diff --git a/cypress/e2e/models/migration/dynamic-report/issues/issues.ts b/cypress/e2e/models/migration/dynamic-report/issues/issues.ts
index 394a8cedb..724f92bd9 100644
--- a/cypress/e2e/models/migration/dynamic-report/issues/issues.ts
+++ b/cypress/e2e/models/migration/dynamic-report/issues/issues.ts
@@ -24,6 +24,7 @@ import {
 } from "../../../../types/constants";
 import { navMenu } from "../../../../views/menu.view";
 import {
+    affectedFilesTable,
     issueColumns,
     searchMenuToggle,
     singleAppDropList,
@@ -168,6 +169,32 @@ export class Issues {
         });
     }
 
+    /**
+     * Opens the side drawer that contains all the affected files of an issue
+     * @param issueName
+     */
+    public static openAffectedFiles(issueName: string): void {
+        performWithin(issueName, () => {
+            cy.get(singleApplicationColumns.files).within(() => {
+                cy.get(button).click({ force: true });
+            });
+        });
+    }
+
+    /**
+     * Opens the dialog of a single file affected by an Issue
+     * @param fileName
+     * @param issueName
+     */
+    public static openAffectedFile(fileName: string, issueName?: string): void {
+        if (issueName) {
+            Issues.openAffectedFiles(issueName);
+        }
+        cy.get(affectedFilesTable).within(() => {
+            cy.contains(fileName).click();
+        });
+    }
+
     public static validateAllFields(issue: AppIssue): void {
         const sections = {
             totalAffectedApps: "Total affected",
diff --git a/cypress/e2e/tests/migration/applicationinventory/analysis/gradle_analysis.ts b/cypress/e2e/tests/migration/applicationinventory/analysis/gradle_analysis.ts
index 23c4aa688..d1266c712 100644
--- a/cypress/e2e/tests/migration/applicationinventory/analysis/gradle_analysis.ts
+++ b/cypress/e2e/tests/migration/applicationinventory/analysis/gradle_analysis.ts
@@ -25,6 +25,7 @@ import {
 import { Analysis } from "../../../../models/migration/applicationinventory/analysis";
 import { AnalysisStatuses } from "../../../../types/constants";
 import { Application } from "../../../../models/migration/applicationinventory/application";
+import { Issues } from "../../../../models/migration/dynamic-report/issues/issues";
 
 const applications: Analysis[] = [];
 
@@ -65,7 +66,31 @@ describe(["@tier2"], "Gradle Analysis", () => {
         application.verifyEffort(application.effort);
     });
 
+    // Automates TC 546
+    it("Bug MTA-3780: Analysis for Gradle JMH application with Open Source libraries", function () {
+        const application = new Analysis(
+            getRandomApplicationData("JMH Gradle OS libs", {
+                sourceData: this.appData["jmh-gradle-example"],
+            }),
+            {
+                source: "Source code + dependencies",
+                target: [],
+                openSourceLibraries: true,
+            }
+        );
+        application.customRule = ["jmh-gradle-serializable-test-rule.yaml"];
+        application.create();
+        applications.push(application);
+        cy.wait("@getApplication");
+        application.analyze();
+        application.verifyAnalysisStatus(AnalysisStatuses.completed);
+        Issues.openSingleApplication(application.name);
+        // Checks that an incident was raised in an open source library with the provided custom rule
+        Issues.openAffectedFile("AbstractRealDistribution.java", "Serializable reference test");
+    });
+
     after("Clear data", function () {
+        Application.open(true);
         deleteByList(applications);
     });
 });
diff --git a/cypress/e2e/views/issue.view.ts b/cypress/e2e/views/issue.view.ts
index b831eaecb..3e2a14c64 100644
--- a/cypress/e2e/views/issue.view.ts
+++ b/cypress/e2e/views/issue.view.ts
@@ -5,6 +5,7 @@ export const archetypeFilterName = "input[class='pf-v5-c-text-input-group__text-
 export const searchMenuToggle = 'button[aria-label="Menu toggle"]';
 export const singleAppDropList = "#application-select";
 export const rightSideBar = "div.pf-v5-c-drawer__panel-main";
+export const affectedFilesTable = "table[aria-label='Affected files table']";
 export enum singleApplicationColumns {
     issue = 'td[data-label="Issue"]',
     category = 'td[data-label="Category"]',
diff --git a/cypress/fixtures/yaml/jmh-gradle-serializable-test-rule.yaml b/cypress/fixtures/yaml/jmh-gradle-serializable-test-rule.yaml
new file mode 100644
index 000000000..c1dac1520
--- /dev/null
+++ b/cypress/fixtures/yaml/jmh-gradle-serializable-test-rule.yaml
@@ -0,0 +1,10 @@
+- category: mandatory
+  customVariables: []
+  description: Serializable reference test rule for https://github.com/melix/jmh-gradle-example
+  effort: 1
+  message: |-
+    Serializable reference test rule for https://github.com/melix/jmh-gradle-example
+  ruleID: serializable-reference-test-rule-jmh-gradle
+  when:
+    java.referenced:
+      pattern: java.io.Serializable