Secondary Structure with DSSP.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "id": "2c5be565",
   "metadata": {},
   "source": [
    "# Extract secondary structure from PDB files easily\n",
    "\n",
    "<a rel=\"license\" href=\"https://creativecommons.org/licenses/by-sa/4.0/\"><img alt=\"Creative Commons Licence\" style=\"border-width:0\" src=\"https://licensebuttons.net/l/by-sa/4.0/88x31.png\" title='This work is licensed under a Creative Commons Attribution 4.0 International License.' align=\"right\"/></a>\n",
    "\n",
    "Author: Dr Antonia Mey   \n",
    "Email: antonia.mey@ed.ac.uk"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 50,
   "id": "01c65ec5",
   "metadata": {},
   "outputs": [],
   "source": [
    "# Imports\n",
    "import pandas as pd\n",
    "import numpy as np\n",
    "import glob \n",
    "import os\n",
    "import urllib\n",
    "from collections import Counter"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 52,
   "id": "dc4af6a9",
   "metadata": {},
   "outputs": [],
   "source": [
    "def get_sec_struct(fname, dssp_path):\n",
    "    \n",
    "    \"\"\" returns secondary structure of protein file\n",
    "    Parameters:\n",
    "    -----------\n",
    "    fname : String\n",
    "        name of alpha fold pdb file\n",
    "        \n",
    "    dssp_path : String\n",
    "        path to the installation of dssp\n",
    "        \n",
    "    Returns:\n",
    "    --------\n",
    "    secstruct : np.array\n",
    "        array containing secondary structure information\n",
    "    \n",
    "    Cheat sheet of secondary structure information:\n",
    "    -----------------------------------------------\n",
    "    H = α-helix\n",
    "    B = residue in isolated β-bridge\n",
    "    E = extended strand, participates in β ladder\n",
    "    G = 3-helix (310 helix)\n",
    "    I = 5 helix (π-helix)\n",
    "    T = hydrogen bonded turn\n",
    "    S = bend\n",
    "    \"\"\"\n",
    "    \n",
    "    # call DSSP\n",
    "    try:\n",
    "        import subprocess\n",
    "        subprocess.check_call(\"%s %s -o result.dssp\"%(dssp_path, fname), shell=True)\n",
    "        fin=open(\"result.dssp\",\"r\")\n",
    "    except Exception as e:\n",
    "        raise Exception(\"Could not calculate secondary structure! %s\"%e)\n",
    "\n",
    "    # parse output\n",
    "    readit=False\n",
    "    secstruct=[]\n",
    "    for line in fin:\n",
    "\n",
    "        if readit:\n",
    "            try:\n",
    "                if line[13:15] == '!*' or line[13] == '!':\n",
    "                    continue\n",
    "                else:\n",
    "                    ss = line[16]\n",
    "                    if line[16] == \" \":\n",
    "                        ss = \"-\"\n",
    "\n",
    "                    secstruct.append(ss)\n",
    "            except:\n",
    "                continue\n",
    "\n",
    "        if \"#\" in line:\n",
    "            readit=True\n",
    "\n",
    "    fin.close()\n",
    "\n",
    "    # clean temporary files\n",
    "    os.remove(\"result.dssp\")\n",
    "\n",
    "    return np.array(secstruct)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 53,
   "id": "a1a7b817",
   "metadata": {},
   "outputs": [],
   "source": [
    "def select_high_confidence_structures(pdb_list, threshold=0.9):\n",
    "    \n",
    "    confidence_info=[]\n",
    "    for p in pdb_list:\n",
    "        f = open(p)\n",
    "        data = f.readlines()\n",
    "        f.close()\n",
    "        confidence_score = []\n",
    "        conf_dic = {}\n",
    "        for l in data:\n",
    "            if l.startswith('ATOM'):\n",
    "                curr_line =l.split()\n",
    "                confidence_score.append(float(curr_line[-2]))\n",
    "        conf_dic['mean'] = np.mean(confidence_score)\n",
    "        conf_dic['std'] = np.std(confidence_score)\n",
    "        conf_dic['name'] = p\n",
    "        confidence_info.append(conf_dic)\n",
    "    confidence_df = pd.DataFrame.from_dict(confidence_info)\n",
    "    filtering = confidence_df[\"mean\"]>90.0\n",
    "    high_confidence_pdbs = confidence_df.where(filfilteringter).dropna()['name']\n",
    "    return high_confidence_pdbs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 252,
   "id": "434ff4f4",
   "metadata": {},
   "outputs": [],
   "source": [
    "def get_alpha_helix_length_and_location(secondary_struc, min_length=7):\n",
    "    helix_regions = []\n",
    "    counter = 0\n",
    "    curr_helix = []\n",
    "    indexes = [i for i, x in enumerate(list(secondary_struc)) if x == 'H']\n",
    "    for i in range(len(indexes)-1):\n",
    "        difference = indexes[i+1]-indexes[i]\n",
    "        if difference == 1:\n",
    "            curr_helix.append(indexes[i])\n",
    "            if i == len(indexes)-2:\n",
    "                if len(curr_helix)>=min_length-1:\n",
    "                    curr_helix.append(indexes[i+1])\n",
    "                    helix_regions.append(curr_helix)\n",
    "        else:\n",
    "            curr_helix.append(indexes[i])\n",
    "            if len(curr_helix)>=min_length-1:\n",
    "                helix_regions.append(curr_helix)\n",
    "            curr_helix = []\n",
    "    return helix_regions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "1e16900f",
   "metadata": {},
   "outputs": [],
   "source": [
    "def get_number_of_serines(sequence):\n",
    "    "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "da4c983c",
   "metadata": {},
   "outputs": [],
   "source": [
    "def check_if_helix_form_part_of_known_folds(helix_regions):"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 55,
   "id": "77661a8b",
   "metadata": {},
   "outputs": [],
   "source": [
    "# Defining Uniprot IDs, also from file\n",
    "#uniprot_ids = ['B7HIJ2', 'F5WVJ2', 'C4LF00', 'O68891']\n",
    "uniprot_ids = ['P01106']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 56,
   "id": "dc64e850",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "At entry 0/1\n",
      "ID: P01106\n"
     ]
    }
   ],
   "source": [
    "# Download alpha fold structures\n",
    "download_alpha_fold_pdbs(uniprot_ids, workdir='data')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 57,
   "id": "7043b44d",
   "metadata": {},
   "outputs": [],
   "source": [
    "pdbs_alpha = glob.glob('data/*.pdb')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 60,
   "id": "e2772a1e",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "['-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'S' 'S' 'S' 'S' 'S' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'T' 'T' 'S' 'T' 'T' 'T' 'G' 'G'\n",
      " 'G' 'S' '-' 'S' '-' '-' '-' '-' '-' '-' 'G' 'G' 'G' 'T' 'T' 'T' 'T' 'T'\n",
      " 'T' 'S' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' '-'\n",
      " 'S' '-' '-' '-' 'S' '-' '-' '-' '-' '-' 'T' 'T' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'S' 'T' 'T' 'T' 'S' '-' '-' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'T' 'T' 'S' '-' 'S' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'T' 'T' 'S' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'T' 'T' '-' '-' '-' '-' 'H' 'H' 'H' 'H' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' 'T' 'T' 'S' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' 'T' 'T' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'T' 'T' 'S' 'T' 'T' 'T' 'T' 'T' '-' 'T' 'T' '-' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' '-' '-']\n"
     ]
    }
   ],
   "source": [
    "# Now write everything out\n",
    "# Feel free to change file name\n",
    "f_name = 'secondary_struc.csv'\n",
    "secstruc_data = []\n",
    "sec_struc_output = 0\n",
    "f = open(f_name, 'w')\n",
    "for p in pdbs_alpha:\n",
    "    sec_struc_output = get_sec_struct(p, '/Users/toni_brain/miniconda3/envs/dssp//bin/mkdssp')\n",
    "    print(sec_struc_output)\n",
    "    #check_alpha_helix_of_length_seven_or_more(sec_struc_output)\n",
    "    uniprot_id = p.split('-')[1]\n",
    "    f.write(uniprot_id+',')\n",
    "    for r in sec_struc_output:\n",
    "        f.write(r)\n",
    "    f.write('\\n')\n",
    "f.close()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 122,
   "id": "18c72d37",
   "metadata": {},
   "outputs": [],
   "source": [
    "helix_regions = get_alpha_helix_length_and_location(sec_struc_output)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 106,
   "id": "d6286bf1",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "439"
      ]
     },
     "execution_count": 106,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(sec_struc_output)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "9bf48956",
   "metadata": {},
   "source": [
    "## Playing around with loading json"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "id": "5b53854c",
   "metadata": {},
   "outputs": [],
   "source": [
    "import json"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 44,
   "id": "53ab9ea0",
   "metadata": {},
   "outputs": [],
   "source": [
    "f = open('test.json')\n",
    "  \n",
    "# returns JSON object as \n",
    "# a dictionary\n",
    "data = json.load(f)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "id": "8d321652",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "dict_keys(['entryType', 'primaryAccession', 'secondaryAccessions', 'uniProtkbId', 'entryAudit', 'annotationScore', 'organism', 'proteinExistence', 'proteinDescription', 'genes', 'comments', 'features', 'keywords', 'references', 'uniProtKBCrossReferences', 'sequence', 'extraAttributes'])"
      ]
     },
     "execution_count": 27,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "data.keys()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 45,
   "id": "e939a3d9",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'P01106'"
      ]
     },
     "execution_count": 45,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "data['primaryAccession']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 127,
   "id": "88b775a1",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "354\n",
      "406\n"
     ]
    }
   ],
   "source": [
    "print(data['features'][1]['location']['start']['value'])\n",
    "print(data['features'][1]['location']['end']['value'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 160,
   "id": "08d9b0c7",
   "metadata": {},
   "outputs": [],
   "source": [
    "# This is collecting known information\n",
    "\n",
    "known_things = {}\n",
    "known_things['Domain'] = []\n",
    "known_things['Region'] = []\n",
    "known_things['Motif'] = []\n",
    "#known_things['Helix'] = []\n",
    "\n",
    "for d in data['features']:\n",
    "    #print(d['type'])\n",
    "    if d['type'] == 'Domain':\n",
    "        known_things['Domain'].append([d['location']['start']['value'], d['location']['end']['value'], d['description']])\n",
    "    elif d['type'] == 'Region':\n",
    "        known_things['Region'].append([d['location']['start']['value'], d['location']['end']['value'], d['description']])\n",
    "    elif d['type'] == 'Motif':\n",
    "        known_things['Motif'].append([d['location']['start']['value'], d['location']['end']['value'], d['description']])\n",
    "    #elif d['type'] == 'Helix':\n",
    "    #    known_things['Helix'].append([d['location']['start']['value'], d['location']['end']['value'], d['description']])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 161,
   "id": "afa15534",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'Domain': [[354, 406, 'bHLH']],\n",
       " 'Region': [[204, 295, 'Disordered'], [413, 434, 'Leucine-zipper']],\n",
       " 'Motif': [[100, 108, '9aaTAD']]}"
      ]
     },
     "execution_count": 161,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "known_things"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 162,
   "id": "5ef6731a",
   "metadata": {},
   "outputs": [],
   "source": [
    "# now we want to match up the known information with the predicted helices:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 163,
   "id": "63c16932",
   "metadata": {},
   "outputs": [],
   "source": [
    "def closest_value(input_list, input_value):\n",
    "    arr = np.asarray(input_list)\n",
    "    i = (np.abs(arr - input_value)).argmin()\n",
    "    return arr[i]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 168,
   "id": "44007c38",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Domain [[354, 406, 'bHLH']]\n",
      "helix to check is: [94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106]\n",
      "248\n",
      "300\n",
      "helix to check is: [121, 122, 123, 124, 125, 126, 127, 128, 129, 130]\n",
      "224\n",
      "276\n",
      "helix to check is: [139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153]\n",
      "201\n",
      "253\n",
      "helix to check is: [175, 176, 177, 178, 179, 180, 181, 182, 183]\n",
      "171\n",
      "223\n",
      "helix to check is: [347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377]\n",
      "0\n",
      "29\n",
      "begginning is part of helix\n",
      "helix to check is: [391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436]\n",
      "37\n",
      "0\n",
      "end is part of helix\n",
      "==========\n",
      "Region [[204, 295, 'Disordered'], [413, 434, 'Leucine-zipper']]\n",
      "helix to check is: [94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106]\n",
      "98\n",
      "189\n",
      "helix to check is: [121, 122, 123, 124, 125, 126, 127, 128, 129, 130]\n",
      "74\n",
      "165\n",
      "helix to check is: [139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153]\n",
      "51\n",
      "142\n",
      "helix to check is: [175, 176, 177, 178, 179, 180, 181, 182, 183]\n",
      "21\n",
      "112\n",
      "helix to check is: [347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377]\n",
      "143\n",
      "52\n",
      "helix to check is: [391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436]\n",
      "187\n",
      "96\n",
      "helix to check is: [94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106]\n",
      "307\n",
      "328\n",
      "helix to check is: [121, 122, 123, 124, 125, 126, 127, 128, 129, 130]\n",
      "283\n",
      "304\n",
      "helix to check is: [139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153]\n",
      "260\n",
      "281\n",
      "helix to check is: [175, 176, 177, 178, 179, 180, 181, 182, 183]\n",
      "230\n",
      "251\n",
      "helix to check is: [347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377]\n",
      "36\n",
      "57\n",
      "helix to check is: [391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436]\n",
      "0\n",
      "0\n",
      "begginning is part of helix\n",
      "==========\n",
      "Motif [[100, 108, '9aaTAD']]\n",
      "helix to check is: [94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106]\n",
      "0\n",
      "2\n",
      "begginning is part of helix\n",
      "helix to check is: [121, 122, 123, 124, 125, 126, 127, 128, 129, 130]\n",
      "21\n",
      "13\n",
      "helix to check is: [139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153]\n",
      "39\n",
      "31\n",
      "helix to check is: [175, 176, 177, 178, 179, 180, 181, 182, 183]\n",
      "75\n",
      "67\n",
      "helix to check is: [347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377]\n",
      "247\n",
      "239\n",
      "helix to check is: [391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436]\n",
      "291\n",
      "283\n",
      "==========\n"
     ]
    }
   ],
   "source": [
    "for key in known_things.keys():\n",
    "    print(key, known_things[key])\n",
    "    for items in known_things[key]:\n",
    "\n",
    "#helix = helix_regions[0]\n",
    "#print(helix)\n",
    "\n",
    "        for helix in helix_regions:\n",
    "            print('helix to check is:',helix)\n",
    "            difference_beginning = np.abs(closest_value(helix,items[0])-items[0])\n",
    "            difference_end = np.abs(closest_value(helix,items[1])-items[1])\n",
    "            print(difference_beginning)\n",
    "            print(difference_end)\n",
    "            if items[0] in helix:\n",
    "                ## check if begin and end are in list\n",
    "                print('begginning is part of helix')\n",
    "            elif items[1] in helix:\n",
    "                print('end is part of helix')\n",
    "            elif difference_beginning and difference_end <=5:\n",
    "                print('helix close to known starts')\n",
    "                print(items[0], items[1])\n",
    "    print(10*'=')\n",
    "\n",
    "            "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 169,
   "id": "41af3b41",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'entryType': 'UniProtKB reviewed (Swiss-Prot)',\n",
       " 'primaryAccession': 'P01106',\n",
       " 'secondaryAccessions': ['A8WFE7', 'P01107', 'Q14026'],\n",
       " 'uniProtkbId': 'MYC_HUMAN',\n",
       " 'entryAudit': {'firstPublicDate': '1986-07-21',\n",
       "  'lastAnnotationUpdateDate': '2022-12-14',\n",
       "  'lastSequenceUpdateDate': '1987-08-13',\n",
       "  'entryVersion': 265,\n",
       "  'sequenceVersion': 1},\n",
       " 'annotationScore': 5.0,\n",
       " 'organism': {'scientificName': 'Homo sapiens',\n",
       "  'commonName': 'Human',\n",
       "  'taxonId': 9606,\n",
       "  'lineage': ['Eukaryota',\n",
       "   'Metazoa',\n",
       "   'Chordata',\n",
       "   'Craniata',\n",
       "   'Vertebrata',\n",
       "   'Euteleostomi',\n",
       "   'Mammalia',\n",
       "   'Eutheria',\n",
       "   'Euarchontoglires',\n",
       "   'Primates',\n",
       "   'Haplorrhini',\n",
       "   'Catarrhini',\n",
       "   'Hominidae',\n",
       "   'Homo']},\n",
       " 'proteinExistence': '1: Evidence at protein level',\n",
       " 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Myc proto-oncogene protein'}},\n",
       "  'alternativeNames': [{'fullName': {'value': 'Class E basic helix-loop-helix protein 39'},\n",
       "    'shortNames': [{'value': 'bHLHe39'}]},\n",
       "   {'fullName': {'value': 'Proto-oncogene c-Myc'}},\n",
       "   {'fullName': {'value': 'Transcription factor p64'}}]},\n",
       " 'genes': [{'geneName': {'value': 'MYC'}, 'synonyms': [{'value': 'BHLHE39'}]}],\n",
       " 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250',\n",
       "       'source': 'UniProtKB',\n",
       "       'id': 'P01108'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20010808'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24940000'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25956029'}],\n",
       "     'value': \"Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808)\"}],\n",
       "   'commentType': 'FUNCTION'},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250',\n",
       "       'source': 'UniProtKB',\n",
       "       'id': 'P01108'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15103331'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15674325'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15723054'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17308053'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17311883'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17632056'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17873522'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25775507'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25956029'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9680483'}],\n",
