60 +PIP5K1C GeneProduct ncbigene:23396 "" ensembl:ENSG00000186111 ncbigene:23396 hgnc.symbol:PIP5K1C uniprot:O60331;uniprot:A0A7P0T808;uniprot:A0A7P0TAE7 +BAD GeneProduct ncbigene:572 "" ensembl:ENSG00000002330 ncbigene:572 hgnc.symbol:BAD uniprot:F5GYS3;uniprot:A8MXU7;uniprot:A0A024R562;uniprot:F5H1R6;uniprot:Q92934;uniprot:F5H3B1 +ITGA1 GeneProduct ensembl:ENSG00000213949 "" ensembl:ENSG00000213949 ncbigene:3672 hgnc.symbol:ITGA1 uniprot:P56199;uniprot:A0A494C0F7 +IGF1R GeneProduct ncbigene:3480 "" ensembl:ENSG00000140443 ncbigene:3480 hgnc.symbol:IGF1R uniprot:C9J5X1;uniprot:H3BSZ8;uniprot:H0YNR0;uniprot:H0YMJ5;uniprot:P08069 +ACTN4 GeneProduct ensembl:ENSG00000130402 "" ensembl:ENSG00000130402 ncbigene:81 hgnc.symbol:ACTN4 uniprot:A0A0S2Z3G9;uniprot:K7EP19;uniprot:O43707;uniprot:H7C144;uniprot:F5GXS2 +SRC GeneProduct ncbigene:6714 "SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]" ensembl:ENSG00000197122 ncbigene:6714 hgnc.symbol:SRC uniprot:P12931 +ACTG1 GeneProduct ncbigene:71 "" ensembl:ENSG00000184009 ncbigene:71 hgnc.symbol:ACTG1 uniprot:I3L3I0;uniprot:I3L1U9;uniprot:I3L3R2;uniprot:A0A804GS07;uniprot:P63261;uniprot:A0A7P0TBL1;uniprot:J3KT65;uniprot:I3L4N8;uniprot:K7EM38 +HRAS GeneProduct ncbigene:3265 "" ensembl:ENSG00000174775 ncbigene:3265 hgnc.symbol:HRAS uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2 +ITGA7 GeneProduct ncbigene:3679 "" ensembl:ENSG00000135424 ncbigene:3679 hgnc.symbol:ITGA7 uniprot:H0YJ26;uniprot:J3KNV4;uniprot:G3V2I4;uniprot:G3V3L8;uniprot:H0YJS5;uniprot:H0YJ98;uniprot:G3V2C6;uniprot:Q13683;uniprot:G3V2Q6 +PDGFA GeneProduct ncbigene:5154 "" ensembl:ENSG00000197461 ncbigene:5154 hgnc.symbol:PDGFA uniprot:H7BYW6;uniprot:A0A0A0MSC4;uniprot:P04085 +BCAR1 GeneProduct ncbigene:9564 "" ensembl:ENSG00000050820 ncbigene:9564 hgnc.symbol:BCAR1 uniprot:P56945;uniprot:H3BVF0;uniprot:H3BSB2;uniprot:H3BU42;uniprot:H3BTB0;uniprot:H3BTL5;uniprot:H3BQJ7;uniprot:H3BSY4;uniprot:F5H855;uniprot:H3BN62 +VCL GeneProduct ncbigene:7414 "VCL; vinculin" ensembl:ENSG00000035403 ncbigene:7414 hgnc.symbol:VCL uniprot:V9HWK2;uniprot:P18206;uniprot:A0A024QZN4;uniprot:A0A096LPE1 +CAV2 GeneProduct ncbigene:858 "CAV2; caveolin 2" ensembl:ENSG00000105971 ncbigene:858 hgnc.symbol:CAV2 uniprot:P51636;uniprot:Q53X57;uniprot:E9PCT3 +PIK3CB GeneProduct ncbigene:5291 "" ensembl:ENSG00000051382 ncbigene:5291 hgnc.symbol:PIK3CB uniprot:C9JYX0;uniprot:C9J345;uniprot:H7C527;uniprot:P42338;uniprot:H7C5C3;uniprot:H7C565;uniprot:Q68DL0;uniprot:H0Y871;uniprot:F8WDJ8 +ITGB5 GeneProduct ncbigene:3693 "" ensembl:ENSG00000082781 ncbigene:3693 hgnc.symbol:ITGB5 uniprot:V9GYD8;uniprot:V9GYZ1;uniprot:F8WBG2;uniprot:P18084;uniprot:H7C5U2;uniprot:L7RT22;uniprot:H7C580;uniprot:H7C4W1;uniprot:V9GZ57 +AKT3 GeneProduct ncbigene:10000 "" ensembl:ENSG00000117020 ncbigene:10000 hgnc.symbol:AKT3 uniprot:A0A7P0T8T9;uniprot:A0A7P0TBJ6;uniprot:A0A5F9ZHU3;uniprot:A0A7P0TB29;uniprot:Q9Y243;uniprot:A0A5F9ZHA9;uniprot:A0A5F9ZGY0;uniprot:A0A5F9ZGZ4;uniprot:A0A5K1VW74;uniprot:A0A7P0T872;uniprot:A0A7P0TB32 +STYK1 GeneProduct ncbigene:55359 "" ensembl:ENSG00000060140 ncbigene:55359 hgnc.symbol:STYK1 uniprot:F5GZF6;uniprot:H0YGL5;uniprot:F5H4G3;uniprot:F5H2I9;uniprot:Q6J9G0;uniprot:F5H366 +TLN1 GeneProduct ncbigene:7094 "" ensembl:ENSG00000137076 ncbigene:7094 hgnc.symbol:TLN1 uniprot:Q9Y490 +ROCK2 GeneProduct ncbigene:9475 "" ensembl:ENSG00000134318 ncbigene:9475 hgnc.symbol:ROCK2 uniprot:A0A2P9DU05;uniprot:O75116;uniprot:C9JFJ0;uniprot:E9PF63;uniprot:D6REE7 +RAC2 GeneProduct ncbigene:5880 "" ensembl:ENSG00000128340 ncbigene:5880 hgnc.symbol:RAC2 uniprot:B1AH79;uniprot:B1AH78;uniprot:B1AH77;uniprot:A0A024R1P2;uniprot:P15153;uniprot:B1AH80 +PIK3CD GeneProduct ncbigene:5293 "" ensembl:ENSG00000171608 ncbigene:5293 hgnc.symbol:PIK3CD uniprot:B7ZM44;uniprot:F8W9P4;uniprot:O00329;uniprot:A0A2K8FKV1 +PDGFC GeneProduct ncbigene:56034 "" ensembl:ENSG00000145431 ncbigene:56034 hgnc.symbol:PDGFC uniprot:H0Y9N2;uniprot:Q9NRA1;uniprot:J3KN71 +VWF GeneProduct ncbigene:7450 "" ensembl:ENSG00000110799 ncbigene:7450 hgnc.symbol:VWF uniprot:P04275;uniprot:I3L4K4 +ITGA11 GeneProduct ncbigene:22801 "" ensembl:ENSG00000137809 ncbigene:22801 hgnc.symbol:ITGA11 uniprot:Q9UKX5 +ITGB4 GeneProduct ncbigene:3691 "" ensembl:ENSG00000132470 ncbigene:3691 hgnc.symbol:ITGB4 uniprot:J3QQL2;uniprot:J3QRK0;uniprot:A0A024R8K7;uniprot:A0A024R8T0;uniprot:P16144;uniprot:J3KSH9 +RAPGEF1 GeneProduct ncbigene:2889 "" ensembl:ENSG00000107263 ncbigene:2889 hgnc.symbol:RAPGEF1 uniprot:A0A804HL87;uniprot:H0Y6R4;uniprot:Q5JUE9;uniprot:Q13905 +ITGB3 GeneProduct ncbigene:3690 "" ensembl:ENSG00000259207 ncbigene:3690 hgnc.symbol:ITGB3 uniprot:P05106;uniprot:I3L4X8;uniprot:Q16157 +EGFR GeneProduct ncbigene:1956 "" ensembl:ENSG00000146648 ncbigene:1956 hgnc.symbol:EGFR uniprot:P00533;uniprot:Q504U8;uniprot:C9JYS6 +VEGFC GeneProduct ncbigene:7424 "" ensembl:ENSG00000150630 ncbigene:7424 hgnc.symbol:VEGFC uniprot:P49767 +PAK2 GeneProduct ncbigene:5062 "" ensembl:ENSG00000180370 ncbigene:5062 hgnc.symbol:PAK2 uniprot:H7C1X3;uniprot:Q13177 +DIAPH1 GeneProduct ensembl:ENSG00000131504 "" ensembl:ENSG00000131504 ncbigene:1729 hgnc.symbol:DIAPH1 uniprot:B4E2I7;uniprot:A0A2R8YEF8;uniprot:H7C2W8;uniprot:O60610;uniprot:A0A2R8Y5N1 +PTK6 GeneProduct ncbigene:5753 "" ensembl:ENSG00000101213 ncbigene:5753 hgnc.symbol:PTK6 uniprot:Q13882 +RHOA GeneProduct ncbigene:387 "" ensembl:ENSG00000067560 ncbigene:387 hgnc.symbol:RHOA uniprot:P61586;uniprot:A0A7I2V5E6;uniprot:C9JNR4;uniprot:A0A024R324;uniprot:A0A7I2YQV1;uniprot:C9JRM1;uniprot:A0A7I2V3G1;uniprot:C9JX21 +RASGRF1 GeneProduct ensembl:ENSG00000058335 "" ensembl:ENSG00000058335 ncbigene:5923 hgnc.symbol:RASGRF1 uniprot:Q13972 +MYLK2 GeneProduct ncbigene:85366 "" ensembl:ENSG00000101306 ncbigene:85366 hgnc.symbol:MYLK2 uniprot:Q9H1R3 +PDGFB GeneProduct ncbigene:5155 "" ensembl:ENSG00000100311 ncbigene:5155 hgnc.symbol:PDGFB uniprot:A9UJP0;uniprot:P01127;uniprot:A0A384NYY3;uniprot:A9UJN9 +MYL5 GeneProduct ensembl:ENSG00000215375 "" ensembl:ENSG00000215375 ncbigene:4636 hgnc.symbol:MYL5 uniprot:D6RJ91;uniprot:Q02045;uniprot:D6RA88;uniprot:D6RB15 +COL4A1 GeneProduct ncbigene:1282 "" ensembl:ENSG00000187498 ncbigene:1282 hgnc.symbol:COL4A1 uniprot:A0A3B3ITS9;uniprot:A0A087WTY5;uniprot:A0A3B3ITC8;uniprot:A0A3B3IU02;uniprot:A0A3B3ITG7;uniprot:A0A3B3ISH5;uniprot:A0A3B3ISV3;uniprot:A0A3B3ISZ8;uniprot:A0A3B3IUD0;uniprot:P02462 +SHC2 GeneProduct ensembl:ENSG00000129946 "SHC1; SHC (Src homology 2 domain containing) transforming protein 1" ensembl:ENSG00000129946 ncbigene:25759 hgnc.symbol:SHC2 uniprot:K7ENB2;uniprot:K7EKS8;uniprot:P98077 +SHC4 GeneProduct ensembl:ENSG00000185634 "SHC1; SHC (Src homology 2 domain containing) transforming protein 1" ensembl:ENSG00000185634 ncbigene:399694 hgnc.symbol:SHC4 uniprot:H0YLU6;uniprot:Q6S5L8;uniprot:F5H5M1;uniprot:H0YLZ2 +PRKCA GeneProduct ensembl:ENSG00000154229 "SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]" ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 +PRKCB GeneProduct ensembl:ENSG00000166501 "SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]" ensembl:ENSG00000166501 ncbigene:5579 hgnc.symbol:PRKCB uniprot:I3L1Z0;uniprot:I3L148;uniprot:H3BV73;uniprot:P05771 +PRKCG GeneProduct ensembl:ENSG00000126583 "SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]" ensembl:ENSG00000126583 ncbigene:5582 hgnc.symbol:PRKCG uniprot:P05129;uniprot:M0R0I9;uniprot:A0A804HIU5;uniprot:H7BZ60;uniprot:M0R0Z4;uniprot:A0A804HHY0 +ARHGAP35 GeneProduct ensembl:ENSG00000160007 "" ensembl:ENSG00000160007 ncbigene:2909 hgnc.symbol:ARHGAP35 uniprot:Q9NRY4 +PPP1R12B GeneProduct ensembl:ENSG00000077157 "" ensembl:ENSG00000077157 ncbigene:4660 hgnc.symbol:PPP1R12B uniprot:A0A0U1RQP2;uniprot:E1CKY7;uniprot:H7C4R6;uniprot:Q6GQY8;uniprot:O60237;uniprot:A0A0U1RQI8 +PPP1R12C GeneProduct ensembl:ENSG00000125503 "" ensembl:ENSG00000125503 ncbigene:54776 hgnc.symbol:PPP1R12C uniprot:K7ER83;uniprot:Q9BZL4;uniprot:K7EL81 +PPP1CA GeneProduct ensembl:ENSG00000172531 "" ensembl:ENSG00000172531 ncbigene:5499 hgnc.symbol:PPP1CA uniprot:P62136;uniprot:A0A7I2V4F7;uniprot:A0A140VJS9;uniprot:E9PMD7 +PPP1CB GeneProduct ensembl:ENSG00000213639 "" ensembl:ENSG00000213639 ncbigene:5500 hgnc.symbol:PPP1CB uniprot:C9JP48;uniprot:H0Y3Y6;uniprot:P62140;uniprot:C9J9S3;uniprot:B4DJ75;uniprot:F8WE71;uniprot:V9HW04;uniprot:E7ETD8 +PPP1CC GeneProduct ensembl:ENSG00000186298 "" ensembl:ENSG00000186298 ncbigene:5501 hgnc.symbol:PPP1CC uniprot:F8VR82;uniprot:F8VYE8;uniprot:A0A087WYY5;uniprot:F8W0W8;uniprot:A0A024RBP2;uniprot:F8W1A0;uniprot:P36873;uniprot:F8W0V8 +PPP1CC GeneProduct ensembl:ENSG00000186298 "" ensembl:ENSG00000186298 ncbigene:5501 hgnc.symbol:PPP1CC uniprot:F8VR82;uniprot:F8VYE8;uniprot:A0A087WYY5;uniprot:F8W0W8;uniprot:A0A024RBP2;uniprot:F8W1A0;uniprot:P36873;uniprot:F8W0V8 +MYL7 GeneProduct ensembl:ENSG00000106631 "" ensembl:ENSG00000106631 ncbigene:58498 hgnc.symbol:MYL7 uniprot:C9JEG4;uniprot:Q01449;uniprot:H7BZE4;uniprot:F8WD94;uniprot:H7C243;uniprot:H7C3E3;uniprot:H7C1B1;uniprot:H7C482 +MYL10 GeneProduct ensembl:ENSG00000106436 "" ensembl:ENSG00000106436 ncbigene:93408 hgnc.symbol:MYL10 uniprot:Q9BUA6;uniprot:A0A2R8YDI2 +MYL12A GeneProduct ensembl:ENSG00000101608 "" ensembl:ENSG00000101608 ncbigene:10627 hgnc.symbol:MYL12A uniprot:J3KT92;uniprot:J3KTJ1;uniprot:J3QRS3;uniprot:P19105 +MYL12B GeneProduct ensembl:ENSG00000118680 "" ensembl:ENSG00000118680 ncbigene:103910 hgnc.symbol:MYL12B uniprot:O14950 +MYL2 GeneProduct ensembl:ENSG00000111245 "" ensembl:ENSG00000111245 ncbigene:4633 hgnc.symbol:MYL2 uniprot:P10916;uniprot:A0A590UJU8;uniprot:A0A590UK07;uniprot:G3V1V8;uniprot:Q6IB42 +MYL9 GeneProduct ensembl:ENSG00000101335 "" ensembl:ENSG00000101335 ncbigene:10398 hgnc.symbol:MYL9 uniprot:A0A384NY64;uniprot:P24844 +MYLPF GeneProduct ensembl:ENSG00000180209 "" ensembl:ENSG00000180209 ncbigene:29895 hgnc.symbol:MYL11 uniprot:H3BN54;uniprot:Q96A32;uniprot:H3BPK4;uniprot:A0A024QZG6;uniprot:H3BML9 +MYLK3 GeneProduct ensembl:ENSG00000140795 "" ensembl:ENSG00000140795 ncbigene:91807 hgnc.symbol:MYLK3 uniprot:Q32MK0 +MYLK4 GeneProduct ensembl:ENSG00000145949 "" ensembl:ENSG00000145949 ncbigene:340156 hgnc.symbol:MYLK4 uniprot:Q86YV6;uniprot:A0A2R8Y4U5 +ACTN1 GeneProduct ncbigene:87 "" ensembl:ENSG00000072110 ncbigene:87 hgnc.symbol:ACTN1 uniprot:G3V380;uniprot:A0A804HJU8;uniprot:G3V2W4;uniprot:A0A804HL31;uniprot:H7C5W8;uniprot:A0A804HJN7;uniprot:H0YJW3;uniprot:P12814;uniprot:G3V2E8;uniprot:A0A7I2V4Y4;uniprot:A0A804HIN7;uniprot:A0A804HJQ9;uniprot:H9KV75;uniprot:G3V5M4;uniprot:A0A804HKE2;uniprot:A0A804HLD0;uniprot:H0YJ11;uniprot:A0A024R694;uniprot:A0A804HII9;uniprot:A0A804HLF4;uniprot:G3V2X9;uniprot:A0A804HK61;uniprot:A0A804HIY0;uniprot:G3V2N5 +PARVA GeneProduct ensembl:ENSG00000197702 "" ensembl:ENSG00000197702 ncbigene:55742 hgnc.symbol:PARVA uniprot:Q9NVD7;uniprot:E9PS97 +PARVG GeneProduct ensembl:ENSG00000138964 "" ensembl:ENSG00000138964 ncbigene:64098 hgnc.symbol:PARVG uniprot:U3KQ67;uniprot:A0A024R4U4;uniprot:Q9HBI0;uniprot:B0QYN0;uniprot:B0QYM9 +FLNB GeneProduct ensembl:ENSG00000136068 "" ensembl:ENSG00000136068 ncbigene:2317 hgnc.symbol:FLNB uniprot:A0A804HL72;uniprot:A0A0C4DGA1;uniprot:A0A804HJC2;uniprot:A0A804HK76;uniprot:O75369;uniprot:E7EN95;uniprot:H7C5L4 +FLNC GeneProduct ensembl:ENSG00000128591 "" ensembl:ENSG00000128591 ncbigene:2318 hgnc.symbol:FLNC uniprot:Q14315 +TLN2 GeneProduct ensembl:ENSG00000171914 "" ensembl:ENSG00000171914 ncbigene:83660 hgnc.symbol:TLN2 uniprot:H0YN01;uniprot:A0A1B0GVU7;uniprot:H0YMT1;uniprot:Q9Y4G6 +MAPK10 GeneProduct ensembl:ENSG00000109339 "" ensembl:ENSG00000109339 ncbigene:5602 hgnc.symbol:MAPK10 uniprot:A0A1P0B7D2;uniprot:A0A286YFM6;uniprot:A0A1W2PQX4;uniprot:P53779;uniprot:A0A286YFI3;uniprot:A0A1W2PRZ2;uniprot:A0A286YFE2;uniprot:A0A1W2PPZ3;uniprot:A0A286YF43;uniprot:A0A286YEW9;uniprot:A0A286YF02;uniprot:A0A286YES9;uniprot:A0A286YES8;uniprot:A0A286YF04;uniprot:A0A286YF80;uniprot:A0A286YF83;uniprot:A0A1W2PPM4;uniprot:A0A286YF85;uniprot:A0A286YES0;uniprot:A0A286YEW4;uniprot:D6RFZ7;uniprot:A0A286YFD7;uniprot:A0A286YFD9;uniprot:A0A286YEN5;uniprot:D6RDG1;uniprot:A0A286YFH4;uniprot:A0A286YEV5;uniprot:A0A286YEV8;uniprot:A0A286YF35;uniprot:A0A286YEZ1;uniprot:D6RAU3;uniprot:A0A286YEV3;uniprot:D6RJF9;uniprot:A0A286YFC3;uniprot:D6RBH2;uniprot:A0A286YFK3;uniprot:F8W9R5;uniprot:A0A286YFC0;uniprot:A0A1W2PRG9;uniprot:A0A286YEQ0;uniprot:D6RCB1;uniprot:A0A286YEQ7;uniprot:A0A286YEY0;uniprot:A0A286YEY2;uniprot:A8MPV1;uniprot:A0A286YF62;uniprot:A0A1W2PQ03;uniprot:D6RAJ0;uniprot:A0A286YFB7;uniprot:D6RFX8;uniprot:A0A286YFB6;uniprot:A0A286YFJ0;uniprot:A0A286YF19;uniprot:A0A286YFJ4;uniprot:A0A1W2PPW1;uniprot:A0A286YFJ6;uniprot:A0A286YEX7;uniprot:A0A286YF53;uniprot:A0A286YF97;uniprot:A0A286YFN2;uniprot:A0A286YFA7;uniprot:A0A1W2PRF2;uniprot:A0A1W2PNF5;uniprot:A0A286YF95;uniprot:A0A286YFA3;uniprot:D6R9C1;uniprot:D6RC26;uniprot:A0A286YFA6;uniprot:A0A286YFE9 +VAV2 GeneProduct ensembl:ENSG00000160293 "" ensembl:ENSG00000160293 ncbigene:7410 hgnc.symbol:VAV2 uniprot:P52735 +VAV3 GeneProduct ensembl:ENSG00000134215 "" ensembl:ENSG00000134215 ncbigene:10451 hgnc.symbol:VAV3 uniprot:H0YDG2;uniprot:E9PMJ5;uniprot:H0YCG7;uniprot:Q9UKW4 diff --git a/pathways/WP306/WP306.gpml b/pathways/WP306/WP306.gpml index ef1620f5f..b429310ce 100644 --- a/pathways/WP306/WP306.gpml +++ b/pathways/WP306/WP306.gpml @@ -1,5 +1,5 @@ - + Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP306 CPTAC Assay Portal] @@ -21,16 +21,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. fed d31 - + - - + + - - + + @@ -235,8 +235,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -494,8 +494,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -819,8 +819,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -1552,7 +1552,7 @@ sitegrpid=447856; ptm=p; direction=u - + @@ -1904,31 +1904,31 @@ sitegrpid=447856; ptm=p; direction=u - diff --git a/pathways/WP306/WP306.json b/pathways/WP306/WP306.json index 1e9e5bb23..04ce90d9a 100644 --- a/pathways/WP306/WP306.json +++ b/pathways/WP306/WP306.json @@ -2705,7 +2705,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "Cell Motility", + "textContent": "Cell motility", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -2771,7 +2771,7 @@ "stroke": "#000000", "strokeWidth": 0, "textAlign": "center", - "textContent": "Cell Proliferation", + "textContent": "Cell proliferation", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3324,7 +3324,7 @@ "fontStyle": "normal", "fontWeight": "bold", "gpmlElementName": "DataNode", - "height": 29.5, + "height": 30, "id": "b15bb", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -3335,7 +3335,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "Wnt Signaling\nPathway", + "textContent": "Wnt signaling\npathway", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3351,7 +3351,7 @@ "x": 1437, "xrefDataSource": "WikiPathways", "xrefIdentifier": "WP428", - "y": 492.5, + "y": 492.25, "zIndex": 32768 }, "b1a": { @@ -3542,7 +3542,7 @@ "fontStyle": "normal", "fontWeight": "bold", "gpmlElementName": "DataNode", - "height": 16, + "height": 25, "id": "b3969", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -3553,7 +3553,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "Cell Cycle", + "textContent": "Cell cycle", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3564,12 +3564,12 @@ ], "verticalAlign": "middle", "whiteSpace": "pre", - "width": 64.33333333333333, + "width": 70, "wpType": "Pathway", - "x": 1684.218507055746, + "x": 1681.3851737224127, "xrefDataSource": "WikiPathways", "xrefIdentifier": "WP179", - "y": 699.4952286209056, + "y": 694.9952286209056, "zIndex": 28672 }, "b3a": { @@ -6361,7 +6361,7 @@ "stroke": "#000000", "strokeWidth": 0, "textAlign": "center", - "textContent": "Filopodia / Lamellipodia \nformation", + "textContent": "Filopodia / lamellipodia formation", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -6370,8 +6370,8 @@ ], "verticalAlign": "middle", "whiteSpace": "pre", - "width": 123.61482627758733, - "x": 1547.3851737224127, + "width": 200, + "x": 1533.1925868612063, "y": 381.8285619542389, "zIndex": 28672 }, @@ -7196,7 +7196,7 @@ "stroke": "#000000", "strokeWidth": 0, "textAlign": "center", - "textContent": "Actin Polymerization", + "textContent": "Actin polymerization", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -8248,7 +8248,7 @@ "stroke": "#000000", "strokeWidth": 0, "textAlign": "center", - "textContent": "Cell Survival", + "textContent": "Cell survival", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -9623,7 +9623,7 @@ "stroke": "#000080", "strokeWidth": 0, "textAlign": "center", - "textContent": "Receptor Tyrosine Kinases", + "textContent": "Receptor tyrosine kinases", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -9645,7 +9645,7 @@ "fontStyle": "normal", "fontWeight": "bold", "gpmlElementName": "DataNode", - "height": 25, + "height": 30, "id": "d2ce3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -9656,7 +9656,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "Phosphatidylinositol\nSignaling", + "textContent": "Phosphatidylinositol\nsignaling", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -9669,7 +9669,7 @@ "width": 136, "wpType": "Pathway", "x": 856, - "y": 652.5, + "y": 650, "zIndex": 32768 }, "d2f48": { @@ -9806,7 +9806,7 @@ 1 ], "x": 1369.0388802918094, - "y": 564.8285619542391 + "y": 563.9142809771196 } ], "stroke": "#000000", @@ -11227,7 +11227,7 @@ "stroke": "#000080", "strokeWidth": 0, "textAlign": "center", - "textContent": "Extracellular Matrix - Receptor Interactions", + "textContent": "Extracellular matrix - receptor interactions", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -14571,7 +14571,7 @@ "stroke": "#000000", "strokeWidth": 0, "textAlign": "center", - "textContent": "Stress Fiber-FA formation", + "textContent": "Stress fiber-FA formation", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -15418,7 +15418,7 @@ "fontStyle": "normal", "fontWeight": "bold", "gpmlElementName": "DataNode", - "height": 28.17143804576085, + "height": 30, "id": "efd70", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -15429,7 +15429,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "PI3K-Akt\nSignaling Pathway", + "textContent": "PI3K-Akt\nsignaling pathway", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -15445,7 +15445,7 @@ "x": 1341.0518403890792, "xrefDataSource": "WikiPathways", "xrefIdentifier": "WP4172", - "y": 564.8285619542391, + "y": 563.9142809771196, "zIndex": 28672 }, "efe6d": { @@ -18313,7 +18313,7 @@ "fontStyle": "normal", "fontWeight": "bold", "gpmlElementName": "DataNode", - "height": 25, + "height": 30, "id": "fd9c0", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, @@ -18324,7 +18324,7 @@ "stroke": "#14961e", "strokeWidth": 1, "textAlign": "center", - "textContent": "Regulation of \nActin cytoskeleton", + "textContent": "Regulation of \nactin cytoskeleton", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -18340,7 +18340,7 @@ "x": 1529, "xrefDataSource": "WikiPathways", "xrefIdentifier": "WP51", - "y": 246.5, + "y": 244, "zIndex": 32768 }, "fddf3": { @@ -18974,7 +18974,7 @@ "id": "publicationXrefa08", "source": "J Cell Sci", "standardName": "Focal adhesion kinase: the first ten years.", - "textContent": "9", + "textContent": "8", "type": [ "PublicationXref", "PubMed:12640026" @@ -18993,7 +18993,7 @@ "id": "publicationXrefa93", "source": "Biochim Biophys Acta", "standardName": "Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.", - "textContent": "14", + "textContent": "12", "type": [ "PublicationXref", "PubMed:15053919" @@ -19029,7 +19029,7 @@ "id": "publicationXrefb50", "source": "Mol Cells", "standardName": "Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.", - "textContent": "12", + "textContent": "13", "type": [ "PublicationXref", "PubMed:15179030" @@ -19083,7 +19083,7 @@ "id": "publicationXrefbd6", "source": "Biol Cell", "standardName": "Focal adhesions: structure and dynamics.", - "textContent": "4", + "textContent": "1", "type": [ "PublicationXref", "PubMed:11229600" @@ -19139,7 +19139,7 @@ "id": "publicationXrefc3a", "source": "Curr Opin Cell Biol", "standardName": "Interactions between growth factor receptors and adhesion molecules: breaking the rules.", - "textContent": "10", + "textContent": "9", "type": [ "PublicationXref", "PubMed:14519391" @@ -19157,7 +19157,7 @@ "id": "publicationXrefc43", "source": "Curr Opin Genet Dev", "standardName": "Multiple connections link FAK to cell motility and invasion.", - "textContent": "13", + "textContent": "14", "type": [ "PublicationXref", "PubMed:15108811" @@ -19213,7 +19213,7 @@ "id": "publicationXrefd05", "source": "Exp Cell Res", "standardName": "Rho GTPases: signaling, migration, and invasion.", - "textContent": "1", + "textContent": "2", "type": [ "PublicationXref", "PubMed:11082269" @@ -19253,7 +19253,7 @@ "id": "publicationXrefd8a", "source": "Biochemistry (Mosc)", "standardName": "Integrins: structure and signaling.", - "textContent": "8", + "textContent": "10", "type": [ "PublicationXref", "PubMed:14756624" @@ -19270,7 +19270,7 @@ "id": "publicationXreffed", "source": "Nat Cell Biol", "standardName": "Paxillin and focal adhesion signalling.", - "textContent": "2", + "textContent": "4", "type": [ "PublicationXref", "PubMed:11146675" @@ -19284,7 +19284,7 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP306/" + "@base": "WP306/" } ], "author": "[169.230.77.174, MaintBot, Thomas, Khanspers, AlexanderPico, Egonw, Zari, Dtruong, MirellaKalafati, Ariutta, Eweitz, Fehrhart]", @@ -19463,7 +19463,7 @@ "f1d2b", "fe7a2" ], - "dataSourceVersion": "WP306_r127184", + "dataSourceVersion": "WP306_r130801", "displayName": "Focal adhesion", "drawAs": "rect", "fill": "white", @@ -19471,9 +19471,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 1022, - "id": "http://identifiers.org/wikipathways/WP306", + "id": "WP306", "kaavioType": "Group", - "lastModified": "20230809175705", + "lastModified": "20240530122945", "name": "Focal adhesion", "organism": "Homo sapiens", "padding": 5, @@ -19482,7 +19482,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Focal adhesion\nLast Modified: 20230809175705\nOrganism: Homo sapiens", + "textContent": "Name: Focal adhesion\nLast Modified: 20240530122945\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000648" diff --git a/pathways/WP306/WP306.png b/pathways/WP306/WP306.png index 91b4e4d01..7678a75fe 100644 Binary files a/pathways/WP306/WP306.png and b/pathways/WP306/WP306.png differ diff --git a/pathways/WP306/WP306.svg b/pathways/WP306/WP306.svg index fe7ea132c..2151e62e8 100644 --- a/pathways/WP306/WP306.svg +++ b/pathways/WP306/WP306.svg @@ -1,5 +1,5 @@ - + @@ -472,8 +472,8 @@ - - + + @@ -725,8 +725,8 @@ - - + + @@ -945,22 +945,22 @@ Nucleus - + - Cell Motility + Cell motility - + - Cell Proliferation + Cell proliferation - - - - Cell Cycle + + + + Cell cycle @@ -969,30 +969,29 @@ Cytokine-cytokine receptor interactions - - - + + + PI3K-Akt - Signaling Pathway + signaling pathway - - - - Filopodia / Lamellipodia - formation + + + + Filopodia / lamellipodia formation - + - Actin Polymerization + Actin polymerization - + - Cell Survival + Cell survival @@ -1001,24 +1000,24 @@ FA turnover - + - Extracellular Matrix - Receptor Interactions + Extracellular matrix - receptor interactions - + - Stress Fiber-FA formation + Stress fiber-FA formation - + - Receptor Tyrosine Kinases + Receptor tyrosine kinases @@ -1190,11 +1189,11 @@ ZYX - - - - Wnt Signaling - Pathway + + + + Wnt signaling + pathway @@ -1323,11 +1322,11 @@ GRB2 - - - + + + Phosphatidylinositol - Signaling + signaling @@ -1456,11 +1455,11 @@ RASGRF1 - - - + + + Regulation of - Actin cytoskeleton + actin cytoskeleton @@ -2647,9 +2646,9 @@ - + Name: Focal adhesion - Last Modified: 20230809175705 + Last Modified: 20240530122945 Organism: Homo sapiens diff --git a/pathways/WP3929/WP3929.gpml b/pathways/WP3929/WP3929.gpml index 694445188..9238c9996 100644 --- a/pathways/WP3929/WP3929.gpml +++ b/pathways/WP3929/WP3929.gpml @@ -1,5 +1,5 @@ - + Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as chemoattractants in guiding migration of cells. Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. This pathway was adapted from [http://www.genome.jp/dbget-bin/www_bget?pathway:map04062 KEGG] @@ -300,11 +300,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - Original kegg element: map;5;path:mmu04060 - - - Original kegg element: gene;1;mmu:12145 mmu:12458 mmu:12765 mmu:12766 mmu:12767 mmu:12768 mmu:12769 mmu:12770 mmu:12771 mmu:12772 mmu:12773 mmu:12774 mmu:12775 mmu:12776 mmu:12777 mmu:13051 mmu:227288 mmu:23832 mmu:80901 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12770 @@ -838,6 +833,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + Original kegg element: gene;11;mmu:18795 mmu:18796 mmu:18797 mmu:18798 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18795 diff --git a/pathways/WP3929/WP3929.json b/pathways/WP3929/WP3929.json index 803e7f08c..55a26c487 100644 --- a/pathways/WP3929/WP3929.json +++ b/pathways/WP3929/WP3929.json @@ -3763,47 +3763,6 @@ "y": 29, "zIndex": 32768 }, - "b0bc8": { - "comments": [ - { - "content": "Original kegg element: map;5;path:mmu04060", - "source": "KeggConverter" - } - ], - "drawAs": "rect", - "fill": "#ffffff", - "fontFamily": "Arial", - "fontSize": 10, - "fontStyle": "normal", - "fontWeight": "normal", - "gpmlElementName": "DataNode", - "height": 20, - "id": "b0bc8", - "kaavioType": "SingleFreeNode", - "lineHeight": 1.1, - "overflow": "hidden", - "padding": 8, - "rx": 15, - "ry": 15, - "stroke": "#000000", - "strokeWidth": 1, - "textAlign": "center", - "textContent": "Cytokine-cytokine receptor interaction", - "textDecoration": "none", - "textOverflow": "clip", - "type": [ - "DataNode", - "SingleFreeNode", - "GeneProduct" - ], - "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 270.42838018741645, - "wpType": "GeneProduct", - "x": 25.421686746987803, - "y": 233.97322623828654, - "zIndex": 32768 - }, "b0c47": { "contains": [ "d3768", @@ -12069,6 +12028,44 @@ ], "zIndex": 32770 }, + "df9e5": { + "drawAs": "rect", + "fill": "#ffffff", + "fontFamily": "Arial", + "fontSize": 12, + "fontStyle": "normal", + "fontWeight": "bold", + "gpmlElementName": "DataNode", + "height": 35, + "id": "df9e5", + "kaavioType": "SingleFreeNode", + "lineHeight": 1.1, + "overflow": "hidden", + "padding": 8, + "rx": 15, + "ry": 15, + "stroke": "#14961e", + "strokeWidth": 1, + "textAlign": "center", + "textContent": "Cytokine-cytokine\nreceptor interaction", + "textDecoration": "none", + "textOverflow": "clip", + "type": [ + "DataNode", + "SingleFreeNode", + "WikiPathways:WP5473", + "Pathway" + ], + "verticalAlign": "middle", + "whiteSpace": "pre", + "width": 140, + "wpType": "Pathway", + "x": 48, + "xrefDataSource": "WikiPathways", + "xrefIdentifier": "WP5473", + "y": 214.5, + "zIndex": 32768 + }, "e014d": { "comments": [ { @@ -17634,7 +17631,6 @@ "acc39", "af19d", "afff6", - "b0bc8", "b36d7", "b3990", "b503a", @@ -17647,6 +17643,7 @@ "ce350", "cecb5", "da125", + "df9e5", "e550d", "e79c9", "e8b89", @@ -17704,7 +17701,7 @@ "a9204", "ed67e" ], - "dataSourceVersion": "WP3929_r129707", + "dataSourceVersion": "WP3929_r130800", "displayName": "Chemokine signaling", "drawAs": "rect", "fill": "white", @@ -17714,7 +17711,7 @@ "height": 1752.182061579652, "id": "WP3929", "kaavioType": "Group", - "lastModified": "20240522013006", + "lastModified": "20240530122130", "name": "Chemokine signaling", "organism": "Homo sapiens", "padding": 5, @@ -17723,7 +17720,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Chemokine signaling\nLast Modified: 20240522013006\nOrganism: Homo sapiens", + "textContent": "Name: Chemokine signaling\nLast Modified: 20240530122130\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000829", diff --git a/pathways/WP3929/WP3929.png b/pathways/WP3929/WP3929.png index fb234884a..359a71e0e 100644 Binary files a/pathways/WP3929/WP3929.png and b/pathways/WP3929/WP3929.png differ diff --git a/pathways/WP3929/WP3929.svg b/pathways/WP3929/WP3929.svg index cc1044f99..73232fc51 100644 --- a/pathways/WP3929/WP3929.svg +++ b/pathways/WP3929/WP3929.svg @@ -22,6 +22,12 @@ + + + + + + @@ -448,7 +454,7 @@ - + @@ -823,12 +829,6 @@ DOCK2 - - - - Cytokine-cytokine receptor interaction - - @@ -901,6 +901,13 @@ NCF1 + + + + Cytokine-cytokine + receptor interaction + + @@ -2254,7 +2261,7 @@ Name: Chemokine signaling - Last Modified: 20240522013006 + Last Modified: 20240530122130 Organism: Homo sapiens diff --git a/pathways/WP3981/WP3981.gpml b/pathways/WP3981/WP3981.gpml index d1e065e5f..9ce0646f9 100644 --- a/pathways/WP3981/WP3981.gpml +++ b/pathways/WP3981/WP3981.gpml @@ -1,5 +1,5 @@ - + Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells. An integrated in silico and computational prediction databases (DIANA-micro T-CDS, miRBase, and TargetScan) were employed to predict potential targets of a subset of highly downregulated miRNAs (>2-fold) in prostate tumors. Note that some targeting miRNAs were removed from the original publication figure for clarity. These are represented in supplementary table S3: http://journals.sagepub.com/doi/suppl/10.1177/1535370216681554. ad0 @@ -734,6 +734,11 @@ Note that some targeting miRNAs were removed from the original publication figur + + prostate cancer + DOID:10283 + Disease + cancer pathway PW:0000605 @@ -759,11 +764,6 @@ Note that some targeting miRNAs were removed from the original publication figur El-Habit OH Abdel-Mageed AB - - prostate cancer - DOID:10283 - Disease - diff --git a/pathways/WP3981/WP3981.json b/pathways/WP3981/WP3981.json index 3636bea76..2104d5a29 100644 --- a/pathways/WP3981/WP3981.json +++ b/pathways/WP3981/WP3981.json @@ -7302,7 +7302,7 @@ "faa9d", "c7f80" ], - "dataSourceVersion": "WP3981_r129791", + "dataSourceVersion": "WP3981_r130804", "displayName": "miRNA regulation of prostate cancer signaling", "drawAs": "rect", "fill": "white", @@ -7312,7 +7312,7 @@ "height": 655, "id": "WP3981", "kaavioType": "Group", - "lastModified": "20240522121254", + "lastModified": "20240530125219", "name": "miRNA regulation of prostate cancer signaling", "organism": "Homo sapiens", "padding": 5, @@ -7321,7 +7321,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: miRNA regulation of prostate cancer signaling\nLast Modified: 20240522121254\nOrganism: Homo sapiens", + "textContent": "Name: miRNA regulation of prostate cancer signaling\nLast Modified: 20240530125219\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000605" diff --git a/pathways/WP3981/WP3981.png b/pathways/WP3981/WP3981.png index ac1460633..13dd9b048 100644 Binary files a/pathways/WP3981/WP3981.png and b/pathways/WP3981/WP3981.png differ diff --git a/pathways/WP3981/WP3981.svg b/pathways/WP3981/WP3981.svg index 69feb5156..fffab600c 100644 --- a/pathways/WP3981/WP3981.svg +++ b/pathways/WP3981/WP3981.svg @@ -472,7 +472,7 @@ - + @@ -1310,7 +1310,7 @@ Name: miRNA regulation of prostate cancer signaling - Last Modified: 20240522121254 + Last Modified: 20240530125219 Organism: Homo sapiens diff --git a/pathways/WP5198/WP5198-datanodes.tsv b/pathways/WP5198/WP5198-datanodes.tsv index a6bfe4bd3..809d89328 100644 --- a/pathways/WP5198/WP5198-datanodes.tsv +++ b/pathways/WP5198/WP5198-datanodes.tsv @@ -2,21 +2,21 @@ Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InCh Peptidoglycan Metabolite chebi:8005 "" wikidata:Q206920 chebi:8005;chebi:8005 MDP Metabolite chebi:183049 "" chebi:183049 NF-kB GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 -IL-18R-beta GeneProduct ensembl:ENSG00000115607 "" ensembl:ENSG00000115607 ncbigene:8807 hgnc.symbol:IL18RAP uniprot:C9JLE2;uniprot:O95256 +IL18RAP GeneProduct ensembl:ENSG00000115607 "" ensembl:ENSG00000115607 ncbigene:8807 hgnc.symbol:IL18RAP uniprot:C9JLE2;uniprot:O95256 STAT1 GeneProduct ensembl:ENSG00000115415 "" ensembl:ENSG00000115415 ncbigene:6772 hgnc.symbol:STAT1 uniprot:E9PH66;uniprot:A0A669KBK4;uniprot:E7EPD2;uniprot:J3KPM9;uniprot:Q67C41;uniprot:A0A669KB17;uniprot:A0A669KB56;uniprot:A0A669KB68;uniprot:A0A669KB52;uniprot:A0A669KB53;uniprot:A0A669KB75;uniprot:D2KFR9;uniprot:P42224;uniprot:A0A669KBA4;uniprot:E7ENM1;uniprot:A0A669KBI6 -IL-5 GeneProduct ensembl:ENSG00000113525 "" ensembl:ENSG00000113525 