       "     'value': 'Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7(PubMed:25775507, PubMed:17558397). Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). Interacts with CIP2A; leading to the stabilization of MYC (PubMed:17632056)'}],\n",
       "   'commentType': 'SUBUNIT'},\n",
       "  {'commentType': 'INTERACTION',\n",
       "   'interactions': [{'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9UBB4',\n",
       "      'geneName': 'ATXN10',\n",
       "      'intActId': 'EBI-702390'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O15169',\n",
       "      'geneName': 'AXIN1',\n",
       "      'intActId': 'EBI-710484'},\n",
       "     'numberOfExperiments': 10,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O00499-10',\n",
       "      'geneName': 'BIN1',\n",
       "      'intActId': 'EBI-7689134'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O00499-11',\n",
       "      'geneName': 'BIN1',\n",
       "      'intActId': 'EBI-7689211'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q15059',\n",
       "      'geneName': 'BRD3',\n",
       "      'intActId': 'EBI-1383460'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P55212',\n",
       "      'geneName': 'CASP6',\n",
       "      'intActId': 'EBI-718729'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P45973',\n",
       "      'geneName': 'CBX5',\n",
       "      'intActId': 'EBI-78219'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q8N163',\n",
       "      'geneName': 'CCAR2',\n",
       "      'intActId': 'EBI-355410'},\n",
       "     'numberOfExperiments': 8,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P06307',\n",
       "      'geneName': 'CCK',\n",
       "      'intActId': 'EBI-6624398'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'A5D8W4',\n",
       "      'geneName': 'CDH1',\n",
       "      'intActId': 'EBI-7793316'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P11802',\n",
       "      'geneName': 'CDK4',\n",
       "      'intActId': 'EBI-295644'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q86XR8',\n",
       "      'geneName': 'CEP57',\n",
       "      'intActId': 'EBI-308614'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P28329-3',\n",
       "      'geneName': 'CHAT',\n",
       "      'intActId': 'EBI-25837549'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q14839',\n",
       "      'geneName': 'CHD4',\n",
       "      'intActId': 'EBI-372916'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O15111',\n",
       "      'geneName': 'CHUK',\n",
       "      'intActId': 'EBI-81249'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q8TCG1',\n",
       "      'geneName': 'CIP2A',\n",
       "      'intActId': 'EBI-1379376'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q01658',\n",
       "      'geneName': 'DR1',\n",
       "      'intActId': 'EBI-750300'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q15029',\n",
       "      'geneName': 'EFTUD2',\n",
       "      'intActId': 'EBI-357897'},\n",
       "     'numberOfExperiments': 5,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q96L91',\n",
       "      'geneName': 'EP400',\n",
       "      'intActId': 'EBI-399163'},\n",
       "     'numberOfExperiments': 6,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q96L91-2',\n",
       "      'geneName': 'EP400',\n",
       "      'intActId': 'EBI-15698003'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q969H0',\n",
       "      'geneName': 'FBXW7',\n",
       "      'intActId': 'EBI-359574'},\n",
       "     'numberOfExperiments': 7,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q8N3Y1',\n",
       "      'geneName': 'FBXW8',\n",
       "      'intActId': 'EBI-914770'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P22607',\n",
       "      'geneName': 'FGFR3',\n",
       "      'intActId': 'EBI-348399'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O43524',\n",
       "      'geneName': 'FOXO3',\n",
       "      'intActId': 'EBI-1644164'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P49841-2',\n",
       "      'geneName': 'GSK3B',\n",
       "      'intActId': 'EBI-15870655'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P06396',\n",
       "      'geneName': 'GSN',\n",
       "      'intActId': 'EBI-351506'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q00403',\n",
       "      'geneName': 'GTF2B',\n",
       "      'intActId': 'EBI-389564'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9Y5Q9',\n",
       "      'geneName': 'GTF3C3',\n",
       "      'intActId': 'EBI-1054873'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q92769',\n",
       "      'geneName': 'HDAC2',\n",
       "      'intActId': 'EBI-301821'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O15379',\n",
       "      'geneName': 'HDAC3',\n",
       "      'intActId': 'EBI-607682'},\n",
       "     'numberOfExperiments': 6,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9Y6K9',\n",
       "      'geneName': 'IKBKG',\n",
       "      'intActId': 'EBI-81279'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O60341',\n",
       "      'geneName': 'KDM1A',\n",
       "      'intActId': 'EBI-710124'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O00629',\n",
       "      'geneName': 'KPNA4',\n",
       "      'intActId': 'EBI-396343'},\n",
       "     'numberOfExperiments': 7,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P13473-2',\n",
       "      'geneName': 'LAMP2',\n",
       "      'intActId': 'EBI-21591415'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P61244',\n",
       "      'geneName': 'MAX',\n",
       "      'intActId': 'EBI-751711'},\n",
       "     'numberOfExperiments': 38,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O95983',\n",
       "      'geneName': 'MBD3',\n",
       "      'intActId': 'EBI-1783068'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P33993',\n",
       "      'geneName': 'MCM7',\n",
       "      'intActId': 'EBI-355924'},\n",
       "     'numberOfExperiments': 6,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'A9UHW6',\n",
       "      'geneName': 'MIF4GD',\n",
       "      'intActId': 'EBI-373498'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O75928',\n",
       "      'geneName': 'PIAS2',\n",
       "      'intActId': 'EBI-348555'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q13526',\n",
       "      'geneName': 'PIN1',\n",
       "      'intActId': 'EBI-714158'},\n",
       "     'numberOfExperiments': 5,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O75400-2',\n",
       "      'geneName': 'PRPF40A',\n",
       "      'intActId': 'EBI-5280197'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P62913',\n",
       "      'geneName': 'RPL11',\n",
       "      'intActId': 'EBI-354380'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9Y371',\n",
       "      'geneName': 'SH3GLB1',\n",
       "      'intActId': 'EBI-2623095'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'O75182',\n",
       "      'geneName': 'SIN3B',\n",
       "      'intActId': 'EBI-540462'},\n",
       "     'numberOfExperiments': 7,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q96EB6',\n",
       "      'geneName': 'SIRT1',\n",
       "      'intActId': 'EBI-1802965'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q8N6T7',\n",
       "      'geneName': 'SIRT6',\n",
       "      'intActId': 'EBI-712415'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q13309',\n",
       "      'geneName': 'SKP2',\n",
       "      'intActId': 'EBI-456291'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q8TAD8',\n",
       "      'geneName': 'SNIP1',\n",
       "      'intActId': 'EBI-749336'},\n",
       "     'numberOfExperiments': 9,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P08047',\n",
       "      'geneName': 'SP1',\n",
       "      'intActId': 'EBI-298336'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P31948',\n",
       "      'geneName': 'STIP1',\n",
       "      'intActId': 'EBI-1054052'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q13148',\n",
       "      'geneName': 'TARDBP',\n",
       "      'intActId': 'EBI-372899'},\n",
       "     'numberOfExperiments': 6,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P37173',\n",
       "      'geneName': 'TGFBR2',\n",
       "      'intActId': 'EBI-296151'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P11387',\n",
       "      'geneName': 'TOP1',\n",
       "      'intActId': 'EBI-876302'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q14669',\n",
       "      'geneName': 'TRIP12',\n",
       "      'intActId': 'EBI-308443'},\n",
       "     'numberOfExperiments': 7,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9Y4A5',\n",
       "      'geneName': 'TRRAP',\n",
       "      'intActId': 'EBI-399128'},\n",
       "     'numberOfExperiments': 6,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P0CG48',\n",
       "      'geneName': 'UBC',\n",
       "      'intActId': 'EBI-3390054'},\n",
       "     'numberOfExperiments': 5,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9UMX0',\n",
       "      'geneName': 'UBQLN1',\n",
       "      'intActId': 'EBI-741480'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P17480',\n",
       "      'geneName': 'UBTF',\n",
       "      'intActId': 'EBI-396235'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q13105',\n",
       "      'geneName': 'ZBTB17',\n",
       "      'intActId': 'EBI-372156'},\n",
       "     'numberOfExperiments': 9,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q9Y649',\n",
       "      'intActId': 'EBI-25900580'},\n",
       "     'numberOfExperiments': 3,\n",
       "     'organismDiffer': False},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P03129',\n",
       "      'geneName': 'E7',\n",
       "      'intActId': 'EBI-866453'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P04020',\n",
       "      'geneName': 'E7',\n",
       "      'intActId': 'EBI-7005254'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P06788',\n",
       "      'geneName': 'E7',\n",
       "      'intActId': 'EBI-1776887'},\n",
       "     'numberOfExperiments': 5,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P03204',\n",
       "      'geneName': 'EBNA6',\n",
       "      'intActId': 'EBI-9255985'},\n",
       "     'numberOfExperiments': 11,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P52164',\n",
       "      'geneName': 'Max',\n",
       "      'intActId': 'EBI-1184963'},\n",
       "     'numberOfExperiments': 4,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'Q62141',\n",
       "      'geneName': 'Sin3b',\n",
       "      'intActId': 'EBI-591450'},\n",
       "     'numberOfExperiments': 8,\n",
       "     'organismDiffer': True},\n",
       "    {'interactantOne': {'uniProtKBAccession': 'P01106',\n",
       "      'intActId': 'EBI-447544'},\n",
       "     'interactantTwo': {'uniProtKBAccession': 'P03070',\n",
       "      'intActId': 'EBI-617698'},\n",
       "     'numberOfExperiments': 2,\n",
       "     'organismDiffer': True}]},\n",
       "  {'commentType': 'SUBCELLULAR LOCATION',\n",
       "   'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "        'source': 'PubMed',\n",
       "        'id': '17558397'}],\n",
       "      'value': 'Nucleus, nucleoplasm',\n",
       "      'id': 'SL-0190'}},\n",
       "    {'location': {'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "        'source': 'PubMed',\n",
       "        'id': '17558397'},\n",
       "       {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25775507'}],\n",
       "      'value': 'Nucleus, nucleolus',\n",
       "      'id': 'SL-0188'}}]},\n",
       "  {'commentType': 'ALTERNATIVE PRODUCTS',\n",
       "   'events': ['Alternative splicing'],\n",
       "   'isoforms': [{'name': {'value': '1'},\n",
       "     'isoformIds': ['P01106-1'],\n",
       "     'isoformSequenceStatus': 'Displayed'},\n",
       "    {'name': {'value': '2'},\n",
       "     'isoformIds': ['P01106-2'],\n",
       "     'sequenceIds': ['VSP_037813'],\n",
       "     'isoformSequenceStatus': 'Described'}]},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "       'source': 'PubMed',\n",
       "       'id': '34342803'}],\n",
       "     'value': 'The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors'}],\n",
       "   'commentType': 'DOMAIN'},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250',\n",
       "       'source': 'UniProtKB',\n",
       "       'id': 'P01108'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15103331'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1597196'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19966300'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20713526'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22307329'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25438055'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25803737'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8386367'}],\n",
       "     'value': 'Phosphorylated by PRKDC (PubMed:1597196). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence (PubMed:19966300, PubMed:20713526). Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58 (PubMed:22307329). Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome (PubMed:15103331, PubMed:17558397, PubMed:8386367). Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (PubMed:25803737, PubMed:25438055)'}],\n",
       "   'commentType': 'PTM'},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250',\n",
       "       'source': 'UniProtKB',\n",
       "       'id': 'P01108'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15103331'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17873522'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20551172'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25775507'},\n",
       "      {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29779948'}],\n",
       "     'value': 'Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome (PubMed:15103331, PubMed:17558397, PubMed:25775507). In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation (PubMed:17873522, PubMed:17558397). In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:17558397, PubMed:25775507). Also polyubiquitinated by the DCX(TRPC4AP) complex (PubMed:20551172, PubMed:29779948). Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity)'}],\n",
       "   'commentType': 'PTM'},\n",
       "  {'commentType': 'DISEASE',\n",
       "   'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "        'source': 'PubMed',\n",
       "        'id': '2069907'}],\n",
       "      'value': 'A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1'}]}},\n",
       "  {'commentType': 'DISEASE',\n",
       "   'disease': {'diseaseId': 'Burkitt lymphoma',\n",
       "    'diseaseAccession': 'DI-02613',\n",
       "    'acronym': 'BL',\n",
       "    'description': 'A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.',\n",
       "    'diseaseCrossReference': {'database': 'MIM', 'id': '113970'},\n",
       "    'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "      'source': 'PubMed',\n",
       "      'id': '2166998'},\n",
       "     {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8220424'}]},\n",
       "   'note': {'texts': [{'value': 'The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci'}]}},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "       'source': 'PubMed',\n",
       "       'id': '18035408'}],\n",
       "     'value': 'POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes'}],\n",
       "   'commentType': 'BIOTECHNOLOGY'},\n",
       "  {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "     'value': 'Initiates from CTG codon'}],\n",
       "   'commentType': 'MISCELLANEOUS',\n",
       "   'molecule': 'Isoform 2'},\n",
       "  {'commentType': 'WEB RESOURCE',\n",
       "   'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology',\n",
       "   'resourceUrl': 'http://atlasgeneticsoncology.org/Genes/MYCID27.html',\n",
       "   'ftp': False},\n",
       "  {'commentType': 'WEB RESOURCE',\n",
       "   'resourceName': 'NIEHS-SNPs',\n",
       "   'resourceUrl': 'http://egp.gs.washington.edu/data/myc/',\n",
       "   'ftp': False},\n",
       "  {'commentType': 'WEB RESOURCE',\n",
       "   'resourceName': 'Wikipedia',\n",
       "   'resourceUrl': 'https://en.wikipedia.org/wiki/Myc',\n",
       "   'ftp': False,\n",
       "   'note': 'Myc entry'}],\n",
       " 'features': [{'type': 'Chain',\n",
       "   'location': {'start': {'value': 1, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 439, 'modifier': 'EXACT'}},\n",
       "   'description': 'Myc proto-oncogene protein',\n",
       "   'featureId': 'PRO_0000127293'},\n",
       "  {'type': 'Domain',\n",
       "   'location': {'start': {'value': 354, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 406, 'modifier': 'EXACT'}},\n",
       "   'description': 'bHLH',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000255',\n",
       "     'source': 'PROSITE-ProRule',\n",
       "     'id': 'PRU00981'}]},\n",
       "  {'type': 'Region',\n",
       "   'location': {'start': {'value': 204, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 295, 'modifier': 'EXACT'}},\n",
       "   'description': 'Disordered',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000256',\n",
       "     'source': 'SAM',\n",
       "     'id': 'MobiDB-lite'}]},\n",
       "  {'type': 'Region',\n",
       "   'location': {'start': {'value': 413, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 434, 'modifier': 'EXACT'}},\n",
       "   'description': 'Leucine-zipper'},\n",
       "  {'type': 'Motif',\n",
       "   'location': {'start': {'value': 100, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 108, 'modifier': 'EXACT'}},\n",
       "   'description': '9aaTAD',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '34342803'}]},\n",
       "  {'type': 'Compositional bias',\n",
       "   'location': {'start': {'value': 204, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 234, 'modifier': 'EXACT'}},\n",
       "   'description': 'Polar residues',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000256',\n",
       "     'source': 'SAM',\n",
       "     'id': 'MobiDB-lite'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 6, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 6, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '20068231'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 8, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 8, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphothreonine; by RAF; in vitro',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9315742'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 58, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 58, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphothreonine; by GSK3; alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15103331'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8386367'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '17081983'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '21406692'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 62, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 62, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine; by DYRK2, GSK3 and CDK2',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15103331'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19966300'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20713526'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22307329'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25438055'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25803737'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8386367'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '21406692'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 71, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 71, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18669648'},\n",
       "    {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 143, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 143, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF; alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 148, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 148, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19608861'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 157, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 157, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 161, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 161, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '20068231'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 275, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 275, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 293, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 293, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '23186163'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 317, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 317, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 323, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 323, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 329, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 329, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phosphoserine; by PIM2; in vitro',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000250',\n",
       "     'source': 'UniProtKB',\n",
       "     'id': 'P01108'}]},\n",
       "  {'type': 'Modified residue',\n",
       "   'location': {'start': {'value': 371, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 371, 'modifier': 'EXACT'}},\n",
       "   'description': 'N6-acetyllysine; by PCAF',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '16126174'}]},\n",
       "  {'type': 'Glycosylation',\n",
       "   'location': {'start': {'value': 58, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 58, 'modifier': 'EXACT'}},\n",
       "   'description': 'O-linked (GlcNAc) threonine; alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '7642555'}],\n",
       "   'featureId': 'CAR_000033'},\n",
       "  {'type': 'Cross-link',\n",
       "   'location': {'start': {'value': 52, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 52, 'modifier': 'EXACT'}},\n",
       "   'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '28112733'}]},\n",
       "  {'type': 'Cross-link',\n",
       "   'location': {'start': {'value': 143, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 143, 'modifier': 'EXACT'}},\n",
       "   'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '28112733'}]},\n",
       "  {'type': 'Cross-link',\n",
       "   'location': {'start': {'value': 148, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 148, 'modifier': 'EXACT'}},\n",
       "   'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '28112733'}]},\n",
       "  {'type': 'Cross-link',\n",
       "   'location': {'start': {'value': 298, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 298, 'modifier': 'EXACT'}},\n",
       "   'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007744',\n",
       "     'source': 'PubMed',\n",
       "     'id': '28112733'}]},\n",
       "  {'type': 'Alternative sequence',\n",
       "   'location': {'start': {'value': 1, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 1, 'modifier': 'EXACT'}},\n",
       "   'description': 'in isoform 2',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000303',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15489334'}],\n",
       "   'featureId': 'VSP_037813',\n",
       "   'alternativeSequence': {'originalSequence': 'M',\n",
       "    'alternativeSequences': ['MDFFRVVENQQPPATM']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 11, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 11, 'modifier': 'EXACT'}},\n",
       "   'description': 'in dbSNP:rs4645959',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs4645959'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'Reference',\n",
       "     'id': 'Ref.11'}],\n",
       "   'featureId': 'VAR_016327',\n",
       "   'alternativeSequence': {'originalSequence': 'N',\n",
       "    'alternativeSequences': ['S']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 39, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 39, 'modifier': 'EXACT'}},\n",
       "   'description': 'in a Burkitt lymphoma sample; dbSNP:rs121918684',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121918684'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '6419122'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8220424'}],\n",
       "   'featureId': 'VAR_063384',\n",
       "   'alternativeSequence': {'originalSequence': 'E',\n",
       "    'alternativeSequences': ['D']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 57, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 57, 'modifier': 'EXACT'}},\n",
       "   'description': 'in a Burkitt lymphoma sample; dbSNP:rs28933407',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28933407'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '8220424'}],\n",
       "   'featureId': 'VAR_063385',\n",
       "   'alternativeSequence': {'originalSequence': 'P',\n",
       "    'alternativeSequences': ['S']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 59, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 59, 'modifier': 'EXACT'}},\n",
       "   'description': 'in a Burkitt lymphoma sample; dbSNP:rs121918685',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121918685'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '8220424'}],\n",
       "   'featureId': 'VAR_063386',\n",
       "   'alternativeSequence': {'originalSequence': 'P',\n",
       "    'alternativeSequences': ['A']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 86, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 86, 'modifier': 'EXACT'}},\n",
       "   'description': 'in a Burkitt lymphoma sample; dbSNP:rs121918683',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121918683'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '8220424'}],\n",
       "   'featureId': 'VAR_063387',\n",
       "   'alternativeSequence': {'originalSequence': 'N',\n",
       "    'alternativeSequences': ['T']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 160, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 160, 'modifier': 'EXACT'}},\n",
       "   'description': 'in dbSNP:rs4645960',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs4645960'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'Reference',\n",
       "     'id': 'Ref.11'}],\n",
       "   'featureId': 'VAR_016328',\n",
       "   'alternativeSequence': {'originalSequence': 'G',\n",
       "    'alternativeSequences': ['C']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 170, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 170, 'modifier': 'EXACT'}},\n",
       "   'description': 'in dbSNP:rs4645961',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs4645961'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'Reference',\n",
       "     'id': 'Ref.11'}],\n",
       "   'featureId': 'VAR_016329',\n",
       "   'alternativeSequence': {'originalSequence': 'V',\n",
       "    'alternativeSequences': ['I']}},\n",
       "  {'type': 'Natural variant',\n",
       "   'location': {'start': {'value': 322, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 322, 'modifier': 'EXACT'}},\n",
       "   'description': 'in dbSNP:rs4645968',\n",
       "   'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs4645968'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'Reference',\n",
       "     'id': 'Ref.11'}],\n",
       "   'featureId': 'VAR_016330',\n",
       "   'alternativeSequence': {'originalSequence': 'A',\n",
       "    'alternativeSequences': ['V']}},\n",
       "  {'type': 'Mutagenesis',\n",
       "   'location': {'start': {'value': 58, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 58, 'modifier': 'EXACT'}},\n",
       "   'description': 'Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Normal inhibition of Ras-induced senescence.',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15103331'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19966300'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20713526'}],\n",
       "   'alternativeSequence': {'originalSequence': 'T',\n",
       "    'alternativeSequences': ['A']}},\n",
       "  {'type': 'Mutagenesis',\n",
       "   'location': {'start': {'value': 62, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 62, 'modifier': 'EXACT'}},\n",
       "   'description': 'Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Impaired inhibition of Ras-induced senescence. Abolishes phosphorylation by DYRK2, and subsequent phosphorylation by GSK3B at Thr-58.',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15103331'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19966300'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20713526'},\n",
       "    {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22307329'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['A']}},\n",
       "  {'type': 'Mutagenesis',\n",
       "   'location': {'start': {'value': 62, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 62, 'modifier': 'EXACT'}},\n",
       "   'description': 'Phospho-mimetic mutant; abolished regulation by AMBRA1.',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '25438055'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['D']}},\n",
       "  {'type': 'Mutagenesis',\n",
       "   'location': {'start': {'value': 435, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 435, 'modifier': 'EXACT'}},\n",
       "   'description': 'Abolished ubiquitination and degradation by the DCX(TRPC4AP) complex.',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000269',\n",
       "     'source': 'PubMed',\n",
       "     'id': '29779948'}],\n",
       "   'alternativeSequence': {'originalSequence': 'R',\n",
       "    'alternativeSequences': ['K']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 6, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 7, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'SF',\n",
       "    'alternativeSequences': ['TI']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 10, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 10, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'R',\n",
       "    'alternativeSequences': ['K']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 56, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 56, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'L',\n",
       "    'alternativeSequences': ['LL']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 62, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 62, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 7; CAA25288',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['P']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 88, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 88, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'G',\n",
       "    'alternativeSequences': ['D']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 92, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 92, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['N']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 114, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 114, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['N']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 120, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 120, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'D',\n",
       "    'alternativeSequences': ['G']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 171, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 171, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'C',\n",
       "    'alternativeSequences': ['S']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 203, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 203, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['R']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 230, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 230, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'S',\n",
       "    'alternativeSequences': ['A']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 240, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 240, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'L',\n",
       "    'alternativeSequences': ['F']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 245, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 245, 'modifier': 'EXACT'}},\n",
       "   'description': 'in Ref. 5; no nucleotide entry',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'P',\n",
       "    'alternativeSequences': ['S']}},\n",
       "  {'type': 'Helix',\n",
       "   'location': {'start': {'value': 98, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 103, 'modifier': 'EXACT'}},\n",
       "   'description': '',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007829',\n",
       "     'source': 'PDB',\n",
       "     'id': '6E16'}]},\n",
       "  {'type': 'Helix',\n",
       "   'location': {'start': {'value': 104, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 106, 'modifier': 'EXACT'}},\n",
       "   'description': '',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007829',\n",
       "     'source': 'PDB',\n",
       "     'id': '6E16'}]},\n",
       "  {'type': 'Helix',\n",
       "   'location': {'start': {'value': 351, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 378, 'modifier': 'EXACT'}},\n",
       "   'description': '',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007829',\n",
       "     'source': 'PDB',\n",
       "     'id': '6G6K'}]},\n",
       "  {'type': 'Helix',\n",
       "   'location': {'start': {'value': 382, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 384, 'modifier': 'EXACT'}},\n",
       "   'description': '',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007829',\n",
       "     'source': 'PDB',\n",
       "     'id': '6G6K'}]},\n",
       "  {'type': 'Helix',\n",
       "   'location': {'start': {'value': 392, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 435, 'modifier': 'EXACT'}},\n",
       "   'description': '',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0007829',\n",
       "     'source': 'PDB',\n",
       "     'id': '6G6K'}]},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 2, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 2, 'modifier': 'EXACT'},\n",
       "    'sequence': 'P01106-2'},\n",
       "   'description': 'in Ref. 7; BAA01374',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'D',\n",
       "    'alternativeSequences': ['N']}},\n",
       "  {'type': 'Sequence conflict',\n",
       "   'location': {'start': {'value': 6, 'modifier': 'EXACT'},\n",
       "    'end': {'value': 6, 'modifier': 'EXACT'},\n",
       "    'sequence': 'P01106-2'},\n",
       "   'description': 'in Ref. 7; BAA01374',\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000305'}],\n",
       "   'alternativeSequence': {'originalSequence': 'V',\n",
       "    'alternativeSequences': ['E']}}],\n",
       " 'keywords': [{'id': 'KW-0002',\n",
       "   'category': 'Technical term',\n",
       "   'name': '3D-structure'},\n",
       "  {'id': 'KW-0007', 'category': 'PTM', 'name': 'Acetylation'},\n",
       "  {'id': 'KW-0010', 'category': 'Molecular function', 'name': 'Activator'},\n",
       "  {'id': 'KW-0025',\n",
       "   'category': 'Coding sequence diversity',\n",
       "   'name': 'Alternative splicing'},\n",
       "  {'id': 'KW-0160',\n",
       "   'category': 'Coding sequence diversity',\n",
       "   'name': 'Chromosomal rearrangement'},\n",
       "  {'id': 'KW-0238', 'category': 'Molecular function', 'name': 'DNA-binding'},\n",
       "  {'id': 'KW-0325', 'category': 'PTM', 'name': 'Glycoprotein'},\n",
       "  {'id': 'KW-1017', 'category': 'PTM', 'name': 'Isopeptide bond'},\n",
       "  {'id': 'KW-0539', 'category': 'Cellular component', 'name': 'Nucleus'},\n",
       "  {'id': 'KW-0597', 'category': 'PTM', 'name': 'Phosphoprotein'},\n",
       "  {'id': 'KW-0656', 'category': 'Disease', 'name': 'Proto-oncogene'},\n",
       "  {'id': 'KW-1185',\n",
       "   'category': 'Technical term',\n",
       "   'name': 'Reference proteome'},\n",
       "  {'id': 'KW-0804', 'category': 'Biological process', 'name': 'Transcription'},\n",
       "  {'id': 'KW-0805',\n",
       "   'category': 'Biological process',\n",
       "   'name': 'Transcription regulation'},\n",
       "  {'id': 'KW-0832', 'category': 'PTM', 'name': 'Ubl conjugation'}],\n",
       " 'references': [{'citation': {'id': '6414718',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Battey J.',\n",
       "     'Moulding C.',\n",
       "     'Taub R.',\n",
       "     'Murphy W.',\n",
       "     'Stewart T.',\n",
       "     'Potter H.',\n",
       "     'Lenoir G.',\n",
       "     'Leder P.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6414718'},\n",
       "     {'database': 'DOI', 'id': '10.1016/0092-8674(83)90534-2'}],\n",
       "    'title': 'The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'Cell',\n",
       "    'firstPage': '779',\n",
       "    'lastPage': '787',\n",
       "    'volume': '34'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORM 1)']},\n",
       "  {'citation': {'id': '6321164',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Bernard O.',\n",
       "     'Cory S.',\n",
       "     'Gerondakis S.',\n",
       "     'Webb E.',\n",
       "     'Adams J.M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6321164'},\n",
       "     {'database': 'DOI', 'id': '10.1002/j.1460-2075.1983.tb01749.x'}],\n",
       "    'title': 'Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'EMBO J.',\n",
       "    'firstPage': '2375',\n",
       "    'lastPage': '2383',\n",
       "    'volume': '2'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORM 1)']},\n",