ncbigene:3567 hgnc.symbol:IL5 uniprot:C9JQP9;uniprot:P05113 +IL5 GeneProduct ensembl:ENSG00000113525 "" ensembl:ENSG00000113525 ncbigene:3567 hgnc.symbol:IL5 uniprot:C9JQP9;uniprot:P05113 IFNG GeneProduct ensembl:ENSG00000111537 "" ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:A0A7R8GUN6;uniprot:P01579 TNFA GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 T-bet GeneProduct ensembl:ENSG00000073861 "" ensembl:ENSG00000073861 ncbigene:30009 hgnc.symbol:TBX21 uniprot:Q9UL17 STAT6 GeneProduct ensembl:ENSG00000166888 "" ensembl:ENSG00000166888 ncbigene:6778 hgnc.symbol:STAT6 uniprot:G3V370;uniprot:A0A1W2PNW1;uniprot:A0A494C0T4;uniprot:G3V5I8;uniprot:Q5FBW6;uniprot:H0YIY2;uniprot:P42226;uniprot:G3V2H4;uniprot:G3V5K5;uniprot:H0YJH6;uniprot:G3V2L2;uniprot:G3V2M3;uniprot:G3V568 -IL-5 GeneProduct ensembl:ENSG00000113525 "" ensembl:ENSG00000113525 ncbigene:3567 hgnc.symbol:IL5 uniprot:C9JQP9;uniprot:P05113 +IL5 GeneProduct ensembl:ENSG00000113525 "" ensembl:ENSG00000113525 ncbigene:3567 hgnc.symbol:IL5 uniprot:C9JQP9;uniprot:P05113 IL17 GeneProduct ensembl:ENSG00000112116 "" ensembl:ENSG00000112116 ncbigene:112744 hgnc.symbol:IL17F uniprot:Q96PD4 IL23A GeneProduct ensembl:ENSG00000110944 "" ensembl:ENSG00000110944 ncbigene:51561 hgnc.symbol:IL23A uniprot:Q9NPF7 STAT3 GeneProduct ensembl:ENSG00000168610 "" ensembl:ENSG00000168610 ncbigene:6774 hgnc.symbol:STAT3 uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9 -IL-2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 -IL-12 GeneProduct ensembl:ENSG00000168811 "" ensembl:ENSG00000168811 ncbigene:3592 hgnc.symbol:IL12A uniprot:E9PGR3;uniprot:P29459;uniprot:O60595;uniprot:E7ENE1 -IL-4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 -IL-10 GeneProduct ensembl:ENSG00000136634 "" ensembl:ENSG00000136634 ncbigene:3586 hgnc.symbol:IL10 uniprot:A0A590UK12;uniprot:A0A286YEX3;uniprot:Q6FGW4;uniprot:P22301 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL12 GeneProduct ensembl:ENSG00000168811 "" ensembl:ENSG00000168811 ncbigene:3592 hgnc.symbol:IL12A uniprot:E9PGR3;uniprot:P29459;uniprot:O60595;uniprot:E7ENE1 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +IL10 GeneProduct ensembl:ENSG00000136634 "" ensembl:ENSG00000136634 ncbigene:3586 hgnc.symbol:IL10 uniprot:A0A590UK12;uniprot:A0A286YEX3;uniprot:Q6FGW4;uniprot:P22301 GATA3 GeneProduct ensembl:ENSG00000107485 "" ensembl:ENSG00000107485 ncbigene:2625 hgnc.symbol:GATA3 uniprot:P23771;uniprot:A0A2R8Y4T2;uniprot:A0A2R8Y2A9 TGFB1 GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 IFNG GeneProduct ensembl:ENSG00000111537 "" ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:A0A7R8GUN6;uniprot:P01579 @@ -25,42 +25,42 @@ IFNGR1 GeneProduct ensembl:ENSG00000027697 "" ensembl:ENSG00000027697 ncbigene:3 NOD2 GeneProduct ensembl:ENSG00000167207 "" ensembl:ENSG00000167207 ncbigene:64127 hgnc.symbol:NOD2 uniprot:E9PK30;uniprot:J3QL80;uniprot:A0A286YF65;uniprot:Q9HC29;uniprot:E9PLF7;uniprot:H0YF53 IL6 GeneProduct ensembl:ENSG00000136244 "" ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 STAT3 GeneProduct ensembl:ENSG00000168610 "" ensembl:ENSG00000168610 ncbigene:6774 hgnc.symbol:STAT3 uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9 -IL-4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 -IL-6 GeneProduct ensembl:ENSG00000136244 "" ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +IL6 GeneProduct ensembl:ENSG00000136244 "" ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 NOD2 GeneProduct ensembl:ENSG00000167207 "" ensembl:ENSG00000167207 ncbigene:64127 hgnc.symbol:NOD2 uniprot:E9PK30;uniprot:J3QL80;uniprot:A0A286YF65;uniprot:Q9HC29;uniprot:E9PLF7;uniprot:H0YF53 RORA GeneProduct ensembl:ENSG00000069667 "" ensembl:ENSG00000069667 ncbigene:6095 hgnc.symbol:RORA uniprot:A0A0C4DFP5;uniprot:H0YLS5;uniprot:P35398;uniprot:H0YII6;uniprot:A0A0C4DG53;uniprot:A0A087X2G0 TLR2 GeneProduct ensembl:ENSG00000137462 "" ensembl:ENSG00000137462 ncbigene:7097 hgnc.symbol:TLR2 uniprot:A0A2R8Y4N9;uniprot:A0A2R8Y7R7;uniprot:A0A0S2Z4S4;uniprot:A0A0S2Z4L7;uniprot:O60603;uniprot:A0A2R8YHF6 IL12RB2 GeneProduct ensembl:ENSG00000081985 "" ensembl:ENSG00000081985 ncbigene:3595 hgnc.symbol:IL12RB2 uniprot:H0Y5V0;uniprot:A0A0A0MTN7;uniprot:Q99665 TLR2 GeneProduct ensembl:ENSG00000137462 "" ensembl:ENSG00000137462 ncbigene:7097 hgnc.symbol:TLR2 uniprot:A0A2R8Y4N9;uniprot:A0A2R8Y7R7;uniprot:A0A0S2Z4S4;uniprot:A0A0S2Z4L7;uniprot:O60603;uniprot:A0A2R8YHF6 TLR5 GeneProduct ensembl:ENSG00000187554 "" ensembl:ENSG00000187554 ncbigene:7100 hgnc.symbol:TLR5 uniprot:A0A2R8Y7Z4;uniprot:B1AZ06;uniprot:A0A2R8Y4Q2;uniprot:O60602 -NF-kB GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 -IL-13 GeneProduct ensembl:ENSG00000169194 "" ensembl:ENSG00000169194 ncbigene:3596 hgnc.symbol:IL13 uniprot:P35225 +NFKB1 GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 +IL13 GeneProduct ensembl:ENSG00000169194 "" ensembl:ENSG00000169194 ncbigene:3596 hgnc.symbol:IL13 uniprot:P35225 IL23R GeneProduct ensembl:ENSG00000162594 "" ensembl:ENSG00000162594 ncbigene:149233 hgnc.symbol:IL23R uniprot:Q5VWK5;uniprot:A0A0D9SFJ7;uniprot:A0A1B0GV19 STAT4 GeneProduct ensembl:ENSG00000138378 "" ensembl:ENSG00000138378 ncbigene:6775 hgnc.symbol:STAT4 uniprot:C9JM11;uniprot:A0A2R8Y693;uniprot:C9JFG0;uniprot:E9PG69;uniprot:Q14765;uniprot:E9PBE2 FOXP3 GeneProduct ensembl:ENSG00000049768 "" ensembl:ENSG00000049768 ncbigene:50943 hgnc.symbol:FOXP3 uniprot:A0A804HK12;uniprot:A0A494BZV0;uniprot:B7ZLG1;uniprot:Q9BZS1;uniprot:A0A494C0B0 -IL-18 GeneProduct ensembl:ENSG00000150782 "" ensembl:ENSG00000150782 ncbigene:3606 hgnc.symbol:IL18 uniprot:A0A024R3E0;uniprot:Q14116 +IL18 GeneProduct ensembl:ENSG00000150782 "" ensembl:ENSG00000150782 ncbigene:3606 hgnc.symbol:IL18 uniprot:A0A024R3E0;uniprot:Q14116 NFATC1 GeneProduct ensembl:ENSG00000131196 "" ensembl:ENSG00000131196 ncbigene:4772 hgnc.symbol:NFATC1 uniprot:K7ER53;uniprot:O95644;uniprot:F5H4S8;uniprot:K7EQ04 STAT3 GeneProduct ensembl:ENSG00000168610 "" ensembl:ENSG00000168610 ncbigene:6774 hgnc.symbol:STAT3 uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9 -IL-13 GeneProduct ensembl:ENSG00000169194 "" ensembl:ENSG00000169194 ncbigene:3596 hgnc.symbol:IL13 uniprot:P35225 +IL13 GeneProduct ensembl:ENSG00000169194 "" ensembl:ENSG00000169194 ncbigene:3596 hgnc.symbol:IL13 uniprot:P35225 IL12RB1 GeneProduct ensembl:ENSG00000096996 "" ensembl:ENSG00000096996 ncbigene:3594 hgnc.symbol:IL12RB1 uniprot:P42701;uniprot:X6RGM1;uniprot:M0QX06;uniprot:M0R382 -IL-4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 TLR4 GeneProduct ensembl:ENSG00000136869 "" ensembl:ENSG00000136869 ncbigene:7099 hgnc.symbol:TLR4 uniprot:O00206;uniprot:A0A2R8Y7P4 TGFB1 GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 TLR2 GeneProduct ensembl:ENSG00000137462 "" ensembl:ENSG00000137462 ncbigene:7097 hgnc.symbol:TLR2 uniprot:A0A2R8Y4N9;uniprot:A0A2R8Y7R7;uniprot:A0A0S2Z4S4;uniprot:A0A0S2Z4L7;uniprot:O60603;uniprot:A0A2R8YHF6 AP1 GeneProduct ensembl:ENSG00000177606 "" ensembl:ENSG00000177606 ncbigene:3725 hgnc.symbol:JUN uniprot:P05412 IL12RB1 GeneProduct ensembl:ENSG00000096996 "" ensembl:ENSG00000096996 ncbigene:3594 hgnc.symbol:IL12RB1 uniprot:P42701;uniprot:X6RGM1;uniprot:M0QX06;uniprot:M0R382 -IL-2 GeneProduct ensembl:ENSG00000109471 "" ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 +IL2 GeneProduct ensembl:ENSG00000109471 "" ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 IL21 GeneProduct ensembl:ENSG00000138684 "" ensembl:ENSG00000138684 ncbigene:59067 hgnc.symbol:IL21 uniprot:Q9HBE4;uniprot:A0A224B028 IL21R GeneProduct ensembl:ENSG00000103522 "" ensembl:ENSG00000103522 ncbigene:50615 hgnc.symbol:IL21R uniprot:Q9HBE5 TGFB GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 -IL-1 GeneProduct ensembl:ENSG00000115008 "" ensembl:ENSG00000115008 ncbigene:3552 hgnc.symbol:IL1A uniprot:P01583 +IL1 GeneProduct ensembl:ENSG00000115008 "" ensembl:ENSG00000115008 ncbigene:3552 hgnc.symbol:IL1A uniprot:P01583 SMAD2 GeneProduct ensembl:ENSG00000175387 "" ensembl:ENSG00000175387 ncbigene:4087 hgnc.symbol:SMAD2 uniprot:Q53XR6;uniprot:B7Z5N5;uniprot:Q15796;uniprot:K7ERC7;uniprot:K7EJX0;uniprot:K7EL92;uniprot:K7ESI8 IL-4RA GeneProduct ensembl:ENSG00000077238 "" ensembl:ENSG00000077238 ncbigene:3566 hgnc.symbol:IL4R uniprot:H3BSE7;uniprot:A0A0G2JLA1;uniprot:H3BRH7;uniprot:P24394;uniprot:I3L4W9;uniprot:I3L4H7;uniprot:J9JII2;uniprot:H3BTD9;uniprot:Q5FC08 c-MAF GeneProduct ensembl:ENSG00000178573 "" ensembl:ENSG00000178573 ncbigene:4094 hgnc.symbol:MAF uniprot:H3BP11;uniprot:O75444 -RORyt GeneProduct ensembl:ENSG00000143365 "" ensembl:ENSG00000143365 ncbigene:6097 hgnc.symbol:RORC uniprot:A0A494C0S6;uniprot:P51449;uniprot:A0A1W2PRM4;uniprot:A0A494C174;uniprot:F1D8P6;uniprot:Q6I9R9;uniprot:A0A494C0H2 +RORC GeneProduct ensembl:ENSG00000143365 "" ensembl:ENSG00000143365 ncbigene:6097 hgnc.symbol:RORC uniprot:A0A494C0S6;uniprot:P51449;uniprot:A0A1W2PRM4;uniprot:A0A494C174;uniprot:F1D8P6;uniprot:Q6I9R9;uniprot:A0A494C0H2 IL22 GeneProduct ensembl:ENSG00000127318 "" ensembl:ENSG00000127318 ncbigene:50616 hgnc.symbol:IL22 uniprot:Q9GZX6;uniprot:A0A7R8C389 IFNG GeneProduct ensembl:ENSG00000111537 "" ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:A0A7R8GUN6;uniprot:P01579 -IL-10 GeneProduct ensembl:ENSG00000136634 "" ensembl:ENSG00000136634 ncbigene:3586 hgnc.symbol:IL10 uniprot:A0A590UK12;uniprot:A0A286YEX3;uniprot:Q6FGW4;uniprot:P22301 -NF-kB GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 +IL10 GeneProduct ensembl:ENSG00000136634 "" ensembl:ENSG00000136634 ncbigene:3586 hgnc.symbol:IL10 uniprot:A0A590UK12;uniprot:A0A286YEX3;uniprot:Q6FGW4;uniprot:P22301 +NFKB1 GeneProduct ensembl:ENSG00000109320 "" ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30 MHC class 2 Protein ensembl:ENSG00000204257 "" ensembl:ENSG00000204257 ncbigene:3108 hgnc.symbol:HLA-DMA uniprot:F6S093;uniprot:Q6ICR9;uniprot:A2AAT8;uniprot:H0Y732;uniprot:P28067;uniprot:Q31604;uniprot:Q5SP00 diff --git a/pathways/WP5198/WP5198.gpml b/pathways/WP5198/WP5198.gpml index 15412e2c3..918c1ca88 100644 --- a/pathways/WP5198/WP5198.gpml +++ b/pathways/WP5198/WP5198.gpml @@ -1,12 +1,12 @@ - + Pathway representing the inflammatory bowel disease showing steps leading to Crohn's disease and ulcerative colitis. - + @@ -14,7 +14,7 @@ - + @@ -34,7 +34,7 @@ - + @@ -54,19 +54,19 @@ - + - + - + - + @@ -110,11 +110,11 @@ - + - + @@ -142,11 +142,11 @@ - - + + - + @@ -162,7 +162,7 @@ - + @@ -178,7 +178,7 @@ - + @@ -186,7 +186,7 @@ - + @@ -214,7 +214,7 @@ - + @@ -234,7 +234,7 @@ - + @@ -250,7 +250,7 @@ - + @@ -266,7 +266,7 @@ - + @@ -274,7 +274,7 @@ - + @@ -282,6 +282,10 @@ + + + + @@ -370,7 +374,7 @@ - + @@ -779,7 +783,7 @@ - + @@ -968,9 +972,6 @@ - @@ -1188,8 +1189,23 @@ - Toll-like receptor signaling pathway - PW:0000814 + disease pathway + PW:0000013 + Pathway Ontology + + + T-helper 2 cell + CL:0000546 + Cell Type + + + Crohn's disease + DOID:8778 + Disease + + + altered cytokine mediated signaling pathway + PW:0000617 Pathway Ontology @@ -1197,6 +1213,11 @@ CL:0000545 Cell Type + + inflammatory bowel disease + DOID:0050589 + Disease + 17332878 PubMed @@ -1207,41 +1228,61 @@ Fuss I Mannon P + + inflammatory bowel disease + DOID:0050589 + Disease + interleukin-2 signaling pathway PW:0000907 Pathway Ontology - disease pathway - PW:0000013 + signaling pathway involving second messengers + PW:0000541 Pathway Ontology - immune system disease - DOID:2914 - Disease + naive thymus-derived CD4-positive, alpha-beta T cell + CL:0000895 + Cell Type - lymphocyte - CL:0000542 + colon macrophage + CL:0009038 Cell Type - professional antigen presenting cell - CL:0000145 + macrophage + CL:0000235 Cell Type - signaling pathway involving second messengers - PW:0000541 - Pathway Ontology + lymphocyte + CL:0000542 + Cell Type + + 33859636 + PubMed + Role of the IL23/IL17 Pathway in Crohn's Disease. + Front Immunol + 2021 + Schmitt H + Neurath MF + Atreya R + - altered cytokine mediated signaling pathway - PW:0000617 + Toll-like receptor signaling pathway + PW:0000814 Pathway Ontology + + T-helper 17 cell + CL:0000899 + Cell Type + 18653729 PubMed @@ -1262,28 +1303,21 @@ Hibi T - macrophage - CL:0000235 - Cell Type - - - T-helper 17 cell - CL:0000899 - Cell Type + ulcerative colitis + DOID:8577 + Disease - - 33859636 + + 31886308 PubMed - Role of the IL23/IL17 Pathway in Crohn's Disease. - Front Immunol - 2021 - Schmitt H - Neurath MF - Atreya R + A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. + J Immunol Res + 2019 + Guan Q - Crohn's disease - DOID:8778 + colonic disease + DOID:5353 Disease @@ -1292,53 +1326,20 @@ Pathway Ontology - naive thymus-derived CD4-positive, alpha-beta T cell - CL:0000895 - Cell Type - - - colitis - DOID:0060180 - Disease - - - inflammatory bowel disease - DOID:0050589 - Disease - - - colon macrophage - CL:0009038 - Cell Type - - - ulcerative colitis - DOID:8577 - Disease - - - inflammatory bowel disease - DOID:0050589 + immune system disease + DOID:2914 Disease - T-helper 2 cell - CL:0000546 + professional antigen presenting cell + CL:0000145 Cell Type - colonic disease - DOID:5353 + colitis + DOID:0060180 Disease - - 31886308 - PubMed - A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. - J Immunol Res - 2019 - Guan Q - diff --git a/pathways/WP5198/WP5198.json b/pathways/WP5198/WP5198.json index 228c95472..383d6ee8b 100644 --- a/pathways/WP5198/WP5198.json +++ b/pathways/WP5198/WP5198.json @@ -63,7 +63,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-18R-beta", + "textContent": "IL18RAP", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -72,7 +72,7 @@ "Ensembl:ENSG00000115607", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000115607", - "IL-18R-beta", + "IL18RAP", "Ensembl:ENSG00000115607", "Entrez Gene:8807", "HGNC:IL18RAP", @@ -321,7 +321,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-5", + "textContent": "IL5", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -330,7 +330,7 @@ "Ensembl:ENSG00000113525", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000113525", - "IL-5", + "IL5", "Ensembl:ENSG00000113525", "Entrez Gene:3567", "HGNC:IL5", @@ -835,7 +835,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-5", + "textContent": "IL5", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -844,7 +844,7 @@ "Ensembl:ENSG00000113525", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000113525", - "IL-5", + "IL5", "Ensembl:ENSG00000113525", "Entrez Gene:3567", "HGNC:IL5", @@ -1289,7 +1289,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-2RG", + "textContent": "IL2RG", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -1298,7 +1298,7 @@ "Ensembl:ENSG00000147168", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000147168", - "IL-2RG", + "IL2RG", "Ensembl:ENSG00000147168", "Entrez Gene:3561", "HGNC:IL2RG", @@ -1465,7 +1465,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-12", + "textContent": "IL12", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -1474,7 +1474,7 @@ "Ensembl:ENSG00000168811", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000168811", - "IL-12", + "IL12", "Ensembl:ENSG00000168811", "Entrez Gene:3592", "HGNC:IL12A", @@ -1511,7 +1511,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-4", + "textContent": "IL4", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -1520,7 +1520,7 @@ "Ensembl:ENSG00000113520", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000113520", - "IL-4", + "IL4", "Ensembl:ENSG00000113520", "Entrez Gene:3565", "HGNC:IL4", @@ -1556,7 +1556,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-10", + "textContent": "IL10", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -1565,7 +1565,7 @@ "Ensembl:ENSG00000136634", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000136634", - "IL-10", + "IL10", "Ensembl:ENSG00000136634", "Entrez Gene:3586", "HGNC:IL10", @@ -2747,7 +2747,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-4", + "textContent": "IL4", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -2756,7 +2756,7 @@ "Ensembl:ENSG00000113520", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000113520", - "IL-4", + "IL4", "Ensembl:ENSG00000113520", "Entrez