       "  {'citation': {'id': '6298632',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Colby W.W.', 'Chen E.Y.', 'Smith D.H.', 'Levinson A.D.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6298632'},\n",
       "     {'database': 'DOI', 'id': '10.1038/301722a0'}],\n",
       "    'title': 'Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '722',\n",
       "    'lastPage': '725',\n",
       "    'volume': '301'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORM 1)']},\n",
       "  {'citation': {'id': '6304538',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Watt R.',\n",
       "     'Stanton L.W.',\n",
       "     'Marcu K.B.',\n",
       "     'Gallo R.C.',\n",
       "     'Croce C.M.',\n",
       "     'Rovera G.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6304538'},\n",
       "     {'database': 'DOI', 'id': '10.1038/303725a0'}],\n",
       "    'title': 'Nucleotide sequence of cloned cDNA of human c-myc oncogene.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '725',\n",
       "    'lastPage': '728',\n",
       "    'volume': '303'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)']},\n",
       "  {'citation': {'id': '6419122',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Rabbitts T.H.', 'Hamlyn P.H.', 'Baer R.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6419122'},\n",
       "     {'database': 'DOI', 'id': '10.1038/306760a0'}],\n",
       "    'title': 'Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '760',\n",
       "    'lastPage': '765',\n",
       "    'volume': '306'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)',\n",
       "    'VARIANT ASP-39']},\n",
       "  {'citation': {'id': '6304729',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Watson D.K.',\n",
       "     'Psallidopoulos M.C.',\n",
       "     'Samuel K.P.',\n",
       "     'Dalla-Favera R.',\n",
       "     'Papas T.S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6304729'},\n",
       "     {'database': 'DOI', 'id': '10.1073/pnas.80.12.3642'}],\n",
       "    'title': 'Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product.',\n",
       "    'publicationDate': '1983',\n",
       "    'journal': 'Proc. Natl. Acad. Sci. U.S.A.',\n",
       "    'firstPage': '3642',\n",
       "    'lastPage': '3645',\n",
       "    'volume': '80'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORM 1)']},\n",
       "  {'citation': {'id': '6547209',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Rabbitts T.H.', 'Forster A.', 'Hamlyn P.', 'Baer R.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6547209'},\n",
       "     {'database': 'DOI', 'id': '10.1038/309592a0'}],\n",
       "    'title': \"Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.\",\n",
       "    'publicationDate': '1984',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '592',\n",
       "    'lastPage': '597',\n",
       "    'volume': '309'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)',\n",
       "    'NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-252']},\n",
       "  {'citation': {'id': '6714223',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Gazin C.',\n",
       "     'Dupont S.',\n",
       "     'de Dinechin D.',\n",
       "     'Hampe A.',\n",
       "     'Masson J.-M.',\n",
       "     'Martin P.',\n",
       "     'Stehelin D.',\n",
       "     'Galibert F.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '6714223'},\n",
       "     {'database': 'DOI', 'id': '10.1002/j.1460-2075.1984.tb01816.x'}],\n",
       "    'title': 'Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.',\n",
       "    'publicationDate': '1984',\n",
       "    'journal': 'EMBO J.',\n",
       "    'firstPage': '383',\n",
       "    'lastPage': '387',\n",
       "    'volume': '3'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORM 1)']},\n",
       "  {'citation': {'id': '8444346',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Tachibana K.',\n",
       "     'Takayama N.',\n",
       "     'Matsuo K.',\n",
       "     'Kato S.',\n",
       "     'Yamamoto K.',\n",
       "     'Ohyama K.',\n",
       "     'Umezawa A.',\n",
       "     'Takano T.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '8444346'},\n",
       "     {'database': 'DOI', 'id': '10.1016/0378-1119(93)90398-m'}],\n",
       "    'title': \"Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.\",\n",
       "    'publicationDate': '1993',\n",
       "    'journal': 'Gene',\n",
       "    'firstPage': '231',\n",
       "    'lastPage': '237',\n",
       "    'volume': '124'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)']},\n",
       "  {'citation': {'id': 'CI-4IUTJLP3044AK',\n",
       "    'citationType': 'submission',\n",
       "    'authors': ['Kalnine N.',\n",
       "     'Chen X.',\n",
       "     'Rolfs A.',\n",
       "     'Halleck A.',\n",
       "     'Hines L.',\n",
       "     'Eisenstein S.',\n",
       "     'Koundinya M.',\n",
       "     'Raphael J.',\n",
       "     'Moreira D.',\n",
       "     'Kelley T.',\n",
       "     'LaBaer J.',\n",
       "     'Lin Y.',\n",
       "     'Phelan M.',\n",
       "     'Farmer A.'],\n",
       "    'title': 'Cloning of human full-length CDSs in BD Creator(TM) system donor vector.',\n",
       "    'publicationDate': 'MAY-2003',\n",
       "    'submissionDatabase': 'EMBL/GenBank/DDBJ databases'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)']},\n",
       "  {'citation': {'id': 'CI-9GAL9GH7V57OH',\n",
       "    'citationType': 'submission',\n",
       "    'authoringGroup': ['NIEHS SNPs program'],\n",
       "    'publicationDate': 'JAN-2003',\n",
       "    'submissionDatabase': 'EMBL/GenBank/DDBJ databases'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [GENOMIC DNA]',\n",
       "    'VARIANTS SER-11; CYS-160; ILE-170 AND VAL-322']},\n",
       "  {'citation': {'id': '14702039',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Ota T.',\n",
       "     'Suzuki Y.',\n",
       "     'Nishikawa T.',\n",
       "     'Otsuki T.',\n",
       "     'Sugiyama T.',\n",
       "     'Irie R.',\n",
       "     'Wakamatsu A.',\n",
       "     'Hayashi K.',\n",
       "     'Sato H.',\n",
       "     'Nagai K.',\n",
       "     'Kimura K.',\n",
       "     'Makita H.',\n",
       "     'Sekine M.',\n",
       "     'Obayashi M.',\n",
       "     'Nishi T.',\n",
       "     'Shibahara T.',\n",
       "     'Tanaka T.',\n",
       "     'Ishii S.',\n",
       "     'Yamamoto J.',\n",
       "     'Saito K.',\n",
       "     'Kawai Y.',\n",
       "     'Isono Y.',\n",
       "     'Nakamura Y.',\n",
       "     'Nagahari K.',\n",
       "     'Murakami K.',\n",
       "     'Yasuda T.',\n",
       "     'Iwayanagi T.',\n",
       "     'Wagatsuma M.',\n",
       "     'Shiratori A.',\n",
       "     'Sudo H.',\n",
       "     'Hosoiri T.',\n",
       "     'Kaku Y.',\n",
       "     'Kodaira H.',\n",
       "     'Kondo H.',\n",
       "     'Sugawara M.',\n",
       "     'Takahashi M.',\n",
       "     'Kanda K.',\n",
       "     'Yokoi T.',\n",
       "     'Furuya T.',\n",
       "     'Kikkawa E.',\n",
       "     'Omura Y.',\n",
       "     'Abe K.',\n",
       "     'Kamihara K.',\n",
       "     'Katsuta N.',\n",
       "     'Sato K.',\n",
       "     'Tanikawa M.',\n",
       "     'Yamazaki M.',\n",
       "     'Ninomiya K.',\n",
       "     'Ishibashi T.',\n",
       "     'Yamashita H.',\n",
       "     'Murakawa K.',\n",
       "     'Fujimori K.',\n",
       "     'Tanai H.',\n",
       "     'Kimata M.',\n",
       "     'Watanabe M.',\n",
       "     'Hiraoka S.',\n",
       "     'Chiba Y.',\n",
       "     'Ishida S.',\n",
       "     'Ono Y.',\n",
       "     'Takiguchi S.',\n",
       "     'Watanabe S.',\n",
       "     'Yosida M.',\n",
       "     'Hotuta T.',\n",
       "     'Kusano J.',\n",
       "     'Kanehori K.',\n",
       "     'Takahashi-Fujii A.',\n",
       "     'Hara H.',\n",
       "     'Tanase T.-O.',\n",
       "     'Nomura Y.',\n",
       "     'Togiya S.',\n",
       "     'Komai F.',\n",
       "     'Hara R.',\n",
       "     'Takeuchi K.',\n",
       "     'Arita M.',\n",
       "     'Imose N.',\n",
       "     'Musashino K.',\n",
       "     'Yuuki H.',\n",
       "     'Oshima A.',\n",
       "     'Sasaki N.',\n",
       "     'Aotsuka S.',\n",
       "     'Yoshikawa Y.',\n",
       "     'Matsunawa H.',\n",
       "     'Ichihara T.',\n",
       "     'Shiohata N.',\n",
       "     'Sano S.',\n",
       "     'Moriya S.',\n",
       "     'Momiyama H.',\n",
       "     'Satoh N.',\n",
       "     'Takami S.',\n",
       "     'Terashima Y.',\n",
       "     'Suzuki O.',\n",
       "     'Nakagawa S.',\n",
       "     'Senoh A.',\n",
       "     'Mizoguchi H.',\n",
       "     'Goto Y.',\n",
       "     'Shimizu F.',\n",
       "     'Wakebe H.',\n",
       "     'Hishigaki H.',\n",
       "     'Watanabe T.',\n",
       "     'Sugiyama A.',\n",
       "     'Takemoto M.',\n",
       "     'Kawakami B.',\n",
       "     'Yamazaki M.',\n",
       "     'Watanabe K.',\n",
       "     'Kumagai A.',\n",
       "     'Itakura S.',\n",
       "     'Fukuzumi Y.',\n",
       "     'Fujimori Y.',\n",
       "     'Komiyama M.',\n",
       "     'Tashiro H.',\n",
       "     'Tanigami A.',\n",
       "     'Fujiwara T.',\n",
       "     'Ono T.',\n",
       "     'Yamada K.',\n",
       "     'Fujii Y.',\n",
       "     'Ozaki K.',\n",
       "     'Hirao M.',\n",
       "     'Ohmori Y.',\n",
       "     'Kawabata A.',\n",
       "     'Hikiji T.',\n",
       "     'Kobatake N.',\n",
       "     'Inagaki H.',\n",
       "     'Ikema Y.',\n",
       "     'Okamoto S.',\n",
       "     'Okitani R.',\n",
       "     'Kawakami T.',\n",
       "     'Noguchi S.',\n",
       "     'Itoh T.',\n",
       "     'Shigeta K.',\n",
       "     'Senba T.',\n",
       "     'Matsumura K.',\n",
       "     'Nakajima Y.',\n",
       "     'Mizuno T.',\n",
       "     'Morinaga M.',\n",
       "     'Sasaki M.',\n",
       "     'Togashi T.',\n",
       "     'Oyama M.',\n",
       "     'Hata H.',\n",
       "     'Watanabe M.',\n",
       "     'Komatsu T.',\n",
       "     'Mizushima-Sugano J.',\n",
       "     'Satoh T.',\n",
       "     'Shirai Y.',\n",
       "     'Takahashi Y.',\n",
       "     'Nakagawa K.',\n",
       "     'Okumura K.',\n",
       "     'Nagase T.',\n",
       "     'Nomura N.',\n",
       "     'Kikuchi H.',\n",
       "     'Masuho Y.',\n",
       "     'Yamashita R.',\n",
       "     'Nakai K.',\n",
       "     'Yada T.',\n",
       "     'Nakamura Y.',\n",
       "     'Ohara O.',\n",
       "     'Isogai T.',\n",
       "     'Sugano S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '14702039'},\n",
       "     {'database': 'DOI', 'id': '10.1038/ng1285'}],\n",
       "    'title': 'Complete sequencing and characterization of 21,243 full-length human cDNAs.',\n",
       "    'publicationDate': '2004',\n",
       "    'journal': 'Nat. Genet.',\n",
       "    'firstPage': '40',\n",
       "    'lastPage': '45',\n",
       "    'volume': '36'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)'],\n",
       "   'referenceComments': [{'value': 'Uterus', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '16421571',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Nusbaum C.',\n",
       "     'Mikkelsen T.S.',\n",
       "     'Zody M.C.',\n",
       "     'Asakawa S.',\n",
       "     'Taudien S.',\n",
       "     'Garber M.',\n",
       "     'Kodira C.D.',\n",
       "     'Schueler M.G.',\n",
       "     'Shimizu A.',\n",
       "     'Whittaker C.A.',\n",
       "     'Chang J.L.',\n",
       "     'Cuomo C.A.',\n",
       "     'Dewar K.',\n",
       "     'FitzGerald M.G.',\n",
       "     'Yang X.',\n",
       "     'Allen N.R.',\n",
       "     'Anderson S.',\n",
       "     'Asakawa T.',\n",
       "     'Blechschmidt K.',\n",
       "     'Bloom T.',\n",
       "     'Borowsky M.L.',\n",
       "     'Butler J.',\n",
       "     'Cook A.',\n",
       "     'Corum B.',\n",
       "     'DeArellano K.',\n",
       "     'DeCaprio D.',\n",
       "     'Dooley K.T.',\n",
       "     'Dorris L. III',\n",
       "     'Engels R.',\n",
       "     'Gloeckner G.',\n",
       "     'Hafez N.',\n",
       "     'Hagopian D.S.',\n",
       "     'Hall J.L.',\n",
       "     'Ishikawa S.K.',\n",
       "     'Jaffe D.B.',\n",
       "     'Kamat A.',\n",
       "     'Kudoh J.',\n",
       "     'Lehmann R.',\n",
       "     'Lokitsang T.',\n",
       "     'Macdonald P.',\n",
       "     'Major J.E.',\n",
       "     'Matthews C.D.',\n",
       "     'Mauceli E.',\n",
       "     'Menzel U.',\n",
       "     'Mihalev A.H.',\n",
       "     'Minoshima S.',\n",
       "     'Murayama Y.',\n",
       "     'Naylor J.W.',\n",
       "     'Nicol R.',\n",
       "     'Nguyen C.',\n",
       "     \"O'Leary S.B.\",\n",
       "     \"O'Neill K.\",\n",
       "     'Parker S.C.J.',\n",
       "     'Polley A.',\n",
       "     'Raymond C.K.',\n",
       "     'Reichwald K.',\n",
       "     'Rodriguez J.',\n",
       "     'Sasaki T.',\n",
       "     'Schilhabel M.',\n",
       "     'Siddiqui R.',\n",
       "     'Smith C.L.',\n",
       "     'Sneddon T.P.',\n",
       "     'Talamas J.A.',\n",
       "     'Tenzin P.',\n",
       "     'Topham K.',\n",
       "     'Venkataraman V.',\n",
       "     'Wen G.',\n",
       "     'Yamazaki S.',\n",
       "     'Young S.K.',\n",
       "     'Zeng Q.',\n",
       "     'Zimmer A.R.',\n",
       "     'Rosenthal A.',\n",
       "     'Birren B.W.',\n",
       "     'Platzer M.',\n",
       "     'Shimizu N.',\n",
       "     'Lander E.S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '16421571'},\n",
       "     {'database': 'DOI', 'id': '10.1038/nature04406'}],\n",
       "    'title': 'DNA sequence and analysis of human chromosome 8.',\n",
       "    'publicationDate': '2006',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '331',\n",
       "    'lastPage': '335',\n",
       "    'volume': '439'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]']},\n",
       "  {'citation': {'id': 'CI-5GBDQ6B103N1E',\n",
       "    'citationType': 'submission',\n",
       "    'authors': ['Mural R.J.',\n",
       "     'Istrail S.',\n",
       "     'Sutton G.G.',\n",
       "     'Florea L.',\n",
       "     'Halpern A.L.',\n",
       "     'Mobarry C.M.',\n",
       "     'Lippert R.',\n",
       "     'Walenz B.',\n",
       "     'Shatkay H.',\n",
       "     'Dew I.',\n",
       "     'Miller J.R.',\n",
       "     'Flanigan M.J.',\n",
       "     'Edwards N.J.',\n",
       "     'Bolanos R.',\n",
       "     'Fasulo D.',\n",
       "     'Halldorsson B.V.',\n",
       "     'Hannenhalli S.',\n",
       "     'Turner R.',\n",
       "     'Yooseph S.',\n",
       "     'Lu F.',\n",
       "     'Nusskern D.R.',\n",
       "     'Shue B.C.',\n",
       "     'Zheng X.H.',\n",
       "     'Zhong F.',\n",
       "     'Delcher A.L.',\n",
       "     'Huson D.H.',\n",
       "     'Kravitz S.A.',\n",
       "     'Mouchard L.',\n",
       "     'Reinert K.',\n",
       "     'Remington K.A.',\n",
       "     'Clark A.G.',\n",
       "     'Waterman M.S.',\n",
       "     'Eichler E.E.',\n",
       "     'Adams M.D.',\n",
       "     'Hunkapiller M.W.',\n",
       "     'Myers E.W.',\n",
       "     'Venter J.C.'],\n",
       "    'publicationDate': 'JUL-2005',\n",
       "    'submissionDatabase': 'EMBL/GenBank/DDBJ databases'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]']},\n",
       "  {'citation': {'id': '15489334',\n",
       "    'citationType': 'journal article',\n",
       "    'authoringGroup': ['The MGC Project Team'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '15489334'},\n",
       "     {'database': 'DOI', 'id': '10.1101/gr.2596504'}],\n",
       "    'title': 'The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).',\n",
       "    'publicationDate': '2004',\n",
       "    'journal': 'Genome Res.',\n",
       "    'firstPage': '2121',\n",
       "    'lastPage': '2127',\n",
       "    'volume': '14'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)'],\n",
       "   'referenceComments': [{'value': 'Cervix', 'type': 'TISSUE'},\n",
       "    {'value': 'Placenta', 'type': 'TISSUE'},\n",
       "    {'value': 'Testis', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '3540591',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Bentley D.L.', 'Groudine M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '3540591'},\n",
       "     {'database': 'DOI', 'id': '10.1128/mcb.6.10.3481-3489.1986'}],\n",
       "    'title': 'Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.',\n",
       "    'publicationDate': '1986',\n",
       "    'journal': 'Mol. Cell. Biol.',\n",
       "    'firstPage': '3481',\n",
       "    'lastPage': '3489',\n",
       "    'volume': '6'},\n",
       "   'referencePositions': ['NUCLEOTIDE SEQUENCE [MRNA] OF 1-170 (ISOFORM 1)'],\n",
       "   'referenceComments': [{'value': 'Promyelocytic leukemia',\n",
       "     'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '2166998',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Magrath I.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '2166998'},\n",
       "     {'database': 'DOI', 'id': '10.1016/s0065-230x(08)60470-4'}],\n",
       "    'title': \"The pathogenesis of Burkitt's lymphoma.\",\n",
       "    'publicationDate': '1990',\n",
       "    'journal': 'Adv. Cancer Res.',\n",
       "    'firstPage': '133',\n",
       "    'lastPage': '270',\n",
       "    'volume': '55'},\n",
       "   'referencePositions': ['INVOLVEMENT IN BURKITT LYMPHOMA']},\n",
       "  {'citation': {'id': '1597196',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Iijima S.', 'Teraoka H.', 'Date T.', 'Tsukada K.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '1597196'},\n",
       "     {'database': 'DOI', 'id': '10.1111/j.1432-1033.1992.tb16964.x'}],\n",
       "    'title': \"DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein.\",\n",
       "    'publicationDate': '1992',\n",
       "    'journal': 'Eur. J. Biochem.',\n",
       "    'firstPage': '595',\n",
       "    'lastPage': '603',\n",
       "    'volume': '206'},\n",
       "   'referencePositions': ['PHOSPHORYLATION']},\n",
       "  {'citation': {'id': '8220424',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Bhatia K.',\n",
       "     'Huppi K.',\n",
       "     'Spangler G.',\n",
       "     'Siwarski D.',\n",
       "     'Iyer R.',\n",
       "     'Magrath I.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '8220424'},\n",
       "     {'database': 'DOI', 'id': '10.1038/ng0993-56'}],\n",
       "    'title': \"Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.\",\n",
       "    'publicationDate': '1993',\n",
       "    'journal': 'Nat. Genet.',\n",
       "    'firstPage': '56',\n",
       "    'lastPage': '61',\n",
       "    'volume': '5'},\n",
       "   'referencePositions': ['INVOLVEMENT IN BURKITT LYMPHOMA',\n",
       "    'VARIANTS ASP-39; SER-57; ALA-59 AND THR-86']},\n",