Gene:3565", "HGNC:IL4", @@ -2824,7 +2824,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-6", + "textContent": "IL6", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -2833,7 +2833,7 @@ "Ensembl:ENSG00000136244", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000136244", - "IL-6", + "IL6", "Ensembl:ENSG00000136244", "Entrez Gene:3569", "HGNC:IL6", @@ -3377,7 +3377,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "NF-kB", + "textContent": "NFKB1", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3386,7 +3386,7 @@ "Ensembl:ENSG00000109320", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000109320", - "NF-kB", + "NFKB1", "Ensembl:ENSG00000109320", "Entrez Gene:4790", "HGNC:NFKB1", @@ -3400,7 +3400,7 @@ "whiteSpace": "pre", "width": 60, "wpType": "GeneProduct", - "x": 860.5083024519067, + "x": 859.5083024519067, "xrefDataSource": "Ensembl", "xrefIdentifier": "ENSG00000109320", "y": 624.0674362089932, @@ -3452,7 +3452,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-13", + "textContent": "IL13", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3461,7 +3461,7 @@ "Ensembl:ENSG00000169194", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000169194", - "IL-13", + "IL13", "Ensembl:ENSG00000169194", "Entrez Gene:3596", "HGNC:IL13", @@ -3792,7 +3792,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-18", + "textContent": "IL18", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -3801,7 +3801,7 @@ "Ensembl:ENSG00000150782", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000150782", - "IL-18", + "IL18", "Ensembl:ENSG00000150782", "Entrez Gene:3606", "HGNC:IL18", @@ -4067,7 +4067,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-13", + "textContent": "IL13", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -4076,7 +4076,7 @@ "Ensembl:ENSG00000169194", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000169194", - "IL-13", + "IL13", "Ensembl:ENSG00000169194", "Entrez Gene:3596", "HGNC:IL13", @@ -4155,39 +4155,6 @@ "y": 256.5, "zIndex": 28672 }, - "e6a57": { - "drawAs": "rect", - "fill": "#ffffff", - "fontFamily": "Arial", - "fontSize": 10, - "fontStyle": "italic", - "fontWeight": "normal", - "gpmlElementName": "Label", - "height": 30, - "id": "e6a57", - "kaavioType": "SingleFreeNode", - "lineHeight": 1.1, - "overflow": "hidden", - "padding": 8, - "rx": 15, - "ry": 15, - "stroke": "#000000", - "strokeWidth": 1, - "textAlign": "center", - "textContent": "Cytokine-cytokine \nreceptor interaction", - "textDecoration": "none", - "textOverflow": "clip", - "type": [ - "Label", - "SingleFreeNode" - ], - "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 120, - "x": 367.92982989064376, - "y": 514.1479343863913, - "zIndex": 28672 - }, "e6c01": { "cellularComponent": "Vesicle", "drawAs": "Ellipse", @@ -4359,7 +4326,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-4", + "textContent": "IL4", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -4368,7 +4335,7 @@ "Ensembl:ENSG00000113520", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000113520", - "IL-4", + "IL4", "Ensembl:ENSG00000113520", "Entrez Gene:3565", "HGNC:IL4", @@ -4387,6 +4354,44 @@ "y": 1118.2902764493203, "zIndex": 32768 }, + "ea0ab": { + "drawAs": "rect", + "fill": "#ffffff", + "fontFamily": "Arial", + "fontSize": 12, + "fontStyle": "normal", + "fontWeight": "bold", + "gpmlElementName": "DataNode", + "height": 30, + "id": "ea0ab", + "kaavioType": "SingleFreeNode", + "lineHeight": 1.1, + "overflow": "hidden", + "padding": 8, + "rx": 15, + "ry": 15, + "stroke": "#14961e", + "strokeWidth": 1, + "textAlign": "center", + "textContent": "Cytokine-cytokine\nreceptor interaction", + "textDecoration": "none", + "textOverflow": "clip", + "type": [ + "DataNode", + "SingleFreeNode", + "WikiPathways:WP288", + "Pathway" + ], + "verticalAlign": "middle", + "whiteSpace": "pre", + "width": 130, + "wpType": "Pathway", + "x": 360, + "xrefDataSource": "WikiPathways", + "xrefIdentifier": "WP288", + "y": 499, + "zIndex": 32799 + }, "eab6a": { "drawAs": "Ellipse", "fill": "transparent", @@ -4890,7 +4895,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-2", + "textContent": "IL2", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -4899,7 +4904,7 @@ "Ensembl:ENSG00000109471", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000109471", - "IL-2", + "IL2", "Ensembl:ENSG00000109471", "Entrez Gene:3558", "HGNC:IL2", @@ -5157,7 +5162,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-1", + "textContent": "IL1", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -5166,7 +5171,7 @@ "Ensembl:ENSG00000115008", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000115008", - "IL-1", + "IL1", "Ensembl:ENSG00000115008", "Entrez Gene:3552", "HGNC:IL1A", @@ -5437,7 +5442,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "RORyt", + "textContent": "RORC", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -5446,7 +5451,7 @@ "Ensembl:ENSG00000143365", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000143365", - "RORyt", + "RORC", "Ensembl:ENSG00000143365", "Entrez Gene:6097", "HGNC:RORC", @@ -5742,7 +5747,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "NF-kB", + "textContent": "NFKB1", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -5751,7 +5756,7 @@ "Ensembl:ENSG00000109320", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000109320", - "NF-kB", + "NFKB1", "Ensembl:ENSG00000109320", "Entrez Gene:4790", "HGNC:NFKB1", @@ -5894,7 +5899,7 @@ "stroke": "#000000", "strokeWidth": 1, "textAlign": "center", - "textContent": "IL-10", + "textContent": "IL10", "textDecoration": "none", "textOverflow": "clip", "type": [ @@ -5903,7 +5908,7 @@ "Ensembl:ENSG00000136634", "GeneProduct", "CompactIdentifier:ensembl:ENSG00000136634", - "IL-10", + "IL10", "Ensembl:ENSG00000136634", "Entrez Gene:3586", "HGNC:IL10", @@ -6896,7 +6901,7 @@ 1, 0 ], - "x": 920.5083024519067, + "x": 919.5083024519067, "y": 642.8174362089932 }, { @@ -10456,7 +10461,7 @@ 1, 0 ], - "x": 860.5083024519067, + "x": 859.5083024519067, "y": 630.3174362089932 } ], @@ -11689,7 +11694,6 @@ "d55a9", "e17f8", "e67fc", - "e6a57", "e6ecf", "eca1d", "f9993", @@ -11788,9 +11792,10 @@ "e6c01", "fe413", "ffbe0", - "d807a" + "d807a", + "ea0ab" ], - "dataSourceVersion": "WP5198_r129326", + "dataSourceVersion": "WP5198_r130805", "displayName": "Inflammatory bowel disease signaling", "drawAs": "rect", "fill": "white", @@ -11800,7 +11805,7 @@ "height": 1338.75, "id": "WP5198", "kaavioType": "Group", - "lastModified": "20240326140438", + "lastModified": "20240530125535", "name": "Inflammatory bowel disease signaling", "organism": "Homo sapiens", "padding": 5, @@ -11809,14 +11814,14 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Inflammatory bowel disease signaling\nLast Modified: 20240326140438\nOrganism: Homo sapiens", + "textContent": "Name: Inflammatory bowel disease signaling\nLast Modified: 20240530125535\nOrganism: Homo sapiens", "type": [ "Pathway", - "http://identifiers.org/pw/PW:0000814", - "http://identifiers.org/pw/PW:0000907", "http://identifiers.org/pw/PW:0000013", - "http://identifiers.org/pw/PW:0000541", "http://identifiers.org/pw/PW:0000617", + "http://identifiers.org/pw/PW:0000907", + "http://identifiers.org/pw/PW:0000541", + "http://identifiers.org/pw/PW:0000814", "http://identifiers.org/pw/PW:0000913" ], "verticalAlign": "top", diff --git a/pathways/WP5198/WP5198.png b/pathways/WP5198/WP5198.png index 72dbd2f14..99e3a41ea 100644 Binary files a/pathways/WP5198/WP5198.png and b/pathways/WP5198/WP5198.png differ diff --git a/pathways/WP5198/WP5198.svg b/pathways/WP5198/WP5198.svg index 80b2af05d..d31a9ad62 100644 --- a/pathways/WP5198/WP5198.svg +++ b/pathways/WP5198/WP5198.svg @@ -472,7 +472,7 @@ - + @@ -535,8 +535,8 @@ - - + + @@ -735,8 +735,8 @@ - - + + @@ -1090,13 +1090,6 @@ Intestinal wall - - - - Cytokine-cytokine - receptor interaction - - @@ -1193,10 +1186,10 @@ NF-kB - + - IL-18R-beta + IL18RAP @@ -1205,10 +1198,10 @@ STAT1 - + - IL-5 + IL5 @@ -1247,16 +1240,16 @@ STAT3 - + - IL-12 + IL12 - + - IL-10 + IL10 @@ -1301,10 +1294,10 @@ MHC class 2 - + - IL-4 + IL4 @@ -1319,16 +1312,16 @@ TLR5 - + - NF-kB + NFKB1 - + - IL-13 + IL13 @@ -1343,10 +1336,10 @@ FOXP3 - + - IL-18 + IL18 @@ -1362,16 +1355,16 @@ STAT3 - + - IL-13 + IL13 - + - IL-4 + IL4 @@ -1398,10 +1391,10 @@ AP1 - + - IL-2 + IL2 @@ -1443,10 +1436,10 @@ - + - IL-2RG + IL2RG @@ -1479,16 +1472,16 @@ TNFA - + - IL-6 + IL6 - + - IL-1 + IL1 @@ -1545,10 +1538,10 @@ RORA - + - RORyt + RORC @@ -1605,25 +1598,25 @@ TGFB1 - + - IL-10 + IL10 - + - IL-5 + IL5 - + - IL-4 + IL4 @@ -1731,10 +1724,10 @@ DNA - + - NF-kB + NFKB1 @@ -1749,9 +1742,16 @@ Tissue injury + + + + Cytokine-cytokine + receptor interaction + + Name: Inflammatory bowel disease signaling - Last Modified: 20240326140438 + Last Modified: 20240530125535 Organism: Homo sapiens diff --git a/pathways/WP5289/WP5289.gpml b/pathways/WP5289/WP5289.gpml index 1f1541f91..e13b26271 100644 --- a/pathways/WP5289/WP5289.gpml +++ b/pathways/WP5289/WP5289.gpml @@ -1,5 +1,5 @@ - + Axon guidance forms neuronal networks. Axons are guided by factors including netrins, ephrins, Slits, and semaphorins. These guidance cues interact with growth cone receptors, and downstream signal transduction pathways converge onto Rho GTPases which change in cytoskeletal organization. Those cytoskeletal changes determine which way the growth cone will turn. This pathway is derived from https://www.kegg.jp/entry/map04360. @@ -732,7 +732,7 @@ This pathway is derived from https://www.kegg.jp/entry/map04360. - + @@ -2054,9 +2054,9 @@ This pathway is derived from https://www.kegg.jp/entry/map04360. - neuron - CL:0000540 - Cell Type + signaling pathway pertinent to the brain and nervous system + PW:0000059 + Pathway Ontology @@ -2065,11 +2065,6 @@ This pathway is derived from https://www.kegg.jp/entry/map04360. https://www.kegg.jp/entry/map04360 - - signaling pathway pertinent to the brain and nervous system - PW:0000059 - Pathway Ontology - 33857633 PubMed @@ -2093,6 +2088,11 @@ This pathway is derived from https://www.kegg.jp/entry/map04360. Rehen SK Junqueira M + + neuron + CL:0000540 + Cell Type + diff --git a/pathways/WP5289/WP5289.json b/pathways/WP5289/WP5289.json index 272872ebf..117f1f096 100644 --- a/pathways/WP5289/WP5289.json +++ b/pathways/WP5289/WP5289.json @@ -541,7 +541,7 @@ "type": [ "DataNode", "SingleFreeNode", - "KEGG Pathway:hsa04060", + "WikiPathways:WP5473", "Pathway" ], "verticalAlign": "middle", @@ -549,8 +549,8 @@ "width": 115, "wpType": "Pathway", "x": 841.4029473684209, - "xrefDataSource": "KEGG Pathway", - "xrefIdentifier": "hsa04060", + "xrefDataSource": "WikiPathways", + "xrefIdentifier": "WP5473", "y": 282.83333333333314, "zIndex": 32768 }, @@ -18092,7 +18092,7 @@ "b78e8", "e6b3a" ], - "dataSourceVersion": "WP5289_r129834", + "dataSourceVersion": "WP5289_r130759", "displayName": "Axon guidance", "drawAs": "rect", "fill": "white", @@ -18102,7 +18102,7 @@ "height": 910.32440729529, "id": "WP5289", "kaavioType": "Group", - "lastModified": "20240523003416", + "lastModified": "20240530031234", "name": "Axon guidance", "organism": "Homo sapiens", "padding": 5, @@ -18111,7 +18111,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Axon guidance\nLast Modified: 20240523003416\nOrganism: Homo sapiens", + "textContent": "Name: Axon guidance\nLast Modified: 20240530031234\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000059" diff --git a/pathways/WP5289/WP5289.png b/pathways/WP5289/WP5289.png index 1e186df7a..aec8cbeae 100644 Binary files a/pathways/WP5289/WP5289.png and b/pathways/WP5289/WP5289.png differ diff --git a/pathways/WP5289/WP5289.svg b/pathways/WP5289/WP5289.svg index 261d3f2ae..05c2e13b5 100644 --- a/pathways/WP5289/WP5289.svg +++ b/pathways/WP5289/WP5289.svg @@ -484,7 +484,7 @@ - + @@ -2180,7 +2180,7 @@ actin cytoskeleton - + Cytokine-cytokine @@ -2301,7 +2301,7 @@ Name: Axon guidance - Last Modified: 20240523003416 + Last Modified: 20240530031234 Organism: Homo sapiens diff --git a/pathways/WP5420/WP5420.gpml b/pathways/WP5420/WP5420.gpml index eb68a398d..70d9f0baa 100644 --- a/pathways/WP5420/WP5420.gpml +++ b/pathways/WP5420/WP5420.gpml @@ -1,5 +1,5 @@ - + Pathways associated with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses. https://kimberly102347.com/the-chart/ @@ -11506,9 +11506,6 @@ VMAT1 (encoded by SLC18A1) primarily transports serotonin and histamine into syn - @@ -11886,182 +11883,191 @@ VMAT1 (encoded by SLC18A1) primarily transports serotonin and histamine into syn - - 11815463 + + 11815450 PubMed - Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. - Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW. + Molecular determinants of regulated exocytosis. + Gerber SH, Südhof TC. - - 20691428 + + 21704641 PubMed - - - - - - 10.1161/hc3801.095585 - DOI - - - - 10.1161/hc3801.095585 + Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. + Life Sci + 2011 + Jiang R + Yamaori S + Takeda S + Yamamoto I + Watanabe K - 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"textContent": "66", + "textContent": "185", "type": [ "PublicationXref", "DOI:10.1016/S1075-6280(01)27007-4" @@ -108356,7 +108325,7 @@ "id": "publicationXrefb24", "source": "Science", "standardName": "Architecture of human mTOR complex 1.", - "textContent": "216", + "textContent": "109", "type": [ "PublicationXref", "PubMed:26678875" @@ -108372,7 +108341,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefb2b", "source": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2", - "textContent": "81", + "textContent": "204", "type": [ "PublicationXref" ], @@ -108390,7 +108359,7 @@ "id": "publicationXrefb2f", "source": "Biochemistry", "standardName": "Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.", - "textContent": "126", + "textContent": "97", "type": [ "PublicationXref", "PubMed:17892308" @@ -108406,7 +108375,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefb35", "standardName": "Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase.", - "textContent": "21", + "textContent": "175", "type": [ "PublicationXref", "PubMed:11873862" @@ -108421,7 +108390,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefb3a", "standardName": "Signals and pools underlying biphasic insulin secretion.", - "textContent": "137", + "textContent": "116", "type": [ "PublicationXref", "PubMed:11815460" @@ -108435,7 +108404,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb3e", - "textContent": "154", + "textContent": "197", "type": [ "PublicationXref", "DOI:10.1038/ng1136" @@ -108449,7 +108418,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb46", - "textContent": "88", + "textContent": "110", "type": [ "PublicationXref", "DOI:10.1038/sj.mp.4002090" @@ -108463,7 +108432,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb47", - "textContent": "192", + "textContent": "190", "type": [ "PublicationXref", "DOI:10.1016/j.euroneuro.2012.07.003" @@ -108477,7 +108446,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb51", - "textContent": "67", + "textContent": "147", "type": [ "PublicationXref" ], @@ -108489,7 +108458,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb58", - "textContent": "165", + "textContent": "121", "type": [ "PublicationXref", "DOI:10.1089/gtmb.2014.0066" @@ -108503,7 +108472,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb65", - "textContent": "80", + "textContent": "183", "type": [ "PublicationXref", "DOI:10.3390/cells12071087" @@ -108517,7 +108486,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb6b", - "textContent": "52", + "textContent": "32", "type": [ "PublicationXref", "DOI:10.3390/ijms23031910" @@ -108531,7 +108500,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb6c", - "textContent": "155", + "textContent": "164", "type": [ "PublicationXref", "URL:https://psychscenehub.com/psychinsights/guanfacine-and-clonidine-for-adhd/" @@ -108545,7 +108514,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb70", - "textContent": "79", + "textContent": "20", "type": [ "PublicationXref", "DOI:10.1007/7854_2011_187" @@ -108559,7 +108528,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb7b", - "textContent": "7", + "textContent": "21", "type": [ "PublicationXref", "DOI:10.1111/pcn.12606" @@ -108573,7 +108542,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb7c", - "textContent": "205", + "textContent": "203", "type": [ "PublicationXref", "URL:https://www.genome.jp/pathway/map04921+K04229" @@ -108587,7 +108556,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb98", - "textContent": "98", + "textContent": "38", "type": [ "PublicationXref", "DOI:10.4088/JCP.14l09346" @@ -108601,7 +108570,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefb9b", - "textContent": "3", + "textContent": "37", "type": [ "PublicationXref", "DOI:10.1161/hc3801.095585" @@ -108615,7 +108584,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefba6", - "textContent": "118", + "textContent": "122", "type": [ "PublicationXref" ], @@ -108627,7 +108596,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbb7", - "textContent": "135", + "textContent": "130", "type": [ "PublicationXref", "DOI:10.3389/fncel.2011.00011" @@ -108643,7 +108612,7 @@ "id": "publicationXrefbba", "source": "Biochem Biophys Res Commun", "standardName": "Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.", - "textContent": "10", + "textContent": "44", "type": [ "PublicationXref", "DOI:10.1038/s41430-020-0657-9" @@ -108658,7 +108627,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefbbb", "standardName": "Mechanisms of inhibition of insulin release.", - "textContent": "189", + "textContent": "26", "type": [ "PublicationXref", "PubMed:8997178" @@ -108687,7 +108656,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbc2", - "textContent": "129", + "textContent": "142", "type": [ "PublicationXref", "DOI:10.1111/j.1600-079X.2011.00902.x" @@ -108701,7 +108670,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbc6", - "textContent": "131", + "textContent": "208", "type": [ "PublicationXref", "DOI:10.1038/tp.2012.7" @@ -108715,7 +108684,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbcf", - "textContent": "99", + "textContent": "124", "type": [ "PublicationXref", "DOI:10.1016/j.euroneuro.2012.07.003" @@ -108729,7 +108698,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbd0", - "textContent": "41", + "textContent": "63", "type": [ "PublicationXref", "DOI:10.3390/nu13093207" @@ -108743,7 +108712,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbd4", - "textContent": "143", + "textContent": "84", "type": [ "PublicationXref" ], @@ -108755,7 +108724,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbdc", - "textContent": "122", + "textContent": "69", "type": [ "PublicationXref" ], @@ -108767,7 +108736,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbe9", - "textContent": "196", + "textContent": "177", "type": [ "PublicationXref" ], @@ -108781,7 +108750,7 @@ "id": "publicationXrefbea", "source": "Exp Mol Med", "standardName": "Regulation and function of AMPK in physiology and diseases.", - "textContent": "27", + "textContent": "206", "type": [ "PublicationXref", "PubMed:27416781" @@ -108796,7 +108765,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefbf2", - "textContent": "107", + "textContent": "91", "type": [ "PublicationXref" ], @@ -108814,7 +108783,7 @@ "id": "publicationXrefbff", "source": "Life Sci", "standardName": "Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.", - "textContent": "111", + "textContent": "3", "type": [ "PublicationXref", "PubMed:21704641" @@ -108828,7 +108797,7 @@ "id": "publicationXrefc00", "source": "J Neurochem", "standardName": "Serum microRNA-501-3p is a potential diagnostic tool for detecting mild cognitive impairment: Ehime genome study.", - "textContent": "29", + "textContent": "189", "type": [ "PublicationXref", "PubMed:37439367" @@ -108843,7 +108812,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc03", - "textContent": "15", + "textContent": "176", "type": [ "PublicationXref" ], @@ -108855,7 +108824,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc13", - "textContent": "55", + "textContent": "108", "type": [ "PublicationXref", "DOI:10.1038/s41598-021-03885-6" @@ -108869,7 +108838,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc14", - "textContent": "47", + "textContent": "165", "type": [ "PublicationXref", "DOI:10.3389/fphar.2019.00452" @@ -108884,7 +108853,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefc17", "standardName": "A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.", - "textContent": "158", + "textContent": "193", "type": [ "PublicationXref", "PubMed:11815462" @@ -108904,7 +108873,7 @@ "id": "publicationXrefc23", "source": "FEBS Lett", "standardName": "mTOR regulation of autophagy.", - "textContent": "4", + "textContent": "101", "type": [ "PublicationXref", "PubMed:20083114" @@ -108919,7 +108888,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc31", - "textContent": "19", + "textContent": "129", "type": [ "PublicationXref" ], @@ -108931,7 +108900,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc40", - "textContent": "75", + "textContent": "140", "type": [ "PublicationXref" ], @@ -108943,7 +108912,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc47", - "textContent": "199", + "textContent": "80", "type": [ "PublicationXref", "DOI:10.1093/jncics/pkad039" @@ -108957,7 +108926,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc4a", - "textContent": "212", + "textContent": "24", "type": [ "PublicationXref" ], @@ -108970,7 +108939,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefc56", "standardName": "Molecular determinants of regulated exocytosis.", - "textContent": "101", + "textContent": "1", "type": [ "PublicationXref", "PubMed:11815450" @@ -108984,7 +108953,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc5b", - "textContent": "116", + "textContent": "62", "type": [ "PublicationXref", "DOI:10.1038/mp.2013.140" @@ -109001,7 +108970,7 @@ "id": "publicationXrefc5e", "source": "J Exp Clin Cancer Res", "standardName": "Deptor: not only a mTOR inhibitor.", - "textContent": "8", + "textContent": "196", "type": [ "PublicationXref", "PubMed:28086984" @@ -109016,7 +108985,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc67", - "textContent": "195", + "textContent": "199", "type": [ "PublicationXref" ], @@ -109028,7 +108997,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc78", - "textContent": "153", + "textContent": "187", "type": [ "PublicationXref", "DOI:10.1021/BI992997S" @@ -109042,7 +109011,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc7b", - "textContent": "17", + "textContent": "173", "type": [ "PublicationXref", "DOI:10.1111/cge.13243" @@ -109056,7 +109025,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc7d", - "textContent": "159", + "textContent": "161", "type": [ "PublicationXref", "DOI:10.1038/s41598-017-06782-z" @@ -109070,7 +109039,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc84", - "textContent": "57", + "textContent": "50", "type": [ "PublicationXref" ], @@ -109082,7 +109051,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc85", - "textContent": "38", + "textContent": "154", "type": [ "PublicationXref", "DOI:10.1097/YPG.0000000000000010" @@ -109096,7 +109065,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc89", - "textContent": "152", + "textContent": "111", "type": [ "PublicationXref", "DOI:10.1038/sj.mp.4002016" @@ -109107,7 +109076,7 @@ "publicationXrefc8e": { "gpmlElementName": "PublicationXref", "id": "publicationXrefc8e", - "textContent": "37", + "textContent": "114", "type": [ "PublicationXref", "PubMed:24889756" @@ -109121,7 +109090,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefc95", - "textContent": "206", + "textContent": "68", "type": [ "PublicationXref" ], @@ -109133,7 +109102,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcb2", - "textContent": "169", + "textContent": "179", "type": [ "PublicationXref", "DOI:10.1093/ijnp/pyw013" @@ -109149,7 +109118,7 @@ "id": "publicationXrefcb5", "source": "Comp Biochem Physiol A Comp Physiol", "standardName": "Circadian variations of hormonal content in the nervous system of the crayfish.", - "textContent": "171", + "textContent": "67", "type": [ "PublicationXref", "DOI:10.1176/appi.ajp.161.4.662" @@ -109164,7 +109133,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcbb", - "textContent": "127", + "textContent": "209", "type": [ "PublicationXref" ], @@ -109184,7 +109153,7 @@ "id": "publicationXrefcbf", "source": "J Hematol Oncol", "standardName": "Targeting the IDO1 pathway in cancer: from bench to bedside.", - "textContent": "188", + "textContent": "119", "type": [ "PublicationXref", "PubMed:30068361" @@ -109199,7 +109168,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcc5", - "textContent": "13", + "textContent": "45", "type": [ "PublicationXref", "DOI:10.3389/fpsyt.2022.904091" @@ -109213,7 +109182,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcc9", - "textContent": "119", + "textContent": "155", "type": [ "PublicationXref", "DOI:10.3389/fnmol.2022.919773" @@ -109229,7 +109198,7 @@ "id": "publicationXrefcd3", "source": "Mol Cell Biol", "standardName": "AMPK -> ULK1 -> autophagy.", - "textContent": "25", + "textContent": "14", "type": [ "PublicationXref", "PubMed:21628530" @@ -109244,7 +109213,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcdb", - "textContent": "87", + "textContent": "72", "type": [ "PublicationXref", "DOI:10.3390/nu8020068" @@ -109258,7 +109227,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefce2", - "textContent": "82", + "textContent": "100", "type": [ "PublicationXref", "DOI:10.1016/j.gene.2017.05.003" @@ -109277,7 +109246,7 @@ "id": "publicationXrefce7", "source": "Mol Genet Metab", "standardName": "Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.", - "textContent": "210", + "textContent": "30", "type": [ "PublicationXref", "PubMed:19700356" @@ -109292,7 +109261,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefcfd", - "textContent": "209", + "textContent": "102", "type": [ "PublicationXref", "DOI:10.1007/s00702-009-0281-2" @@ -109307,7 +109276,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefd00", "standardName": "Insulin vesicle release: walk, kiss, pause ... then run.", - "textContent": "49", + "textContent": "107", "type": [ "PublicationXref", "PubMed:16714477" @@ -109321,7 +109290,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd01", - "textContent": "156", + "textContent": "184", "type": [ "PublicationXref", "DOI:10.1016/j.biopha.2020.110496" @@ -109335,7 +109304,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd02", - "textContent": "180", + "textContent": "29", "type": [ "PublicationXref", "DOI:10.3390/cells10051081" @@ -109350,7 +109319,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefd06", "standardName": "The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.", - "textContent": "78", + "textContent": "65", "type": [ "PublicationXref", "PubMed:17660294" @@ -109367,7 +109336,7 @@ "id": "publicationXrefd0e", "source": "https://doi.org/10.1016/B978-0-12-405546-9.00005-4", "standardName": "Chapter 5 Combined Immune Deficiencies", - "textContent": "70", + "textContent": "10", "type": [ "PublicationXref", "DOI:10.1016/B978-0-12-405546-9.00005-4" @@ -109390,7 +109359,7 @@ "id": "publicationXrefd1f", "source": "Conference: International Meeting for Autism Research 2008", "standardName": "Genes Analysed for Association with Autism and DBH Level", - "textContent": "203", + "textContent": "9", "type": [ "PublicationXref" ], @@ -109403,7 +109372,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd22", - "textContent": "56", + "textContent": "126", "type": [ "PublicationXref", "DOI:10.1016/j.tips.2017.04.001" @@ -109420,7 +109389,7 @@ "id": "publicationXrefd25", "source": "Clin Pharmacokinet", "standardName": "Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.", - "textContent": "151", + "textContent": "47", "type": [ "PublicationXref", "PubMed:27106177" @@ -109436,7 +109405,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefd2e", "standardName": "Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.", - "textContent": "145", + "textContent": "115", "type": [ "PublicationXref", "PubMed:16443778" @@ -109450,7 +109419,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd3f", - "textContent": "204", + "textContent": "138", "type": [ "PublicationXref", "DOI:10.1016/j.psychres.2016.10.044" @@ -109478,7 +109447,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd4e", - "textContent": "95", + "textContent": "118", "type": [ "PublicationXref", "PubMed:10.1016/j.nbd.2020.105061" @@ -109492,7 +109461,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd5a", - "textContent": "182", + "textContent": "128", "type": [ "PublicationXref", "DOI:10.3389/fneur.2021.683275" @@ -109506,7 +109475,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd5c", - "textContent": "108", + "textContent": "52", "type": [ "PublicationXref", "DOI:10.1016/j.neures.2008.11.007" @@ -109520,7 +109489,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd5f", - "textContent": "34", + "textContent": "12", "type": [ "PublicationXref", "DOI:10.3389/fphar.2018.00279" @@ -109534,7 +109503,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXrefd63", - 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"textContent": "183", + "textContent": "49", "type": [ "PublicationXref" ], @@ -110870,7 +110839,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffa7", "standardName": "Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system.", - "textContent": "134", + "textContent": "6", "type": [ "PublicationXref", "PubMed:10424882" @@ -110885,7 +110854,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffbf", "standardName": "The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.", - "textContent": "54", + "textContent": "210", "type": [ "PublicationXref", "PubMed:16868246" @@ -110899,7 +110868,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffc8", - "textContent": "113", + "textContent": "159", "type": [ "PublicationXref", "DOI:10.1093/nar/gkab1016" @@ -110913,7 +110882,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffcc", - "textContent": "164", + "textContent": "146", "type": [ "PublicationXref", "DOI:10.1073/pnas.1002404107" @@ -110928,7 +110897,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffcd", "standardName": "Insulin secretion: a high-affinity Ca2+ sensor after all?", - "textContent": "132", + "textContent": "64", "type": [ "PublicationXref", "PubMed:15572341" @@ -110943,7 +110912,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffd0", "standardName": "Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.", - "textContent": "53", + "textContent": "127", "type": [ "PublicationXref", "PubMed:15504896" @@ -110957,7 +110926,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffde", - "textContent": "89", + "textContent": "166", "type": [ "PublicationXref" ], @@ -110969,7 +110938,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffe1", - "textContent": "160", + "textContent": "207", "type": [ "PublicationXref", "DOI:10.1371/journal.pone.0053727" @@ -110983,7 +110952,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffe5", - "textContent": "173", + "textContent": "216", "type": [ "PublicationXref", "DOI:10.1016/j.molmet.2018.01.007" @@ -110998,7 +110967,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffe6", "standardName": "Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.", - "textContent": "147", + "textContent": "200", "type": [ "PublicationXref", "PubMed:1309948" @@ -111012,7 +110981,7 @@ ], "gpmlElementName": "PublicationXref", "id": "publicationXreffef", - "textContent": "45", + "textContent": "48", "type": [ "PublicationXref", "DOI:10.1016/j.psychres.2016.10.044" @@ -111041,7 +111010,7 @@ "id": "publicationXrefffd", "source": "Front Genet", "standardName": "MECP2 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.", - "textContent": "28", + "textContent": "78", "type": [ "PublicationXref", "PubMed:30619462" @@ -111057,7 +111026,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffff", "standardName": "Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.", - "textContent": "198", + "textContent": "213", "type": [ "PublicationXref", "PubMed:12887316" @@ -114159,7 +114128,7 @@ "@base": "WP5420/" } ], - "author": "[Alexmadsen1, Egonw, Khanspers, Larsgw, Eweitz]", + "author": "[Alexmadsen1, Egonw, Khanspers, Larsgw, Eweitz, DeSl]", "comments": [ { "content": "Pathways associated with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses. \r\nhttps://kimberly102347.com/the-chart/ \r\n\r\nPathways included in this map:\r\nOne-Carbon (1C),\r\nMetabolism Folate Cycle,\r\nMethionine Cycle,\r\nTetrahydrobiopterin (BH4) Pathway,\r\nNeurotransmitter Synthesis, Reuptake, and Breakdown,\r\nKynurenine Pathway (KP),\r\nEndocannabinoid System (ECS),\r\nNeuroreceptor Dynamics in the Synaptic Cleft,\r\nROS Reactive Oxygen Stress.", @@ -114836,7 +114805,6 @@ "f0fcb", "b1995", "fc96b", - "f6754", "e4c11", "b8d61", "cb5fa", @@ -115723,7 +115691,7 @@ "cdc0e", "b8614" ], - "dataSourceVersion": "WP5420_r129619", + "dataSourceVersion": "WP5420_r130790", "displayName": "ASD pathways", "drawAs": "rect", "fill": "white", @@ -115733,7 +115701,7 @@ "height": 2054.309392265194, "id": "WP5420", "kaavioType": "Group", - "lastModified": "20240519160620", + "lastModified": "20240530090741", "name": "ADHD and autism (ASD) pathways", "organism": "Homo sapiens", "padding": 5, @@ -115742,18 +115710,18 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: ADHD and autism (ASD) pathways\nLast Modified: 20240519160620\nOrganism: Homo sapiens", + "textContent": "Name: ADHD and autism (ASD) pathways\nLast Modified: 20240530090741\nOrganism: Homo sapiens", "type": [ "Pathway", - "http://identifiers.org/pw/PW:0001164", - "http://identifiers.org/pw/PW:0001282", "http://identifiers.org/pw/PW:0000140", - "http://identifiers.org/pw/PW:0000790", + "http://identifiers.org/pw/PW:0000407", "http://identifiers.org/pw/PW:0000217", "http://identifiers.org/pw/PW:0001166", - "http://identifiers.org/pw/PW:0000407", + "http://identifiers.org/pw/PW:0001164", + "http://identifiers.org/pw/PW:0001282", "http://identifiers.org/pw/PW:0000048", - "http://identifiers.org/pw/PW:0000189" + "http://identifiers.org/pw/PW:0000189", + "http://identifiers.org/pw/PW:0000790" ], "verticalAlign": "top", "width": 6603.643410852716, diff --git a/pathways/WP5420/WP5420.png b/pathways/WP5420/WP5420.png index 7efdd253c..d635fdcb8 100644 Binary files a/pathways/WP5420/WP5420.png and b/pathways/WP5420/WP5420.png differ diff --git a/pathways/WP5420/WP5420.svg b/pathways/WP5420/WP5420.svg index 888202ea1..970b5f37a 100644 --- a/pathways/WP5420/WP5420.svg +++ b/pathways/WP5420/WP5420.svg @@ -556,7 +556,7 @@ - + @@ -4766,16 +4766,6 @@ Synthesis - - - - Alex Madsen - 2023 - copyright (c) 2024 - CC0 1.0 Universal (CC0 1.0) - Public Domain Dedication - - @@ -12621,7 +12611,7 @@ Name: ADHD and autism (ASD) pathways - Last Modified: 20240519160620 + Last Modified: 20240530090741 Organism: Homo sapiens diff --git a/pathways/WP5473/WP5473-bibliography.tsv b/pathways/WP5473/WP5473-bibliography.tsv new file mode 100644 index 000000000..357ec6926 --- /dev/null +++ b/pathways/WP5473/WP5473-bibliography.tsv @@ -0,0 +1,18 @@ +ID Database Citation +12189384 Pubmed "Targeting death and decoy receptors of the tumour-necrosis factor superfamily. 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PubMed Europe PMC Scholia" +23612460 Pubmed "Beyond TGFβ: roles of other TGFβ superfamily members in cancer. Wakefield LM, Hill CS. Nat Rev Cancer. 2013 May;13(5):328–41. PubMed Europe PMC Scholia" +23847622 Pubmed "Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease. Lopetuso LR, Chowdhry S, Pizarro TT. Front Immunol. 2013 Jul 9;4:181. PubMed Europe PMC Scholia" +24381786 Pubmed "The enigmatic cytokine oncostatin m and roles in disease. Richards CD. ISRN Inflamm. 2013 Dec 8;2013:512103. PubMed Europe PMC Scholia" +24892271 Pubmed "Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Turner MD, Nedjai B, Hurst T, Pennington DJ. Biochim Biophys Acta. 2014 Nov;1843(11):2563–82. PubMed Europe PMC Scholia" +26115564 Pubmed "The TGF-β superfamily in dendritic cell biology. Seeger P, Musso T, Sozzani S. Cytokine Growth Factor Rev. 2015 Dec;26(6):647–57. 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PubMed Europe PMC Scholia" diff --git a/pathways/WP5473/WP5473-datanodes.tsv b/pathways/WP5473/WP5473-datanodes.tsv new file mode 100644 index 000000000..d9ba494f8 --- /dev/null +++ b/pathways/WP5473/WP5473-datanodes.tsv @@ -0,0 +1,366 @@ +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI +CCL1 GeneProduct ensembl:ENSG00000108702 "" ensembl:ENSG00000108702 ncbigene:6346 hgnc.symbol:CCL1 uniprot:P22362 +CCR8 GeneProduct ensembl:ENSG00000179934 "" ensembl:ENSG00000179934 ncbigene:1237 hgnc.symbol:CCR8 uniprot:C9JIP9;uniprot:P51685 +CCL25 GeneProduct ensembl:ENSG00000131142 "" ensembl:ENSG00000131142 ncbigene:6370 hgnc.symbol:CCL25 uniprot:C9JDZ7;uniprot:A0A7P0TBH2;uniprot:F8VWI0;uniprot:O15444 +CCR9 GeneProduct ensembl:ENSG00000173585 "" ensembl:ENSG00000173585 ncbigene:10803 hgnc.symbol:CCR9 uniprot:C9JWC0;uniprot:P51686 +CCL19 GeneProduct ensembl:ENSG00000172724 "" ensembl:ENSG00000172724 ncbigene:6363 hgnc.symbol:CCL19 uniprot:Q6IBD6;uniprot:Q99731;uniprot:Q5VZ75 +ACKR4 GeneProduct ensembl:ENSG00000129048 "" ensembl:ENSG00000129048 ncbigene:51554 hgnc.symbol:ACKR4 uniprot:H0Y9Z2;uniprot:Q9NPB9 +CCR7 GeneProduct ensembl:ENSG00000126353 "" ensembl:ENSG00000126353 ncbigene:1236 hgnc.symbol:CCR7 uniprot:J3KTN5;uniprot:A0N0Q0;uniprot:P32248;uniprot:J3KSS9 +CCL21 GeneProduct ensembl:ENSG00000137077 "" ensembl:ENSG00000137077 ncbigene:6366 hgnc.symbol:CCL21 uniprot:Q5VZ73;uniprot:O00585 +CCL3L1 GeneProduct ensembl:ENSG00000205021 "" +CCL4 GeneProduct ensembl:ENSG00000275302 "" ensembl:ENSG00000275302 ncbigene:6351 hgnc.symbol:CCL4 uniprot:P13236;uniprot:Q7M4M2 +CCL4L1 GeneProduct ensembl:ENSG00000205020 "" +CCL4L2 GeneProduct ensembl:ENSG00000276070 "" ensembl:ENSG00000276070 ncbigene:388372;ncbigene:9560 hgnc.symbol:CCL4L2 uniprot:Q8NHW4 +CCL5 GeneProduct ensembl:ENSG00000271503 "" ensembl:ENSG00000271503 ncbigene:6352 hgnc.symbol:CCL5 uniprot:D0EI67;uniprot:P13501;uniprot:A0A494C1Q1 +CCL3 GeneProduct 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ensembl:ENSG00000163735 "" ensembl:ENSG00000163735 ncbigene:6374 hgnc.symbol:CXCL5 uniprot:P42830;uniprot:Q6I9S7 +CXCL6 GeneProduct ensembl:ENSG00000124875 "" ensembl:ENSG00000124875 ncbigene:6372 hgnc.symbol:CXCL6 uniprot:D6RF92;uniprot:P80162 +CXCL8 GeneProduct ensembl:ENSG00000169429 "" ensembl:ENSG00000169429 ncbigene:3576 hgnc.symbol:CXCL8 uniprot:C9J4T6;uniprot:A0A024RDA5;uniprot:P10145 +CXCL2 GeneProduct ensembl:ENSG00000081041 "" ensembl:ENSG00000081041 ncbigene:2920 hgnc.symbol:CXCL2 uniprot:A0A024RDD9;uniprot:P19875 +CXCL3 GeneProduct ensembl:ENSG00000163734 "" ensembl:ENSG00000163734 ncbigene:2921 hgnc.symbol:CXCL3 uniprot:P19876 +CXCL7 GeneProduct ensembl:ENSG00000163736 "" ensembl:ENSG00000163736 ncbigene:5473 hgnc.symbol:PPBP uniprot:P02775 +CXCL4 GeneProduct ensembl:ENSG00000163737 "" ensembl:ENSG00000163737 ncbigene:5196 hgnc.symbol:PF4 uniprot:P02776 +CXCL4L1 GeneProduct ensembl:ENSG00000109272 "" ensembl:ENSG00000109272 ncbigene:5197 hgnc.symbol:PF4V1 uniprot:P10720 +CXCL9 GeneProduct ensembl:ENSG00000138755 "" ensembl:ENSG00000138755 ncbigene:4283 hgnc.symbol:CXCL9 uniprot:Q07325 +CXCL10 GeneProduct ensembl:ENSG00000169245 "" ensembl:ENSG00000169245 ncbigene:3627 hgnc.symbol:CXCL10 uniprot:P02778 +CXCL11 GeneProduct ensembl:ENSG00000169248 "" ensembl:ENSG00000169248 ncbigene:6373 hgnc.symbol:CXCL11 uniprot:O14625 +CXCL13 GeneProduct ensembl:ENSG00000156234 "" ensembl:ENSG00000156234 ncbigene:10563 hgnc.symbol:CXCL13 uniprot:Q53X90;uniprot:O43927 +CXCL12 GeneProduct ensembl:ENSG00000107562 "" ensembl:ENSG00000107562 ncbigene:6387 hgnc.symbol:CXCL12 uniprot:P48061 +CXCL16 GeneProduct ensembl:ENSG00000161921 "" ensembl:ENSG00000161921 ncbigene:58191 hgnc.symbol:CXCL16 uniprot:I3L333;uniprot:Q9H2A7;uniprot:A0A6I8PIU7 +CXCL14 GeneProduct ensembl:ENSG00000145824 "" ensembl:ENSG00000145824 ncbigene:9547 hgnc.symbol:CXCL14 uniprot:O95715;uniprot:A0A0C4DGC1 +CXCL17 GeneProduct ensembl:ENSG00000189377 "" ensembl:ENSG00000189377 ncbigene:284340 hgnc.symbol:CXCL17 uniprot:X6R584;uniprot:Q6UXB2 +XCL1 GeneProduct ensembl:ENSG00000143184 "" ensembl:ENSG00000143184 ncbigene:6375 hgnc.symbol:XCL1 uniprot:P47992 +XCL2 GeneProduct ensembl:ENSG00000143185 "" ensembl:ENSG00000143185 ncbigene:6846 hgnc.symbol:XCL2 uniprot:Q9UBD3 +CX3CL1 GeneProduct ensembl:ENSG00000006210 "" ensembl:ENSG00000006210 ncbigene:6376 hgnc.symbol:CX3CL1 uniprot:H3BV86;uniprot:H3BSR6;uniprot:P78423;uniprot:J3QRA1;uniprot:A0N0N7 +CXCR1 GeneProduct ensembl:ENSG00000163464 "" ensembl:ENSG00000163464 ncbigene:3577 hgnc.symbol:CXCR1 uniprot:P25024 +CXCR2 GeneProduct ensembl:ENSG00000180871 "" ensembl:ENSG00000180871 ncbigene:3579 hgnc.symbol:CXCR2 uniprot:Q6LCZ7;uniprot:C9J1J7;uniprot:C9JG19;uniprot:C9JW47;uniprot:C9J2F9;uniprot:P25025;uniprot:Q53PC4 +CXCL3 GeneProduct ensembl:ENSG00000163734 "" ensembl:ENSG00000163734 ncbigene:2921 hgnc.symbol:CXCL3 uniprot:P19876 +CXCR5 GeneProduct ensembl:ENSG00000160683 "" ensembl:ENSG00000160683 ncbigene:643 hgnc.symbol:CXCR5 uniprot:A0N0R2;uniprot:P32302 +CXCR4 GeneProduct ensembl:ENSG00000121966 "" ensembl:ENSG00000121966 ncbigene:7852 hgnc.symbol:CXCR4 uniprot:P61073 +CXCR7 GeneProduct ensembl:ENSG00000144476 "" ensembl:ENSG00000144476 ncbigene:57007 hgnc.symbol:ACKR3 uniprot:P25106;uniprot:A0A140T9K6 +CXCR6 GeneProduct ensembl:ENSG00000172215 "" ensembl:ENSG00000172215 ncbigene:10663 hgnc.symbol:CXCR6 uniprot:A0N0N3;uniprot:O00574 +XCR1 GeneProduct ensembl:ENSG00000173578 "" ensembl:ENSG00000173578 ncbigene:2829 hgnc.symbol:XCR1 uniprot:P46094;uniprot:Q689E2 +CX3CR1 GeneProduct ensembl:ENSG00000168329 "" ensembl:ENSG00000168329 ncbigene:1524 hgnc.symbol:CX3CR1 uniprot:C9JLM2;uniprot:C9JN40;uniprot:P49238 +IL2 GeneProduct ensembl:ENSG00000109471 "" ensembl:ENSG00000109471 ncbigene:3558 hgnc.symbol:IL2 uniprot:Q0GK43;uniprot:P60568 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +IL7 GeneProduct ensembl:ENSG00000104432 "" ensembl:ENSG00000104432 ncbigene:3574 hgnc.symbol:IL7 uniprot:A0A0A0MTG5;uniprot:Q5FBX5;uniprot:Q5FBY6;uniprot:Q5FBY3;uniprot:P13232 +IL9 GeneProduct ensembl:ENSG00000145839 "" ensembl:ENSG00000145839 ncbigene:3578 hgnc.symbol:IL9 uniprot:P15248 +IL15 GeneProduct ensembl:ENSG00000164136 "" ensembl:ENSG00000164136 ncbigene:3600 hgnc.symbol:IL15 uniprot:P40933 +IL21 GeneProduct ensembl:ENSG00000138684 "" ensembl:ENSG00000138684 ncbigene:59067 hgnc.symbol:IL21 uniprot:Q9HBE4;uniprot:A0A224B028 +TSLP GeneProduct ensembl:ENSG00000145777 "" ensembl:ENSG00000145777 ncbigene:85480 hgnc.symbol:TSLP uniprot:A0A0C4DG43;uniprot:Q969D9 +IL3 GeneProduct ensembl:ENSG00000164399 "" ensembl:ENSG00000164399 ncbigene:3562 hgnc.symbol:IL3 uniprot:P08700 +IL5 GeneProduct ensembl:ENSG00000113525 "" ensembl:ENSG00000113525 ncbigene:3567 hgnc.symbol:IL5 uniprot:C9JQP9;uniprot:P05113 +CSF2 GeneProduct ensembl:ENSG00000164400 "" ensembl:ENSG00000164400 ncbigene:1437 hgnc.symbol:CSF2 uniprot:P04141 +IL4 GeneProduct ensembl:ENSG00000113520 "" ensembl:ENSG00000113520 ncbigene:3565 hgnc.symbol:IL4 uniprot:D4HNR6;uniprot:Q5FC01;uniprot:U3LVN1;uniprot:P05112 +IL13 GeneProduct ensembl:ENSG00000169194 "" ensembl:ENSG00000169194 ncbigene:3596 hgnc.symbol:IL13 uniprot:P35225 +EPO GeneProduct ensembl:ENSG00000130427 "" ensembl:ENSG00000130427 ncbigene:2056 hgnc.symbol:EPO uniprot:P01588;uniprot:G9JKG7 +GH1 GeneProduct ensembl:ENSG00000259384 "" ensembl:ENSG00000259384 ncbigene:2688 hgnc.symbol:GH1 uniprot:B1A4G9;uniprot:B1A4G7;uniprot:B1A4G6;uniprot:B1A4H0;uniprot:P01241 +GH2 GeneProduct ensembl:ENSG00000136487 "" ensembl:ENSG00000136487 ncbigene:2689 hgnc.symbol:GH2 uniprot:A0A087WXJ5;uniprot:P01242;uniprot:A0A0M6L0J9 +PRL GeneProduct ensembl:ENSG00000172179 "" ensembl:ENSG00000172179 ncbigene:5617 hgnc.symbol:PRL uniprot:A0A494C1P2;uniprot:P01236;uniprot:A0A494C0Z0;uniprot:Q5THQ0;uniprot:Q5I0G2 +TPO GeneProduct ensembl:ENSG00000115705 "" ensembl:ENSG00000115705 ncbigene:7173 hgnc.symbol:TPO uniprot:H7C5B6;uniprot:E9PFM6;uniprot:P07202;uniprot:C9J511;uniprot:H0Y6H4;uniprot:H7C1F5 +CSF3 GeneProduct ensembl:ENSG00000108342 "" ensembl:ENSG00000108342 ncbigene:1440 hgnc.symbol:CSF3 uniprot:Q6FH65;uniprot:P09919;uniprot:J3QRD4;uniprot:J3KTH8;uniprot:Q8N4W3;uniprot:J3QRX2 +LEP GeneProduct ensembl:ENSG00000174697 "" ensembl:ENSG00000174697 ncbigene:3952 hgnc.symbol:LEP uniprot:A4D0Y8;uniprot:P41159 +IL2RA GeneProduct ensembl:ENSG00000134460 "" ensembl:ENSG00000134460 ncbigene:3559 hgnc.symbol:IL2RA uniprot:H0Y5Z0;uniprot:P01589;uniprot:Q5W006;uniprot:Q5W005 +IL2RB GeneProduct ensembl:ENSG00000100385 "" ensembl:ENSG00000100385 ncbigene:3560 hgnc.symbol:IL2RB uniprot:B0QYC2;uniprot:H7C1H9;uniprot:B0QYC1;uniprot:P14784;uniprot:B0QYC0 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL2RA GeneProduct ensembl:ENSG00000134460 "" ensembl:ENSG00000134460 ncbigene:3559 hgnc.symbol:IL2RA uniprot:H0Y5Z0;uniprot:P01589;uniprot:Q5W006;uniprot:Q5W005 +IL2RB GeneProduct ensembl:ENSG00000100385 "" ensembl:ENSG00000100385 ncbigene:3560 hgnc.symbol:IL2RB uniprot:B0QYC2;uniprot:H7C1H9;uniprot:B0QYC1;uniprot:P14784;uniprot:B0QYC0 +IL4R GeneProduct ensembl:ENSG00000077238 "" ensembl:ENSG00000077238 ncbigene:3566 hgnc.symbol:IL4R uniprot:H3BSE7;uniprot:A0A0G2JLA1;uniprot:H3BRH7;uniprot:P24394;uniprot:I3L4W9;uniprot:I3L4H7;uniprot:J9JII2;uniprot:H3BTD9;uniprot:Q5FC08 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL7R GeneProduct ensembl:ENSG00000168685 "" ensembl:ENSG00000168685 ncbigene:3575 hgnc.symbol:IL7R uniprot:D6RDM4;uniprot:H0YA41;uniprot:D6RCR9;uniprot:D6RG28;uniprot:B8YG18;uniprot:P16871 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL9R GeneProduct ensembl:ENSG00000292373 "" +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL15RA GeneProduct ensembl:ENSG00000134470 "" ensembl:ENSG00000134470 ncbigene:3601 hgnc.symbol:IL15RA uniprot:E7ETI1;uniprot:K9N2Q6;uniprot:A0A0A0MS77;uniprot:K9N2S2;uniprot:E9PQ64;uniprot:K9N163;uniprot:Q5JVA3;uniprot:H0Y6E8;uniprot:K9N1J3;uniprot:Q13261;uniprot:H0Y4R3;uniprot:H0YD11 +IL2RB GeneProduct ensembl:ENSG00000100385 "" ensembl:ENSG00000100385 ncbigene:3560 hgnc.symbol:IL2RB uniprot:B0QYC2;uniprot:H7C1H9;uniprot:B0QYC1;uniprot:P14784;uniprot:B0QYC0 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL21R GeneProduct ensembl:ENSG00000103522 "" ensembl:ENSG00000103522 ncbigene:50615 hgnc.symbol:IL21R uniprot:Q9HBE5 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL21R GeneProduct ensembl:ENSG00000103522 "" ensembl:ENSG00000103522 ncbigene:50615 hgnc.symbol:IL21R uniprot:Q9HBE5 +IL2RG GeneProduct ensembl:ENSG00000147168 "" ensembl:ENSG00000147168 ncbigene:3561 hgnc.symbol:IL2RG uniprot:P31785;uniprot:D6R964;uniprot:D6RDW9;uniprot:H0Y8J6 +IL3RA GeneProduct ensembl:ENSG00000292332 "" +CSF2RB GeneProduct ensembl:ENSG00000100368 "" ensembl:ENSG00000100368 ncbigene:1439 hgnc.symbol:CSF2RB uniprot:B0QY07;uniprot:P32927 +IL5RA GeneProduct ensembl:ENSG00000091181 "" ensembl:ENSG00000091181 ncbigene:3568 hgnc.symbol:IL5RA uniprot:E7ERY4;uniprot:C9J3K8;uniprot:Q01344;uniprot:A0A024R2E8;uniprot:C9J6C4 +CSF2RB GeneProduct ensembl:ENSG00000100368 "" ensembl:ENSG00000100368 ncbigene:1439 hgnc.symbol:CSF2RB uniprot:B0QY07;uniprot:P32927 +CSF2RA GeneProduct ensembl:ENSG00000292357 "" +CSF2RB GeneProduct ensembl:ENSG00000100368 "" ensembl:ENSG00000100368 ncbigene:1439 hgnc.symbol:CSF2RB uniprot:B0QY07;uniprot:P32927 +IL4R GeneProduct ensembl:ENSG00000077238 "" ensembl:ENSG00000077238 ncbigene:3566 hgnc.symbol:IL4R uniprot:H3BSE7;uniprot:A0A0G2JLA1;uniprot:H3BRH7;uniprot:P24394;uniprot:I3L4W9;uniprot:I3L4H7;uniprot:J9JII2;uniprot:H3BTD9;uniprot:Q5FC08 +IL4R GeneProduct ensembl:ENSG00000077238 "" ensembl:ENSG00000077238 ncbigene:3566 hgnc.symbol:IL4R uniprot:H3BSE7;uniprot:A0A0G2JLA1;uniprot:H3BRH7;uniprot:P24394;uniprot:I3L4W9;uniprot:I3L4H7;uniprot:J9JII2;uniprot:H3BTD9;uniprot:Q5FC08 +IL13RA1 GeneProduct ensembl:ENSG00000131724 "" ensembl:ENSG00000131724 ncbigene:3597 hgnc.symbol:IL13RA1 uniprot:A0A494C1C4;uniprot:P78552 +IL4R GeneProduct ensembl:ENSG00000077238 "" ensembl:ENSG00000077238 ncbigene:3566 hgnc.symbol:IL4R uniprot:H3BSE7;uniprot:A0A0G2JLA1;uniprot:H3BRH7;uniprot:P24394;uniprot:I3L4W9;uniprot:I3L4H7;uniprot:J9JII2;uniprot:H3BTD9;uniprot:Q5FC08 +IL13RA2 GeneProduct ensembl:ENSG00000123496 "" ensembl:ENSG00000123496 ncbigene:3598 hgnc.symbol:IL13RA2 uniprot:Q14627 +IL3RA GeneProduct ensembl:ENSG00000292332 "" +IL13RA2 GeneProduct ensembl:ENSG00000123496 "" ensembl:ENSG00000123496 ncbigene:3598 hgnc.symbol:IL13RA2 uniprot:Q14627 +EPOR GeneProduct ensembl:ENSG00000187266 "" ensembl:ENSG00000187266 ncbigene:2057 hgnc.symbol:EPOR uniprot:K7EN47;uniprot:K7EP50;uniprot:P19235;uniprot:K7ERB5 +GHR GeneProduct ensembl:ENSG00000112964 "" ensembl:ENSG00000112964 ncbigene:2690 hgnc.symbol:GHR uniprot:A0A087X0H5;uniprot:A0A087X162;uniprot:P10912;uniprot:E9PCN7;uniprot:E7ES05 +PRLR GeneProduct ensembl:ENSG00000113494 "" ensembl:ENSG00000113494 ncbigene:5618 hgnc.symbol:PRLR uniprot:D6RAN9;uniprot:D6R9V7;uniprot:D6RJC8;uniprot:D6R9P5;uniprot:D6RC67;uniprot:P16471;uniprot:D6RD41;uniprot:D6R9E1 +MPL GeneProduct ensembl:ENSG00000117400 "" ensembl:ENSG00000117400 ncbigene:4352 hgnc.symbol:MPL uniprot:P40238;uniprot:Q5JUY5;uniprot:A0A2R8YE13 +CSF3R GeneProduct ensembl:ENSG00000119535 "" ensembl:ENSG00000119535 ncbigene:1441 hgnc.symbol:CSF3R uniprot:Q99062;uniprot:E9PK56;uniprot:H0YE86 +LEPR GeneProduct ensembl:ENSG00000116678 "" ensembl:ENSG00000116678 ncbigene:3953 hgnc.symbol:LEPR uniprot:P48357 +IL6 GeneProduct ensembl:ENSG00000136244 "" ensembl:ENSG00000136244 ncbigene:3569 hgnc.symbol:IL6 uniprot:B5MCZ3;uniprot:C9J5B0;uniprot:B5MC21;uniprot:B4DNV3;uniprot:P05231;uniprot:B5MC14;uniprot:Q75MH2 +IL6R GeneProduct ensembl:ENSG00000160712 "" ensembl:ENSG00000160712 ncbigene:3570 hgnc.symbol:IL6R uniprot:H0Y949;uniprot:D6R9R8;uniprot:H0Y9B1;uniprot:P08887;uniprot:A0A087WTB5;uniprot:A0N0L5 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +IL11 GeneProduct ensembl:ENSG00000095752 "" ensembl:ENSG00000095752 ncbigene:3589 hgnc.symbol:IL11 uniprot:A8K3F7;uniprot:K7ESD5;uniprot:P20809 +IL11RA GeneProduct ensembl:ENSG00000137070 "" ensembl:ENSG00000137070 ncbigene:3590 hgnc.symbol:IL11RA uniprot:G3V2G0;uniprot:G3V2J5;uniprot:Q14626;uniprot:G3V3V2;uniprot:G3V571;uniprot:Q5VZ79;uniprot:G3V2A5;uniprot:H0YCS8;uniprot:G3V428 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +IL12RB1 GeneProduct ensembl:ENSG00000096996 "" ensembl:ENSG00000096996 ncbigene:3594 hgnc.symbol:IL12RB1 uniprot:P42701;uniprot:X6RGM1;uniprot:M0QX06;uniprot:M0R382 +IL12RB2 GeneProduct ensembl:ENSG00000081985 "" ensembl:ENSG00000081985 ncbigene:3595 hgnc.symbol:IL12RB2 uniprot:H0Y5V0;uniprot:A0A0A0MTN7;uniprot:Q99665 +IL23A GeneProduct ensembl:ENSG00000110944 "" ensembl:ENSG00000110944 ncbigene:51561 hgnc.symbol:IL23A uniprot:Q9NPF7 +IL23R GeneProduct ensembl:ENSG00000162594 "" ensembl:ENSG00000162594 ncbigene:149233 hgnc.symbol:IL23R uniprot:Q5VWK5;uniprot:A0A0D9SFJ7;uniprot:A0A1B0GV19 +IL12RB1 GeneProduct ensembl:ENSG00000096996 "" ensembl:ENSG00000096996 ncbigene:3594 hgnc.symbol:IL12RB1 uniprot:P42701;uniprot:X6RGM1;uniprot:M0QX06;uniprot:M0R382 +IL27 GeneProduct ensembl:ENSG00000197272 "" ensembl:ENSG00000197272 ncbigene:246778 hgnc.symbol:IL27 uniprot:Q8NEV9;uniprot:H3BQY2 +IL27RA GeneProduct ensembl:ENSG00000104998 "" ensembl:ENSG00000104998 ncbigene:9466 hgnc.symbol:IL27RA uniprot:Q6UWB1 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +IL31 GeneProduct ensembl:ENSG00000204671 "" ensembl:ENSG00000204671 ncbigene:386653 hgnc.symbol:IL31 uniprot:Q6EBC2 +IL31RA GeneProduct ensembl:ENSG00000164509 "" ensembl:ENSG00000164509 ncbigene:133396 hgnc.symbol:IL31RA uniprot:A0A494BZY2;uniprot:Q8NI17;uniprot:A0A0C4DGU4;uniprot:A0A499FJ31;uniprot:A0A494C190 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +IL12RB2 GeneProduct ensembl:ENSG00000081985 "" ensembl:ENSG00000081985 ncbigene:3595 hgnc.symbol:IL12RB2 uniprot:H0Y5V0;uniprot:A0A0A0MTN7;uniprot:Q99665 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +CNTFR GeneProduct ensembl:ENSG00000122756 "" ensembl:ENSG00000122756 ncbigene:1271 hgnc.symbol:CNTFR uniprot:Q5T8H6;uniprot:P26992 +LIFR GeneProduct ensembl:ENSG00000113594 "" ensembl:ENSG00000113594 ncbigene:3977 hgnc.symbol:LIFR uniprot:P42702;uniprot:H0YAF2;uniprot:D6RF33;uniprot:D6RJ94 +CLCF1 GeneProduct ensembl:ENSG00000175505 "" ensembl:ENSG00000175505 ncbigene:23529 hgnc.symbol:CLCF1 uniprot:Q9UBD9 +CNTF GeneProduct ensembl:ENSG00000242689 "" ensembl:ENSG00000242689 ncbigene:1270 hgnc.symbol:CNTF uniprot:P26441 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +CTF GeneProduct ensembl:ENSG00000141905 "" ensembl:ENSG00000141905 ncbigene:4782 hgnc.symbol:NFIC uniprot:A0A286YEX4;uniprot:P08651 +CNTFR GeneProduct ensembl:ENSG00000122756 "" ensembl:ENSG00000122756 ncbigene:1271 hgnc.symbol:CNTFR uniprot:Q5T8H6;uniprot:P26992 +LIFR GeneProduct ensembl:ENSG00000113594 "" ensembl:ENSG00000113594 ncbigene:3977 hgnc.symbol:LIFR uniprot:P42702;uniprot:H0YAF2;uniprot:D6RF33;uniprot:D6RJ94 +IL6ST GeneProduct ensembl:ENSG00000134352 "" ensembl:ENSG00000134352 ncbigene:3572 hgnc.symbol:IL6ST uniprot:Q5FC07;uniprot:A0A0A0N0L5;uniprot:D6RH03;uniprot:A0A0A0N0L2;uniprot:Q5FC05;uniprot:A0A494BZU0;uniprot:Q5FC02;uniprot:P40189 +CNTFR GeneProduct ensembl:ENSG00000122756 "" ensembl:ENSG00000122756 ncbigene:1271 hgnc.symbol:CNTFR uniprot:Q5T8H6;uniprot:P26992 +LIFR GeneProduct ensembl:ENSG00000113594 "" ensembl:ENSG00000113594 ncbigene:3977 hgnc.symbol:LIFR uniprot:P42702;uniprot:H0YAF2;uniprot:D6RF33;uniprot:D6RJ94 +LIF GeneProduct ensembl:ENSG00000128342 "" ensembl:ENSG00000128342 ncbigene:3976 hgnc.symbol:LIF uniprot:P15018 +CNTF GeneProduct ensembl:ENSG00000242689 "" ensembl:ENSG00000242689 ncbigene:1270 hgnc.symbol:CNTF uniprot:P26441 +CTF GeneProduct ensembl:ENSG00000141905 "" ensembl:ENSG00000141905 ncbigene:4782 hgnc.symbol:NFIC uniprot:A0A286YEX4;uniprot:P08651 +CNTFR GeneProduct ensembl:ENSG00000122756 "" ensembl:ENSG00000122756 ncbigene:1271 hgnc.symbol:CNTFR uniprot:Q5T8H6;uniprot:P26992 +LIFR GeneProduct ensembl:ENSG00000113594 "" ensembl:ENSG00000113594 ncbigene:3977 hgnc.symbol:LIFR uniprot:P42702;uniprot:H0YAF2;uniprot:D6RF33;uniprot:D6RJ94 +IL10 GeneProduct ensembl:ENSG00000136634 "" ensembl:ENSG00000136634 ncbigene:3586 hgnc.symbol:IL10 uniprot:A0A590UK12;uniprot:A0A286YEX3;uniprot:Q6FGW4;uniprot:P22301 +IL10RA GeneProduct ensembl:ENSG00000110324 "" ensembl:ENSG00000110324 ncbigene:3587 hgnc.symbol:IL10RA uniprot:E9PKU2;uniprot:E9PPU4;uniprot:Q13651 +IL10RB GeneProduct ensembl:ENSG00000243646 "" ensembl:ENSG00000243646 ncbigene:3588 hgnc.symbol:IL10RB uniprot:H7C0Z5;uniprot:Q08334;uniprot:A0A1B0GU52;uniprot:A0A1B0GTI5;uniprot:F8WDX2 +IL19 GeneProduct ensembl:ENSG00000142224 "" ensembl:ENSG00000142224 ncbigene:29949 hgnc.symbol:IL19 uniprot:Q9UHD0 +IL20RA GeneProduct ensembl:ENSG00000016402 "" ensembl:ENSG00000016402 ncbigene:53832 hgnc.symbol:IL20RA uniprot:A0A0U1RRA1;uniprot:A0A0U1RQU9;uniprot:Q96SH7;uniprot:A0A0U1RQS0;uniprot:Q9UHF4 +IL20RB GeneProduct ensembl:ENSG00000174564 "" ensembl:ENSG00000174564 ncbigene:53833 hgnc.symbol:IL20RB uniprot:H7C5S5;uniprot:Q6UXL0;uniprot:F8WC67;uniprot:F8WAV8 +IL20 GeneProduct ensembl:ENSG00000162891 "" ensembl:ENSG00000162891 ncbigene:50604 hgnc.symbol:IL20 uniprot:A0A7R8C4W0;uniprot:Q9NYY1 +IL24 GeneProduct ensembl:ENSG00000162892 "" ensembl:ENSG00000162892 ncbigene:11009 hgnc.symbol:IL24 uniprot:A0A7R8C2Y5;uniprot:E7ER64;uniprot:Q13007;uniprot:E7ETP6 +IL22RA1 GeneProduct ensembl:ENSG00000142677 "" ensembl:ENSG00000142677 ncbigene:58985 hgnc.symbol:IL22RA1 uniprot:Q8N6P7 +IL20RB GeneProduct ensembl:ENSG00000174564 "" ensembl:ENSG00000174564 ncbigene:53833 hgnc.symbol:IL20RB uniprot:H7C5S5;uniprot:Q6UXL0;uniprot:F8WC67;uniprot:F8WAV8 +IL22 GeneProduct ensembl:ENSG00000127318 "" ensembl:ENSG00000127318 ncbigene:50616 hgnc.symbol:IL22 uniprot:Q9GZX6;uniprot:A0A7R8C389 +IL26 GeneProduct ensembl:ENSG00000111536 "" ensembl:ENSG00000111536 ncbigene:55801 hgnc.symbol:IL26 uniprot:Q9NPH9;uniprot:A0A7R8GUW8 +IL10RB GeneProduct ensembl:ENSG00000243646 "" ensembl:ENSG00000243646 ncbigene:3588 hgnc.symbol:IL10RB uniprot:H7C0Z5;uniprot:Q08334;uniprot:A0A1B0GU52;uniprot:A0A1B0GTI5;uniprot:F8WDX2 +IL20RA GeneProduct ensembl:ENSG00000016402 "" ensembl:ENSG00000016402 ncbigene:53832 hgnc.symbol:IL20RA uniprot:A0A0U1RRA1;uniprot:A0A0U1RQU9;uniprot:Q96SH7;uniprot:A0A0U1RQS0;uniprot:Q9UHF4 +IL22RA1 GeneProduct ensembl:ENSG00000142677 "" ensembl:ENSG00000142677 ncbigene:58985 hgnc.symbol:IL22RA1 uniprot:Q8N6P7 +IL20RB GeneProduct ensembl:ENSG00000243646 "" ensembl:ENSG00000243646 ncbigene:3588 hgnc.symbol:IL10RB uniprot:H7C0Z5;uniprot:Q08334;uniprot:A0A1B0GU52;uniprot:A0A1B0GTI5;uniprot:F8WDX2 +IL28B GeneProduct ensembl:ENSG00000197110 "" ensembl:ENSG00000197110 ncbigene:282617 hgnc.symbol:IFNL3 uniprot:Q8IZI9;uniprot:A0A7R8C2Z6;uniprot:A0A0C4DGW8 +IL28A GeneProduct ensembl:ENSG00000183709 "" ensembl:ENSG00000183709 ncbigene:282616 hgnc.symbol:IFNL2 uniprot:Q8IZJ0 +IL29 GeneProduct ensembl:ENSG00000182393 "" ensembl:ENSG00000182393 ncbigene:282618 hgnc.symbol:IFNL1 uniprot:A0A7R8C391;uniprot:Q8IU54 +IL10RB GeneProduct ensembl:ENSG00000243646 "" ensembl:ENSG00000243646 ncbigene:3588 hgnc.symbol:IL10RB uniprot:H7C0Z5;uniprot:Q08334;uniprot:A0A1B0GU52;uniprot:A0A1B0GTI5;uniprot:F8WDX2 +IL28RA GeneProduct ensembl:ENSG00000185436 "" ensembl:ENSG00000185436 ncbigene:163702 hgnc.symbol:IFNLR1 uniprot:Q8IU57;uniprot:Q5VTX9 +IFNA GeneProduct ensembl:ENSG00000188379 "" ensembl:ENSG00000188379 ncbigene:3440 hgnc.symbol:IFNA2 uniprot:P01563;uniprot:A0A7R8GUN5 +IFNB1 GeneProduct ensembl:ENSG00000171855 "" ensembl:ENSG00000171855 ncbigene:3456 hgnc.symbol:IFNB1 uniprot:P01574;uniprot:A0A7R8GV38 +IFNW1 GeneProduct ensembl:ENSG00000177047 "" ensembl:ENSG00000177047 ncbigene:3467 hgnc.symbol:IFNW1 uniprot:A0A7R8GUW6;uniprot:P05000 +IFNK GeneProduct ensembl:ENSG00000147896 "" ensembl:ENSG00000147896 ncbigene:56832 hgnc.symbol:IFNK uniprot:Q9P0W0 +IFNG GeneProduct ensembl:ENSG00000111537 "" ensembl:ENSG00000111537 ncbigene:3458 hgnc.symbol:IFNG uniprot:A0A7R8GUN6;uniprot:P01579 +IFNAR1 GeneProduct ensembl:ENSG00000142166 "" ensembl:ENSG00000142166 ncbigene:3454 hgnc.symbol:IFNAR1 uniprot:P17181;uniprot:C9J114;uniprot:A0A494C0P2;uniprot:A0A494BZU5;uniprot:A0A494C0E2;uniprot:A0A494C0K3 +IFNAR2 GeneProduct ensembl:ENSG00000159110 "" ensembl:ENSG00000159110 ncbigene:3455 hgnc.symbol:IFNAR2 uniprot:P48551;uniprot:C9JCU0;uniprot:C9JM33;uniprot:C9K067;uniprot:F8WDE1;uniprot:A0A804HLE8;uniprot:H7C176 +IFNGR1 GeneProduct ensembl:ENSG00000027697 "" ensembl:ENSG00000027697 ncbigene:3459 hgnc.symbol:IFNGR1 uniprot:A0A0S2Z3Y2;uniprot:A0A2R8YEN6;uniprot:A0A2R8YFL3;uniprot:A0A2R8Y4U4;uniprot:P15260;uniprot:Q5TFC9;uniprot:A0A2R8Y792;uniprot:A0A2R8Y7R1;uniprot:Q5TFD1 +IFNGR2 GeneProduct ensembl:ENSG00000159128 "" ensembl:ENSG00000159128 ncbigene:3460 hgnc.symbol:IFNGR2 uniprot:E7EUY1;uniprot:F8WE34;uniprot:F8WF11;uniprot:P38484;uniprot:A8K881;uniprot:H7C1V5;uniprot:B5MCZ0 +IL1A GeneProduct ensembl:ENSG00000115008 "" ensembl:ENSG00000115008 ncbigene:3552 hgnc.symbol:IL1A uniprot:P01583 +IL1R1 GeneProduct ensembl:ENSG00000115594 "" ensembl:ENSG00000115594 ncbigene:3554 hgnc.symbol:IL1R1 uniprot:B8ZZW4;uniprot:C9J3W8;uniprot:C9J686;uniprot:C9JQ36;uniprot:B8ZZ73;uniprot:C9JW84;uniprot:B9A040;uniprot:P14778;uniprot:H7BZM5;uniprot:F8WF92;uniprot:C9JWB2 +IL1RAP GeneProduct ensembl:ENSG00000196083 "" ensembl:ENSG00000196083 ncbigene:3556 hgnc.symbol:IL1RAP uniprot:C9J9W1;uniprot:Q9NPH3;uniprot:C9JT28;uniprot:C9J1D9;uniprot:H7C3W4 +IL1R2 GeneProduct ensembl:ENSG00000115590 "" ensembl:ENSG00000115590 ncbigene:7850 hgnc.symbol:IL1R2 uniprot:P27930;uniprot:C9JNR0 +IL1F5 GeneProduct ensembl:ENSG00000136695 "" ensembl:ENSG00000136695 ncbigene:26525 hgnc.symbol:IL36RN uniprot:A0A024R518;uniprot:U3KPW9;uniprot:C9JTH1;uniprot:Q9UBH0 +IL1F6 GeneProduct ensembl:ENSG00000136694 "" ensembl:ENSG00000136694 ncbigene:27179 hgnc.symbol:IL36A uniprot:Q9UHA7 +IL1F8 GeneProduct ensembl:ENSG00000136696 "" ensembl:ENSG00000136696 ncbigene:27177 hgnc.symbol:IL36B uniprot:Q9NZH7 +IL1F9 GeneProduct ensembl:ENSG00000136688 "" ensembl:ENSG00000136688 ncbigene:56300 hgnc.symbol:IL36G uniprot:Q9NZH8;uniprot:C9J681 +IL1F10 GeneProduct ensembl:ENSG00000136697 "" ensembl:ENSG00000136697 ncbigene:84639 hgnc.symbol:IL1F10 uniprot:Q8WWZ1 +IL1RN GeneProduct ensembl:ENSG00000136689 "" ensembl:ENSG00000136689 ncbigene:3557 hgnc.symbol:IL1RN uniprot:A0A024R528;uniprot:P18510 +IL1RL2 GeneProduct ensembl:ENSG00000115598 "" ensembl:ENSG00000115598 ncbigene:8808 hgnc.symbol:IL1RL2 uniprot:C9K0I8;uniprot:Q9HB29 +IL18RAP GeneProduct ensembl:ENSG00000115607 "" ensembl:ENSG00000115607 ncbigene:8807 hgnc.symbol:IL18RAP uniprot:C9JLE2;uniprot:O95256 +IL1F7 GeneProduct ensembl:ENSG00000125571 "" ensembl:ENSG00000125571 ncbigene:27178 hgnc.symbol:IL37 uniprot:Q9NZH6 +IL18 GeneProduct ensembl:ENSG00000150782 "" ensembl:ENSG00000150782 ncbigene:3606 hgnc.symbol:IL18 uniprot:A0A024R3E0;uniprot:Q14116 +IL18R1 GeneProduct ensembl:ENSG00000115604 "" ensembl:ENSG00000115604 ncbigene:8809 hgnc.symbol:IL18R1 uniprot:Q13478;uniprot:Q86YL8 +IL18RAP GeneProduct ensembl:ENSG00000115607 "" ensembl:ENSG00000115607 ncbigene:8807 hgnc.symbol:IL18RAP uniprot:C9JLE2;uniprot:O95256 +IL33 GeneProduct ensembl:ENSG00000137033 "" ensembl:ENSG00000137033 ncbigene:90865 hgnc.symbol:IL33 uniprot:O95760 +ST2 GeneProduct ensembl:ENSG00000115602 "" ensembl:ENSG00000115602 ncbigene:9173 hgnc.symbol:IL1RL1 uniprot:C9JSY6;uniprot:E9PC41;uniprot:Q01638 +IL1RAP GeneProduct ensembl:ENSG00000196083 "" ensembl:ENSG00000196083 ncbigene:3556 hgnc.symbol:IL1RAP uniprot:C9J9W1;uniprot:Q9NPH3;uniprot:C9JT28;uniprot:C9J1D9;uniprot:H7C3W4 +IL17A GeneProduct ensembl:ENSG00000112115 "" ensembl:ENSG00000112115 ncbigene:3605 hgnc.symbol:IL17A uniprot:Q16552 +IL17F GeneProduct ensembl:ENSG00000112116 "" ensembl:ENSG00000112116 ncbigene:112744 hgnc.symbol:IL17F uniprot:Q96PD4 +IL17RA GeneProduct ensembl:ENSG00000177663 "" ensembl:ENSG00000177663 ncbigene:23765 hgnc.symbol:IL17RA uniprot:Q96F46 +IL17RC GeneProduct ensembl:ENSG00000163702 "" ensembl:ENSG00000163702 ncbigene:84818 hgnc.symbol:IL17RC uniprot:C9K0M1;uniprot:A8K3Q5;uniprot:B4DI24;uniprot:G3V177;uniprot:Q8NAC3;uniprot:F8WEG5;uniprot:F6X4Z5;uniprot:F8WC09;uniprot:F8WE27;uniprot:F8WB43;uniprot:Q8N2D7;uniprot:C9JSZ3;uniprot:F8WD65 +IL17RB GeneProduct ensembl:ENSG00000056736 "" ensembl:ENSG00000056736 ncbigene:55540 hgnc.symbol:IL17RB uniprot:C9IZN0;uniprot:Q9NRM6 +IL17B GeneProduct ensembl:ENSG00000127743 "" ensembl:ENSG00000127743 ncbigene:27190 hgnc.symbol:IL17B uniprot:Q9UHF5 +IL17E GeneProduct ensembl:ENSG00000166090 "" ensembl:ENSG00000166090 ncbigene:64806 hgnc.symbol:IL25 uniprot:Q9H293 +IL17RA GeneProduct ensembl:ENSG00000177663 "" ensembl:ENSG00000177663 ncbigene:23765 hgnc.symbol:IL17RA uniprot:Q96F46 +IL17RB GeneProduct ensembl:ENSG00000056736 "" ensembl:ENSG00000056736 ncbigene:55540 hgnc.symbol:IL17RB uniprot:C9IZN0;uniprot:Q9NRM6 +IL17RE GeneProduct ensembl:ENSG00000166090 "" ensembl:ENSG00000166090 ncbigene:64806 hgnc.symbol:IL25 uniprot:Q9H293 +IL17C GeneProduct ensembl:ENSG00000124391 "" ensembl:ENSG00000124391 ncbigene:27189 hgnc.symbol:IL17C uniprot:Q9P0M4 +IL17D GeneProduct ensembl:ENSG00000172458 "" ensembl:ENSG00000172458 ncbigene:53342 hgnc.symbol:IL17D uniprot:A0A087WW17;uniprot:A0A087WWZ4;uniprot:Q8TAD2 +IL1R2 GeneProduct ensembl:ENSG00000115590 "" ensembl:ENSG00000115590 ncbigene:7850 hgnc.symbol:IL1R2 uniprot:P27930;uniprot:C9JNR0 +IL1RN GeneProduct ensembl:ENSG00000136689 "" ensembl:ENSG00000136689 ncbigene:3557 hgnc.symbol:IL1RN uniprot:A0A024R528;uniprot:P18510 +IL34 GeneProduct ensembl:ENSG00000157368 "" ensembl:ENSG00000157368 ncbigene:146433 hgnc.symbol:IL34 uniprot:J3QQT3;uniprot:A0A024QZ87;uniprot:Q6ZMJ4 +CSF1 GeneProduct ensembl:ENSG00000184371 "" ensembl:ENSG00000184371 ncbigene:1435 hgnc.symbol:CSF1 uniprot:E9PJA2;uniprot:E9PQ08;uniprot:E9PKP4;uniprot:H7BY18;uniprot:P09603 +CSF1R GeneProduct ensembl:ENSG00000182578 "" ensembl:ENSG00000182578 ncbigene:1436 hgnc.symbol:CSF1R uniprot:H0YAL5;uniprot:D6RGW1;uniprot:E9PEK4;uniprot:P07333 +IL1RN GeneProduct ensembl:ENSG00000136689 "" ensembl:ENSG00000136689 ncbigene:3557 hgnc.symbol:IL1RN uniprot:A0A024R528;uniprot:P18510 +TNF GeneProduct ensembl:ENSG00000232810 "" ensembl:ENSG00000232810 ncbigene:7124 hgnc.symbol:TNF uniprot:Q5STB3;uniprot:P01375 +TNFR1 GeneProduct ensembl:ENSG00000067182 "" ensembl:ENSG00000067182 ncbigene:7132 hgnc.symbol:TNFRSF1A uniprot:F5H8A6;uniprot:F5H7N1;uniprot:F5H061;uniprot:P19438;uniprot:F5H6Z2;uniprot:F5H4T5;uniprot:F5GWJ4;uniprot:F5H6V7 +TNFR2 GeneProduct ensembl:ENSG00000028137 "" ensembl:ENSG00000028137 ncbigene:7133 hgnc.symbol:TNFRSF1B uniprot:B5A977;uniprot:P20333 +LTA GeneProduct ensembl:ENSG00000226979 "" ensembl:ENSG00000226979 ncbigene:4049 hgnc.symbol:LTA uniprot:P01374;uniprot:Q5STV3 +LTBR GeneProduct ensembl:ENSG00000111321 "" ensembl:ENSG00000111321 ncbigene:4055 hgnc.symbol:LTBR uniprot:F5H627;uniprot:F5H2E7;uniprot:F5H1S5;uniprot:F5H6F8;uniprot:P36941 +HVEM GeneProduct ensembl:ENSG00000157873 "" ensembl:ENSG00000157873 ncbigene:8764 hgnc.symbol:TNFRSF14 uniprot:F6UPZ7;uniprot:F6Q0M4;uniprot:A0A024R052;uniprot:B9A034;uniprot:A0A0D9SF52;uniprot:Q92956 +LTB GeneProduct ensembl:ENSG00000227507 "" ensembl:ENSG00000227507 ncbigene:4050 hgnc.symbol:LTB uniprot:Q06643;uniprot:Q5STB2 +LIGHT GeneProduct ensembl:ENSG00000125735 "" ensembl:ENSG00000125735 ncbigene:8740 hgnc.symbol:TNFSF14 uniprot:O43557 +DCR3 GeneProduct ensembl:ENSG00000215788 "" ensembl:ENSG00000215788 ncbigene:8718 hgnc.symbol:TNFRSF25 uniprot:K7EJY9;uniprot:A0A3B3ISD9;uniprot:A0A0C4DGF3;uniprot:Q93038 +FASLG GeneProduct ensembl:ENSG00000117560 "" ensembl:ENSG00000117560 ncbigene:356 hgnc.symbol:FASLG uniprot:P48023;uniprot:Q53ZZ1 +VEGI GeneProduct ensembl:ENSG00000181634 "" ensembl:ENSG00000181634 ncbigene:9966 hgnc.symbol:TNFSF15 uniprot:A0A0U5JA19;uniprot:O95150;uniprot:X6R8I9 +FAS GeneProduct ensembl:ENSG00000026103 "" ensembl:ENSG00000026103 ncbigene:355 hgnc.symbol:FAS uniprot:P25445;uniprot:Q59FU8;uniprot:K9J972;uniprot:A0A087WTM9 +DR3 GeneProduct ensembl:ENSG00000215788 "" ensembl:ENSG00000215788 ncbigene:8718 hgnc.symbol:TNFRSF25 uniprot:K7EJY9;uniprot:A0A3B3ISD9;uniprot:A0A0C4DGF3;uniprot:Q93038 +TNFSF10 GeneProduct ensembl:ENSG00000121858 "" ensembl:ENSG00000121858 ncbigene:8743 hgnc.symbol:TNFSF10 uniprot:Q6IBA9;uniprot:H7C246;uniprot:P50591 +DR4 GeneProduct ensembl:ENSG00000104689 "" ensembl:ENSG00000104689 ncbigene:8797 hgnc.symbol:TNFRSF10A uniprot:F8U8C0;uniprot:O00220;uniprot:E5RFH1 +DR5 GeneProduct ensembl:ENSG00000120889 "" ensembl:ENSG00000120889 ncbigene:8795 hgnc.symbol:TNFRSF10B uniprot:E9PBT3;uniprot:O14763 +DCR1 GeneProduct ensembl:ENSG00000173535 "" ensembl:ENSG00000173535 ncbigene:8794 hgnc.symbol:TNFRSF10C uniprot:E5RJI1;uniprot:O14798 +DCR2 GeneProduct ensembl:ENSG00000112486 "" ensembl:ENSG00000112486 ncbigene:1235 hgnc.symbol:CCR6 uniprot:P51684 +DR6 GeneProduct ensembl:ENSG00000146072 "" ensembl:ENSG00000146072 ncbigene:27242 hgnc.symbol:TNFRSF21 uniprot:O75509;uniprot:A0A024RD71 +EDA GeneProduct ensembl:ENSG00000158813 "" ensembl:ENSG00000158813 ncbigene:1896 hgnc.symbol:EDA uniprot:A0A0U5J797;uniprot:Q92838;uniprot:D6RA95;uniprot:A0A0C4DGX3 +EDA GeneProduct ensembl:ENSG00000158813 "" ensembl:ENSG00000158813 ncbigene:1896 hgnc.symbol:EDA uniprot:A0A0U5J797;uniprot:Q92838;uniprot:D6RA95;uniprot:A0A0C4DGX3 +EDAR GeneProduct ensembl:ENSG00000135960 "" ensembl:ENSG00000135960 ncbigene:10913 hgnc.symbol:EDAR uniprot:Q9UNE0 +XEDAR GeneProduct ensembl:ENSG00000131080 "" ensembl:ENSG00000131080 ncbigene:60401 hgnc.symbol:EDA2R uniprot:Q9HAV5 +NGF GeneProduct ensembl:ENSG00000134259 "" ensembl:ENSG00000134259 ncbigene:4803 hgnc.symbol:NGF uniprot:A0A7P0TAZ6;uniprot:P01138 +NGFR GeneProduct ensembl:ENSG00000064300 "" ensembl:ENSG00000064300 ncbigene:4804 hgnc.symbol:NGFR uniprot:P08138 +OPG GeneProduct ensembl:ENSG00000164761 "" ensembl:ENSG00000164761 ncbigene:4982 hgnc.symbol:TNFRSF11B uniprot:E5RFV7;uniprot:O00300 +RANKL GeneProduct ensembl:ENSG00000120659 "" ensembl:ENSG00000120659 ncbigene:8600 hgnc.symbol:TNFSF11 uniprot:Q54A98;uniprot:O14788;uniprot:Q5T9Y4 +RANK GeneProduct ensembl:ENSG00000141655 "" ensembl:ENSG00000141655 ncbigene:8792 hgnc.symbol:TNFRSF11A uniprot:Q9Y6Q6 +TWEAK GeneProduct ensembl:ENSG00000239697 "" ensembl:ENSG00000239697 ncbigene:8742 hgnc.symbol:TNFSF12 uniprot:Q4ACW9;uniprot:O43508;uniprot:C0H5Y4;uniprot:A0A0U5J5F5 +FN14 GeneProduct ensembl:ENSG00000006327 "" ensembl:ENSG00000006327 ncbigene:51330 hgnc.symbol:TNFRSF12A uniprot:I3L3P4;uniprot:Q9NP84;uniprot:I3L0S4;uniprot:I3L1J9;uniprot:I3L539 +CD70 GeneProduct ensembl:ENSG00000125726 "" ensembl:ENSG00000125726 ncbigene:970 hgnc.symbol:CD70 uniprot:M0QZW2;uniprot:P32970;uniprot:A0A0U5JA32 +CD27 GeneProduct ensembl:ENSG00000139193 "" ensembl:ENSG00000139193 ncbigene:939 hgnc.symbol:CD27 uniprot:P26842 +CD30 GeneProduct ensembl:ENSG00000120949 "" ensembl:ENSG00000120949 ncbigene:943 hgnc.symbol:TNFRSF8 uniprot:D6RAG8;uniprot:P28908 +CD40LG GeneProduct ensembl:ENSG00000102245 "" ensembl:ENSG00000102245 ncbigene:959 hgnc.symbol:CD40LG uniprot:P29965;uniprot:Q3L8U2 +CD40 GeneProduct ensembl:ENSG00000101017 "" ensembl:ENSG00000101017 ncbigene:958 hgnc.symbol:CD40 uniprot:A0A087X1D0;uniprot:P25942;uniprot:A0A0S2Z3C7;uniprot:H0YE23 +TNFSF9 GeneProduct ensembl:ENSG00000125657 "" ensembl:ENSG00000125657 ncbigene:8744 hgnc.symbol:TNFSF9 uniprot:P41273;uniprot:A0A0U5J8I0 +TNFRSF9 GeneProduct ensembl:ENSG00000049249 "" ensembl:ENSG00000049249 ncbigene:3604 hgnc.symbol:TNFRSF9 uniprot:A0A6I8PRR4;uniprot:K7EJQ2;uniprot:K7EJ11;uniprot:Q07011 +TNFSF4 GeneProduct ensembl:ENSG00000117586 "" ensembl:ENSG00000117586 ncbigene:7292 hgnc.symbol:TNFSF4 uniprot:A0A024R937;uniprot:P23510 +TNFRSF4 GeneProduct ensembl:ENSG00000186827 "" ensembl:ENSG00000186827 ncbigene:7293 hgnc.symbol:TNFRSF4 uniprot:P43489 +GITR GeneProduct ensembl:ENSG00000186891 "" ensembl:ENSG00000186891 ncbigene:8784 hgnc.symbol:TNFRSF18 uniprot:J3KT02;uniprot:Q9Y5U5 +APRIL GeneProduct ensembl:ENSG00000136938 "" ensembl:ENSG00000136938 ncbigene:10541 hgnc.symbol:ANP32B uniprot:Q92688 +BAFF GeneProduct ensembl:ENSG00000102524 "" ensembl:ENSG00000102524 ncbigene:10673 hgnc.symbol:TNFSF13B uniprot:A0A0U5J7Q1;uniprot:Q9Y275 +BCMA GeneProduct ensembl:ENSG00000048462 "" ensembl:ENSG00000048462 ncbigene:608 hgnc.symbol:TNFRSF17 uniprot:H3BMB5;uniprot:Q02223 +TACI GeneProduct ensembl:ENSG00000240505 "" ensembl:ENSG00000240505 ncbigene:23495 hgnc.symbol:TNFRSF13B uniprot:J3QR67;uniprot:O14836;uniprot:E7ER05;uniprot:Q4ACX1 +BAFFR GeneProduct ensembl:ENSG00000159958 "" ensembl:ENSG00000159958 ncbigene:115650 hgnc.symbol:TNFRSF13C uniprot:Q96RJ3;uniprot:Q5H8V1 +TROY GeneProduct ensembl:ENSG00000127863 "" ensembl:ENSG00000127863 ncbigene:55504 hgnc.symbol:TNFRSF19 uniprot:A0A024RDM5;uniprot:Q9NS68 +RELT GeneProduct ensembl:ENSG00000054967 "" ensembl:ENSG00000054967 ncbigene:84957 hgnc.symbol:RELT uniprot:F5GYS9;uniprot:F5H2T5;uniprot:Q969Z4;uniprot:A0A024R5N3 +TGFB1 GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8 +TGFB2 GeneProduct ensembl:ENSG00000092969 "" ensembl:ENSG00000092969 ncbigene:7042 hgnc.symbol:TGFB2 uniprot:P61812 +TGFB3 GeneProduct ensembl:ENSG00000119699 "" ensembl:ENSG00000119699 ncbigene:7043 hgnc.symbol:TGFB3 uniprot:A0A6Q8PGK5;uniprot:A5YM40;uniprot:P10600 +GDF15 GeneProduct ensembl:ENSG00000130513 "" ensembl:ENSG00000130513 ncbigene:9518 hgnc.symbol:GDF15 uniprot:A0A0A0MTT8;uniprot:Q99988 +GDF2 GeneProduct ensembl:ENSG00000263761 "" ensembl:ENSG00000263761 ncbigene:2658 hgnc.symbol:GDF2 uniprot:Q9UK05 +BMP10 GeneProduct ensembl:ENSG00000163217 "" ensembl:ENSG00000163217 ncbigene:27302 hgnc.symbol:BMP10 uniprot:O95393 +GDF10 GeneProduct ensembl:ENSG00000266524 "" ensembl:ENSG00000266524 ncbigene:2662 hgnc.symbol:GDF10 uniprot:P55107 +GDF11 GeneProduct ensembl:ENSG00000135414 "" ensembl:ENSG00000135414 ncbigene:10220 hgnc.symbol:GDF11 uniprot:O95390;uniprot:A0A024RB20;uniprot:H0YI30 +MSTN GeneProduct ensembl:ENSG00000138379 "" ensembl:ENSG00000138379 ncbigene:2660 hgnc.symbol:MSTN uniprot:O14793;uniprot:Q53S46 +INHBA GeneProduct ensembl:ENSG00000122641 "" ensembl:ENSG00000122641 ncbigene:3624 hgnc.symbol:INHBA uniprot:A4D1W7;uniprot:P08476 +INHBB GeneProduct ensembl:ENSG00000163083 "" ensembl:ENSG00000163083 ncbigene:3625 hgnc.symbol:INHBB uniprot:P09529 +GDF1 GeneProduct ensembl:ENSG00000130283 "" ensembl:ENSG00000130283 ncbigene:2657 hgnc.symbol:GDF1 uniprot:P27539;uniprot:A0A024R7N8 +GDF3 GeneProduct ensembl:ENSG00000184344 "" ensembl:ENSG00000184344 ncbigene:9573 hgnc.symbol:GDF3 uniprot:Q9NR23 +NODAL GeneProduct ensembl:ENSG00000156574 "" ensembl:ENSG00000156574 ncbigene:4838 hgnc.symbol:NODAL uniprot:Q96S42;uniprot:H7C0E4 +GDF9 GeneProduct ensembl:ENSG00000164404 "" ensembl:ENSG00000164404 ncbigene:2661 hgnc.symbol:GDF9 uniprot:O60383;uniprot:B4DXG3 +INHBC GeneProduct ensembl:ENSG00000175189 "" ensembl:ENSG00000175189 ncbigene:3626 hgnc.symbol:INHBC uniprot:P55103 +INHBE GeneProduct ensembl:ENSG00000139269 "" ensembl:ENSG00000139269 ncbigene:83729 hgnc.symbol:INHBE uniprot:P58166 +AMH GeneProduct ensembl:ENSG00000104899 "" ensembl:ENSG00000104899 ncbigene:268 hgnc.symbol:AMH uniprot:P03971 +INHA GeneProduct ensembl:ENSG00000123999 "" ensembl:ENSG00000123999 ncbigene:3623 hgnc.symbol:INHA uniprot:P05111 +BMP3 GeneProduct ensembl:ENSG00000152785 "" ensembl:ENSG00000152785 ncbigene:651 hgnc.symbol:BMP3 uniprot:P12645 +TGFBR1 GeneProduct ensembl:ENSG00000106799 "" ensembl:ENSG00000106799 ncbigene:7046 hgnc.symbol:TGFBR1 uniprot:F8VVC4;uniprot:F8W1R9;uniprot:B4DY26;uniprot:F8W0K6;uniprot:F8VRH6;uniprot:Q5T7S2;uniprot:H0YHS4;uniprot:P36897;uniprot:F8VXZ5 +TGFBR2 GeneProduct ensembl:ENSG00000163513 "" ensembl:ENSG00000163513 ncbigene:7048 hgnc.symbol:TGFBR2 uniprot:D2JYI1;uniprot:P37173;uniprot:A3QNQ0 +ACVRL1 GeneProduct ensembl:ENSG00000139567 "" ensembl:ENSG00000139567 ncbigene:94 hgnc.symbol:ACVRL1 uniprot:D9IPD9;uniprot:P37023;uniprot:G3V1W8;uniprot:E7EN07;uniprot:H3BTZ2;uniprot:A0A0S2Z310;uniprot:F8W0N2 +TGFBR2 GeneProduct ensembl:ENSG00000163513 "" ensembl:ENSG00000163513 ncbigene:7048 hgnc.symbol:TGFBR2 uniprot:D2JYI1;uniprot:P37173;uniprot:A3QNQ0 +TGFBR2 GeneProduct ensembl:ENSG00000163513 "" ensembl:ENSG00000163513 ncbigene:7048 hgnc.symbol:TGFBR2 uniprot:D2JYI1;uniprot:P37173;uniprot:A3QNQ0 +ACVRL1 GeneProduct ensembl:ENSG00000139567 "" ensembl:ENSG00000139567 ncbigene:94 hgnc.symbol:ACVRL1 uniprot:D9IPD9;uniprot:P37023;uniprot:G3V1W8;uniprot:E7EN07;uniprot:H3BTZ2;uniprot:A0A0S2Z310;uniprot:F8W0N2 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +ACVRL1 GeneProduct ensembl:ENSG00000139567 "" ensembl:ENSG00000139567 ncbigene:94 hgnc.symbol:ACVRL1 uniprot:D9IPD9;uniprot:P37023;uniprot:G3V1W8;uniprot:E7EN07;uniprot:H3BTZ2;uniprot:A0A0S2Z310;uniprot:F8W0N2 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +TGFBR1 GeneProduct ensembl:ENSG00000106799 "" ensembl:ENSG00000106799 ncbigene:7046 hgnc.symbol:TGFBR1 uniprot:F8VVC4;uniprot:F8W1R9;uniprot:B4DY26;uniprot:F8W0K6;uniprot:F8VRH6;uniprot:Q5T7S2;uniprot:H0YHS4;uniprot:P36897;uniprot:F8VXZ5 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +TGFBR1 GeneProduct ensembl:ENSG00000106799 "" ensembl:ENSG00000106799 ncbigene:7046 hgnc.symbol:TGFBR1 uniprot:F8VVC4;uniprot:F8W1R9;uniprot:B4DY26;uniprot:F8W0K6;uniprot:F8VRH6;uniprot:Q5T7S2;uniprot:H0YHS4;uniprot:P36897;uniprot:F8VXZ5 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +ACVR1B GeneProduct ensembl:ENSG00000135503 "" ensembl:ENSG00000135503 ncbigene:91 hgnc.symbol:ACVR1B uniprot:F5H5Q2;uniprot:P36896 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +ACVR1B GeneProduct ensembl:ENSG00000135503 "" ensembl:ENSG00000135503 ncbigene:91 hgnc.symbol:ACVR1B uniprot:F5H5Q2;uniprot:P36896 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +ACVR1C GeneProduct ensembl:ENSG00000123612 "" ensembl:ENSG00000123612 ncbigene:130399 hgnc.symbol:ACVR1C uniprot:Q8NER5 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +ACVR1C GeneProduct ensembl:ENSG00000123612 "" ensembl:ENSG00000123612 ncbigene:130399 hgnc.symbol:ACVR1C uniprot:Q8NER5 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +ACVR1C GeneProduct ensembl:ENSG00000123612 "" ensembl:ENSG00000123612 ncbigene:130399 hgnc.symbol:ACVR1C uniprot:Q8NER5 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +ACVR1 GeneProduct ensembl:ENSG00000115170 "" ensembl:ENSG00000115170 ncbigene:90 hgnc.symbol:ACVR1 uniprot:Q04771;uniprot:C9JW28;uniprot:A0A804HJQ0;uniprot:D3DPA4;uniprot:A0A1B0GXA9;uniprot:A0A804HHZ2;uniprot:C9JHJ7 +AMHR2 GeneProduct ensembl:ENSG00000135409 "" ensembl:ENSG00000135409 ncbigene:269 hgnc.symbol:AMHR2 uniprot:H3BPI9;uniprot:Q16671 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +AMHR2 GeneProduct ensembl:ENSG00000135409 "" ensembl:ENSG00000135409 ncbigene:269 hgnc.symbol:AMHR2 uniprot:H3BPI9;uniprot:Q16671 +BMP2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +BMP4 GeneProduct ensembl:ENSG00000125378 "" ensembl:ENSG00000125378 ncbigene:652 hgnc.symbol:BMP4 uniprot:H0YM53;uniprot:P12644;uniprot:Q53XC5;uniprot:V9GYF1;uniprot:H0YMP9;uniprot:H0YLW3 +GDF5 GeneProduct ensembl:ENSG00000125965 "" ensembl:ENSG00000125965 ncbigene:8200 hgnc.symbol:GDF5 uniprot:F1T0J1;uniprot:P43026 +GDF6 GeneProduct ensembl:ENSG00000156466 "" ensembl:ENSG00000156466 ncbigene:392255 hgnc.symbol:GDF6 uniprot:A0A0S2A5D6;uniprot:Q6KF10 +GDF7 GeneProduct ensembl:ENSG00000143869 "" ensembl:ENSG00000143869 ncbigene:151449 hgnc.symbol:GDF7 uniprot:Q7Z4P5 +BMP15 GeneProduct ensembl:ENSG00000130385 "" ensembl:ENSG00000130385 ncbigene:9210 hgnc.symbol:BMP15 uniprot:O95972 +BMP5 GeneProduct ensembl:ENSG00000112175 "" ensembl:ENSG00000112175 ncbigene:653 hgnc.symbol:BMP5 uniprot:M9VUD0;uniprot:P22003 +BMP6 GeneProduct ensembl:ENSG00000153162 "" ensembl:ENSG00000153162 ncbigene:654 hgnc.symbol:BMP6 uniprot:P22004 +BMP7 GeneProduct ensembl:ENSG00000101144 "" ensembl:ENSG00000101144 ncbigene:655 hgnc.symbol:BMP7 uniprot:B1AKZ9;uniprot:P18075;uniprot:H0Y4B5;uniprot:A8K571;uniprot:B1AL00 +BMP8 GeneProduct ensembl:ENSG00000116985 "" ensembl:ENSG00000116985 ncbigene:656 hgnc.symbol:BMP8B uniprot:P34820 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +ACVR1 GeneProduct ensembl:ENSG00000115170 "" ensembl:ENSG00000115170 ncbigene:90 hgnc.symbol:ACVR1 uniprot:Q04771;uniprot:C9JW28;uniprot:A0A804HJQ0;uniprot:D3DPA4;uniprot:A0A1B0GXA9;uniprot:A0A804HHZ2;uniprot:C9JHJ7 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +ACVR1 GeneProduct ensembl:ENSG00000115170 "" ensembl:ENSG00000115170 ncbigene:90 hgnc.symbol:ACVR1 uniprot:Q04771;uniprot:C9JW28;uniprot:A0A804HJQ0;uniprot:D3DPA4;uniprot:A0A1B0GXA9;uniprot:A0A804HHZ2;uniprot:C9JHJ7 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +ACVR1 GeneProduct ensembl:ENSG00000115170 "" ensembl:ENSG00000115170 ncbigene:90 hgnc.symbol:ACVR1 uniprot:Q04771;uniprot:C9JW28;uniprot:A0A804HJQ0;uniprot:D3DPA4;uniprot:A0A1B0GXA9;uniprot:A0A804HHZ2;uniprot:C9JHJ7 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +BMPR1A GeneProduct ensembl:ENSG00000107779 "" ensembl:ENSG00000107779 ncbigene:657 hgnc.symbol:BMPR1A uniprot:P36894;uniprot:A0A087X0P8 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +ACVR2A GeneProduct ensembl:ENSG00000121989 "" ensembl:ENSG00000121989 ncbigene:92 hgnc.symbol:ACVR2A uniprot:P27037 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +ACVR2B GeneProduct ensembl:ENSG00000114739 "" ensembl:ENSG00000114739 ncbigene:93 hgnc.symbol:ACVR2B uniprot:Q13705 +BMPR1B GeneProduct ensembl:ENSG00000138696 "" ensembl:ENSG00000138696 ncbigene:658 hgnc.symbol:BMPR1B uniprot:O00238;uniprot:D6RGW8 +BMPR2 GeneProduct ensembl:ENSG00000204217 "" ensembl:ENSG00000204217 ncbigene:659 hgnc.symbol:BMPR2 uniprot:Q13873 diff --git a/pathways/WP5473/WP5473.gpml b/pathways/WP5473/WP5473.gpml new file mode 100644 index 000000000..41c7db421 --- /dev/null +++ b/pathways/WP5473/WP5473.gpml @@ -0,0 +1,3271 @@ + + + Interactions between cytokines and their receptors. 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