       "  {'citation': {'id': '8386367',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Gupta S.', 'Seth A.', 'Davis R.J.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '8386367'},\n",
       "     {'database': 'DOI', 'id': '10.1073/pnas.90.8.3216'}],\n",
       "    'title': 'Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.',\n",
       "    'publicationDate': '1993',\n",
       "    'journal': 'Proc. Natl. Acad. Sci. U.S.A.',\n",
       "    'firstPage': '3216',\n",
       "    'lastPage': '3220',\n",
       "    'volume': '90'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT THR-58 AND SER-62']},\n",
       "  {'citation': {'id': '7642555',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Chou T.-Y.', 'Hart G.W.', 'Dang C.V.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '7642555'},\n",
       "     {'database': 'DOI', 'id': '10.1074/jbc.270.32.18961'}],\n",
       "    'title': 'c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas.',\n",
       "    'publicationDate': '1995',\n",
       "    'journal': 'J. Biol. Chem.',\n",
       "    'firstPage': '18961',\n",
       "    'lastPage': '18965',\n",
       "    'volume': '270'},\n",
       "   'referencePositions': ['GLYCOSYLATION AT THR-58']},\n",
       "  {'citation': {'id': '9315742',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Alexandrov I.',\n",
       "     'Shlyakhova L.',\n",
       "     'Vartanian A.',\n",
       "     'Zajac-Kaye M.',\n",
       "     'Alexandrova N.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '9315742'},\n",
       "     {'database': 'DOI', 'id': '10.1016/s0014-5793(97)00992-7'}],\n",
       "    'title': 'c-Raf kinase binds to N-terminal domain of c-Myc.',\n",
       "    'publicationDate': '1997',\n",
       "    'journal': 'FEBS Lett.',\n",
       "    'firstPage': '465',\n",
       "    'lastPage': '470',\n",
       "    'volume': '414'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT THR-8']},\n",
       "  {'citation': {'id': '15103331',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Yada M.',\n",
       "     'Hatakeyama S.',\n",
       "     'Kamura T.',\n",
       "     'Nishiyama M.',\n",
       "     'Tsunematsu R.',\n",
       "     'Imaki H.',\n",
       "     'Ishida N.',\n",
       "     'Okumura F.',\n",
       "     'Nakayama K.',\n",
       "     'Nakayama K.I.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '15103331'},\n",
       "     {'database': 'DOI', 'id': '10.1038/sj.emboj.7600217'}],\n",
       "    'title': 'Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.',\n",
       "    'publicationDate': '2004',\n",
       "    'journal': 'EMBO J.',\n",
       "    'firstPage': '2116',\n",
       "    'lastPage': '2125',\n",
       "    'volume': '23'},\n",
       "   'referencePositions': ['UBIQUITINATION',\n",
       "    'INTERACTION WITH FBXW7',\n",
       "    'PHOSPHORYLATION AT THR-58 AND SER-62',\n",
       "    'MUTAGENESIS OF THR-58 AND SER-62']},\n",
       "  {'citation': {'id': '16126174',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Zhang K.', 'Faiola F.', 'Martinez E.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '16126174'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.bbrc.2005.08.075'}],\n",
       "    'title': 'Six lysine residues on c-Myc are direct substrates for acetylation by p300.',\n",
       "    'publicationDate': '2005',\n",
       "    'journal': 'Biochem. Biophys. Res. Commun.',\n",
       "    'firstPage': '274',\n",
       "    'lastPage': '280',\n",
       "    'volume': '336'},\n",
       "   'referencePositions': ['ACETYLATION AT LYS-143; LYS-157; LYS-275; LYS-317; LYS-323 AND LYS-371',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY']},\n",
       "  {'citation': {'id': '15723054',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Grandori C.',\n",
       "     'Gomez-Roman N.',\n",
       "     'Felton-Edkins Z.A.',\n",
       "     'Ngouenet C.',\n",
       "     'Galloway D.A.',\n",
       "     'Eisenman R.N.',\n",
       "     'White R.J.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '15723054'},\n",
       "     {'database': 'DOI', 'id': '10.1038/ncb1224'}],\n",
       "    'title': 'c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.',\n",
       "    'publicationDate': '2005',\n",
       "    'journal': 'Nat. Cell Biol.',\n",
       "    'firstPage': '311',\n",
       "    'lastPage': '318',\n",
       "    'volume': '7'},\n",
       "   'referencePositions': ['INTERACTION WITH TAF1C']},\n",
       "  {'citation': {'id': '15674325',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Yu M.',\n",
       "     'Schreek S.',\n",
       "     'Cerni C.',\n",
       "     'Schamberger C.',\n",
       "     'Lesniewicz K.',\n",
       "     'Poreba E.',\n",
       "     'Vervoorts J.',\n",
       "     'Walsemann G.',\n",
       "     'Groetzinger J.',\n",
       "     'Kremmer E.',\n",
       "     'Mehraein Y.',\n",
       "     'Mertsching J.',\n",
       "     'Kraft R.',\n",
       "     'Austen M.',\n",
       "     'Luescher-Firzlaff J.',\n",
       "     'Luescher B.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '15674325'},\n",
       "     {'database': 'DOI', 'id': '10.1038/sj.onc.1208410'}],\n",
       "    'title': 'PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.',\n",
       "    'publicationDate': '2005',\n",
       "    'journal': 'Oncogene',\n",
       "    'firstPage': '1982',\n",
       "    'lastPage': '1993',\n",
       "    'volume': '24'},\n",
       "   'referencePositions': ['INTERACTION WITH PARP10']},\n",
       "  {'citation': {'id': '17081983',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Olsen J.V.',\n",
       "     'Blagoev B.',\n",
       "     'Gnad F.',\n",
       "     'Macek B.',\n",
       "     'Kumar C.',\n",
       "     'Mortensen P.',\n",
       "     'Mann M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17081983'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.cell.2006.09.026'}],\n",
       "    'title': 'Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.',\n",
       "    'publicationDate': '2006',\n",
       "    'journal': 'Cell',\n",
       "    'firstPage': '635',\n",
       "    'lastPage': '648',\n",
       "    'volume': '127'},\n",
       "   'referencePositions': ['PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]'],\n",
       "   'referenceComments': [{'value': 'Cervix carcinoma', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '17632056',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Junttila M.R.',\n",
       "     'Puustinen P.',\n",
       "     'Niemelae M.',\n",
       "     'Ahola R.',\n",
       "     'Arnold H.',\n",
       "     'Boettzauw T.',\n",
       "     'Ala-Aho R.',\n",
       "     'Nielsen C.',\n",
       "     'Ivaska J.',\n",
       "     'Taya Y.',\n",
       "     'Lu S.-L.',\n",
       "     'Lin S.',\n",
       "     'Chan E.K.L.',\n",
       "     'Wang X.-J.',\n",
       "     'Grenman R.',\n",
       "     'Kast J.',\n",
       "     'Kallunki T.',\n",
       "     'Sears R.',\n",
       "     'Kaehaeri V.-M.',\n",
       "     'Westermarck J.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17632056'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.cell.2007.04.044'}],\n",
       "    'title': 'CIP2A inhibits PP2A in human malignancies.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Cell',\n",
       "    'firstPage': '51',\n",
       "    'lastPage': '62',\n",
       "    'volume': '130'},\n",
       "   'referencePositions': ['INTERACTION WITH CIP2A']},\n",
       "  {'citation': {'id': '18035408',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Takahashi K.',\n",
       "     'Tanabe K.',\n",
       "     'Ohnuki M.',\n",
       "     'Narita M.',\n",
       "     'Ichisaka T.',\n",
       "     'Tomoda K.',\n",
       "     'Yamanaka S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '18035408'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.cell.2007.11.019'}],\n",
       "    'title': 'Induction of pluripotent stem cells from adult human fibroblasts by defined factors.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Cell',\n",
       "    'firstPage': '861',\n",
       "    'lastPage': '872',\n",
       "    'volume': '131'},\n",
       "   'referencePositions': ['BIOTECHNOLOGY']},\n",
       "  {'citation': {'id': '17873522',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Popov N.',\n",
       "     'Herold S.',\n",
       "     'Llamazares M.',\n",
       "     'Schulein C.',\n",
       "     'Eilers M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17873522'},\n",
       "     {'database': 'DOI', 'id': '10.4161/cc.6.19.4804'}],\n",
       "    'title': 'Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Cell Cycle',\n",
       "    'firstPage': '2327',\n",
       "    'lastPage': '2331',\n",
       "    'volume': '6'},\n",
       "   'referencePositions': ['UBIQUITINATION',\n",
       "    'DEUBIQUITINATION BY USP28',\n",
       "    'INTERACTION WITH FBXW7']},\n",
       "  {'citation': {'id': '17311883',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Secombe J.', 'Li L.', 'Carlos L.', 'Eisenman R.N.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17311883'},\n",
       "     {'database': 'DOI', 'id': '10.1101/gad.1523007'}],\n",
       "    'title': 'The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Genes Dev.',\n",
       "    'firstPage': '537',\n",
       "    'lastPage': '551',\n",
       "    'volume': '21'},\n",
       "   'referencePositions': ['INTERACTION WITH KDM5A AND KDM5B']},\n",
       "  {'citation': {'id': '17308053',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Suzuki C.',\n",
       "     'Takahashi K.',\n",
       "     'Hayama S.',\n",
       "     'Ishikawa N.',\n",
       "     'Kato T.',\n",
       "     'Ito T.',\n",
       "     'Tsuchiya E.',\n",
       "     'Nakamura Y.',\n",
       "     'Daigo Y.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17308053'},\n",
       "     {'database': 'DOI', 'id': '10.1158/1535-7163.mct-06-0659'}],\n",
       "    'title': 'Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Mol. Cancer Ther.',\n",
       "    'firstPage': '542',\n",
       "    'lastPage': '551',\n",
       "    'volume': '6'},\n",
       "   'referencePositions': ['INTERACTION WITH RIOX1']},\n",
       "  {'citation': {'id': '17558397',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Popov N.',\n",
       "     'Wanzel M.',\n",
       "     'Madiredjo M.',\n",
       "     'Zhang D.',\n",
       "     'Beijersbergen R.',\n",
       "     'Bernards R.',\n",
       "     'Moll R.',\n",
       "     'Elledge S.J.',\n",
       "     'Eilers M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '17558397'},\n",
       "     {'database': 'DOI', 'id': '10.1038/ncb1601'}],\n",
       "    'title': 'The ubiquitin-specific protease USP28 is required for MYC stability.',\n",
       "    'publicationDate': '2007',\n",
       "    'journal': 'Nat. Cell Biol.',\n",
       "    'firstPage': '765',\n",
       "    'lastPage': '774',\n",
       "    'volume': '9'},\n",
       "   'referencePositions': ['UBIQUITINATION',\n",
       "    'DEUBIQUITINATION BY USP28',\n",
       "    'INTERACTION WITH FBXW7',\n",
       "    'SUBCELLULAR LOCATION',\n",
       "    'PHOSPHORYLATION AT THR-58 AND SER-62',\n",
       "    'MUTAGENESIS OF THR-58 AND SER-62']},\n",
       "  {'citation': {'id': '18669648',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Dephoure N.',\n",
       "     'Zhou C.',\n",
       "     'Villen J.',\n",
       "     'Beausoleil S.A.',\n",
       "     'Bakalarski C.E.',\n",
       "     'Elledge S.J.',\n",
       "     'Gygi S.P.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '18669648'},\n",
       "     {'database': 'DOI', 'id': '10.1073/pnas.0805139105'}],\n",
       "    'title': 'A quantitative atlas of mitotic phosphorylation.',\n",
       "    'publicationDate': '2008',\n",
       "    'journal': 'Proc. Natl. Acad. Sci. U.S.A.',\n",
       "    'firstPage': '10762',\n",
       "    'lastPage': '10767',\n",
       "    'volume': '105'},\n",
       "   'referencePositions': ['PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58; SER-62 AND SER-71',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]'],\n",
       "   'referenceComments': [{'value': 'Cervix carcinoma', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '19413330',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Gauci S.',\n",
       "     'Helbig A.O.',\n",
       "     'Slijper M.',\n",
       "     'Krijgsveld J.',\n",
       "     'Heck A.J.',\n",
       "     'Mohammed S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '19413330'},\n",
       "     {'database': 'DOI', 'id': '10.1021/ac9004309'}],\n",
       "    'title': 'Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.',\n",
       "    'publicationDate': '2009',\n",
       "    'journal': 'Anal. Chem.',\n",
       "    'firstPage': '4493',\n",
       "    'lastPage': '4501',\n",
       "    'volume': '81'},\n",
       "   'referencePositions': ['IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]']},\n",
       "  {'citation': {'id': '19608861',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Choudhary C.',\n",
       "     'Kumar C.',\n",
       "     'Gnad F.',\n",
       "     'Nielsen M.L.',\n",
       "     'Rehman M.',\n",
       "     'Walther T.C.',\n",
       "     'Olsen J.V.',\n",
       "     'Mann M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '19608861'},\n",
       "     {'database': 'DOI', 'id': '10.1126/science.1175371'}],\n",
       "    'title': 'Lysine acetylation targets protein complexes and co-regulates major cellular functions.',\n",
       "    'publicationDate': '2009',\n",
       "    'journal': 'Science',\n",
       "    'firstPage': '834',\n",
       "    'lastPage': '840',\n",
       "    'volume': '325'},\n",
       "   'referencePositions': ['ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]']},\n",
       "  {'citation': {'id': '20713526',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Hydbring P.', 'Larsson L.-G.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '20713526'},\n",
       "     {'database': 'DOI', 'id': '10.1158/0008-5472.can-10-1383'}],\n",
       "    'title': 'Tipping the balance: Cdk2 enables Myc to suppress senescence.',\n",
       "    'publicationDate': '2010',\n",
       "    'journal': 'Cancer Res.',\n",
       "    'firstPage': '6687',\n",
       "    'lastPage': '6691',\n",
       "    'volume': '70'},\n",
       "   'referencePositions': ['REVIEW ON SENESCENCE',\n",
       "    'PHOSPHORYLATION AT SER-62 BY CDK2',\n",
       "    'MUTAGENESIS OF THR-58 AND SER-62']},\n",
       "  {'citation': {'id': '20010808',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['David C.J.',\n",
       "     'Chen M.',\n",
       "     'Assanah M.',\n",
       "     'Canoll P.',\n",
       "     'Manley J.L.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '20010808'},\n",
       "     {'database': 'DOI', 'id': '10.1038/nature08697'}],\n",
       "    'title': 'HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.',\n",
       "    'publicationDate': '2010',\n",
       "    'journal': 'Nature',\n",
       "    'firstPage': '364',\n",
       "    'lastPage': '368',\n",
       "    'volume': '463'},\n",
       "   'referencePositions': ['FUNCTION']},\n",
       "  {'citation': {'id': '19966300',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Hydbring P.',\n",
       "     'Bahram F.',\n",
       "     'Su Y.',\n",
       "     'Tronnersjoe S.',\n",
       "     'Hoegstrand K.',\n",
       "     'von der Lehr N.',\n",
       "     'Sharifi H.R.',\n",
       "     'Lilischkis R.',\n",
       "     'Hein N.',\n",
       "     'Wu S.',\n",
       "     'Vervoorts J.',\n",
       "     'Henriksson M.',\n",
       "     'Grandien A.',\n",
       "     'Luescher B.',\n",
       "     'Larsson L.-G.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '19966300'},\n",
       "     {'database': 'DOI', 'id': '10.1073/pnas.0900121106'}],\n",
       "    'title': 'Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.',\n",
       "    'publicationDate': '2010',\n",
       "    'journal': 'Proc. Natl. Acad. Sci. U.S.A.',\n",
       "    'firstPage': '58',\n",
       "    'lastPage': '63',\n",
       "    'volume': '107'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT SER-62 BY CDK2',\n",
       "    'MUTAGENESIS OF THR-58 AND SER-62']},\n",
       "  {'citation': {'id': '20551172',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Choi S.H.', 'Wright J.B.', 'Gerber S.A.', 'Cole M.D.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '20551172'},\n",
       "     {'database': 'DOI', 'id': '10.1101/gad.1920310'}],\n",
       "    'title': 'Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.',\n",
       "    'publicationDate': '2010',\n",
       "    'journal': 'Genes Dev.',\n",
       "    'firstPage': '1236',\n",
       "    'lastPage': '1241',\n",
       "    'volume': '24'},\n",
       "   'referencePositions': ['UBIQUITINATION']},\n",
       "  {'citation': {'id': '20068231',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Olsen J.V.',\n",
       "     'Vermeulen M.',\n",
       "     'Santamaria A.',\n",
       "     'Kumar C.',\n",
       "     'Miller M.L.',\n",
       "     'Jensen L.J.',\n",
       "     'Gnad F.',\n",
       "     'Cox J.',\n",
       "     'Jensen T.S.',\n",
       "     'Nigg E.A.',\n",
       "     'Brunak S.',\n",
       "     'Mann M.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '20068231'},\n",
       "     {'database': 'DOI', 'id': '10.1126/scisignal.2000475'}],\n",
       "    'title': 'Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.',\n",
       "    'publicationDate': '2010',\n",
       "    'journal': 'Sci. Signal.',\n",
       "    'firstPage': 'RA3',\n",
       "    'lastPage': 'RA3',\n",
       "    'volume': '3'},\n",
       "   'referencePositions': ['PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-161',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]'],\n",
       "   'referenceComments': [{'value': 'Cervix carcinoma', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '21406692',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Rigbolt K.T.',\n",
       "     'Prokhorova T.A.',\n",
       "     'Akimov V.',\n",
       "     'Henningsen J.',\n",
       "     'Johansen P.T.',\n",
       "     'Kratchmarova I.',\n",
       "     'Kassem M.',\n",
       "     'Mann M.',\n",
       "     'Olsen J.V.',\n",
       "     'Blagoev B.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '21406692'},\n",
       "     {'database': 'DOI', 'id': '10.1126/scisignal.2001570'}],\n",
       "    'title': 'System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.',\n",
       "    'publicationDate': '2011',\n",
       "    'journal': 'Sci. Signal.',\n",
       "    'firstPage': 'RS3',\n",
       "    'lastPage': 'RS3',\n",
       "    'volume': '4'},\n",
       "   'referencePositions': ['PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58 AND SER-62',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]']},\n",
       "  {'citation': {'id': '22307329',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Taira N.',\n",
       "     'Mimoto R.',\n",
       "     'Kurata M.',\n",
       "     'Yamaguchi T.',\n",
       "     'Kitagawa M.',\n",
       "     'Miki Y.',\n",
       "     'Yoshida K.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '22307329'},\n",
       "     {'database': 'DOI', 'id': '10.1172/jci60818'}],\n",
       "    'title': 'DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.',\n",
       "    'publicationDate': '2012',\n",
       "    'journal': 'J. Clin. Invest.',\n",
       "    'firstPage': '859',\n",
       "    'lastPage': '872',\n",
       "    'volume': '122'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT SER-62',\n",
       "    'MUTAGENESIS OF SER-62']},\n",
       "  {'citation': {'id': '23186163',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Zhou H.',\n",
       "     'Di Palma S.',\n",
       "     'Preisinger C.',\n",
       "     'Peng M.',\n",
       "     'Polat A.N.',\n",
       "     'Heck A.J.',\n",
       "     'Mohammed S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '23186163'},\n",
       "     {'database': 'DOI', 'id': '10.1021/pr300630k'}],\n",
       "    'title': 'Toward a comprehensive characterization of a human cancer cell phosphoproteome.',\n",
       "    'publicationDate': '2013',\n",
       "    'journal': 'J. Proteome Res.',\n",
       "    'firstPage': '260',\n",
       "    'lastPage': '271',\n",
       "    'volume': '12'},\n",
       "   'referencePositions': ['PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-58; SER-62; SER-71 AND SER-293',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]'],\n",
       "   'referenceComments': [{'value': 'Cervix carcinoma', 'type': 'TISSUE'},\n",
       "    {'value': 'Erythroleukemia', 'type': 'TISSUE'}]},\n",
       "  {'citation': {'id': '24940000',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Shi Y.',\n",
       "     'Xu X.',\n",
       "     'Zhang Q.',\n",
       "     'Fu G.',\n",
       "     'Mo Z.',\n",
       "     'Wang G.S.',\n",
       "     'Kishi S.',\n",
       "     'Yang X.L.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '24940000'},\n",
       "     {'database': 'DOI', 'id': '10.7554/elife.02349'}],\n",
       "    'title': 'tRNA synthetase counteracts c-Myc to develop functional vasculature.',\n",
       "    'publicationDate': '2014',\n",
       "    'journal': 'Elife',\n",
       "    'firstPage': 'E02349',\n",
       "    'lastPage': 'E02349',\n",
       "    'volume': '3'},\n",
       "   'referencePositions': ['FUNCTION']},\n",
       "  {'citation': {'id': '25956029',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Kim J.Y.', 'Cho Y.E.', 'Park J.H.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '25956029'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.ajpath.2015.03.016'}],\n",
       "    'title': 'The nucleolar protein GLTSCR2 is an upstream negative regulator of the oncogenic Nucleophosmin-MYC axis.',\n",
       "    'publicationDate': '2015',\n",
       "    'journal': 'Am. J. Pathol.',\n",
       "    'firstPage': '2061',\n",
       "    'lastPage': '2068',\n",
       "    'volume': '185'},\n",
       "   'referencePositions': ['FUNCTION', 'INTERACTION WITH NPM1']},\n",
       "  {'citation': {'id': '25803737',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Cianfanelli V.', \"D'Orazio M.\", 'Cecconi F.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '25803737'},\n",
       "     {'database': 'DOI', 'id': '10.1080/15384101.2015.1021526'}],\n",
       "    'title': 'AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation.',\n",
       "    'publicationDate': '2015',\n",
       "    'journal': 'Cell Cycle',\n",
       "    'firstPage': '959',\n",
       "    'lastPage': '963',\n",
       "    'volume': '14'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT SER-62']},\n",
       "  {'citation': {'id': '25438055',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Cianfanelli V.',\n",
       "     'Fuoco C.',\n",
       "     'Lorente M.',\n",
       "     'Salazar M.',\n",
       "     'Quondamatteo F.',\n",
       "     'Gherardini P.F.',\n",
       "     'De Zio D.',\n",
       "     'Nazio F.',\n",
       "     'Antonioli M.',\n",
       "     \"D'Orazio M.\",\n",
       "     'Skobo T.',\n",
       "     'Bordi M.',\n",
       "     'Rohde M.',\n",
       "     'Dalla Valle L.',\n",
       "     'Helmer-Citterich M.',\n",
       "     'Gretzmeier C.',\n",
       "     'Dengjel J.',\n",
       "     'Fimia G.M.',\n",
       "     'Piacentini M.',\n",
       "     'Di Bartolomeo S.',\n",
       "     'Velasco G.',\n",
       "     'Cecconi F.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '25438055'},\n",
       "     {'database': 'DOI', 'id': '10.1038/ncb3072'}],\n",
       "    'title': 'AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.',\n",
       "    'publicationDate': '2015',\n",
       "    'journal': 'Nat. Cell Biol.',\n",
       "    'firstPage': '20',\n",
       "    'lastPage': '30',\n",
       "    'volume': '17'},\n",
       "   'referencePositions': ['PHOSPHORYLATION AT SER-62',\n",
       "    'DEPHOSPHORYLATION',\n",
       "    'MUTAGENESIS OF SER-62']},\n",
       "  {'citation': {'id': '25775507',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Sun X.X.',\n",
       "     'He X.',\n",
       "     'Yin L.',\n",
       "     'Komada M.',\n",
       "     'Sears R.C.',\n",
       "     'Dai M.S.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '25775507'},\n",
       "     {'database': 'DOI', 'id': '10.1073/pnas.1411713112'}],\n",
       "    'title': 'The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.',\n",
       "    'publicationDate': '2015',\n",
       "    'journal': 'Proc. Natl. Acad. Sci. U.S.A.',\n",
       "    'firstPage': '3734',\n",
       "    'lastPage': '3739',\n",
       "    'volume': '112'},\n",
       "   'referencePositions': ['UBIQUITINATION',\n",
       "    'DEUBIQUITINATION BY USP36',\n",
       "    'INTERACTION WITH FBXW7',\n",
       "    'SUBCELLULAR LOCATION']},\n",
       "  {'citation': {'id': '28112733',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Hendriks I.A.',\n",
       "     'Lyon D.',\n",
       "     'Young C.',\n",
       "     'Jensen L.J.',\n",
       "     'Vertegaal A.C.',\n",
       "     'Nielsen M.L.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '28112733'},\n",
       "     {'database': 'DOI', 'id': '10.1038/nsmb.3366'}],\n",
       "    'title': 'Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.',\n",
       "    'publicationDate': '2017',\n",
       "    'journal': 'Nat. Struct. Mol. Biol.',\n",
       "    'firstPage': '325',\n",
       "    'lastPage': '336',\n",
       "    'volume': '24'},\n",
       "   'referencePositions': ['SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-52; LYS-143; LYS-148 AND LYS-298',\n",
       "    'IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]']},\n",
       "  {'citation': {'id': '29779948',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Koren I.',\n",
       "     'Timms R.T.',\n",
       "     'Kula T.',\n",
       "     'Xu Q.',\n",
       "     'Li M.Z.',\n",
       "     'Elledge S.J.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '29779948'},\n",
       "     {'database': 'DOI', 'id': '10.1016/j.cell.2018.04.028'}],\n",
       "    'title': 'The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.',\n",
       "    'publicationDate': '2018',\n",
       "    'journal': 'Cell',\n",
       "    'firstPage': '1622',\n",
       "    'lastPage': '1635',\n",
       "    'volume': '173'},\n",
       "   'referencePositions': ['UBIQUITINATION', 'MUTAGENESIS OF ARG-435']},\n",
       "  {'citation': {'id': '34342803',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Piskacek M.', 'Otasevic T.', 'Repko M.', 'Knight A.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '34342803'},\n",
       "     {'database': 'DOI', 'id': '10.1007/s12015-021-10225-8'}],\n",
       "    'title': 'The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.',\n",
       "    'publicationDate': '2021',\n",
       "    'journal': 'Stem. Cell. Rev. Rep.',\n",
       "    'firstPage': '1934',\n",
       "    'lastPage': '1936',\n",
       "    'volume': '17'},\n",
       "   'referencePositions': ['9AATAD MOTIF']},\n",
       "  {'citation': {'id': '9680483',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Lavigne P.',\n",
       "     'Crump M.P.',\n",
       "     'Gagne S.M.',\n",
       "     'Hodges R.S.',\n",
       "     'Kay C.M.',\n",
       "     'Sykes B.D.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '9680483'},\n",
       "     {'database': 'DOI', 'id': '10.1006/jmbi.1998.1914'}],\n",
       "    'title': 'Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.',\n",
       "    'publicationDate': '1998',\n",
       "    'journal': 'J. Mol. Biol.',\n",
       "    'firstPage': '165',\n",
       "    'lastPage': '181',\n",
       "    'volume': '281'},\n",
       "   'referencePositions': ['STRUCTURE BY NMR OF 402-434 IN COMPLEX WITH MAX']},\n",
       "  {'citation': {'id': '2069907',\n",
       "    'citationType': 'journal article',\n",
       "    'authors': ['Rimokh R.',\n",
       "     'Rouault J.P.',\n",
       "     'Wahbi K.',\n",
       "     'Gadoux M.',\n",
       "     'Lafage M.',\n",
       "     'Archimbaud E.',\n",
       "     'Charrin C.',\n",
       "     'Gentilhomme O.',\n",
       "     'Germain D.',\n",
       "     'Samarut J.'],\n",
       "    'citationCrossReferences': [{'database': 'PubMed', 'id': '2069907'},\n",
       "     {'database': 'DOI', 'id': '10.1002/gcc.2870030106'}],\n",
       "    'title': 'A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.',\n",
       "    'publicationDate': '1991',\n",
       "    'journal': 'Genes Chromosomes Cancer',\n",
       "    'firstPage': '24',\n",
       "    'lastPage': '36',\n",
       "    'volume': '3'},\n",
       "   'referencePositions': ['CHROMOSOMAL TRANSLOCATION WITH BTG1']}],\n",
       " 'uniProtKBCrossReferences': [{'database': 'EMBL',\n",
       "   'id': 'L00058',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59882.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'L00057',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59882.1'},\n",
       "    {'key': 'Status', 'value': 'JOINED'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K00535',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59880.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K00534',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59880.1'},\n",
       "    {'key': 'Status', 'value': 'JOINED'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K00535',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ABW69847.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K00534',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ABW69847.1'},\n",
       "    {'key': 'Status', 'value': 'JOINED'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'X00196',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'CAA25015.2'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'X00198',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'CAA25015.2'},\n",
       "    {'key': 'Status', 'value': 'JOINED'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'X00364',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'CAA25106.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'V00568',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'CAA23831.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K01906',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59881.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K01905',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA59881.1'},\n",
       "    {'key': 'Status', 'value': 'JOINED'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'K02276',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA36340.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'X00676',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'CAA25288.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'D10493',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'BAA01374.2'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'D10493',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'BAA01375.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'BT019768',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAV38573.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'AY214166',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAO21131.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'AK312883',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'BAG35731.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'AC103819',\n",
       "   'properties': [{'key': 'ProteinId', 'value': '-'},\n",
       "    {'key': 'Status', 'value': 'NOT_ANNOTATED_CDS'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'CH471060',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'EAW92098.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'BC000141',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAH00141.2'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'BC000917',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAH00917.2'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'BC058901',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAH58901.2'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'EMBL',\n",
       "   'id': 'M13929',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'AAA88092.1'},\n",
       "    {'key': 'Status', 'value': '-'},\n",
       "    {'key': 'MoleculeType', 'value': 'mRNA'}]},\n",
       "  {'database': 'CCDS',\n",
       "   'id': 'CCDS6359.2',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}],\n",
       "   'isoformId': 'P01106-2'},\n",
       "  {'database': 'PIR',\n",
       "   'id': 'A01349',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'TVHUM'}]},\n",
       "  {'database': 'PIR',\n",
       "   'id': 'A01350',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'TVHUT'}]},\n",
       "  {'database': 'RefSeq',\n",
       "   'id': 'NP_002458.2',\n",
       "   'properties': [{'key': 'NucleotideSequenceId', 'value': 'NM_002467.4'}],\n",
       "   'isoformId': 'P01106-2'},\n",
       "  {'database': 'PDB',\n",
       "   'id': '1A93',\n",
       "   'properties': [{'key': 'Method', 'value': 'NMR'},\n",
       "    {'key': 'Resolution', 'value': '-'},\n",
       "    {'key': 'Chains', 'value': 'A=406-434'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '1EE4',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.10 A'},\n",
       "    {'key': 'Chains', 'value': 'C/D/E/F=320-328'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '1MV0',\n",
       "   'properties': [{'key': 'Method', 'value': 'NMR'},\n",
       "    {'key': 'Resolution', 'value': '-'},\n",
       "    {'key': 'Chains', 'value': 'A=55-68'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '1NKP',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '1.80 A'},\n",
       "    {'key': 'Chains', 'value': 'A/D=353-434'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '2A93',\n",
       "   'properties': [{'key': 'Method', 'value': 'NMR'},\n",
       "    {'key': 'Resolution', 'value': '-'},\n",
       "    {'key': 'Chains', 'value': 'A=406-434'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '2OR9',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.70 A'},\n",
       "    {'key': 'Chains', 'value': 'P=410-419'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '4Y7R',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '1.90 A'},\n",
       "    {'key': 'Chains', 'value': 'B=260-267'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '5I4Z',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '1.95 A'},\n",
       "    {'key': 'Chains', 'value': 'A/B=350-439'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '5I50',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.70 A'},\n",
       "    {'key': 'Chains', 'value': 'A/B=350-439'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6C4U',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.60 A'},\n",
       "    {'key': 'Chains', 'value': 'G/H/I/J/K/L=54-62'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6E16',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.40 A'},\n",
       "    {'key': 'Chains', 'value': 'A=96-125'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6E24',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '3.00 A'},\n",
       "    {'key': 'Chains', 'value': 'A=96-125'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6G6J',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.25 A'},\n",
       "    {'key': 'Chains', 'value': 'A/C=351-437'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6G6K',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '1.35 A'},\n",
       "    {'key': 'Chains', 'value': 'A/C=351-437'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '6G6L',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.20 A'},\n",
       "    {'key': 'Chains', 'value': 'A/C/E/G=351-437'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '7T1Y',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.55 A'},\n",
       "    {'key': 'Chains', 'value': 'C=235-265'}]},\n",
       "  {'database': 'PDB',\n",
       "   'id': '7T1Z',\n",
       "   'properties': [{'key': 'Method', 'value': 'X-ray'},\n",
       "    {'key': 'Resolution', 'value': '2.77 A'},\n",
       "    {'key': 'Chains', 'value': 'C=47-66'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '1A93',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '1EE4',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '1MV0',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '1NKP',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '2A93',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '2OR9',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '4Y7R',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '5I4Z',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '5I50',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6C4U',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6E16',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6E24',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6G6J',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6G6K',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '6G6L',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '7T1Y',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PDBsum',\n",
       "   'id': '7T1Z',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'AlphaFoldDB',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BMRB',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'SMR',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BioGRID',\n",
       "   'id': '110694',\n",
       "   'properties': [{'key': 'Interactions', 'value': '2816'}]},\n",
       "  {'database': 'ComplexPortal',\n",
       "   'id': 'CPX-1123',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'FOXO3-MYC complex'}]},\n",
       "  {'database': 'ComplexPortal',\n",
       "   'id': 'CPX-514',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'c-MYC-BIN1 complex'}]},\n",
       "  {'database': 'ComplexPortal',\n",
       "   'id': 'CPX-91',\n",
       "   'properties': [{'key': 'EntryName',\n",
       "     'value': 'Transcriptional activator Myc-Max complex'}]},\n",
       "  {'database': 'CORUM',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'DIP',\n",
       "   'id': 'DIP-28143N',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'IntAct',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Interactions', 'value': '834'}]},\n",
       "  {'database': 'MINT',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'STRING',\n",
       "   'id': '9606.ENSP00000479618',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BindingDB',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'ChEMBL',\n",
       "   'id': 'CHEMBL1250348',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'DrugBank',\n",
       "   'id': 'DB00945',\n",
       "   'properties': [{'key': 'GenericName', 'value': 'Acetylsalicylic acid'}]},\n",
       "  {'database': 'DrugBank',\n",
       "   'id': 'DB08813',\n",
       "   'properties': [{'key': 'GenericName', 'value': 'Nadroparin'}]},\n",
       "  {'database': 'GlyConnect',\n",
       "   'id': '426',\n",
       "   'properties': [{'key': 'glycosylation',\n",
       "     'value': '1 O-GlcNAc glycan (1 site)'}]},\n",
       "  {'database': 'GlyGen',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'glycosylation',\n",
       "     'value': '1 site, 1 O-linked glycan (1 site), 1 Thr glycan (1 site)'}]},\n",
       "  {'database': 'iPTMnet',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PhosphoSitePlus',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BioMuta',\n",
       "   'id': 'MYC',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'DMDM',\n",
       "   'id': '127619',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'SWISS-2DPAGE',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'EPD',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'jPOST',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'MassIVE',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'MaxQB',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PaxDb',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PeptideAtlas',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'ProteomicsDB',\n",
       "   'id': '51318',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}],\n",
       "   'isoformId': 'P01106-1'},\n",
       "  {'database': 'ProteomicsDB',\n",
       "   'id': '51319',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}],\n",
       "   'isoformId': 'P01106-2'},\n",
       "  {'database': 'ABCD',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'antibodies', 'value': '7 sequenced antibodies'}]},\n",
       "  {'database': 'Antibodypedia',\n",
       "   'id': '3520',\n",
       "   'properties': [{'key': 'antibodies',\n",
       "     'value': '4251 antibodies from 52 providers'}]},\n",
       "  {'database': 'DNASU',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Ensembl',\n",
       "   'id': 'ENST00000377970.6',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ENSP00000367207.3'},\n",
       "    {'key': 'GeneId', 'value': 'ENSG00000136997.21'}],\n",
       "   'isoformId': 'P01106-1'},\n",
       "  {'database': 'Ensembl',\n",
       "   'id': 'ENST00000621592.8',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ENSP00000478887.2'},\n",
       "    {'key': 'GeneId', 'value': 'ENSG00000136997.21'}],\n",
       "   'isoformId': 'P01106-2'},\n",
       "  {'database': 'Ensembl',\n",
       "   'id': 'ENST00000652288.1',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ENSP00000499105.1'},\n",
       "    {'key': 'GeneId', 'value': 'ENSG00000136997.21'}],\n",
       "   'isoformId': 'P01106-1'},\n",
       "  {'database': 'GeneID',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'KEGG',\n",
       "   'id': 'hsa:4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'MANE-Select',\n",
       "   'id': 'ENST00000621592.8',\n",
       "   'properties': [{'key': 'ProteinId', 'value': 'ENSP00000478887.2'},\n",
       "    {'key': 'RefSeqNucleotideId', 'value': 'NM_002467.6'},\n",
       "    {'key': 'RefSeqProteinId', 'value': 'NP_002458.2'}],\n",
       "   'isoformId': 'P01106-2'},\n",
       "  {'database': 'UCSC',\n",
       "   'id': 'uc064qdj.1',\n",
       "   'properties': [{'key': 'OrganismName', 'value': 'human'}],\n",
       "   'isoformId': 'P01106-1'},\n",
       "  {'database': 'AGR',\n",
       "   'id': 'HGNC:7553',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'CTD',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'DisGeNET',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'GeneCards',\n",
       "   'id': 'MYC',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'HGNC',\n",
       "   'id': 'HGNC:7553',\n",
       "   'properties': [{'key': 'GeneName', 'value': 'MYC'}]},\n",
       "  {'database': 'HPA',\n",
       "   'id': 'ENSG00000136997',\n",
       "   'properties': [{'key': 'ExpressionPatterns',\n",
       "     'value': 'Tissue enhanced (adipose tissue, skin)'}]},\n",
       "  {'database': 'MalaCards',\n",
       "   'id': 'MYC',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'MIM',\n",
       "   'id': '113970',\n",
       "   'properties': [{'key': 'Type', 'value': 'phenotype'}]},\n",
       "  {'database': 'MIM',\n",
       "   'id': '190080',\n",
       "   'properties': [{'key': 'Type', 'value': 'gene'}]},\n",
       "  {'database': 'neXtProt',\n",
       "   'id': 'NX_P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'OpenTargets',\n",
       "   'id': 'ENSG00000136997',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Orphanet',\n",
       "   'id': '543',\n",
       "   'properties': [{'key': 'Disease', 'value': 'Burkitt lymphoma'}]},\n",
       "  {'database': 'Orphanet',\n",
       "   'id': '480541',\n",
       "   'properties': [{'key': 'Disease',\n",
       "     'value': 'High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement'}]},\n",
       "  {'database': 'Orphanet',\n",
       "   'id': '99861',\n",
       "   'properties': [{'key': 'Disease',\n",
       "     'value': 'Precursor T-cell acute lymphoblastic leukemia'}]},\n",
       "  {'database': 'PharmGKB',\n",
       "   'id': 'PA31353',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'VEuPathDB',\n",
       "   'id': 'HostDB:ENSG00000136997',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'eggNOG',\n",
       "   'id': 'KOG2483',\n",
       "   'properties': [{'key': 'ToxonomicScope', 'value': 'Eukaryota'}]},\n",
       "  {'database': 'GeneTree',\n",
       "   'id': 'ENSGT00940000155285',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'HOGENOM',\n",
       "   'id': 'CLU_052560_0_0_1',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'InParanoid',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'OMA',\n",
       "   'id': 'EQLRNCC',\n",
       "   'properties': [{'key': 'Fingerprint', 'value': '-'}]},\n",
       "  {'database': 'PhylomeDB',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'TreeFam',\n",
       "   'id': 'TF106001',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BioCyc',\n",
       "   'id': 'MetaCyc:ENSG00000136997-MON',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'PathwayCommons',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-1362277',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Transcription of E2F targets under negative control by DREAM complex'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-201556',\n",
       "   'properties': [{'key': 'PathwayName', 'value': 'Signaling by ALK'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-2122947',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'NOTCH1 Intracellular Domain Regulates Transcription'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-2173796',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-2644606',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Constitutive Signaling by NOTCH1 PEST Domain Mutants'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-2894862',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-4411364',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Binding of TCF/LEF:CTNNB1 to target gene promoters'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-5687128',\n",
       "   'properties': [{'key': 'PathwayName', 'value': 'MAPK6/MAPK4 signaling'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-5689880',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Ub-specific processing proteases'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-6785807',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Interleukin-4 and Interleukin-13 signaling'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-69202',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Cyclin E associated events during G1/S transition'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-69656',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Cyclin A:Cdk2-associated events at S phase entry'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-8866911',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'TFAP2 (AP-2) family regulates transcription of cell cycle factors'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-8951430',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'RUNX3 regulates WNT signaling'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-9018519',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Estrogen-dependent gene expression'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-9616222',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Transcriptional regulation of granulopoiesis'}]},\n",
       "  {'database': 'Reactome',\n",
       "   'id': 'R-HSA-9759194',\n",
       "   'properties': [{'key': 'PathwayName',\n",
       "     'value': 'Nuclear events mediated by NFE2L2'}]},\n",
       "  {'database': 'SignaLink',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'SIGNOR',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'BioGRID-ORCS',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'hits',\n",
       "     'value': '813 hits in 1120 CRISPR screens'}]},\n",
       "  {'database': 'ChiTaRS',\n",
       "   'id': 'MYC',\n",
       "   'properties': [{'key': 'OrganismName', 'value': 'human'}]},\n",
       "  {'database': 'EvolutionaryTrace',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'GeneWiki',\n",
       "   'id': 'Myc',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'GenomeRNAi',\n",
       "   'id': '4609',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Pharos',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'DevelopmentLevel', 'value': 'Tchem'}]},\n",
       "  {'database': 'PRO',\n",
       "   'id': 'PR:P01106',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Proteomes',\n",
       "   'id': 'UP000005640',\n",
       "   'properties': [{'key': 'Component', 'value': 'Chromosome 8'}]},\n",
       "  {'database': 'RNAct',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'moleculeType', 'value': 'protein'}]},\n",
       "  {'database': 'Bgee',\n",
       "   'id': 'ENSG00000136997',\n",
       "   'properties': [{'key': 'ExpressionPatterns',\n",
       "     'value': 'Expressed in upper leg skin and 180 other tissues'}]},\n",
       "  {'database': 'ExpressionAtlas',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'ExpressionPatterns',\n",
       "     'value': 'baseline and differential'}]},\n",
       "  {'database': 'Genevisible',\n",
       "   'id': 'P01106',\n",
       "   'properties': [{'key': 'OrganismId', 'value': 'HS'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000785',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:chromatin'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '12837246'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0071943',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:Myc-Max complex'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IPI:ComplexPortal'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000353',\n",
       "     'source': 'PubMed',\n",
       "     'id': '12553908'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0005730',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:nucleolus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '25775507'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0005654',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:nucleoplasm'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17558397'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0005634',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:nucleus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '11793365'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0032991',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'C:protein-containing complex'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17873522'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0090571',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'C:RNA polymerase II transcription repressor complex'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IPI:ComplexPortal'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000353',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15992821'},\n",
       "    {'evidenceCode': 'ECO:0000353', 'source': 'PubMed', 'id': '18393360'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0001046',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:core promoter sequence-specific DNA binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:ARUK-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '30873824'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0003677',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'F:DNA binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0001228',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:DNA-binding transcription activator activity, RNA polymerase II-specific'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:NTNU_SB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10723141'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '27791094'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0003700',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:DNA-binding transcription factor activity'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000981',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:DNA-binding transcription factor activity, RNA polymerase II-specific'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '25956029'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0140297',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:DNA-binding transcription factor binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IPI:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000353',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15674325'},\n",
       "    {'evidenceCode': 'ECO:0000353', 'source': 'PubMed', 'id': '15674325'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0001227',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:DNA-binding transcription repressor activity, RNA polymerase II-specific'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19786833'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0070888',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'F:E-box binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18818310'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0046983',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:protein dimerization activity'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IEA:InterPro'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0044877',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:protein-containing complex binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18987311'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000978',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:NTNU_SB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10723141'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0001221',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:transcription coregulator binding'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IPI:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000353',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15674325'},\n",
       "    {'evidenceCode': 'ECO:0000353', 'source': 'PubMed', 'id': '15674325'},\n",
       "    {'evidenceCode': 'ECO:0000353', 'source': 'PubMed', 'id': '15674325'},\n",
       "    {'evidenceCode': 'ECO:0000353', 'source': 'PubMed', 'id': '15674325'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0140537',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'F:transcription regulator activator activity'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IEP:DisProt'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000270',\n",
       "     'source': 'PubMed',\n",
       "     'id': '8755740'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0001658',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:branching involved in ureteric bud morphogenesis'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0006879',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:cellular iron ion homeostasis'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0006974',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:cellular response to DNA damage stimulus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17873522'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0071456',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:cellular response to hypoxia'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:CAFA'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15459207'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0034644',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:cellular response to UV'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IEP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000270',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17873522'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0071466',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:cellular response to xenobiotic stimulus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17873522'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '19179467'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0006338',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:chromatin remodeling'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '21533051'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0051276',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:chromosome organization'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0006112',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:energy reserve metabolic process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'NAS:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000303',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0070371',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:ERK1 and ERK2 cascade'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:CAFA'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15459207'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0044346',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:fibroblast apoptotic process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'TAS:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000304',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000082',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:G1/S transition of mitotic cell cycle'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '25438055'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000165',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:MAPK cascade'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17873522'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0043066',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of apoptotic process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0051782',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of cell division'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0048147',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of fibroblast proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0045656',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of monocyte differentiation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0032873',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of stress-activated MAPK cascade'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0000122',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:negative regulation of transcription by RNA polymerase II'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0015671',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:oxygen transport'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'NAS:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000303',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0008284',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of cell population proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:MGI'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15994933'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '19160485'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0043280',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19179467'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:2000573',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of DNA biosynthetic process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:1905643',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of DNA methylation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19786833'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0045893',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of DNA-templated transcription'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '17558397'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '18818310'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0050679',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of epithelial cell proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18987311'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0048146',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of fibroblast proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18987311'},\n",
       "    {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9924025'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0010628',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of gene expression'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:CAFA'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '15459207'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:1902255',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10962037'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0002053',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of mesenchymal cell proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0090096',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of metanephric cap mesenchymal cell proliferation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:1902895',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of miRNA transcription'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:ARUK-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '27791094'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:2001022',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of response to DNA damage stimulus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19179467'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0051973',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of telomerase activity'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:BHF-UCL'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0045944',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:positive regulation of transcription by RNA polymerase II'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:NTNU_SB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '10723141'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0032986',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:protein-DNA complex disassembly'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:CAFA'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19160485'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0010564',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:regulation of cell cycle process'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:ComplexPortal'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '8782822'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0010468',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:regulation of gene expression'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:MGI'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '21447833'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:1904672',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:regulation of somatic stem cell population maintenance'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0032204',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:regulation of telomere maintenance'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000315',\n",
       "     'source': 'PubMed',\n",
       "     'id': '17765874'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0006357',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:regulation of transcription by RNA polymerase II'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IBA:GO_Central'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000318',\n",
       "     'source': 'PubMed',\n",
       "     'id': '21873635'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0010332',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:response to gamma radiation'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000314',\n",
       "     'source': 'PubMed',\n",
       "     'id': '19179467'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0070848',\n",
       "   'properties': [{'key': 'GoTerm', 'value': 'P:response to growth factor'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'TAS:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000304',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18987311'}]},\n",
       "  {'database': 'GO',\n",
       "   'id': 'GO:0009410',\n",
       "   'properties': [{'key': 'GoTerm',\n",
       "     'value': 'P:response to xenobiotic stimulus'},\n",
       "    {'key': 'GoEvidenceType', 'value': 'IEP:UniProtKB'}],\n",
       "   'evidences': [{'evidenceCode': 'ECO:0000270',\n",
       "     'source': 'PubMed',\n",
       "     'id': '18291362'}]},\n",
       "  {'database': 'DisProt',\n",
       "   'id': 'DP00260',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'Gene3D',\n",
       "   'id': '4.10.280.10',\n",
       "   'properties': [{'key': 'EntryName', 'value': '-'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'IDEAL',\n",
       "   'id': 'IID00012',\n",
       "   'properties': [{'key': 'Description', 'value': '-'}]},\n",
       "  {'database': 'InterPro',\n",
       "   'id': 'IPR011598',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'bHLH_dom'}]},\n",
       "  {'database': 'InterPro',\n",
       "   'id': 'IPR036638',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'HLH_DNA-bd_sf'}]},\n",
       "  {'database': 'InterPro',\n",
       "   'id': 'IPR003327',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Myc-LZ'}]},\n",
       "  {'database': 'InterPro',\n",
       "   'id': 'IPR002418',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Tscrpt_reg_Myc'}]},\n",
       "  {'database': 'InterPro',\n",
       "   'id': 'IPR012682',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Tscrpt_reg_Myc_N'}]},\n",
       "  {'database': 'Pfam',\n",
       "   'id': 'PF00010',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'HLH'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'Pfam',\n",
       "   'id': 'PF02344',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Myc-LZ'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'Pfam',\n",
       "   'id': 'PF01056',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Myc_N'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'PIRSF',\n",
       "   'id': 'PIRSF001705',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'Myc_protein'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'PRINTS',\n",
       "   'id': 'PR00044',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'LEUZIPPRMYC'}]},\n",
       "  {'database': 'SMART',\n",
       "   'id': 'SM00353',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'HLH'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'SUPFAM',\n",
       "   'id': 'SSF47459',\n",
       "   'properties': [{'key': 'EntryName',\n",
       "     'value': 'HLH, helix-loop-helix DNA-binding domain'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]},\n",
       "  {'database': 'PROSITE',\n",
       "   'id': 'PS50888',\n",
       "   'properties': [{'key': 'EntryName', 'value': 'BHLH'},\n",
       "    {'key': 'MatchStatus', 'value': '1'}]}],\n",
       " 'sequence': {'value': 'MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA',\n",
       "  'length': 439,\n",
       "  'molWeight': 48804,\n",
       "  'crc64': 'ED5C028029A4C5D1',\n",
       "  'md5': 'FC5B2496C9FC9D11EC7387583745EF41'},\n",
       " 'extraAttributes': {'countByCommentType': {'FUNCTION': 1,\n",
       "   'SUBUNIT': 1,\n",
       "   'INTERACTION': 67,\n",
       "   'SUBCELLULAR LOCATION': 1,\n",
       "   'ALTERNATIVE PRODUCTS': 2,\n",
       "   'DOMAIN': 1,\n",
       "   'PTM': 2,\n",
       "   'DISEASE': 2,\n",
       "   'BIOTECHNOLOGY': 1,\n",
       "   'MISCELLANEOUS': 1,\n",
       "   'WEB RESOURCE': 3},\n",
       "  'countByFeatureType': {'Chain': 1,\n",
       "   'Domain': 1,\n",
       "   'Region': 2,\n",
       "   'Motif': 1,\n",
       "   'Compositional bias': 1,\n",
       "   'Modified residue': 15,\n",
       "   'Glycosylation': 1,\n",
       "   'Cross-link': 4,\n",
       "   'Alternative sequence': 1,\n",
       "   'Natural variant': 8,\n",
       "   'Mutagenesis': 4,\n",
       "   'Sequence conflict': 15,\n",
       "   'Helix': 5},\n",
       "  'uniParcId': 'UPI0000000C1A'}}"
      ]
     },
     "execution_count": 169,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "data"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "bedb6d16",
   "metadata": {},
   "source": [
    "## Trying to download uniprot json files and alphafold files"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 170,
   "id": "961bc8fb",
   "metadata": {},
   "outputs": [],
   "source": [
    "import urllib"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 233,
   "id": "1a61e8d6",
   "metadata": {},
   "outputs": [],
   "source": [
    "def download_uniprot_json_file(uni_prot_id, workdir = '.'):\n",
    "    #check if there is uniprot information available for the protein\n",
    "    try:\n",
    "        url_2 = 'https://www.uniprot.org/uniprot/' + uni_prot_id + '.json'\n",
    "        html_2 = urllib.request.urlopen(url_2)\n",
    "        #print(html_2)\n",
    "        # now try and write to file\n",
    "        f = open(os.path.join(workdir,uni_prot_id)+'.json', 'w')\n",
    "        f.write(lines.decode('utf-8'))\n",
    "        f.close()\n",
    "        \n",
    "    except Exception as e:\n",
    "        raise Exception('Failed to obtain UNIPROT data. %s'%e)\n",
    "    \n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 51,
   "id": "4d9151d6",
   "metadata": {},
   "outputs": [],
   "source": [
    "def download_alpha_fold_pdbs(uniprot_id_list, workdir = '.'):\n",
    "    counter = 0\n",
    "    for uniprot_id in uniprot_id_list:\n",
    "        print(f\"At entry {counter}/{len(uniprot_id_list)}\")\n",
    "        print(f\"ID: {uniprot_id}\")\n",
    "        download = f\"https://alphafold.ebi.ac.uk/files/AF-{uniprot_id}-F1-model_v2.pdb\"\n",
    "        \n",
    "        try:\n",
    "            file_name = os.path.join(workdir,f'AF-{uniprot_id}-F1-model_v2.pdb')\n",
    "            #file_name = f\"../data/alphafold/pdb_files/AF-{uniprot_id}-F1-model_v2.pdb\"\n",
    "            urllib.request.urlretrieve(download, file_name)\n",
    "        except urllib.error.HTTPError:\n",
    "            print(\"No such file.\")\n",
    "        counter = counter+1"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "507aa561",
   "metadata": {},
   "source": [
    "## Let's try the workflow on one uniprot id"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 236,
   "id": "da343b49",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "At entry 0/1\n",
      "ID: P01106\n"
     ]
    }
   ],
   "source": [
    "# Downloading uniprot file and alphafold file\n",
    "download_uniprot_json_file('P01106', 'temp')\n",
    "download_alpha_fold_pdbs(['P01106'], workdir ='temp')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 237,
   "id": "0051069c",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "['-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'S' 'S' 'S' 'S' 'S' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'T' 'T' 'S' 'T' 'T' 'T' 'G' 'G'\n",
      " 'G' 'S' '-' 'S' '-' '-' '-' '-' '-' '-' 'G' 'G' 'G' 'T' 'T' 'T' 'T' 'T'\n",
      " 'T' 'S' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' '-'\n",
      " 'S' '-' '-' '-' 'S' '-' '-' '-' '-' '-' 'T' 'T' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'S' 'T' 'T' 'T' 'S' '-' '-' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'T' 'T' 'S' '-' 'S' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' 'T' 'T' 'S' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'T' 'T' '-' '-' '-' '-' 'H' 'H' 'H' 'H' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' 'T' 'T' 'S' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-' '-'\n",
      " '-' '-' '-' 'T' 'T' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'T' 'T' 'S' 'T' 'T' 'T' 'T' 'T' '-' 'T' 'T' '-' '-' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H' 'H'\n",
      " 'H' 'H' 'H' 'H' 'H' '-' '-']\n"
     ]
    }
   ],
   "source": [
    "# get secondary structure from alphafold file\n",
    "p = 'temp/AF-P01106-F1-model_v2.pdb'\n",
    "sec_struc_output = get_sec_struct(p, '/Users/toni_brain/miniconda3/envs/dssp//bin/mkdssp')\n",
    "print(sec_struc_output)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 256,
   "id": "5ea2c4fe",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "P01106\n",
      "MYC\n",
      "NP_002458.2\n",
      "MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA\n"
     ]
    }
   ],
   "source": [
    "# Process uniprot file\n",
    "f = open('temp/P01106.json')\n",
    "data = json.load(f)\n",
    "f.close()\n",
    "# Some basics:\n",
    "uni_id = data['primaryAccession'] \n",
    "print(uni_id)\n",
    "gene_name = data['genes'][0]['geneName']['value']\n",
    "print(gene_name)\n",
    "ref_seq_id = 0\n",
    "for db in new_data['uniProtKBCrossReferences']:\n",
    "    if db['database'] == \"RefSeq\":\n",
    "        ref_seq_id = (db['id'])\n",
    "print(ref_seq_id)\n",
    "sequence = data['sequence']['value']\n",
    "print(sequence)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "16c5f1ad",
   "metadata": {},
   "source": [
    "## Check that sequence is the same length as secondary_structure_output!!"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 254,
   "id": "b2b78438",
   "metadata": {},
   "outputs": [],
   "source": [
    "# Let's get the Helix regions:\n",
    "alpha_helix_index_list = get_alpha_helix_length_and_location(sec_struc_output, min_length=7)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 259,
   "id": "bc77dd40",
   "metadata": {},
   "outputs": [],
   "source": [
    "firstAA_position_in_HELIDR = alpha_helix_index_list[0][0]+1\n",
    "lastAA_position_in_HELIDR = alpha_helix_index_list[0][-1]+1"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 270,
   "id": "385e2af7",
   "metadata": {},
   "outputs": [],
   "source": [
    "HELIDR_seq = sequence[alpha_helix_index_list[0][0]:alpha_helix_index_list[0][-1]+1]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 303,
   "id": "3fd4294d",
   "metadata": {},
   "outputs": [],
   "source": [
    "# Note the +2 here does not include the last helix AA. \n",
    "# We have to make sure here that we check the arrays are not out of bounds!\n",
    "down_stream_seq = sequence[alpha_helix_index_list[0][-1]+2:alpha_helix_index_list[0][-1]+12]\n",
    "up_stream_seq = sequence[alpha_helix_index_list[0][0]-10:alpha_helix_index_list[0][0]]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 312,
   "id": "0470e776",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "down_stream_seq DMVNQSFICD\n",
      "up_stream_seq DNDGGGGSFS\n"
     ]
    }
   ],
   "source": [
    "print('down_stream_seq',down_stream_seq)\n",
    "print('up_stream_seq', up_stream_seq)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 315,
   "id": "be923f89",
   "metadata": {},
   "outputs": [],
   "source": [
    "def count_serines(sequence):\n",
    "    n_serine = sequence.count('S')\n",
    "    if n_serine >=2:\n",
    "        return 1\n",
    "    else:\n",
    "        return 0"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 322,
   "id": "a0b89aa3",
   "metadata": {},
   "outputs": [],
   "source": [
    "Two_S5P_down = count_serines(down_stream_seq[:5])\n",
    "Two_S5P_up = count_serines(up_stream_seq[5:])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 323,
   "id": "d87bcdff",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0\n",
      "1\n"
     ]
    }
   ],
   "source": [
    "print(Two_S5P_down)\n",
    "print(Two_S5P_up)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 311,
   "id": "b6ed4d7d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'DNDGGGGSFS'"
      ]
     },
     "execution_count": 311,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "up_stream_seq"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 297,
   "id": "8320ff21",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array(['H', 'H', 'H', 'H', 'H', 'H', 'H', 'H', 'H', 'H', 'H', 'H', 'H'],\n",
       "      dtype='<U1')"
      ]
     },
     "execution_count": 297,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "sec_struc_output[alpha_helix_index_list[0][0]:alpha_helix_index_list[0][-1]+1]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "0243bcc4",
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3 (ipykernel)",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.11.0"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}